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Fusion gene ID: 16875 |
FusionGeneSummary for HSPA8_VSTM5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSPA8_VSTM5 | Fusion gene ID: 16875 | Hgene | Tgene | Gene symbol | HSPA8 | VSTM5 | Gene ID | 3312 | 387804 |
| Gene name | heat shock protein family A (Hsp70) member 8 | V-set and transmembrane domain containing 5 | |
| Synonyms | HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71 | C11orf90 | |
| Cytomap | 11q24.1 | 11q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heat shock cognate 71 kDa proteinLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kDa protein 8heat shock | V-set and transmembrane domain-containing protein 5 | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | P11142 | A8MXK1 | |
| Ensembl transtripts involved in fusion gene | ENST00000532636, ENST00000533540, ENST00000453788, ENST00000534624, ENST00000227378, ENST00000534319, ENST00000526110, ENST00000526862, | ENST00000409977, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/72*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: HSPA8 [Title/Abstract] AND VSTM5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HSPA8 | GO:0042026 | protein refolding | 21231916|25719862 |
| Hgene | HSPA8 | GO:0045892 | negative regulation of transcription, DNA-templated | 10722728 |
| Hgene | HSPA8 | GO:0046034 | ATP metabolic process | 23921388 |
| Hgene | HSPA8 | GO:1902904 | negative regulation of supramolecular fiber organization | 23921388 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-KU-A6H7-01A | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000532636 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| intron-3CDS | ENST00000533540 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| In-frame | ENST00000453788 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| In-frame | ENST00000534624 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| Frame-shift | ENST00000227378 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| intron-3CDS | ENST00000534319 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| Frame-shift | ENST00000526110 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
| intron-3CDS | ENST00000526862 | ENST00000409977 | HSPA8 | chr11 | 122931301 | - | VSTM5 | chr11 | 93554489 | - |
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FusionProtFeatures for HSPA8_VSTM5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSPA8 | VSTM5 |
| Molecular chaperone implicated in a wide variety ofcellular processes, including protection of the proteome fromstress, folding and transport of newly synthesized polypeptides,activation of proteolysis of misfolded proteins and the formationand dissociation of protein complexes. Plays a pivotal role in theprotein quality control system, ensuring the correct folding ofproteins, the re-folding of misfolded proteins and controlling thetargeting of proteins for subsequent degradation (PubMed:21150129,PubMed:21148293, PubMed:24732912, PubMed:27916661,PubMed:23018488). This is achieved through cycles of ATP binding,ATP hydrolysis and ADP release, mediated by co-chaperones(PubMed:21150129, PubMed:21148293, PubMed:24732912,PubMed:27916661, PubMed:23018488). The co-chaperones have beenshown to not only regulate different steps of the ATPase cycle ofHSP70, but they also have an individual specificity such that oneco-chaperone may promote folding of a substrate while another maypromote degradation (PubMed:21150129, PubMed:21148293,PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinityof HSP70 for polypeptides is regulated by its nucleotide boundstate. In the ATP-bound form, it has a low affinity for substrateproteins. However, upon hydrolysis of the ATP to ADP, it undergoesa conformational change that increases its affinity for substrateproteins. HSP70 goes through repeated cycles of ATP hydrolysis andnucleotide exchange, which permits cycles of substrate binding andrelease. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis byHSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3(facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPRdomain chaperones such as HOPX and STUB1 (PubMed:24318877,PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as arepressor of transcriptional activation. Inhibits thetranscriptional coactivator activity of CITED1 on Smad-mediatedtranscription. Component of the PRP19-CDC5L complex that forms anintegral part of the spliceosome and is required for activatingpre-mRNA splicing. May have a scaffolding role in the spliceosomeassembly as it contacts all other components of the core complex.Binds bacterial lipopolysaccharide (LPS) and mediates LPS-inducedinflammatory response, including TNF secretion by monocytes(PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway inconjunction with J domain-containing co-chaperones and the E3ligase STUB1 (PubMed:23990462). {ECO:0000269|PubMed:10722728,ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:21148293,ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488,ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739,ECO:0000269|PubMed:27916661, ECO:0000303|PubMed:24121476,ECO:0000303|PubMed:26865365}. | Cell adhesion-like membrane protein of the centralnervous system (CNS) which modulates both the position andcomplexity of central neurons by altering their membranemorphology and dynamics. Involved in the formation of neuronaldendrites and protrusions including dendritic filopodia. Insynaptogenesis, regulates synapse formation by altering dendriticspine morphology and actin distribution. Promotes formation ofunstable neuronal spines such as thin and branched types.Regulates neuronal morphogenesis and migration during corticaldevelopment in the brain. {ECO:0000250|UniProtKB:Q9D806}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSPA8_VSTM5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HSPA8_ENST00000453788_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_307aa MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHW PFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKVRVCPYTFLRPPSMPLSKKTSCSQLSTPVMECPPSNGHIHPIG ERRRSWSGNQGLRPTSLKATRTESAPLTTAPSSSSAWEXGIPATMSSPXRSAWGAASLAPSCCTSLRSSMKTCTLSLSSLLFSLLWPQYX >In-frame_HSPA8_ENST00000534624_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_307aa MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHW PFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKVRVCPYTFLRPPSMPLSKKTSCSQLSTPVMECPPSNGHIHPIG ERRRSWSGNQGLRPTSLKATRTESAPLTTAPSSSSAWEXGIPATMSSPXRSAWGAASLAPSCCTSLRSSMKTCTLSLSSLLFSLLWPQYX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HSPA8_ENST00000453788_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_923nt ATGTCCAAGGGACCTGCAGTTGGTATTGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTCGAGATAATTGCC AATGATCAGGGAAACCGAACCACTCCAAGCTATGTCGCCTTTACGGACACTGAACGGTTGATCGGTGATGCCGCAAAGAATCAAGTTGCA ATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAACATTGG CCCTTTATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATACAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTGTCT TCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGGTCAGGGTGTGTCCCTATACATTCCTCAGGCCACCATCA ATGCCACTGTCAAAGAAGACATCCTGCTCTCAGTTGAGTACTCCTGTCATGGAGTGCCCACCATCGAATGGACATATTCATCCAATTGGG GAACGCAGAAGATCGTGGAGTGGAAACCAGGGACTCAGGCCAACATCTCTCAAAGCCACAAGGACAGAGTCTGCACCTTTGACAACGGCT CCATCCAGCTCTTCAGCGTGGGAGTGAGGGATTCCGGCTACTATGTCATCACCGTGACGGAGCGCCTGGGGAGCAGCCAGTTTGGCACCA TCGTGCTGCACGTCTCTGAGATCCTCTATGAAGACCTGCACTTTGTCGCTGTCATCCTTGCTTTTCTCGCTGCTGTGGCCGCAGTATTAA TCAGCCTCATGTGGGTTTGTAATAAGTGTGCATATAAATTTCAGAGGAAGAGAAGACACAAACTCAAAGAAAGCACAACTGAGGAGATTG >In-frame_HSPA8_ENST00000534624_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_923nt ATGTCCAAGGGACCTGCAGTTGGTATTGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTCGAGATAATTGCC AATGATCAGGGAAACCGAACCACTCCAAGCTATGTCGCCTTTACGGACACTGAACGGTTGATCGGTGATGCCGCAAAGAATCAAGTTGCA ATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAACATTGG CCCTTTATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATACAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTGTCT TCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGGTCAGGGTGTGTCCCTATACATTCCTCAGGCCACCATCA ATGCCACTGTCAAAGAAGACATCCTGCTCTCAGTTGAGTACTCCTGTCATGGAGTGCCCACCATCGAATGGACATATTCATCCAATTGGG GAACGCAGAAGATCGTGGAGTGGAAACCAGGGACTCAGGCCAACATCTCTCAAAGCCACAAGGACAGAGTCTGCACCTTTGACAACGGCT CCATCCAGCTCTTCAGCGTGGGAGTGAGGGATTCCGGCTACTATGTCATCACCGTGACGGAGCGCCTGGGGAGCAGCCAGTTTGGCACCA TCGTGCTGCACGTCTCTGAGATCCTCTATGAAGACCTGCACTTTGTCGCTGTCATCCTTGCTTTTCTCGCTGCTGTGGCCGCAGTATTAA TCAGCCTCATGTGGGTTTGTAATAAGTGTGCATATAAATTTCAGAGGAAGAGAAGACACAAACTCAAAGAAAGCACAACTGAGGAGATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HSPA8_ENST00000453788_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_3537nt ATCGTGAGGCGGAGCGCGGTGGGGTGGGTGCGGAAGGGGGCGAGGCCCGAGGAGTGGAGCCGGGCTTGTGATTGGGTCTTGTAAGGGCAG CCGGGCGTCTATTGGCCGGGGAAGCCGTAATGGCAGGCAGCAGGGGCGGGCCCCTTCTGGAAGGTTCTAAGATAGGGTATAAGAGGCAGG GTGGCGGGCGGAAACCGGTCTCATTGAACTCGCCTGCAGCTCTTGGGTTTTTTGTGGCTTCCTTCGTTATTGGAGCCAGGCCTACACCCC AGCAACCATGTCCAAGGGACCTGCAGTTGGTATTGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTCGAGAT AATTGCCAATGATCAGGGAAACCGAACCACTCCAAGCTATGTCGCCTTTACGGACACTGAACGGTTGATCGGTGATGCCGCAAAGAATCA AGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAA ACATTGGCCCTTTATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATACAAGGGAGAGACCAAAAGCTTCTATCCAGAGGA GGTGTCTTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGGTCAGGGTGTGTCCCTATACATTCCTCAGGCC ACCATCAATGCCACTGTCAAAGAAGACATCCTGCTCTCAGTTGAGTACTCCTGTCATGGAGTGCCCACCATCGAATGGACATATTCATCC AATTGGGGAACGCAGAAGATCGTGGAGTGGAAACCAGGGACTCAGGCCAACATCTCTCAAAGCCACAAGGACAGAGTCTGCACCTTTGAC AACGGCTCCATCCAGCTCTTCAGCGTGGGAGTGAGGGATTCCGGCTACTATGTCATCACCGTGACGGAGCGCCTGGGGAGCAGCCAGTTT GGCACCATCGTGCTGCACGTCTCTGAGATCCTCTATGAAGACCTGCACTTTGTCGCTGTCATCCTTGCTTTTCTCGCTGCTGTGGCCGCA GTATTAATCAGCCTCATGTGGGTTTGTAATAAGTGTGCATATAAATTTCAGAGGAAGAGAAGACACAAACTCAAAGAAAGCACAACTGAG GAGATTGAGCTGGAAGATGTTGAGTGTTAGCCAAGGCTGGGCCTGACTGCATTCCTACCTCAAGAGGAAACCATTCTCCAACAAAAAGAG CAAGCACAGCTATTATACCCATTGTGTGTGGTCCTGTTGCAGCCCGCTCCTAACAGGACAGTGGGAGATTAACAACATTGACTGCATGGA GTTGAGGACTGTGGATGGGACAAAGCTAGTATTAGGACTCGCGCTAAGTTCAAGGAGAAGAGTGATTGAGGCTTTGAACCAGGAGCTTCG CTTGGCTGCAGCATCAGGGCCGTGCTGACACATAACCAATGGGTGAGTGCAGGCGTTGGCTGCTTGCTCACGACACTTGCTCTGGTGTGC AGGATGGCCTGTTGTCAGAGTCCCTGTATCAGAGGCCAGAGGATTTCCAGATGGATGTGCAGCCAGCATTAGAACATGCTTTCTGTGCTC CTGTCTGCTCTGCAACTGCTGTGCCAACCAGCCCCCCATCTGGTATCCCACAAGCAAGCACTGCTGTGGGAGCTATTGTGAGAAAACCTG AGGCTTTTAGACAATCTGCTGCCTCAGAGCAGAGGTGGAAAGAGACTGGGGGTGGGGGTTGGTGCTGTTGTGCTGCAGAGTTTTTCATTG GTGAGGCCCGGTGGCTGGGAGTTTTATGGGAGAGGAGCTCAATGGACTCCTGAGAGGCCAGCTTTGGATACAAGGAATAGAGAAAATTAT CTTTCTCTTCCTCCCTCATTCCAACGTTAATTGGATTTTCCCTCCCATGGCTCAAACTTAGGCCATTGTAAGTAAAACAACAGCTCATCT CCATTATGGGCAGCACCTGGCCTCCTGACGAGCTGGATGCCACCTGTGTGAAAGCTGAGCTTGCATAGTGGGTGATGCAGCTGGAAAATC AGTCATCTCGGGCTTTGCATCTGTCCCCCTCAGTCACTAACACTTCACGTCTCAAGTCAGGCCCTTGCCCTCTCCTACCTGGGCTGAGGA ACGCTTGGCCCTTGCCTACCTCACAGTCAGAGTATCAAGAGAAGCCCACAGTATGCACAGAGTTCTCTGAGCAACTTACGAAATGCATGA GGCTTCTTCAAGGATCTGGAAAGCTATACTGGAAAACGCTATTCTGAGTATTAGAAATTGATAAAATCCTCTGAGGTCTTGGGGCTCCAG GTGAGATTGGGGACTGGACCACAGCTGGCCTTGGCCATTATTCCCTCAGGTTGTTGGTCACCATGTTCACCTGTAAGTTTCTCCATCCCA ACTTCCATTTGACAAGCTCTAAAAGCAGGCATGGATTTATTTTCCATTCTCTTATCTCTCCAATATTCATAGCTACAGACCAAAGGTACC ATCCGATGATGATGTGTTCCTAGTCCTCAGTTGCAAATTCACCCATGCAAAGGTTAAGAAGTCTTAGAACATTCCTTTCTCTTCTTCCTC CTTTCAGGCCTCCAATGTCCATATCTTCTCTATTTCCTATGTGGCAGAGGAGTTGCTTGGATAAGTTACAGCCCTTTCCCTCAATATTGA ATCCAGAGTTTTGGGAAGGGATCTCTCAGAATATTCAGACAGGAACTCTCAGTATCCAGAGCAGGACTCCCAAGGCACTGCTTGATTCAA AAGGCGACAGCAGTTGGTCTACACAACGGATGTGTAGCTCTAGCACCTGACAGGTAGAAGATACCCTCAAGGCGCCTCCTGTAGACACAC GGGTAAACTCACACACTATGTCCTATCCCCACGCAGCAGTCGGAGGAACCAGGCTCTGGGCCAGGACAGTTTCCAGTGCTGTGAAGAAAC GAGGTGAGCAGTATCCAAGGGGCTCAAGGATAATCTGCTGATTTCTTTCTTGTCTTTCACACAGAGAGGCCACCAGCAGGAAAGCAGTGG GAGTTGGGTAGCTGCTGGGGCCAGCATGTCCTCTTCCACACTACCTGCCTTTCAGAACTCTGCTCTTCCGCTTGTCCCGAAGTCAGGGCT GGCAATCTTCATAATCAAAGGGGAGTTGGAAAAGAACACCCACTAAGAGGCCTCCATGGCAGATGTCAATTAAATTGCCCCCCCGCCCAA ATCTCATGACAGTTTATTCACATCAGTAGTGTGGGAAGTTACAATGTTTTTTTTAAAAAAAGCTTCTTTCCTTGGCTTTCCATTTCTTTG AAAAAAGGGTTTCTTTTGAATTTTTAAAGCTCTGCCATACTGAACATTCCTGTGGAAAGGTTTAAAATGCAGAGCCTGAGGTTTTTGCTT TTCAGAAAAATAAAAATCTTAGAGATTAGCTAGTGTAAATGTTAAGCTATAAATTATATTTCAAACTGTGAAAAAAAAAAGTTTTAAAGA >In-frame_HSPA8_ENST00000534624_chr11_122931301_-_VSTM5_ENST00000409977_chr11_93554489_-_3537nt ATCGTGAGGCGGAGCGCGGTGGGGTGGGTGCGGAAGGGGGCGAGGCCCGAGGAGTGGAGCCGGGCTTGTGATTGGGTCTTGTAAGGGCAG CCGGGCGTCTATTGGCCGGGGAAGCCGTAATGGCAGGCAGCAGGGGCGGGCCCCTTCTGGAAGGTTCTAAGATAGGGTATAAGAGGCAGG GTGGCGGGCGGAAACCGGTCTCATTGAACTCGCCTGCAGCTCTTGGGTTTTTTGTGGCTTCCTTCGTTATTGGAGCCAGGCCTACACCCC AGCAACCATGTCCAAGGGACCTGCAGTTGGTATTGATCTTGGCACCACCTACTCTTGTGTGGGTGTTTTCCAGCACGGAAAAGTCGAGAT AATTGCCAATGATCAGGGAAACCGAACCACTCCAAGCTATGTCGCCTTTACGGACACTGAACGGTTGATCGGTGATGCCGCAAAGAATCA AGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAA ACATTGGCCCTTTATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATACAAGGGAGAGACCAAAAGCTTCTATCCAGAGGA GGTGTCTTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGGTCAGGGTGTGTCCCTATACATTCCTCAGGCC ACCATCAATGCCACTGTCAAAGAAGACATCCTGCTCTCAGTTGAGTACTCCTGTCATGGAGTGCCCACCATCGAATGGACATATTCATCC AATTGGGGAACGCAGAAGATCGTGGAGTGGAAACCAGGGACTCAGGCCAACATCTCTCAAAGCCACAAGGACAGAGTCTGCACCTTTGAC AACGGCTCCATCCAGCTCTTCAGCGTGGGAGTGAGGGATTCCGGCTACTATGTCATCACCGTGACGGAGCGCCTGGGGAGCAGCCAGTTT GGCACCATCGTGCTGCACGTCTCTGAGATCCTCTATGAAGACCTGCACTTTGTCGCTGTCATCCTTGCTTTTCTCGCTGCTGTGGCCGCA GTATTAATCAGCCTCATGTGGGTTTGTAATAAGTGTGCATATAAATTTCAGAGGAAGAGAAGACACAAACTCAAAGAAAGCACAACTGAG GAGATTGAGCTGGAAGATGTTGAGTGTTAGCCAAGGCTGGGCCTGACTGCATTCCTACCTCAAGAGGAAACCATTCTCCAACAAAAAGAG CAAGCACAGCTATTATACCCATTGTGTGTGGTCCTGTTGCAGCCCGCTCCTAACAGGACAGTGGGAGATTAACAACATTGACTGCATGGA GTTGAGGACTGTGGATGGGACAAAGCTAGTATTAGGACTCGCGCTAAGTTCAAGGAGAAGAGTGATTGAGGCTTTGAACCAGGAGCTTCG CTTGGCTGCAGCATCAGGGCCGTGCTGACACATAACCAATGGGTGAGTGCAGGCGTTGGCTGCTTGCTCACGACACTTGCTCTGGTGTGC AGGATGGCCTGTTGTCAGAGTCCCTGTATCAGAGGCCAGAGGATTTCCAGATGGATGTGCAGCCAGCATTAGAACATGCTTTCTGTGCTC CTGTCTGCTCTGCAACTGCTGTGCCAACCAGCCCCCCATCTGGTATCCCACAAGCAAGCACTGCTGTGGGAGCTATTGTGAGAAAACCTG AGGCTTTTAGACAATCTGCTGCCTCAGAGCAGAGGTGGAAAGAGACTGGGGGTGGGGGTTGGTGCTGTTGTGCTGCAGAGTTTTTCATTG GTGAGGCCCGGTGGCTGGGAGTTTTATGGGAGAGGAGCTCAATGGACTCCTGAGAGGCCAGCTTTGGATACAAGGAATAGAGAAAATTAT CTTTCTCTTCCTCCCTCATTCCAACGTTAATTGGATTTTCCCTCCCATGGCTCAAACTTAGGCCATTGTAAGTAAAACAACAGCTCATCT CCATTATGGGCAGCACCTGGCCTCCTGACGAGCTGGATGCCACCTGTGTGAAAGCTGAGCTTGCATAGTGGGTGATGCAGCTGGAAAATC AGTCATCTCGGGCTTTGCATCTGTCCCCCTCAGTCACTAACACTTCACGTCTCAAGTCAGGCCCTTGCCCTCTCCTACCTGGGCTGAGGA ACGCTTGGCCCTTGCCTACCTCACAGTCAGAGTATCAAGAGAAGCCCACAGTATGCACAGAGTTCTCTGAGCAACTTACGAAATGCATGA GGCTTCTTCAAGGATCTGGAAAGCTATACTGGAAAACGCTATTCTGAGTATTAGAAATTGATAAAATCCTCTGAGGTCTTGGGGCTCCAG GTGAGATTGGGGACTGGACCACAGCTGGCCTTGGCCATTATTCCCTCAGGTTGTTGGTCACCATGTTCACCTGTAAGTTTCTCCATCCCA ACTTCCATTTGACAAGCTCTAAAAGCAGGCATGGATTTATTTTCCATTCTCTTATCTCTCCAATATTCATAGCTACAGACCAAAGGTACC ATCCGATGATGATGTGTTCCTAGTCCTCAGTTGCAAATTCACCCATGCAAAGGTTAAGAAGTCTTAGAACATTCCTTTCTCTTCTTCCTC CTTTCAGGCCTCCAATGTCCATATCTTCTCTATTTCCTATGTGGCAGAGGAGTTGCTTGGATAAGTTACAGCCCTTTCCCTCAATATTGA ATCCAGAGTTTTGGGAAGGGATCTCTCAGAATATTCAGACAGGAACTCTCAGTATCCAGAGCAGGACTCCCAAGGCACTGCTTGATTCAA AAGGCGACAGCAGTTGGTCTACACAACGGATGTGTAGCTCTAGCACCTGACAGGTAGAAGATACCCTCAAGGCGCCTCCTGTAGACACAC GGGTAAACTCACACACTATGTCCTATCCCCACGCAGCAGTCGGAGGAACCAGGCTCTGGGCCAGGACAGTTTCCAGTGCTGTGAAGAAAC GAGGTGAGCAGTATCCAAGGGGCTCAAGGATAATCTGCTGATTTCTTTCTTGTCTTTCACACAGAGAGGCCACCAGCAGGAAAGCAGTGG GAGTTGGGTAGCTGCTGGGGCCAGCATGTCCTCTTCCACACTACCTGCCTTTCAGAACTCTGCTCTTCCGCTTGTCCCGAAGTCAGGGCT GGCAATCTTCATAATCAAAGGGGAGTTGGAAAAGAACACCCACTAAGAGGCCTCCATGGCAGATGTCAATTAAATTGCCCCCCCGCCCAA ATCTCATGACAGTTTATTCACATCAGTAGTGTGGGAAGTTACAATGTTTTTTTTAAAAAAAGCTTCTTTCCTTGGCTTTCCATTTCTTTG AAAAAAGGGTTTCTTTTGAATTTTTAAAGCTCTGCCATACTGAACATTCCTGTGGAAAGGTTTAAAATGCAGAGCCTGAGGTTTTTGCTT TTCAGAAAAATAAAAATCTTAGAGATTAGCTAGTGTAAATGTTAAGCTATAAATTATATTTCAAACTGTGAAAAAAAAAAGTTTTAAAGA |
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FusionGenePPI for HSPA8_VSTM5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HSPA8 | BAG1, HSPBP1, PPID, TCERG1, BRCA1, FANCC, PPP1R15A, HCFC1, HDAC3, CITED1, NOA1, TM4SF1, TADA3, ERH, FBP1, UBC, RGS2, DNAJA3, JAK2, DNAJB1, DNAJA1, CFTR, HSP90AA1, PPP1CA, PPP1R12B, RBX1, BAG2, BAG3, DNAJC3, CYCS, POLR3D, TP53, BAG4, TNFRSF1A, STMN1, GOT2, STUB1, HSF1, PARK2, GPR37, CDC5L, HGS, HNRNPD, MAPT, RUVBL1, GPN1, RPAP1, PACSIN1, PACSIN2, PACSIN3, HDAC10, EGFR, MST1R, VCP, RFWD2, ESR1, SOD1, CDK11B, CCND1, CDK4, TSSK6, HIST3H3, MEN1, IL16, CENPA, WDR82, RAF1, CDK5RAP3, FGFR3, ERG, USP50, LALBA, CLTA, HTT, AGO4, CD4, DGCR8, MME, TLR4, TLR9, MDM2, DYRK2, UBE3A, YWHAQ, INSIG2, HMGB1, BCR, ABL1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, PSMA3, MAPK8, VHL, SF3A2, ARRB1, ARRB2, MKKS, ATXN1, PARD3, ISG15, FBXO25, DNAJB2, UCHL1, PPP1CC, PSMA2, CUL3, CUL4A, SNCA, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, MCL1, PPP2R1A, EEF1A1, HERC5, SGTA, FAF1, KCND3, BCAS2, CWC15, AIPL1, HSPA4, APP, LRRK2, RBSN, AKT1, SPRTN, CAPZB, CAPZA1, DNAJB14, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, ATP13A2, LMAN1, RAD23A, IRAK1, GCH1, HSPA5, HSPD1, VAMP2, HSPA2, PRKDC, RNPS1, PDIA3, HNRNPA3, RPS4X, SAMM50, EEF2, SEC24C, DNAJB12, STIP1, SSBP1, RPS15A, RPL18A, NECAP2, SON, RPL8, SEC31A, POU2F1, HSPA1A, KCNH2, NLRP12, EIF4A3, MAGOH, SMURF1, CTNNB1, TRAF3IP1, KCNQ4, SUGT1, ESR2, FN1, VCAM1, SRRT, CCAR2, CDH1, C1QBP, BRAF, MAP2K1, YWHAE, IQCB1, PPP5C, SYNPO2, CAMKMT, METTL20, METTL21A, METTL21B, METTL21C, METTL22, UBL4A, ITGA4, SLC12A3, PAN2, ST13, RAD52, HDAC6, DNAJC7, TTC1, LAMP2, HIF1A, TGM2, HLTF, JUN, FBXO6, TARDBP, TOPBP1, RELA, CDKN2A, ASNA1, ATXN10, HSPA6, NAPRT, RPS6KA3, TUBA4B, YARS, SHFM1, RPA3, RPA2, RPA1, WWOX, ZBTB1, ERRFI1, HSPH1, DNAJB6, EDRF1, DNAJC9, GABRB1, HSPA4L, HYOU1, TUBA1A, AMT, DNAJA2, FLYWCH2, IVNS1ABP, STAU1, AIRE, AURKA, HAUS1, CDC20, CDKN1A, CEP250, HAUS2, LGALS3BP, TUBG1, TUBGCP2, TUBGCP3, TUBGCP4, IL32, FUS, NMI, TRIM38, C17orf49, EED, MCF2, SUMO2, SIRT6, CCNI2, DRG2, LPGAT1, LRRC28, POC1A, VASH1, EBNA1BP2, FAM189B, KIAA1191, NXF5, RIC3, TSSK1B, USP46, VSX1, ZSCAN32, WDR37, APBB2, NDRG2, KCNJ10, CCDC117, DENND2D, CYP3A4, KNSTRN, RPS6KB2, HNRNPA1, AMBRA1, APOA1BP, DNAJA4, DNAJB4, DNAJC1, DNAJC13, DNAJC2, DUT, FDPS, GAPDH, C12orf10, CAD, CPS1, DNAJB11, GRPEL1, HSP90AB1, HSPA9, HSPB1, PABPC1, RPLP0, TECR, IPO7, LMNB1, NACA, RPL13A, RPL7, TUBB, NTRK1, PTEN, ATM, NPHP4, AHSA1, PPME1, AKAP5, LRPPRC, KIF1C, KIAA1107, SDHAF2, CDCA5, ID2, RNF207, GAN, HEMGN, SKI, CRY2, ALKBH3, MCM2, MCM5, HTN3, CDKN1B, SNW1, KCNA5, OTUB1, ERBB3, ESRRB, CDC37, NANOG, POU5F1, ZNF618, U2AF2, NFATC2, CDC73, PHF8, HYPK, RFX1, DERL1, HSF2, CD207, ARMC1, ABL2, PDPK1, GAK, TBC1D23, ARFIP1, GMNN, HMCES, HIST2H3PS2, RPRD2, TBCE, C6orf106, EP300, SRP54, CYP8B1, TACC3, MAPRE2, SNX20, SERPINA1, ABHD15, KLHL34, ZNF703, KCTD15, SF3A1, HBB, KCND2, VILL, HBA2, SF3A3, SLC27A3, TCAP, ALOXE3, DGCR14, HDLBP, GNA15, ILK, C21orf59, NUS1, CSNK1E, NOX5, FAM73B, FUZ, HIST1H1B, DCDC2B, VWA2, PRODH, NFS1, CDK10, TRIM16L, ARNT, MAP2K2, QRICH1, TAB1, CNN2, WNK1, ENDOG, CKAP5, GANAB, RNF34, GFAP, PPP1R8, C19orf45, HCFC2, SPATA5L1, MAVS, TRMT12, CAPG, LRRC56, NMNAT3, VSIG8, TYSND1, SSMEM1, THSD4, TTC30B, KCNV2, DSCR4, FOXRED1, KLHL10, SETMAR, ZNF488, VANGL2, EPB42, LEPREL2, HAO2, BPNT1, FRMD8P1, RNF25, DET1, KLHL36, PRKACG, MAD1L1, CHD1L, AGPAT3, NPAS1, DHX57, CPLX4, GPR6, PNPLA5, KCNC4, PANK2, NLRX1, FOXC1, ATF1, CSTF3, IER2, CFAP52, HTR1E, THAP4, BBS1, CSNK1D, ALB, POLE, PPEF1, C9orf116, PTGIR, EXOC3L2, C1orf94, SSH3, CYB5R3, KBTBD4, F12, GK2, TAF6L, PTRF, DOCK5, FCRL3, C20orf96, FAM187B, CDK3, TSPYL6, MVP, IL17RC, ARHGEF16, CHI3L1, CSDE1, CDKL3, MPZL1, RCCD1, GLIPR1, SP1, MYB, FANCA, CYLD, DDX59, CREBBP, EDEM3, TRIM25, UBE2S, HEY1, MTF1, DCAF4L2, TXNIP, SLC6A4, UBQLN2 | VSTM5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSPA8_VSTM5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HSPA8 | P11142 | DB01254 | Dasatinib | Heat shock cognate 71 kDa protein | small molecule | approved|investigational |
| Hgene | HSPA8 | P11142 | DB11638 | Artenimol | Heat shock cognate 71 kDa protein | small molecule | approved|investigational |
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RelatedDiseases for HSPA8_VSTM5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HSPA8 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | HSPA8 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | HSPA8 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | HSPA8 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | HSPA8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | HSPA8 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
| Hgene | HSPA8 | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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