|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16802 |
FusionGeneSummary for HSD17B11_UGT2A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSD17B11_UGT2A3 | Fusion gene ID: 16802 | Hgene | Tgene | Gene symbol | HSD17B11 | UGT2A3 | Gene ID | 51170 | 79799 |
| Gene name | hydroxysteroid 17-beta dehydrogenase 11 | UDP glucuronosyltransferase family 2 member A3 | |
| Synonyms | 17-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C2 | - | |
| Cytomap | 4q22.1 | 4q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | estradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-ch | UDP-glucuronosyltransferase 2A3UDP glucuronosyltransferase 2 family, polypeptide A3UDPGT 2A3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NBQ5 | Q6UWM9 | |
| Ensembl transtripts involved in fusion gene | ENST00000358290, ENST00000507518, ENST00000507286, | ENST00000251566, ENST00000420231, ENST00000547910, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 1 X 3=12 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HSD17B11 [Title/Abstract] AND UGT2A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HSD17B11 | GO:0006710 | androgen catabolic process | 12697717 |
| Tgene | UGT2A3 | GO:0052695 | cellular glucuronidation | 19858781 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BD-A2L6-01A | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000358290 | ENST00000251566 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-5UTR | ENST00000358290 | ENST00000420231 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-intron | ENST00000358290 | ENST00000547910 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| intron-3CDS | ENST00000507518 | ENST00000251566 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| intron-5UTR | ENST00000507518 | ENST00000420231 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| intron-intron | ENST00000507518 | ENST00000547910 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| In-frame | ENST00000507286 | ENST00000251566 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-5UTR | ENST00000507286 | ENST00000420231 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-intron | ENST00000507286 | ENST00000547910 | HSD17B11 | chr4 | 88312013 | - | UGT2A3 | chr4 | 69798477 | - |
Top |
FusionProtFeatures for HSD17B11_UGT2A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSD17B11 | UGT2A3 |
| Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participatein androgen metabolism during steroidogenesis. May act bymetabolizing compounds that stimulate steroid synthesis and/or bygenerating metabolites that inhibit it. Has no activity towardDHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. | UDP-glucuronosyltransferases catalyze phase IIbiotransformation reactions in which lipophilic substrates areconjugated with glucuronic acid to increase water solubility andenhance excretion. They are of major importance in the conjugationand subsequent elimination of potentially toxic xenobiotics andendogenous compounds (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HSD17B11 | chr4:88312013 | chr4:69798477 | ENST00000358290 | - | 1 | 7 | 40_64 | 70 | 301 | Nucleotide binding | NADP |
| Tgene | >UGT2A3 | chr4:88312013 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 513_527 | 288 | 528 | Topological domain | Cytoplasmic |
| Tgene | >UGT2A3 | chr4:88312013 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 492_512 | 288 | 528 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | UGT2A3 | chr4:88312013 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 24_491 | 288 | 528 | Topological domain | Extracellular |
Top |
FusionGeneSequence for HSD17B11_UGT2A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HSD17B11_ENST00000358290_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_310aa MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS >In-frame_HSD17B11_ENST00000507286_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_310aa MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKEMENFVQSSGEDGIVVFSLG SLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQL DNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HSD17B11_ENST00000358290_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_930nt ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGG AGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA AGCAAGCTGGTTCTCTGGGATATAAATAAGGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGG TCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAA GGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCT TTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTT GATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGA ACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCA GTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCT ATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAAT >In-frame_HSD17B11_ENST00000507286_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_930nt ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGG AGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA AGCAAGCTGGTTCTCTGGGATATAAATAAGGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGG TCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAA GGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCT TTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTT GATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGA ACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCA GTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCT ATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HSD17B11_ENST00000358290_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_2596nt TGGTGTAAAAGACAATCGCGGCCACACACCGCGTGGGGGCTGCGCAAAGCAGAACTAGGAAGCTTTGCTCCGGTCTGGACTTCGTCCCTC CCAGATCTCTGAGCTAGCAAGCACTGCAGCCCGAGCCAATTGCGAAAGACCAACAAAGCCCAGCCCAGCGGAAGGAACGGTTTCGGAGTT GTTTTTCTTTGATACGGGAGTTCCTCCTTGCTCTCGCCCCTACTCTTTCTGGTGTTAGATCGAGCTACCCTCTAAAAGCAGTTTAGAGTG GTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGAT CGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTGATTACAGGAGCTGG GCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGTTCTCTGGGATATAAATAAGGAAATGGAAAATTT TGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGC TTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGA TTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTA CCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAAT AAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATT ATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCA CCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTAT ATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTC AAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATT TTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTC TCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATA ACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCAC AAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAAT AAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTA TTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACC TTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTA TTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATAT GTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTT CTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAG GTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATG TTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATA AATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATG >In-frame_HSD17B11_ENST00000507286_chr4_88312013_-_UGT2A3_ENST00000251566_chr4_69798477_-_2359nt GATCGAGCTACCCTCTAAAAGCAGTTTAGAGTGGTAAAAAAAAAAAAAAACACACCAAACGCTCGCAGCCACAAAAGGGATGAAATTTCT TCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAGTCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGT CACCGGCGAAATCGTGCTGATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAAAGCAAGCTGGT TCTCTGGGATATAAATAAGGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCA AAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACC ATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCA TGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGC TCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTAC CGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGAT CGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGAT TGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAA GATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAA CCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCAT TCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGA TATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACA TGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGA GAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGAT GACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAAT ACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAA CATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAAT TTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTAT AATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTC ATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAA GCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTT AGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTA TATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAATAAATATAAGTATTTTTCTTGTGTATGTATACAATAAATATAAATAAA |
Top |
FusionGenePPI for HSD17B11_UGT2A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HSD17B11 | ELAVL1, FBXO6, PEX19, NTRK1, IL13RA2, UBC | UGT2A3 | UGT2A2, UGT2B15, HBA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HSD17B11_UGT2A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HSD17B11_UGT2A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|