FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 16811

FusionGeneSummary for HSD17B4_TNFAIP8

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD17B4_TNFAIP8
Fusion gene ID: 16811
HgeneTgene
Gene symbol

HSD17B4

TNFAIP8

Gene ID

3295

25816

Gene namehydroxysteroid 17-beta dehydrogenase 4TNF alpha induced protein 8
SynonymsDBP|MFE-2|MPF-2|PRLTS1|SDR8C1GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2
Cytomap

5q23.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratasetumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8
Modification date2018052220180523
UniProtAcc

P51659

O95379

Ensembl transtripts involved in fusion geneENST00000256216, ENST00000515320, 
ENST00000510025, ENST00000504811, 
ENST00000414835, ENST00000513628, 
ENST00000509514, ENST00000522415, 
ENST00000274456, ENST00000513374, 
ENST00000504771, ENST00000503646, 
ENST00000504642, ENST00000415806, 
Fusion gene scores* DoF score2 X 3 X 3=185 X 4 X 4=80
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSD17B4 [Title/Abstract] AND TNFAIP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

HgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

HgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

HgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

HgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-JW-A5VL-01AHSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
TCGARVSTADTCGA-CD-A4MH-01AHSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000256216ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000256216ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000515320ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3UTRENST00000510025ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000504811ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000504811ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000504811ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3UTRENST00000414835ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000513628ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000509514ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000522415ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000256216ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000515320ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000510025ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000504811ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000414835ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000513628ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000509514ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3UTRENST00000522415ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+

Top

FusionProtFeatures for HSD17B4_TNFAIP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD17B4

P51659

TNFAIP8

O95379

Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. {ECO:0000269|PubMed:8902629,ECO:0000269|PubMed:9089413}. Acts as a negative mediator of apoptosis and may play arole in tumor progression. Suppresses the TNF-mediated apoptosisby inhibiting caspase-8 activity but not the processing ofprocaspase-8, subsequently resulting in inhibition of BID cleavageand caspase-3 activation. {ECO:0000269|PubMed:10644768,ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HSD17B4_TNFAIP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HSD17B4_TNFAIP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSD17B4UBA5, UBC, NDRG1, MYC, GRB2, SNCA, ACAA1, SCP2, CAT, GRHPR, SSBP1, FIS1, GNB2L1, VAMP2, PEX5, PEX14, ADRB2, CASP9, BAK1, CDK7, MAPK8, HECW2, STAU1, CUL7, CCDC8, DECR1, EEF2, IDH1, NTRK1, SCARNA22, RPGRIP1, FOS, HNRNPD, HNRNPU, SORT1, RACGAP1, NF2, CDC73, PPM1A, DUSP22, DUSP4, IKZF1, DLD, DLST, PDHA1, SDHATNFAIP8MED4, PTP4A2, PTP4A1, ACOT7, DLD, DPP3, EIF6, HSPA9, IPO5, NHLRC2, PPP1R2, ASS1, ATG3, YWHAE, SDCBP, PRR13, PLEKHF2, TIFA, INO80E, SHMT2, LATS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HSD17B4_TNFAIP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HSD17B4_TNFAIP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSD17B4C0342870Bifunctional peroxisomal enzyme deficiency4CTD_human;ORPHANET;UNIPROT
HgeneHSD17B4C0282528Peroxisomal Disorders2CTD_human
HgeneHSD17B4C0685838Gonadal dysgenesis XX type deafness2CTD_human;ORPHANET;UNIPROT
HgeneHSD17B4C0037769West Syndrome1CTD_human
HgeneHSD17B4C0043459Zellweger Syndrome1CTD_human
TgeneTNFAIP8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTNFAIP8C0027627Neoplasm Metastasis1CTD_human
TgeneTNFAIP8C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTNFAIP8C3495559Juvenile arthritis1CTD_human