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Fusion gene ID: 16937 |
FusionGeneSummary for HTN3_OSBPL1A |
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Fusion gene information | Fusion gene name: HTN3_OSBPL1A | Fusion gene ID: 16937 | Hgene | Tgene | Gene symbol | HTN3 | OSBPL1A | Gene ID | 3347 | 114876 |
Gene name | histatin 3 | oxysterol binding protein like 1A | |
Synonyms | HIS2|HTN2|HTN5 | ORP-1|ORP1|OSBPL1B | |
Cytomap | 4q13.3 | 18q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | histatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst | oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P15516 | Q9BXW6 | |
Ensembl transtripts involved in fusion gene | ENST00000526767, ENST00000530128, ENST00000381057, | ENST00000319481, ENST00000399443, ENST00000357041, ENST00000399441, ENST00000582618, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 11 X 9 X 9=891 |
# samples | 3 | 12 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/891*10)=-2.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HTN3 [Title/Abstract] AND OSBPL1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP334921 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000526767 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-3CDS | ENST00000526767 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-3CDS | ENST00000526767 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-intron | ENST00000526767 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-intron | ENST00000526767 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
intron-3CDS | ENST00000530128 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
intron-3CDS | ENST00000530128 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
intron-3CDS | ENST00000530128 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
intron-intron | ENST00000530128 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
intron-intron | ENST00000530128 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-3CDS | ENST00000381057 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-3CDS | ENST00000381057 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-3CDS | ENST00000381057 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-intron | ENST00000381057 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
3UTR-intron | ENST00000381057 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
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FusionProtFeatures for HTN3_OSBPL1A |
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Hgene | Tgene |
HTN3 | OSBPL1A |
Histatins are salivary proteins that are considered tobe major precursors of the protective proteinaceous structure ontooth surfaces (enamel pellicle). In addition, histatins exhibitantibacterial and antifungal activities. His3-(20-43)-peptide(histatin-5) is especially effective against C.albicans andC.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB)from P.gingivalis. In addition, His3-(20-43)-peptide is a potentinhibitor of metalloproteinases MMP2 and MMP9.{ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}. | Binds phospholipids; exhibits strong binding tophosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on lateendosomes/lysosomes and alters functional properties of lateendocytic compartments via its interaction with RAB7A(PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol(PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980,ECO:0000269|PubMed:17428193}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HTN3_OSBPL1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HTN3_OSBPL1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HTN3_OSBPL1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HTN3_OSBPL1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |