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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16814

FusionGeneSummary for HSDL1_CORO1A

check button Fusion gene summary
Fusion gene informationFusion gene name: HSDL1_CORO1A
Fusion gene ID: 16814
HgeneTgene
Gene symbol

HSDL1

CORO1A

Gene ID

83693

11151

Gene namehydroxysteroid dehydrogenase like 1coronin 1A
SynonymsSDR12C3CLABP|CLIPINA|HCORO1|IMD8|TACO|p57
Cytomap

16q24.1

16p11.2

Type of geneprotein-codingprotein-coding
Descriptioninactive hydroxysteroid dehydrogenase-like protein 1short chain dehydrogenase/reductase family 12C member 3steroid dehydrogenase-like proteincoronin-1Aclipin-Acoronin, actin binding protein, 1Acoronin-1coronin-like protein Acoronin-like protein p57tryptophan aspartate-containing coat protein
Modification date2018052320180519
UniProtAcc

Q3SXM5

P31146

Ensembl transtripts involved in fusion geneENST00000219439, ENST00000565275, 
ENST00000434463, 
ENST00000219150, 
ENST00000566619, ENST00000570045, 
ENST00000565497, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: HSDL1 [Title/Abstract] AND CORO1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCORO1A

GO:0050918

positive chemotaxis

17442961

TgeneCORO1A

GO:0051126

negative regulation of actin nucleation

17442961


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1469-01AHSDL1chr16

84178685

-CORO1Achr16

30196530

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000219439ENST00000219150HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-3UTRENST00000219439ENST00000566619HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-5UTRENST00000219439ENST00000570045HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-5UTRENST00000219439ENST00000565497HSDL1chr16

84178685

-CORO1Achr16

30196530

+
intron-5UTRENST00000565275ENST00000219150HSDL1chr16

84178685

-CORO1Achr16

30196530

+
intron-3UTRENST00000565275ENST00000566619HSDL1chr16

84178685

-CORO1Achr16

30196530

+
intron-5UTRENST00000565275ENST00000570045HSDL1chr16

84178685

-CORO1Achr16

30196530

+
intron-5UTRENST00000565275ENST00000565497HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-5UTRENST00000434463ENST00000219150HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-3UTRENST00000434463ENST00000566619HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-5UTRENST00000434463ENST00000570045HSDL1chr16

84178685

-CORO1Achr16

30196530

+
5UTR-5UTRENST00000434463ENST00000565497HSDL1chr16

84178685

-CORO1Achr16

30196530

+

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FusionProtFeatures for HSDL1_CORO1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSDL1

Q3SXM5

CORO1A

P31146

May be a crucial component of the cytoskeleton of highlymotile cells, functioning both in the invagination of large piecesof plasma membrane, as well as in forming protrusions of theplasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane preventsfusion between phagosomes and lysosomes.{ECO:0000269|PubMed:10338208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSDL1_CORO1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSDL1_CORO1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSDL1TM4SF20, EDA2R, TRABD, NT5E, LYPD3, RTN4, FAM63B, NTRK1, COQ9, SCN3B, GPR21, TSPAN2, FPR2, PPTC7, RNF19B, TOMM22, HTR3D, IMPDH1, VIPR2, C3AR1, KCNJ6, MGRN1CORO1ADKK1, UBE2G2, FMNL1, STAT3, MAGOH, TAB1, POLR1C, FHL3, LMO2, SMAD3, SMARCD1, GIT2, POT1, SPATA20, YTHDC1, GOLGA2, FSD2, POC1A, SLC25A41, IFT57, POC1B, CORO6, CORO1B, BICD2, IFT172, VARS, RABGAP1L, RABGAP1, IFT20, TRAF7, TJAP1, IFT80, FAM208A, CEP44, CORO2A, ACTR2, ACTR3, ASPDH, NHP2L1, U2AF2, CORO1C, NELL2, TMCC2, COX4I1, MRPL12, RASSF8, TMEM205, FOXA3, DNAJC1, DDX24


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSDL1_CORO1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSDL1_CORO1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCORO1AC0024667Animal Mammary Neoplasms1CTD_human
TgeneCORO1AC0041296Tuberculosis1CTD_human
TgeneCORO1AC3809383IMMUNODEFICIENCY 81ORPHANET;UNIPROT