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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16933

FusionGeneSummary for HTATSF1_GAS6

check button Fusion gene summary
Fusion gene informationFusion gene name: HTATSF1_GAS6
Fusion gene ID: 16933
HgeneTgene
Gene symbol

HTATSF1

GAS6

Gene ID

27336

2621

Gene nameHIV-1 Tat specific factor 1growth arrest specific 6
SynonymsTAT-SF1|TATSF1|dJ196E23.2AXLLG|AXSF
Cytomap

Xq26.3

13q34

Type of geneprotein-codingprotein-coding
DescriptionHIV Tat-specific factor 1HIV TAT specific factor 1cofactor required for Tat activation of HIV-1 transcriptiongrowth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factor
Modification date2018052320180527
UniProtAcc

O43719

Q14393

Ensembl transtripts involved in fusion geneENST00000535601, ENST00000218364, 
ENST00000357389, ENST00000327773, 
ENST00000476291, ENST00000418959, 
ENST00000450766, ENST00000355761, 
Fusion gene scores* DoF score4 X 4 X 8=1283 X 5 X 2=30
# samples 114
** MAII scorelog2(11/128*10)=-0.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HTATSF1 [Title/Abstract] AND GAS6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAS6

GO:0001934

positive regulation of protein phosphorylation

7854420|16723520|20103767

TgeneGAS6

GO:0006468

protein phosphorylation

16359517

TgeneGAS6

GO:0006909

phagocytosis

21501828

TgeneGAS6

GO:0007165

signal transduction

7854420|18680538

TgeneGAS6

GO:0010628

positive regulation of gene expression

19657094

TgeneGAS6

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

19657094

TgeneGAS6

GO:0018105

peptidyl-serine phosphorylation

18680538|20103767

TgeneGAS6

GO:0019064

fusion of virus membrane with host plasma membrane

21501828

TgeneGAS6

GO:0019079

viral genome replication

21501828

TgeneGAS6

GO:0032689

negative regulation of interferon-gamma production

18840707

TgeneGAS6

GO:0032715

negative regulation of interleukin-6 production

19657094

TgeneGAS6

GO:0032720

negative regulation of tumor necrosis factor production

19657094|20103767

TgeneGAS6

GO:0032825

positive regulation of natural killer cell differentiation

18840707

TgeneGAS6

GO:0033138

positive regulation of peptidyl-serine phosphorylation

16723520

TgeneGAS6

GO:0033159

negative regulation of protein import into nucleus, translocation

20103767

TgeneGAS6

GO:0035457

cellular response to interferon-alpha

19657094

TgeneGAS6

GO:0035690

cellular response to drug

16359517

TgeneGAS6

GO:0035754

B cell chemotaxis

19922767

TgeneGAS6

GO:0043066

negative regulation of apoptotic process

19922767

TgeneGAS6

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

16723520

TgeneGAS6

GO:0043277

apoptotic cell clearance

21501828

TgeneGAS6

GO:0043433

negative regulation of DNA binding transcription factor activity

18680538

TgeneGAS6

GO:0043491

protein kinase B signaling

16723520|20103767

TgeneGAS6

GO:0045860

positive regulation of protein kinase activity

7854420

TgeneGAS6

GO:0045892

negative regulation of transcription, DNA-templated

18680538

TgeneGAS6

GO:0046718

viral entry into host cell

21501828

TgeneGAS6

GO:0046813

receptor-mediated virion attachment to host cell

21501828

TgeneGAS6

GO:0046827

positive regulation of protein export from nucleus

18680538

TgeneGAS6

GO:0048146

positive regulation of fibroblast proliferation

7854420|15184064

TgeneGAS6

GO:0050711

negative regulation of interleukin-1 secretion

20103767

TgeneGAS6

GO:0050766

positive regulation of phagocytosis

18395422

TgeneGAS6

GO:0051897

positive regulation of protein kinase B signaling

16359517|16723520|18680538

TgeneGAS6

GO:0061098

positive regulation of protein tyrosine kinase activity

20103767

TgeneGAS6

GO:0070168

negative regulation of biomineral tissue development

20048160

TgeneGAS6

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15184064

TgeneGAS6

GO:0070588

calcium ion transmembrane transport

18395422

TgeneGAS6

GO:0071307

cellular response to vitamin K

16359517

TgeneGAS6

GO:0072659

protein localization to plasma membrane

16359517

TgeneGAS6

GO:0097241

hematopoietic stem cell migration to bone marrow

19922767

TgeneGAS6

GO:1900142

negative regulation of oligodendrocyte apoptotic process

16723520

TgeneGAS6

GO:1900165

negative regulation of interleukin-6 secretion

20103767

TgeneGAS6

GO:2000270

negative regulation of fibroblast apoptotic process

16359517

TgeneGAS6

GO:2000352

negative regulation of endothelial cell apoptotic process

16359517|18680538|18760998

TgeneGAS6

GO:2000510

positive regulation of dendritic cell chemotaxis

19657094

TgeneGAS6

GO:2000669

negative regulation of dendritic cell apoptotic process

19657094


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM689183HTATSF1chrX

135586281

+GAS6chr13

114526421

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000535601ENST00000357389HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-3CDSENST00000535601ENST00000327773HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000535601ENST00000476291HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000535601ENST00000418959HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000535601ENST00000450766HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000535601ENST00000355761HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-3CDSENST00000218364ENST00000357389HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-3CDSENST00000218364ENST00000327773HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000218364ENST00000476291HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000218364ENST00000418959HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000218364ENST00000450766HTATSF1chrX

135586281

+GAS6chr13

114526421

-
intron-intronENST00000218364ENST00000355761HTATSF1chrX

135586281

+GAS6chr13

114526421

-

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FusionProtFeatures for HTATSF1_GAS6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HTATSF1

O43719

GAS6

Q14393

Functions as a general transcription factor playing arole in the process of transcriptional elongation. May mediate thereciprocal stimulatory effect of splicing on transcriptionalelongation. In case of infection by HIV-1, it is up-regulated bythe HIV-1 proteins NEF and gp120, acts as a cofactor required forthe Tat-enhanced transcription of the virus.{ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543,ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046,ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670,ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. Ligand for tyrosine-protein kinase receptors AXL, TYRO3and MER whose signaling is implicated in cell growth and survival,cell adhesion and cell migration. GAS6/AXL signaling plays a rolein various processes such as endothelial cell survival duringacidification by preventing apoptosis, optimal cytokine signalingduring human natural killer cell development, hepaticregeneration, gonadotropin-releasing hormone neuron survival andmigration, platelet activation, or regulation of thromboticresponses. {ECO:0000269|PubMed:12364394,ECO:0000269|PubMed:18840707}. (Microbial infection) Can bridges virus envelopephosphatidylserine to the TAM receptor tyrosine kinase Axl tomediate viral entry by apoptotic mimicry (PubMed:21501828). Playsa role in Dengue cell entry by apoptotic mimicry(PubMed:23084921). Plays a role in Vaccinia virus cell entry byapoptotic mimicry (PubMed:21501828). Plays a role in ebolavirusand marburgvirus cell entry by apoptotic mimicry(PubMed:17005688). {ECO:0000269|PubMed:17005688,ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HTATSF1_GAS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HTATSF1_GAS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HTATSF1_GAS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HTATSF1_GAS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGAS6C0040053Thrombosis4CTD_human
TgeneGAS6C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneGAS6C0011881Diabetic Nephropathy1CTD_human
TgeneGAS6C0018800Cardiomegaly1CTD_human
TgeneGAS6C0036095Salivary Gland Neoplasms1CTD_human
TgeneGAS6C0040038Thromboembolism1CTD_human
TgeneGAS6C2609414Acute kidney injury1CTD_human