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Fusion gene ID: 16856 |
FusionGeneSummary for HSPA13_CCDC88C |
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Fusion gene information | Fusion gene name: HSPA13_CCDC88C | Fusion gene ID: 16856 | Hgene | Tgene | Gene symbol | HSPA13 | CCDC88C | Gene ID | 6782 | 440193 |
Gene name | heat shock protein family A (Hsp70) member 13 | coiled-coil domain containing 88C | |
Synonyms | STCH | DAPLE|HKRP2|KIAA1509|SCA40 | |
Cytomap | 21q11.2 | 14q32.11-q32.12 | |
Type of gene | protein-coding | protein-coding | |
Description | heat shock 70 kDa protein 13heat shock protein 70kDa family, member 13microsomal stress 70 protein ATPase corestress 70 protein chaperone, microsome-associated, 60kDstress 70 protein chaperone, microsome-associated, 60kDastress-70 protein chaperone m | protein DapleDvl-associating protein with a high frequency of leucine residueshook-related protein 2spinocerebellar ataxia 40 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P48723 | Q9P219 | |
Ensembl transtripts involved in fusion gene | ENST00000285667, ENST00000544452, ENST00000478035, | ENST00000389857, ENST00000331194, ENST00000389856, ENST00000553403, ENST00000554165, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 7 X 5=245 |
# samples | 3 | 8 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HSPA13 [Title/Abstract] AND CCDC88C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU124561 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - | ||
ChiTaRS3.1 | AK022593 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000285667 | ENST00000389857 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-3CDS | ENST00000285667 | ENST00000331194 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000285667 | ENST00000389856 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000285667 | ENST00000553403 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000285667 | ENST00000554165 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-3CDS | ENST00000544452 | ENST00000389857 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-3CDS | ENST00000544452 | ENST00000331194 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000544452 | ENST00000389856 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000544452 | ENST00000553403 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000544452 | ENST00000554165 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-3CDS | ENST00000478035 | ENST00000389857 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-3CDS | ENST00000478035 | ENST00000331194 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000478035 | ENST00000389856 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000478035 | ENST00000553403 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
intron-intron | ENST00000478035 | ENST00000554165 | HSPA13 | chr21 | 15744824 | - | CCDC88C | chr14 | 91745632 | - |
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FusionProtFeatures for HSPA13_CCDC88C |
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Hgene | Tgene |
HSPA13 | CCDC88C |
Has peptide-independent ATPase activity. | Negative regulator of the canonical Wnt signalingpathway, acting downstream of DVL to inhibit CTNNB1/Beta-cateninstabilization (By similarity). May also activate the JNK signalingpathway (PubMed:25062847). {ECO:0000250|UniProtKB:Q6VGS5,ECO:0000269|PubMed:25062847}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSPA13_CCDC88C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HSPA13_CCDC88C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSPA13_CCDC88C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HSPA13_CCDC88C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |