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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 16886

FusionGeneSummary for HSPB1_CAMKK2

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPB1_CAMKK2
Fusion gene ID: 16886
HgeneTgene
Gene symbol

HSPB1

CAMKK2

Gene ID

3315

10645

Gene nameheat shock protein family B (small) member 1calcium/calmodulin dependent protein kinase kinase 2
SynonymsCMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27CAMKK|CAMKKB
Cytomap

7q11.23

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27calcium/calmodulin-dependent protein kinase kinase 2CAMKK beta proteincaM-KK 2caM-KK betacaM-kinase kinase 2caM-kinase kinase betacalcium/calmodulin-dependent protein kinase betacalcium/calmodulin-dependent protein kinase kinase 2, beta
Modification date2018052720180522
UniProtAcc

P04792

Q96RR4

Ensembl transtripts involved in fusion geneENST00000248553, ENST00000429938, 
ENST00000392474, ENST00000538733, 
ENST00000337174, ENST00000347034, 
ENST00000324774, ENST00000545538, 
ENST00000412367, ENST00000404169, 
ENST00000402834, ENST00000446440, 
ENST00000392473, ENST00000535524, 
Fusion gene scores* DoF score20 X 13 X 6=15602 X 2 X 2=8
# samples 212
** MAII scorelog2(21/1560*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: HSPB1 [Title/Abstract] AND CAMKK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMKK2

GO:0006468

protein phosphorylation

11395482

TgeneCAMKK2

GO:0046777

protein autophosphorylation

11395482


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XA-A8JR-01AHSPB1chr7

75933612

+CAMKK2chr12

121682418

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000248553ENST00000392474HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000538733HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000337174HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000347034HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000324774HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000545538HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000412367HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000404169HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000402834HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000446440HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000392473HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000248553ENST00000535524HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
In-frameENST00000429938ENST00000392474HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000538733HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000337174HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000347034HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000324774HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000545538HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000412367HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000404169HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000402834HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000446440HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000392473HSPB1chr7

75933612

+CAMKK2chr12

121682418

-
5CDS-intronENST00000429938ENST00000535524HSPB1chr7

75933612

+CAMKK2chr12

121682418

-

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FusionProtFeatures for HSPB1_CAMKK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSPB1

P04792

CAMKK2

Q96RR4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSPB1chr7:75933612chr12:121682418ENST00000248553+3376_184246206DomainsHSP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174-016165_446-193542DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367-016165_446-36542DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733-015165_446-193499DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174-016171_179-193542Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367-016171_179-36542Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733-015171_179-193499Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174-016204_226-193542RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174-016472_477-193542RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000337174-016475_500-193542RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000347034-1316472_477474546RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000347034-1316475_500474546RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367-016204_226-36542RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367-016472_477-36542RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000412367-016475_500-36542RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000446440-1316472_477474491RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000446440-1316475_500474491RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733-015204_226-193499RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733-015472_477-193499RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000538733-015475_500-193499RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000324774-1417165_446517589DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000347034-1316165_446474546DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392473-1417165_446517534DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392474-1316165_446517557DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000402834-1417165_446517589DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000404169-1417165_446517589DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000446440-1316165_446474491DomainProtein kinase
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000324774-1417171_179517589Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000347034-1316171_179474546Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392473-1417171_179517534Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392474-1316171_179517557Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000402834-1417171_179517589Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000404169-1417171_179517589Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000446440-1316171_179474491Nucleotide bindingATP
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000324774-1417204_226517589RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000324774-1417472_477517589RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000324774-1417475_500517589RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000347034-1316204_226474546RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392473-1417204_226517534RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392473-1417472_477517534RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392473-1417475_500517534RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392474-1316204_226517557RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392474-1316472_477517557RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000392474-1316475_500517557RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000402834-1417204_226517589RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000402834-1417472_477517589RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000402834-1417475_500517589RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000404169-1417204_226517589RegionNote=RP domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000404169-1417472_477517589RegionAutoinhibitory domain
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000404169-1417475_500517589RegionCalmodulin-binding
TgeneCAMKK2chr7:75933612chr12:121682418ENST00000446440-1316204_226474491RegionNote=RP domain


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FusionGeneSequence for HSPB1_CAMKK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HSPB1_ENST00000248553_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_286aa
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRH
TADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAKXSLSPDAHPCCRHWLCLPRHLCVLLIHLSSVFLKXSSKQPPVKKPTRECESLSELKGTKKKKGLD

>In-frame_HSPB1_ENST00000429938_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_118aa
MPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAKXSLSPDAHPCCRHWLCLPRHLCVLLIHLSSVFLKXSSKQPPVKKPTRECESLS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HSPB1_ENST00000248553_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_858nt
ATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCATAGCCGCCTCTTCGAC
CAGGCCTTCGGGCTGCCCCGGCTGCCGGAGGAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCC
GCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAACTCAGCAGCGGGGTCTCGGAGATCCGGCAC
ACTGCGGACCGCTGGCGCGTGTCCCTGGATGTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATC
ACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCC
ACCCAAGTTTCCTCCTCCCTGTCCCCTGAGGGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACC
ATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCG
GATGCCCACCCCTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAA
AGTTCAAAGCAACCACCTGTCAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGGGACAAAAAAAAAAAAAGGACTTGAC

>In-frame_HSPB1_ENST00000429938_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_354nt
ATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAA
TCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTT
CTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACCTGTCAAAAAACCAACCAGGGAATGTGAGTCCCTGTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HSPB1_ENST00000248553_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_3801nt
GCTGGGGGAGGAGTGCATGGGGAGGGGCGGCCCTCAAACGGGTCATTGCCATTAATAGAGACCTCAAACACCGCCTGCTAAAAATACCCG
ACTGGAGGAGCATAAAAGCGCAGCCGAGCCCAGCGCCCCGCACTTTTCTGAGCAGACGTCCAGAGCAGAGTCAGCCAGCATGACCGAGCG
CCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGG
GCTGCCCCGGCTGCCGGAGGAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCCGCCGCCATCGA
GAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAACTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCG
CTGGCGCGTGTCCCTGGATGTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATCACCGGCAAGCA
CGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTC
CTCCTCCCTGTCCCCTGAGGGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCAC
CTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCC
CTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCA
ACCACCTGTCAAAAAACCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGGGACAAAAAAAAAAAAAGGACTTGACTCCATGACGTC
GACCGTGGCCGCTGGCTGGCTGGACAGGCGGGTGTGAGGAGTTGCAGACCCAAACCCACGTGCATTTTGGGACAATTGCTTTTTAAAACG
TTTTTATGCCAAAAATCCTTCATTGTGATTTTCAGAACCACGTCAGATATACCAAGTGACTGTGTGTGGGGTTTGACAACTGTGGAAAGG
CGAGCAGAAAACTCCGGCGGTCTGAGGCCATGGAGGTGGTTGCTGCATTTGAGAGGGAGTAGGGGGCTAGATGTGGCTCCTAGTGCAAAC
CGGAAACCATGGCACCTTCCAGAGCCGTGGTCTCAAGGAGTCAGAGCAGGGCTGGCCCTCAGTAGCTGCAGGGAGCTTTGATGCAACTTA
TTTGTAAGAAGGATTTTTAAATTTTTTATGGGTAGAATTGTAGTCAGGAAAACAGAAAGGGCTTGAAATTTAATAAGTGCTGCTGGAAGG
GGATTTTCCAAGCCTGGAAGGGTATTCAGCAGCTGTGGTGGGGAAACATTTCTCCTGAAAGACTGAACGTGTTTCTTCATGACAGCTGCT
CAAAGCAGGTTTCTGAGATAGCTGACCGAGCTCTGGTAAATCTCTTTGTCAAATTACGAAAACTTCAGGGTGAAATCCTATGCTTCCATG
TACATTACATGGCTTAAGATTAAACAAAAACATTTTTCAAGTCTCTAACTAGAGTGAACTCTAGAGCACAGTAGTTCAGAAACTATTTAG
AGCTTCCAGGATATATTTCACAGCTTCAGGCATGTGATCAGTTAGAGCCGATGAAACCTATGCCCGCCTGTATATATATTAGCAGCTTAG
CTAGTTCATAACCTGTATATTCTAAAGACTGCTAAGGTTTTGTTTTCATTTTAAATCCTAGCTGATTGTTGTGGTCAATGAAATACCCAG
TTTCTGGAGGGCCAGGTGGGAAATGCTTTCACTGGACCAACACACAAATGATCATCCTGAGGATCTGAGCTTCCCTAGACTCCACACAAT
AACCTTGGGGCACCCTTTTAGAGAAGACTGTTGAAACCCACAGCACTCGTTGGGGTATGAGGAAACCAGGGCTTGGCACAGGAAGTTCCC
CTTTGTAGCTAAAAGTCCAGAAAGAAAGGGTTCATCTTTTTGACTTCCAACTGATATTGGGAAGTTTGGTTGAGGTTCAAGTGTGACTCC
TTCCAGAGCCACAGGTAGGGGAGTGTGAAGTTGAGGGGGAGGAAAGCTGGAAGGACTCTGCCTTGGGAGATTCCCAGCTCTGCTTTCCAG
CGCTTGGTGGAATCTGGGCTGGGGAAAGACGGCACCGGGAAACTCTGCTTCCCCATTGTTTCCATCTGATCAGCTGTGGTGTGAGGACTT
CTCAGACAAAGGCAAGGCCTCGTGCCCCTGCCCAGCCCATTCATGGAGCCCTGGGCCTTCTTGGCTTCCATAGATCCTAAGCTCTTGACT
GTAGTTTAGCCAGACTTGTTTTGCTATCTTATAAGCAGTTCAGAATTAGGGAATGCTGGTTTTGAAGAGCAAAGGACAGGTAGTCTAGAG
AGGGTCGTCTGGCCTGCTTGCTGGGTCTTTGTAACCCAGCACTTCCTCTTGCCCTCCTGGCTTTATGTTTATGGGGAGAGGACTCAATAG
CTCCACCCCTTCTGGCACCAGATGGGGCTTGGTTAGTTTGCAATAAGCACCTTGCAGAGGTTAAAGCCAGCGGGTCCCTAGTCTTAGGCC
CAGCCTGCTTGTGTGGGCTCTGGCCTGGCCTGGTGGCTGGCCCAGGGGGCAGCAGTGCTTAGAGCTTCTGCAGGGCTTCTCTTGTTTACA
CAGCTGCATCAGACAATGCCATTTCTCCCCACCACGGAACCTTCCATCTAAGATTTCTTCCAGGGAATGCCAGCAATCAGGCAGCACCCA
GCTGTGGGGGCAGTGGGGTGGGGGAGACCCACATTGATGACTTTTTTTTTTTCTTTTAATGAAGAAACACCAAAGAAAGCTGTGGAAAGG
ACCTGCCCCACATGAAAAGGATAAGCCAAGATGGCTGTAAACACAGAGCATTTGAGCTGCCACTCTTGGAGCACATTGATTTTTCAAAAG
CCAGCTCTGTCAGGAAAGGAGGTGCTGTTATGAGCAGCTCTTCCAGTGGGCAAAGAGGACGCCCATAATTTCTTCCATTGCTAGCTCATC
TGTGGGACCAATTTGGTGTAAGCAACCTGTGGCCTGCACTTGTGGCCTCGAAGGAAGCACAAACCCTCCATCCACTTCCCATTTCCTCTG
CCCTTTTCCACCTCCCCCTTCCATCCCACCAGCTGCCAGTGGCTCCCAGAAAGCCTTATTGAGCCCCTTGTTGACACTTGGGGCTGCGGA
GGCCTCTCCCTACTGGTCTGGCCTTTCCTGAGAGGCAGGTCTTCCGTCCTCAGAGCCTTTCTGGAACAAGGAGAATGCCTGTGCAGGTGG
ACACACAGGCCTGGCCTGTCGCTCTCACTTGTCTTCCAGCGGGGAGCTTCACGTTGCCGAGTGGAAGAACCATGACCTCCACTTGCTTCC
AAGGTGCTAGGGAAGTTTCAGGGTACGCTGGTTCCCCTCTCCAGCTGGAGGCCGAGTTTCTGGGGACTGCAGATTTTTCTACTCTGTGAT
CGATTCAATGCCCGATGCTTCTGTTTCATTCCCGACCCTTTCTACTATGCATTTTCCTTTTATCAGGTGTATAAAGTTAAATACTGTGTA
TTTATCACTAAAAAGTACATGAACTTAAGAGACAACTAAGCCTTTCGTGTTTTTCCACAGGTGTTTAAGCTTCTCTGTACAGTTGAAATA

>In-frame_HSPB1_ENST00000429938_chr7_75933612_+_CAMKK2_ENST00000392474_chr12_121682418_-_3419nt
AGCTCCGCGCCCTGCTCCGTTCCTCCCAAAACTCTGAATCGAAGAACTTTCCGGAAGTTTCTGAGAGCCCAGACCGGCGGGCACGCCCCC
ATCCCCAACCCCCTCTGTTAATCCCTACCAGCCTGCAGTCCTGGCTGCTTCCAAGCAGGAGGCAAGCACGAGGAGCGGCAGGACGAGCAT
GGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAGGGC
ACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTT
GGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGC
CTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACCTGTCAAAAAACCAACC
AGGGAATGTGAGTCCCTGTCTGAGCTCAAGGGGACAAAAAAAAAAAAAGGACTTGACTCCATGACGTCGACCGTGGCCGCTGGCTGGCTG
GACAGGCGGGTGTGAGGAGTTGCAGACCCAAACCCACGTGCATTTTGGGACAATTGCTTTTTAAAACGTTTTTATGCCAAAAATCCTTCA
TTGTGATTTTCAGAACCACGTCAGATATACCAAGTGACTGTGTGTGGGGTTTGACAACTGTGGAAAGGCGAGCAGAAAACTCCGGCGGTC
TGAGGCCATGGAGGTGGTTGCTGCATTTGAGAGGGAGTAGGGGGCTAGATGTGGCTCCTAGTGCAAACCGGAAACCATGGCACCTTCCAG
AGCCGTGGTCTCAAGGAGTCAGAGCAGGGCTGGCCCTCAGTAGCTGCAGGGAGCTTTGATGCAACTTATTTGTAAGAAGGATTTTTAAAT
TTTTTATGGGTAGAATTGTAGTCAGGAAAACAGAAAGGGCTTGAAATTTAATAAGTGCTGCTGGAAGGGGATTTTCCAAGCCTGGAAGGG
TATTCAGCAGCTGTGGTGGGGAAACATTTCTCCTGAAAGACTGAACGTGTTTCTTCATGACAGCTGCTCAAAGCAGGTTTCTGAGATAGC
TGACCGAGCTCTGGTAAATCTCTTTGTCAAATTACGAAAACTTCAGGGTGAAATCCTATGCTTCCATGTACATTACATGGCTTAAGATTA
AACAAAAACATTTTTCAAGTCTCTAACTAGAGTGAACTCTAGAGCACAGTAGTTCAGAAACTATTTAGAGCTTCCAGGATATATTTCACA
GCTTCAGGCATGTGATCAGTTAGAGCCGATGAAACCTATGCCCGCCTGTATATATATTAGCAGCTTAGCTAGTTCATAACCTGTATATTC
TAAAGACTGCTAAGGTTTTGTTTTCATTTTAAATCCTAGCTGATTGTTGTGGTCAATGAAATACCCAGTTTCTGGAGGGCCAGGTGGGAA
ATGCTTTCACTGGACCAACACACAAATGATCATCCTGAGGATCTGAGCTTCCCTAGACTCCACACAATAACCTTGGGGCACCCTTTTAGA
GAAGACTGTTGAAACCCACAGCACTCGTTGGGGTATGAGGAAACCAGGGCTTGGCACAGGAAGTTCCCCTTTGTAGCTAAAAGTCCAGAA
AGAAAGGGTTCATCTTTTTGACTTCCAACTGATATTGGGAAGTTTGGTTGAGGTTCAAGTGTGACTCCTTCCAGAGCCACAGGTAGGGGA
GTGTGAAGTTGAGGGGGAGGAAAGCTGGAAGGACTCTGCCTTGGGAGATTCCCAGCTCTGCTTTCCAGCGCTTGGTGGAATCTGGGCTGG
GGAAAGACGGCACCGGGAAACTCTGCTTCCCCATTGTTTCCATCTGATCAGCTGTGGTGTGAGGACTTCTCAGACAAAGGCAAGGCCTCG
TGCCCCTGCCCAGCCCATTCATGGAGCCCTGGGCCTTCTTGGCTTCCATAGATCCTAAGCTCTTGACTGTAGTTTAGCCAGACTTGTTTT
GCTATCTTATAAGCAGTTCAGAATTAGGGAATGCTGGTTTTGAAGAGCAAAGGACAGGTAGTCTAGAGAGGGTCGTCTGGCCTGCTTGCT
GGGTCTTTGTAACCCAGCACTTCCTCTTGCCCTCCTGGCTTTATGTTTATGGGGAGAGGACTCAATAGCTCCACCCCTTCTGGCACCAGA
TGGGGCTTGGTTAGTTTGCAATAAGCACCTTGCAGAGGTTAAAGCCAGCGGGTCCCTAGTCTTAGGCCCAGCCTGCTTGTGTGGGCTCTG
GCCTGGCCTGGTGGCTGGCCCAGGGGGCAGCAGTGCTTAGAGCTTCTGCAGGGCTTCTCTTGTTTACACAGCTGCATCAGACAATGCCAT
TTCTCCCCACCACGGAACCTTCCATCTAAGATTTCTTCCAGGGAATGCCAGCAATCAGGCAGCACCCAGCTGTGGGGGCAGTGGGGTGGG
GGAGACCCACATTGATGACTTTTTTTTTTTCTTTTAATGAAGAAACACCAAAGAAAGCTGTGGAAAGGACCTGCCCCACATGAAAAGGAT
AAGCCAAGATGGCTGTAAACACAGAGCATTTGAGCTGCCACTCTTGGAGCACATTGATTTTTCAAAAGCCAGCTCTGTCAGGAAAGGAGG
TGCTGTTATGAGCAGCTCTTCCAGTGGGCAAAGAGGACGCCCATAATTTCTTCCATTGCTAGCTCATCTGTGGGACCAATTTGGTGTAAG
CAACCTGTGGCCTGCACTTGTGGCCTCGAAGGAAGCACAAACCCTCCATCCACTTCCCATTTCCTCTGCCCTTTTCCACCTCCCCCTTCC
ATCCCACCAGCTGCCAGTGGCTCCCAGAAAGCCTTATTGAGCCCCTTGTTGACACTTGGGGCTGCGGAGGCCTCTCCCTACTGGTCTGGC
CTTTCCTGAGAGGCAGGTCTTCCGTCCTCAGAGCCTTTCTGGAACAAGGAGAATGCCTGTGCAGGTGGACACACAGGCCTGGCCTGTCGC
TCTCACTTGTCTTCCAGCGGGGAGCTTCACGTTGCCGAGTGGAAGAACCATGACCTCCACTTGCTTCCAAGGTGCTAGGGAAGTTTCAGG
GTACGCTGGTTCCCCTCTCCAGCTGGAGGCCGAGTTTCTGGGGACTGCAGATTTTTCTACTCTGTGATCGATTCAATGCCCGATGCTTCT
GTTTCATTCCCGACCCTTTCTACTATGCATTTTCCTTTTATCAGGTGTATAAAGTTAAATACTGTGTATTTATCACTAAAAAGTACATGA


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FusionGenePPI for HSPB1_CAMKK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSPB1HSPB8, MAGED1, ILK, IGSF21, PPA1, MED31, RBM48, LRIF1, TP53, AKT1, MAPKAPK2, CRYAB, CYCS, MAPKAPK5, CRYAA, CRYBB2, HNRNPD, TGFB1I1, USP38, USP1, DMWD, SRRM2, PRKD1, UBC, MYC, G6PD, GATA1, UCHL5, YWHAQ, MME, UBE2I, HSF1, TNF, UNG, STAT2, HDAC6, CASP3, PRKCD, SNCA, CUL3, COPS5, ISG15, CRYGC, PHLDA1, SMN1, DAXX, SMURF2, PNPT1, PUM1, PALLD, NRD1, PEX19, CRK, TPM3, RNF114, CFTR, CHUK, IKBKB, VCP, FN1, VCAM1, SF3B3, EFTUD2, PRPF19, MFAP1, HSPB1, WDR83, ATF2, IQCB1, NOS2, UBL4A, ITGA4, CS, INS, MAPKAPK3, PLG, NPM1, SOX2, LBP, PPM1A, SMARCD1, SERTAD1, ESR1, RPA1, RPA2, RPA3, WWOX, ASB4, ASB6, ASB10, ASB17, ZBTB1, MAP3K7, AARSD1, BAG3, LCE3A, IRS4, HAUS1, CEP57, HUWE1, PCSK9, EZH2, AATK, ARAF, BUB1B, IRAK1, LIMK2, SIK2, SRMS, TYK2, BTRC, HSPB6, HNRNPA1, ACBD6, ACTN1, ACTN4, ADCY9, ADPRHL2, AGAP5, AGAP4, ALPI, ANK1, ANXA1, SLC7A9, C11orf98, C15orf57, UQCC2, C6orf211, CALR, CCHCR1, CDC123, CDK5RAP3, CENPK, CEP78, AGAP7P, DFFA, EIF1AX, EIF2S1, EIF4A2, EPB41L1, FTH1, GARS, HAUS8, HECTD1, HNRNPH2, HSP90AA1, KCMF1, KCTD3, KIAA0368, KPNA3, KRT18, LSM3, MCM6, MYL12A, MRPS23, MSL1, MTIF2, NAP1L1, NEXN, NSMCE4A, NVL, PELO, PSMA3, PSMA6, PSMB2, PSMD1, PTGES3, PTPRA, RASSF9, RBM25, RBX1, RPAP3, RYBP, S100A4, SAT1, SF3A3, SNRNP200, SNRPF, SQSTM1, STUB1, TARBP2, TARS, TOMM70A, TOX4, TPT1, UFD1L, UQCRB, WWP1, XPO1, XRCC5, YWHAB, ZBTB17, ZNF197, EIF3M, EIF5, EIF4G3, FLNB, FKBP4, GSTO1, MRPL40, OBSL1, PGM2, PAF1, RAD23A, RBPJ, TJP2, THOC5, ACTN2, ADRBK2, AGAP3, AMD1, ANAPC7, ANKRD7, AP2B1, ARHGAP28, ARHGEF7, ARIH1, ARRDC5, BVES, C12orf10, SPACA7, ERICH6, CAMK1, CBX1, CCDC53, CCDC64, CCDC70, CCNC, CETN3, CLCN3, CPSF3, CRNKL1, DES, DMAP1, EHD1, ENPP2, EPB41L3, ERCC5, FAM71D, C2orf73, FXR1, GAPVD1, GLMN, GNPAT, GUCA1A, HNRNPA2B1, HNRNPU, HSPA4, IARS2, INPP5K, ISG20L2, KANSL1, KLC1, KRT72, LONRF1, LUZP1, MRPL28, MYL9, MYLK, NBAS, NAPA, NCKIPSD, NEK10, NFU1, OPTN, OSBPL9, PALM3, PHYHIPL, PPP2R3C, PRPF40A, PTPN3, RAB41, RALA, RPSA, RSPH3, SBF1, SEC13, PNISR, SMARCA2, SPATA7, SPIN1, SPTBN1, SRP72, SUPT5H, SYCE1, TBC1D1, TBC1D3B, TMCO3, TRIM24, TRIM54, TSNAXIP1, TTC3, TTC39C, TXNL1, WDR66, YWHAE, ZBTB37, ZFAT, ZNRF3, ACAP2, RBM39, ADD3, ATXN10, KNSTRN, MRGBP, CCNDBP1, CCNO, DNAJC21, EIF4G2, EPB41L2, GDI2, GOLGA8A, GRIPAP1, GTSF1, HDLBP, HNRNPF, HSP90AB1, HSPA5, IGBP1, LIG1, MPHOSPH6, MYL12B, PSMC1, SMARCA4, SNW1, VIM, YWHAH, YWHAZ, ZNF131, TCPT, AHCY, AHNAK, ARHGDIA, ATIC, CARHSP1, CDK1, CSRP1, DUT, EEF1A1, EEF1B2, GLO1, GLOD4, GMPS, GRPEL1, HMGN5, HN1, HN1L, HNRNPH1, HSPA8, HSPA9, EEF1D, EIF4B, ERP29, HNRNPH3, LASP1, NAMPT, OXCT1, PAICS, PKM, PTBP1, SARS, SDHA, SEPHS1, USP14, IPO7, ITPA, MSN, OLA1, PDLIM1, PFDN2, PITPNA, PITPNB, PRDX6, PSAT1, STIP1, STMN1, TARDBP, TES, TKT, TUBA4A, UAP1, UBA2, UBE2N, UGDH, ZYX, NTRK1, STRN, TUBA1C, ARMC6, MCM2, CDC5L, EGFR, CTGLF10P, CDC73, PHF12, HYPK, DUSP16, PTPN22, CYLD, DLST, PDHA1, EDEM3, TRIM25, CCND2, BRCA1, YAP1, MAPK14CAMKK2SGK1, CAMK1, PRKACA, OBSL1, CALM1, FLNC, PRKAA2, GCN1L1, XPOT, IQGAP2, PRKDC, PRKAG1, FLNA, ATG4B, ESYT2, MAPK14, FANCI, SMC1A, SMC3, SLC25A11, IRAK1, CEP63, NEDD4, APP, HSP90AA1, GCHFR, ALOX5, C6orf141, FAM196A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHSPB1chr7:75933612chr12:121682418ENST00000248553+3370_205246206TGFB1I1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSPB1_CAMKK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHSPB1P04792DB11638ArtenimolHeat shock protein beta-1small moleculeapproved|investigational

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RelatedDiseases for HSPB1_CAMKK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPB1C2608087NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIB9CTD_human;UNIPROT
HgeneHSPB1C1847823CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F6CTD_human;ORPHANET;UNIPROT
HgeneHSPB1C0007134Renal Cell Carcinoma1CTD_human
HgeneHSPB1C0007137Squamous cell carcinoma1CTD_human
HgeneHSPB1C0007194Hypertrophic Cardiomyopathy1CTD_human
HgeneHSPB1C0009375Colonic Neoplasms1CTD_human
HgeneHSPB1C0011616Contact Dermatitis1CTD_human
HgeneHSPB1C0018801Heart failure1CTD_human
HgeneHSPB1C0019693HIV Infections1CTD_human
HgeneHSPB1C0020507Hyperplasia1CTD_human
HgeneHSPB1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneHSPB1C0026640Mouth Neoplasms1CTD_human
HgeneHSPB1C0026764Multiple Myeloma1CTD_human
HgeneHSPB1C0035126Reperfusion Injury1CTD_human
HgeneHSPB1C0038220Status Epilepticus1CTD_human
HgeneHSPB1C0038356Stomach Neoplasms1CTD_human
HgeneHSPB1C0040411Tongue Neoplasms1CTD_human
HgeneHSPB1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneHSPB1C2239176Liver carcinoma1CTD_human
TgeneCAMKK2C0036341Schizophrenia1PSYGENET