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Fusion gene ID: 16866 |
FusionGeneSummary for HSPA4L_INIP |
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Fusion gene information | Fusion gene name: HSPA4L_INIP | Fusion gene ID: 16866 | Hgene | Tgene | Gene symbol | HSPA4L | INIP | Gene ID | 22824 | 58493 |
Gene name | heat shock protein family A (Hsp70) member 4 like | INTS3 and NABP interacting protein | |
Synonyms | APG-1|HSPH3|Osp94 | C9orf80|HSPC043|MISE|SOSSC|SSBIP1|hSSBIP1 | |
Cytomap | 4q28.1 | 9q32 | |
Type of gene | protein-coding | protein-coding | |
Description | heat shock 70 kDa protein 4Lheat shock 70 kDa protein 4-like proteinheat shock 70-related protein APG-1heat shock 70kDa protein 4-likeheat shock protein (hsp110 family)osmotic stress protein 94testis tissue sperm-binding protein Li 64n | SOSS complex subunit CSSB-interacting protein 1hSSB-interacting protein 1minute INTS3/hSSB-associated elementsensor of single-strand DNA complex subunit Csensor of ssDNA subunit Csingle-stranded DNA-binding protein-interacting protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O95757 | Q9NRY2 | |
Ensembl transtripts involved in fusion gene | ENST00000439123, ENST00000508776, ENST00000296464, ENST00000505726, ENST00000515262, | ENST00000374242, ENST00000374238, ENST00000497712, ENST00000374236, ENST00000374234, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: HSPA4L [Title/Abstract] AND INIP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC013097 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000439123 | ENST00000374242 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000439123 | ENST00000374238 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000439123 | ENST00000497712 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000439123 | ENST00000374236 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000439123 | ENST00000374234 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000508776 | ENST00000374242 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000508776 | ENST00000374238 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000508776 | ENST00000497712 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000508776 | ENST00000374236 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000508776 | ENST00000374234 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000296464 | ENST00000374242 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000296464 | ENST00000374238 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000296464 | ENST00000497712 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000296464 | ENST00000374236 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000296464 | ENST00000374234 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000505726 | ENST00000374242 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000505726 | ENST00000374238 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000505726 | ENST00000497712 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000505726 | ENST00000374236 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000505726 | ENST00000374234 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000515262 | ENST00000374242 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000515262 | ENST00000374238 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000515262 | ENST00000497712 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000515262 | ENST00000374236 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
intron-intron | ENST00000515262 | ENST00000374234 | HSPA4L | chr4 | 128730752 | + | INIP | chr9 | 115454569 | + |
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FusionProtFeatures for HSPA4L_INIP |
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Hgene | Tgene |
HSPA4L | INIP |
Possesses chaperone activity in vitro where it inhibitsaggregation of citrate synthase. {ECO:0000250}. | Component of the SOSS complex, a multiprotein complexthat functions downstream of the MRN complex to promote DNA repairand G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints inthe cellular DNA damage response including cell-cycle checkpointactivation, recombinational repair and maintenance of genomicstability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependentsignaling pathways. {ECO:0000269|PubMed:19605351,ECO:0000269|PubMed:19683501}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSPA4L_INIP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HSPA4L_INIP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSPA4L_INIP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HSPA4L_INIP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |