![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 16814 |
FusionGeneSummary for HSDL1_CORO1A |
![]() |
Fusion gene information | Fusion gene name: HSDL1_CORO1A | Fusion gene ID: 16814 | Hgene | Tgene | Gene symbol | HSDL1 | CORO1A | Gene ID | 83693 | 11151 |
Gene name | hydroxysteroid dehydrogenase like 1 | coronin 1A | |
Synonyms | SDR12C3 | CLABP|CLIPINA|HCORO1|IMD8|TACO|p57 | |
Cytomap | 16q24.1 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | inactive hydroxysteroid dehydrogenase-like protein 1short chain dehydrogenase/reductase family 12C member 3steroid dehydrogenase-like protein | coronin-1Aclipin-Acoronin, actin binding protein, 1Acoronin-1coronin-like protein Acoronin-like protein p57tryptophan aspartate-containing coat protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q3SXM5 | P31146 | |
Ensembl transtripts involved in fusion gene | ENST00000219439, ENST00000565275, ENST00000434463, | ENST00000219150, ENST00000566619, ENST00000570045, ENST00000565497, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: HSDL1 [Title/Abstract] AND CORO1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CORO1A | GO:0050918 | positive chemotaxis | 17442961 |
Tgene | CORO1A | GO:0051126 | negative regulation of actin nucleation | 17442961 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-1469-01A | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000219439 | ENST00000219150 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-3UTR | ENST00000219439 | ENST00000566619 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-5UTR | ENST00000219439 | ENST00000570045 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-5UTR | ENST00000219439 | ENST00000565497 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
intron-5UTR | ENST00000565275 | ENST00000219150 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
intron-3UTR | ENST00000565275 | ENST00000566619 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
intron-5UTR | ENST00000565275 | ENST00000570045 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
intron-5UTR | ENST00000565275 | ENST00000565497 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-5UTR | ENST00000434463 | ENST00000219150 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-3UTR | ENST00000434463 | ENST00000566619 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-5UTR | ENST00000434463 | ENST00000570045 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
5UTR-5UTR | ENST00000434463 | ENST00000565497 | HSDL1 | chr16 | 84178685 | - | CORO1A | chr16 | 30196530 | + |
Top |
FusionProtFeatures for HSDL1_CORO1A |
![]() |
Hgene | Tgene |
HSDL1 | CORO1A |
May be a crucial component of the cytoskeleton of highlymotile cells, functioning both in the invagination of large piecesof plasma membrane, as well as in forming protrusions of theplasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane preventsfusion between phagosomes and lysosomes.{ECO:0000269|PubMed:10338208}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HSDL1_CORO1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HSDL1_CORO1A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HSDL1 | TM4SF20, EDA2R, TRABD, NT5E, LYPD3, RTN4, FAM63B, NTRK1, COQ9, SCN3B, GPR21, TSPAN2, FPR2, PPTC7, RNF19B, TOMM22, HTR3D, IMPDH1, VIPR2, C3AR1, KCNJ6, MGRN1 | CORO1A | DKK1, UBE2G2, FMNL1, STAT3, MAGOH, TAB1, POLR1C, FHL3, LMO2, SMAD3, SMARCD1, GIT2, POT1, SPATA20, YTHDC1, GOLGA2, FSD2, POC1A, SLC25A41, IFT57, POC1B, CORO6, CORO1B, BICD2, IFT172, VARS, RABGAP1L, RABGAP1, IFT20, TRAF7, TJAP1, IFT80, FAM208A, CEP44, CORO2A, ACTR2, ACTR3, ASPDH, NHP2L1, U2AF2, CORO1C, NELL2, TMCC2, COX4I1, MRPL12, RASSF8, TMEM205, FOXA3, DNAJC1, DDX24 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HSDL1_CORO1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HSDL1_CORO1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CORO1A | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | CORO1A | C0041296 | Tuberculosis | 1 | CTD_human |
Tgene | CORO1A | C3809383 | IMMUNODEFICIENCY 8 | 1 | ORPHANET;UNIPROT |