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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 16950

FusionGeneSummary for HTT_GRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: HTT_GRK4
Fusion gene ID: 16950
HgeneTgene
Gene symbol

HTT

GRK4

Gene ID

6532

2868

Gene namesolute carrier family 6 member 4G protein-coupled receptor kinase 4
Synonyms5-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|SERT1|hSERTGPRK2L|GPRK4|GRK4a|IT11
Cytomap

17q11.2

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent serotonin transporter5-hydroxytryptamine (serotonin) transporter5HT transporterNa+/Cl- dependent serotonin transporterserotonin transporter 1solute carrier family 6 (neurotransmitter transporter), member 4solute carrier family 6 (neG protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like
Modification date2018052720180519
UniProtAcc

P42858

P32298

Ensembl transtripts involved in fusion geneENST00000355072, ENST00000513806, 
ENST00000398051, ENST00000398052, 
ENST00000504933, ENST00000345167, 
ENST00000503518, ENST00000442472, 
ENST00000509545, 
Fusion gene scores* DoF score8 X 12 X 8=7684 X 7 X 6=168
# samples 127
** MAII scorelog2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HTT [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHTT

GO:0006837

serotonin transport

19270731

HgeneHTT

GO:0009636

response to toxic substance

17575980

HgeneHTT

GO:0015844

monoamine transport

16024787

HgeneHTT

GO:0051610

serotonin uptake

8987735|16870614|17506858|18227069|19270731

TgeneGRK4

GO:0031623

receptor internalization

20074556


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-CU-A3QU-01AHTTchr4

3132150

+GRK4chr4

3015415

+
TCGALDLIHCTCGA-BC-A10R-01AHTTchr4

3127356

+GRK4chr4

3029639

+
TCGARVLUSCTCGA-98-7454-01AHTTchr4

3101121

+GRK4chr4

3021368

+
TCGALDUCECTCGA-DI-A2QY-01AHTTchr4

3076815

+GRK4chr4

3042299

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355072ENST00000398051HTTchr4

3132150

+GRK4chr4

3015415

+
In-frameENST00000355072ENST00000398052HTTchr4

3132150

+GRK4chr4

3015415

+
In-frameENST00000355072ENST00000504933HTTchr4

3132150

+GRK4chr4

3015415

+
In-frameENST00000355072ENST00000345167HTTchr4

3132150

+GRK4chr4

3015415

+
5CDS-intronENST00000355072ENST00000503518HTTchr4

3132150

+GRK4chr4

3015415

+
5CDS-intronENST00000355072ENST00000442472HTTchr4

3132150

+GRK4chr4

3015415

+
5CDS-intronENST00000355072ENST00000509545HTTchr4

3132150

+GRK4chr4

3015415

+
intron-3CDSENST00000513806ENST00000398051HTTchr4

3132150

+GRK4chr4

3015415

+
intron-3CDSENST00000513806ENST00000398052HTTchr4

3132150

+GRK4chr4

3015415

+
intron-3CDSENST00000513806ENST00000504933HTTchr4

3132150

+GRK4chr4

3015415

+
intron-3CDSENST00000513806ENST00000345167HTTchr4

3132150

+GRK4chr4

3015415

+
intron-intronENST00000513806ENST00000503518HTTchr4

3132150

+GRK4chr4

3015415

+
intron-intronENST00000513806ENST00000442472HTTchr4

3132150

+GRK4chr4

3015415

+
intron-intronENST00000513806ENST00000509545HTTchr4

3132150

+GRK4chr4

3015415

+
In-frameENST00000355072ENST00000398051HTTchr4

3127356

+GRK4chr4

3029639

+
In-frameENST00000355072ENST00000398052HTTchr4

3127356

+GRK4chr4

3029639

+
In-frameENST00000355072ENST00000504933HTTchr4

3127356

+GRK4chr4

3029639

+
In-frameENST00000355072ENST00000345167HTTchr4

3127356

+GRK4chr4

3029639

+
5CDS-intronENST00000355072ENST00000503518HTTchr4

3127356

+GRK4chr4

3029639

+
5CDS-intronENST00000355072ENST00000442472HTTchr4

3127356

+GRK4chr4

3029639

+
5CDS-intronENST00000355072ENST00000509545HTTchr4

3127356

+GRK4chr4

3029639

+
intron-3CDSENST00000513806ENST00000398051HTTchr4

3127356

+GRK4chr4

3029639

+
intron-3CDSENST00000513806ENST00000398052HTTchr4

3127356

+GRK4chr4

3029639

+
intron-3CDSENST00000513806ENST00000504933HTTchr4

3127356

+GRK4chr4

3029639

+
intron-3CDSENST00000513806ENST00000345167HTTchr4

3127356

+GRK4chr4

3029639

+
intron-intronENST00000513806ENST00000503518HTTchr4

3127356

+GRK4chr4

3029639

+
intron-intronENST00000513806ENST00000442472HTTchr4

3127356

+GRK4chr4

3029639

+
intron-intronENST00000513806ENST00000509545HTTchr4

3127356

+GRK4chr4

3029639

+
In-frameENST00000355072ENST00000398051HTTchr4

3101121

+GRK4chr4

3021368

+
In-frameENST00000355072ENST00000398052HTTchr4

3101121

+GRK4chr4

3021368

+
In-frameENST00000355072ENST00000504933HTTchr4

3101121

+GRK4chr4

3021368

+
In-frameENST00000355072ENST00000345167HTTchr4

3101121

+GRK4chr4

3021368

+
5CDS-intronENST00000355072ENST00000503518HTTchr4

3101121

+GRK4chr4

3021368

+
5CDS-intronENST00000355072ENST00000442472HTTchr4

3101121

+GRK4chr4

3021368

+
5CDS-intronENST00000355072ENST00000509545HTTchr4

3101121

+GRK4chr4

3021368

+
intron-3CDSENST00000513806ENST00000398051HTTchr4

3101121

+GRK4chr4

3021368

+
intron-3CDSENST00000513806ENST00000398052HTTchr4

3101121

+GRK4chr4

3021368

+
intron-3CDSENST00000513806ENST00000504933HTTchr4

3101121

+GRK4chr4

3021368

+
intron-3CDSENST00000513806ENST00000345167HTTchr4

3101121

+GRK4chr4

3021368

+
intron-intronENST00000513806ENST00000503518HTTchr4

3101121

+GRK4chr4

3021368

+
intron-intronENST00000513806ENST00000442472HTTchr4

3101121

+GRK4chr4

3021368

+
intron-intronENST00000513806ENST00000509545HTTchr4

3101121

+GRK4chr4

3021368

+
Frame-shiftENST00000355072ENST00000398051HTTchr4

3076815

+GRK4chr4

3042299

+
Frame-shiftENST00000355072ENST00000398052HTTchr4

3076815

+GRK4chr4

3042299

+
Frame-shiftENST00000355072ENST00000504933HTTchr4

3076815

+GRK4chr4

3042299

+
Frame-shiftENST00000355072ENST00000345167HTTchr4

3076815

+GRK4chr4

3042299

+
5CDS-intronENST00000355072ENST00000503518HTTchr4

3076815

+GRK4chr4

3042299

+
5CDS-intronENST00000355072ENST00000442472HTTchr4

3076815

+GRK4chr4

3042299

+
5CDS-intronENST00000355072ENST00000509545HTTchr4

3076815

+GRK4chr4

3042299

+
intron-3CDSENST00000513806ENST00000398051HTTchr4

3076815

+GRK4chr4

3042299

+
intron-3CDSENST00000513806ENST00000398052HTTchr4

3076815

+GRK4chr4

3042299

+
intron-3CDSENST00000513806ENST00000504933HTTchr4

3076815

+GRK4chr4

3042299

+
intron-3CDSENST00000513806ENST00000345167HTTchr4

3076815

+GRK4chr4

3042299

+
intron-intronENST00000513806ENST00000503518HTTchr4

3076815

+GRK4chr4

3042299

+
intron-intronENST00000513806ENST00000442472HTTchr4

3076815

+GRK4chr4

3042299

+
intron-intronENST00000513806ENST00000509545HTTchr4

3076815

+GRK4chr4

3042299

+

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FusionProtFeatures for HTT_GRK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HTT

P42858

GRK4

P32298

May play a role in microtubule-mediated transport orvesicle function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+36718_381563143Compositional biasNote=Poly-Gln
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+36739_491563143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+36763_781563143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+116718_384673143Compositional biasNote=Poly-Gln
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+116739_494673143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+116763_784673143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+146718_386623143Compositional biasNote=Poly-Gln
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+146739_496623143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+146763_786623143Compositional biasNote=Poly-Pro
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167204_2414673143RepeatNote=HEAT 1
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167246_2834673143RepeatNote=HEAT 2
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167316_3604673143RepeatNote=HEAT 3
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467204_2416623143RepeatNote=HEAT 1
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467246_2836623143RepeatNote=HEAT 2
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467316_3606623143RepeatNote=HEAT 3
TgeneGRK4chr4:3101121chr4:3021368ENST00000345167+615450_515215547DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000398051+614450_515215501DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000398052+716450_515247579DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000504933+715450_515247533DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000345167+815450_515291547DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000398051+814450_515291501DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000398052+916450_515323579DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000504933+915450_515323533DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000345167+515187_449168547DomainProtein kinase
TgeneGRK4chr4:3132150chr4:3015415ENST00000345167+515450_515168547DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000398051+514187_449168501DomainProtein kinase
TgeneGRK4chr4:3132150chr4:3015415ENST00000398051+514450_515168501DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000398052+616450_515200579DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000504933+615450_515200533DomainNote=AGC-kinase C-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000345167+515193_201168547Nucleotide bindingATP
TgeneGRK4chr4:3132150chr4:3015415ENST00000398051+514193_201168501Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+3671437_14401563143Compositional biasNote=Poly-Thr
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+3672341_23451563143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+3672638_26431563143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+11671437_14404673143Compositional biasNote=Poly-Thr
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+11672341_23454673143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+11672638_26434673143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+14671437_14406623143Compositional biasNote=Poly-Thr
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+14672341_23456623143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+14672638_26436623143Compositional biasNote=Poly-Glu
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+3672395_24041563143MotifNuclear export signal
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+11672395_24044673143MotifNuclear export signal
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+14672395_24046623143MotifNuclear export signal
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367204_2411563143RepeatNote=HEAT 1
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367246_2831563143RepeatNote=HEAT 2
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367316_3601563143RepeatNote=HEAT 3
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367802_8391563143RepeatNote=HEAT 4
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367902_9401563143RepeatNote=HEAT 5
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167802_8394673143RepeatNote=HEAT 4
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167902_9404673143RepeatNote=HEAT 5
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467802_8396623143RepeatNote=HEAT 4
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467902_9406623143RepeatNote=HEAT 5
TgeneGRK4chr4:3101121chr4:3021368ENST00000345167+615187_449215547DomainProtein kinase
TgeneGRK4chr4:3101121chr4:3021368ENST00000345167+61552_172215547DomainRGS
TgeneGRK4chr4:3101121chr4:3021368ENST00000398051+614187_449215501DomainProtein kinase
TgeneGRK4chr4:3101121chr4:3021368ENST00000398051+61452_172215501DomainRGS
TgeneGRK4chr4:3101121chr4:3021368ENST00000398052+716187_449247579DomainProtein kinase
TgeneGRK4chr4:3101121chr4:3021368ENST00000398052+71652_172247579DomainRGS
TgeneGRK4chr4:3101121chr4:3021368ENST00000504933+715187_449247533DomainProtein kinase
TgeneGRK4chr4:3101121chr4:3021368ENST00000504933+71552_172247533DomainRGS
TgeneGRK4chr4:3127356chr4:3029639ENST00000345167+815187_449291547DomainProtein kinase
TgeneGRK4chr4:3127356chr4:3029639ENST00000345167+81552_172291547DomainRGS
TgeneGRK4chr4:3127356chr4:3029639ENST00000398051+814187_449291501DomainProtein kinase
TgeneGRK4chr4:3127356chr4:3029639ENST00000398051+81452_172291501DomainRGS
TgeneGRK4chr4:3127356chr4:3029639ENST00000398052+916187_449323579DomainProtein kinase
TgeneGRK4chr4:3127356chr4:3029639ENST00000398052+91652_172323579DomainRGS
TgeneGRK4chr4:3127356chr4:3029639ENST00000504933+915187_449323533DomainProtein kinase
TgeneGRK4chr4:3127356chr4:3029639ENST00000504933+91552_172323533DomainRGS
TgeneGRK4chr4:3132150chr4:3015415ENST00000345167+51552_172168547DomainRGS
TgeneGRK4chr4:3132150chr4:3015415ENST00000398051+51452_172168501DomainRGS
TgeneGRK4chr4:3132150chr4:3015415ENST00000398052+616187_449200579DomainProtein kinase
TgeneGRK4chr4:3132150chr4:3015415ENST00000398052+61652_172200579DomainRGS
TgeneGRK4chr4:3132150chr4:3015415ENST00000504933+615187_449200533DomainProtein kinase
TgeneGRK4chr4:3132150chr4:3015415ENST00000504933+61552_172200533DomainRGS
TgeneGRK4chr4:3101121chr4:3021368ENST00000345167+615193_201215547Nucleotide bindingATP
TgeneGRK4chr4:3101121chr4:3021368ENST00000398051+614193_201215501Nucleotide bindingATP
TgeneGRK4chr4:3101121chr4:3021368ENST00000398052+716193_201247579Nucleotide bindingATP
TgeneGRK4chr4:3101121chr4:3021368ENST00000504933+715193_201247533Nucleotide bindingATP
TgeneGRK4chr4:3127356chr4:3029639ENST00000345167+815193_201291547Nucleotide bindingATP
TgeneGRK4chr4:3127356chr4:3029639ENST00000398051+814193_201291501Nucleotide bindingATP
TgeneGRK4chr4:3127356chr4:3029639ENST00000398052+916193_201323579Nucleotide bindingATP
TgeneGRK4chr4:3127356chr4:3029639ENST00000504933+915193_201323533Nucleotide bindingATP
TgeneGRK4chr4:3132150chr4:3015415ENST00000398052+616193_201200579Nucleotide bindingATP
TgeneGRK4chr4:3132150chr4:3015415ENST00000504933+615193_201200533Nucleotide bindingATP
TgeneGRK4chr4:3101121chr4:3021368ENST00000345167+6151_154215547RegionNote=N-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000398051+6141_154215501RegionNote=N-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000398052+7161_154247579RegionNote=N-terminal
TgeneGRK4chr4:3101121chr4:3021368ENST00000504933+7151_154247533RegionNote=N-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000345167+8151_154291547RegionNote=N-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000398051+8141_154291501RegionNote=N-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000398052+9161_154323579RegionNote=N-terminal
TgeneGRK4chr4:3127356chr4:3029639ENST00000504933+9151_154323533RegionNote=N-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000345167+5151_154168547RegionNote=N-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000398051+5141_154168501RegionNote=N-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000398052+6161_154200579RegionNote=N-terminal
TgeneGRK4chr4:3132150chr4:3015415ENST00000504933+6151_154200533RegionNote=N-terminal


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FusionGeneSequence for HTT_GRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398051_chr4_3015415_+_995aa
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKK
ELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAP
RSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTA
AGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL
TLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA
LEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAV
PSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLL
KNMSHCRQPSDSSVDKFVLRDEATEPGDQENKVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKD
ALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVG
TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGE
GAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVE

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398052_chr4_3015415_+_1041aa
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKK
ELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAP
RSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTA
AGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL
TLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA
LEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAV
PSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLL
KNMSHCRQPSDSSVDKFVLRDEATEPGDQENKVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKD
ALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVG
TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGE
GAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKS

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000504933_chr4_3015415_+_995aa
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKK
ELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAP
RSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTA
AGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL
TLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA
LEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAV
PSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLL
KNMSHCRQPSDSSVDKFVLRDEATEPGDQENKVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKD
ALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVG
TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGE
GAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVE

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000345167_chr4_3015415_+_1041aa
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKK
ELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAP
RSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTA
AGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL
TLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA
LEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAV
PSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLL
KNMSHCRQPSDSSVDKFVLRDEATEPGDQENKVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKD
ALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVG
TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGE
GAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398051_chr4_3015415_+_2985nt
ATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGAGTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCCGCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCG
CTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCCCCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAA
GAACTTTCAGCTACCAAGAAAGACCGTGTGAATCATTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAA
TTTCAGAAACTTCTGGGCATCGCTATGGAACTTTTTCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGC
CTCAACAAAGTTATCAAAGCTTTGATGGATTCTAATCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCT
CGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGAGCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTG
CCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGAATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGC
AATTTTGCAAATGACAATGAAATTAAGGTTTTGTTAAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCG
GCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAGAAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTT
CCTGTCGAGGATGAACACTCCACTCTGCTGATTCTTGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAG
GACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAGGAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTG
ACGTTACATCATACACAGCACCAAGACCACAATGTTGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAG
CTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGGGCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATT
GTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAGCCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCC
TTGGAGGATGACTCTGAATCGAGATCGGATGTCAGCAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCT
TCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCATGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTG
GATCTGGCCAGCTGTGACTTGACAAGCTCTGCCACTGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTC
CCATCTGACCCTGCCATGGACCTGAATGATGGGACCCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGAT
TCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGTGTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGAT
GAAGATGAGGAAGCCACAGGTATTCTTCCTGATGAAGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTG
AAAAACATGAGTCACTGCAGGCAGCCTTCTGACAGCAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAA
AACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGGAAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGT
GAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGAGAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGAT
GCCTTGTGCTTGGTGCTCACCATTATGAATGGAGGGGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGA
GCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTTGGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATT
CTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGA
ACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAA
ATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAG
TATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAG
GGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCT
GATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGAC
TTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAA

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398052_chr4_3015415_+_3123nt
ATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGAGTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCCGCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCG
CTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCCCCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAA
GAACTTTCAGCTACCAAGAAAGACCGTGTGAATCATTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAA
TTTCAGAAACTTCTGGGCATCGCTATGGAACTTTTTCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGC
CTCAACAAAGTTATCAAAGCTTTGATGGATTCTAATCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCT
CGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGAGCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTG
CCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGAATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGC
AATTTTGCAAATGACAATGAAATTAAGGTTTTGTTAAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCG
GCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAGAAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTT
CCTGTCGAGGATGAACACTCCACTCTGCTGATTCTTGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAG
GACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAGGAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTG
ACGTTACATCATACACAGCACCAAGACCACAATGTTGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAG
CTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGGGCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATT
GTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAGCCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCC
TTGGAGGATGACTCTGAATCGAGATCGGATGTCAGCAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCT
TCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCATGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTG
GATCTGGCCAGCTGTGACTTGACAAGCTCTGCCACTGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTC
CCATCTGACCCTGCCATGGACCTGAATGATGGGACCCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGAT
TCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGTGTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGAT
GAAGATGAGGAAGCCACAGGTATTCTTCCTGATGAAGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTG
AAAAACATGAGTCACTGCAGGCAGCCTTCTGACAGCAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAA
AACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGGAAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGT
GAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGAGAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGAT
GCCTTGTGCTTGGTGCTCACCATTATGAATGGAGGGGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGA
GCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTTGGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATT
CTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGA
ACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAA
ATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAG
TATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAG
GGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCT
GATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGAC
TTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGT
GAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAAGAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTC

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000504933_chr4_3015415_+_2985nt
ATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGAGTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCCGCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCG
CTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCCCCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAA
GAACTTTCAGCTACCAAGAAAGACCGTGTGAATCATTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAA
TTTCAGAAACTTCTGGGCATCGCTATGGAACTTTTTCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGC
CTCAACAAAGTTATCAAAGCTTTGATGGATTCTAATCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCT
CGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGAGCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTG
CCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGAATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGC
AATTTTGCAAATGACAATGAAATTAAGGTTTTGTTAAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCG
GCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAGAAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTT
CCTGTCGAGGATGAACACTCCACTCTGCTGATTCTTGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAG
GACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAGGAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTG
ACGTTACATCATACACAGCACCAAGACCACAATGTTGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAG
CTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGGGCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATT
GTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAGCCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCC
TTGGAGGATGACTCTGAATCGAGATCGGATGTCAGCAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCT
TCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCATGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTG
GATCTGGCCAGCTGTGACTTGACAAGCTCTGCCACTGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTC
CCATCTGACCCTGCCATGGACCTGAATGATGGGACCCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGAT
TCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGTGTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGAT
GAAGATGAGGAAGCCACAGGTATTCTTCCTGATGAAGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTG
AAAAACATGAGTCACTGCAGGCAGCCTTCTGACAGCAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAA
AACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGGAAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGT
GAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGAGAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGAT
GCCTTGTGCTTGGTGCTCACCATTATGAATGGAGGGGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGA
GCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTTGGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATT
CTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGA
ACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAA
ATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAG
TATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAG
GGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCT
GATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGAC
TTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAA

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000345167_chr4_3015415_+_3123nt
ATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGAGTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCCGCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCG
CTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCCCCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAA
GAACTTTCAGCTACCAAGAAAGACCGTGTGAATCATTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAA
TTTCAGAAACTTCTGGGCATCGCTATGGAACTTTTTCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGC
CTCAACAAAGTTATCAAAGCTTTGATGGATTCTAATCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCT
CGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGAGCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTG
CCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGAATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGC
AATTTTGCAAATGACAATGAAATTAAGGTTTTGTTAAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCG
GCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAGAAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTT
CCTGTCGAGGATGAACACTCCACTCTGCTGATTCTTGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAG
GACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAGGAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTG
ACGTTACATCATACACAGCACCAAGACCACAATGTTGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAG
CTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGGGCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATT
GTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAGCCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCC
TTGGAGGATGACTCTGAATCGAGATCGGATGTCAGCAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCT
TCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCATGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTG
GATCTGGCCAGCTGTGACTTGACAAGCTCTGCCACTGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTC
CCATCTGACCCTGCCATGGACCTGAATGATGGGACCCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGAT
TCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGTGTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGAT
GAAGATGAGGAAGCCACAGGTATTCTTCCTGATGAAGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTG
AAAAACATGAGTCACTGCAGGCAGCCTTCTGACAGCAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAA
AACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGGAAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGT
GAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGAGAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGAT
GCCTTGTGCTTGGTGCTCACCATTATGAATGGAGGGGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGA
GCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTTGGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATT
CTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGA
ACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAA
ATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAG
TATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAG
GGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCT
GATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGAC
TTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGT
GAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAAGAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398051_chr4_3015415_+_3232nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGG
AAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGTGAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGA
GAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGATGCCTTGTGCTTGGTGCTCACCATTATGAATGGAGG
GGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGAGCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTT
GGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGA
CCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAA
TGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAA
AGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTAT
CTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAA
GGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGA
TATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCAT
CCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACA

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000398052_chr4_3015415_+_3390nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGG
AAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGTGAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGA
GAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGATGCCTTGTGCTTGGTGCTCACCATTATGAATGGAGG
GGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGAGCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTT
GGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGA
CCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAA
TGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAA
AGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTAT
CTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAA
GGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGA
TATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCAT
CCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAA
GAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACCATGGTCCCCAGTGA
GAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTC

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000504933_chr4_3015415_+_3252nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGG
AAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGTGAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGA
GAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGATGCCTTGTGCTTGGTGCTCACCATTATGAATGGAGG
GGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGAGCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTT
GGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGA
CCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAA
TGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAA
AGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTAT
CTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAA
GGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGA
TATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCAT
CCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACA
GAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACCTGGAATTGTAATAAATACATCTAAATAAAACATGCCTTGG

>In-frame_HTT_ENST00000355072_chr4_3132150_+_GRK4_ENST00000345167_chr4_3015415_+_3390nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGGTTTGCGCCTGTCAAGTGCGAGCCACAGG
AAAAATGTATGCCTGCAAAAAGCTACAAAAAAAAAGAATAAAGAAGAGGAAAGGTGAAGCTATGGCTCTAAATGAGAAAAGAATTCTGGA
GAAAGTGCAAAGTAGATTCGTAGTTAGTTTAGCCTACGCTTATGAAACCAAAGATGCCTTGTGCTTGGTGCTCACCATTATGAATGGAGG
GGATTTGAAGTTTCACATTTACAACCTGGGCAATCCCGGCTTTGATGAGCAGAGAGCCGTTTTCTATGCTGCAGAGCTGTGTTGCGGCTT
GGAAGATTTACAGAGGGAAAGAATTGTATACAGAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGA
CCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAA
TGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAA
AGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTAT
CTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAA
GGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGA
TATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCAT
CCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAA
GAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACCATGGTCCCCAGTGA
GAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTC


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FusionGenePPI for HTT_GRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HTTSETD2, HAP1, ZDHHC17, HYPK, TRIP10, NEUROD1, PRPF40A, PRPF40B, MAGEA3, FICD, UBE2K, AP2A2, OPTN, HYPM, CREBBP, SH3GL3, SP1, MAP3K10, HIP1, EGFR, GRB2, RASA1, TCERG1, TP53, PACSIN1, F8A1, NCOR1, CTBP1, AGO2, KAT2B, SYVN1, AMFR, VCP, CHUK, IKBKB, HSPA8, TRAF6, UBQLN1, IKBKG, AXIN1, CTNNB1, GAPDH, SIAH1, MED31, CRMP1, FEZ1, GIT1, CHD3, ECH1, IKBKAP, XRCC6, PFN2, PIAS4, GPRASP2, UTP14A, DNALI1, GRM1, HSP90AB1, DNAJB1, DNAJA1, HBS1L, TUBA1A, TUBB, PSMC5, ATG5, SQSTM1, NBR1, MAP1LC3A, HTT, TAF4, PIAS1, ZNF451, HOXC4, EVL, UBAC1, HMG20A, ERCC6L, FTL, TTC23, RNF20, HEY2, ZNF655, PIK3R1, ZFYVE19, GOLPH3L, MAGEB18, MRFAP1, UBE2E3, ZMAT2, DUSP10, MRFAP1L1, GGA2, ING5, IFT20, HEYL, TACC1, MBD4, DPPA4, ETV4, MAGEB6, MED21, HIST1H3H, PEX11B, MBD1, TRAFD1, HOXC11, OSTF1, NUPL1, XAGE3, PTGES2, MIPEP, PSMB7, NME4, RPL4, ZFC3H1, UPF3A, CCDC126, HMGA1, FAM71F1, RCN2, USP8, MGRN1, PML, ITCH, USP14, MID1, RPS6KB1, PPP2CA, CREB1, HLA-B, PRMT2, ULK1, RFXANK, LLGL1, MAPK3, KIF23, BAG3, RAPGEF2, HUWE1, MORC3, UBQLN2, RAB30, SNX21, SYT12, MPP1, NPY2R, OPRM1, CRYL1, IL17RA, C5AR2, TKT, RHEB, MTORGRK4CALM1, FSHR, IKBKG, NEDD4, HSP90AA1, ADRB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHTTchr4:3132150chr4:3015415ENST00000355072+1467491_5026623143ZDHHC17


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHTTchr4:3101121chr4:3021368ENST00000355072+367491_5021563143ZDHHC17
HgeneHTTchr4:3127356chr4:3029639ENST00000355072+1167491_5024673143ZDHHC17


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HTT_GRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HTT_GRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHTTC0020179Huntington Disease9CTD_human;ORPHANET
HgeneHTTC0011570Mental Depression4PSYGENET
HgeneHTTC0011581Depressive disorder4HPO;PSYGENET
HgeneHTTC0525045Mood Disorders2PSYGENET
HgeneHTTC0006635Cadmium poisoning1CTD_human
HgeneHTTC0026650Movement Disorders1CTD_human;HPO
HgeneHTTC0677050Manganese Poisoning1CTD_human