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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16939

FusionGeneSummary for HTN3_RPL6

check button Fusion gene summary
Fusion gene informationFusion gene name: HTN3_RPL6
Fusion gene ID: 16939
HgeneTgene
Gene symbol

HTN3

RPL6

Gene ID

3347

6128

Gene namehistatin 3ribosomal protein L6
SynonymsHIS2|HTN2|HTN5L6|SHUJUN-2|TAXREB107|TXREB1
Cytomap

4q13.3

12q24.13

Type of geneprotein-codingprotein-coding
Descriptionhistatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst60S ribosomal protein L6DNA-binding protein TAXREB107large ribosomal subunit protein eL6neoplasm-related protein C140tax-responsive enhancer element-binding protein 107
Modification date2018051920180523
UniProtAcc

P15516

Q02878

Ensembl transtripts involved in fusion geneENST00000526767, ENST00000530128, 
ENST00000381057, 
ENST00000202773, 
ENST00000424576, 
Fusion gene scores* DoF score3 X 3 X 1=95 X 5 X 2=50
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: HTN3 [Title/Abstract] AND RPL6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL6

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP333196HTN3chr4

70902213

+RPL6chr12

112843119

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000526767ENST00000202773HTN3chr4

70902213

+RPL6chr12

112843119

-
3UTR-3CDSENST00000526767ENST00000424576HTN3chr4

70902213

+RPL6chr12

112843119

-
intron-3CDSENST00000530128ENST00000202773HTN3chr4

70902213

+RPL6chr12

112843119

-
intron-3CDSENST00000530128ENST00000424576HTN3chr4

70902213

+RPL6chr12

112843119

-
3UTR-3CDSENST00000381057ENST00000202773HTN3chr4

70902213

+RPL6chr12

112843119

-
3UTR-3CDSENST00000381057ENST00000424576HTN3chr4

70902213

+RPL6chr12

112843119

-

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FusionProtFeatures for HTN3_RPL6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HTN3

P15516

RPL6

Q02878

Histatins are salivary proteins that are considered tobe major precursors of the protective proteinaceous structure ontooth surfaces (enamel pellicle). In addition, histatins exhibitantibacterial and antifungal activities. His3-(20-43)-peptide(histatin-5) is especially effective against C.albicans andC.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB)from P.gingivalis. In addition, His3-(20-43)-peptide is a potentinhibitor of metalloproteinases MMP2 and MMP9.{ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}. Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. (Microbial infection) Specifically binds to domain C ofthe Tax-responsive enhancer element in the long terminal repeat ofHTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HTN3_RPL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HTN3_RPL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HTN3_RPL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HTN3_RPL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPL6C0024667Animal Mammary Neoplasms1CTD_human
TgeneRPL6C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneRPL6C0030567Parkinson Disease1CTD_human