![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 16897 |
FusionGeneSummary for HSPB1_RAPGEF5 |
![]() |
Fusion gene information | Fusion gene name: HSPB1_RAPGEF5 | Fusion gene ID: 16897 | Hgene | Tgene | Gene symbol | HSPB1 | RAPGEF5 | Gene ID | 3315 | 9771 |
Gene name | heat shock protein family B (small) member 1 | Rap guanine nucleotide exchange factor 5 | |
Synonyms | CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27 | GFR|MR-GEF|REPAC | |
Cytomap | 7q11.23 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | heat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27 | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P04792 | Q92565 | |
Ensembl transtripts involved in fusion gene | ENST00000248553, ENST00000429938, | ENST00000344041, ENST00000475788, ENST00000405243, ENST00000401957, | |
Fusion gene scores | * DoF score | 20 X 13 X 6=1560 | 4 X 4 X 2=32 |
# samples | 21 | 4 | |
** MAII score | log2(21/1560*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HSPB1 [Title/Abstract] AND RAPGEF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA283619 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000248553 | ENST00000344041 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
5CDS-intron | ENST00000248553 | ENST00000475788 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
5CDS-intron | ENST00000248553 | ENST00000405243 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
5CDS-3UTR | ENST00000248553 | ENST00000401957 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
intron-3UTR | ENST00000429938 | ENST00000344041 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
intron-intron | ENST00000429938 | ENST00000475788 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
intron-intron | ENST00000429938 | ENST00000405243 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
intron-3UTR | ENST00000429938 | ENST00000401957 | HSPB1 | chr7 | 75932104 | + | RAPGEF5 | chr7 | 22159963 | - |
Top |
FusionProtFeatures for HSPB1_RAPGEF5 |
![]() |
Hgene | Tgene |
HSPB1 | RAPGEF5 |
Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HSPB1_RAPGEF5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HSPB1_RAPGEF5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HSPB1_RAPGEF5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HSPB1 | P04792 | DB11638 | Artenimol | Heat shock protein beta-1 | small molecule | approved|investigational |
Top |
RelatedDiseases for HSPB1_RAPGEF5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HSPB1 | C2608087 | NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIB | 9 | CTD_human;UNIPROT |
Hgene | HSPB1 | C1847823 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | HSPB1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | HSPB1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | HSPB1 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
Hgene | HSPB1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | HSPB1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | HSPB1 | C0018801 | Heart failure | 1 | CTD_human |
Hgene | HSPB1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | HSPB1 | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | HSPB1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | HSPB1 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | HSPB1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Hgene | HSPB1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | HSPB1 | C0038220 | Status Epilepticus | 1 | CTD_human |
Hgene | HSPB1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | HSPB1 | C0040411 | Tongue Neoplasms | 1 | CTD_human |
Hgene | HSPB1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | HSPB1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | RAPGEF5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RAPGEF5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | RAPGEF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | RAPGEF5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | RAPGEF5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | RAPGEF5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | RAPGEF5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |