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Fusion gene ID: 16801 |
FusionGeneSummary for HSD17B11_SPARCL1 |
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Fusion gene information | Fusion gene name: HSD17B11_SPARCL1 | Fusion gene ID: 16801 | Hgene | Tgene | Gene symbol | HSD17B11 | SPARCL1 | Gene ID | 51170 | 8404 |
Gene name | hydroxysteroid 17-beta dehydrogenase 11 | SPARC like 1 | |
Synonyms | 17-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C2 | MAST 9|MAST9|PIG33|SC1 | |
Cytomap | 4q22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | estradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-ch | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NBQ5 | Q14515 | |
Ensembl transtripts involved in fusion gene | ENST00000358290, ENST00000507518, ENST00000507286, | ENST00000282470, ENST00000418378, ENST00000503414, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 10 X 8 X 5=400 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HSD17B11 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HSD17B11 | GO:0006710 | androgen catabolic process | 12697717 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-DD-AAE9-01A | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000358290 | ENST00000282470 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000358290 | ENST00000418378 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000358290 | ENST00000503414 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000507518 | ENST00000282470 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000507518 | ENST00000418378 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000507518 | ENST00000503414 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000507286 | ENST00000282470 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000507286 | ENST00000418378 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000507286 | ENST00000503414 | HSD17B11 | chr4 | 88303407 | - | SPARCL1 | chr4 | 88420737 | - |
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FusionProtFeatures for HSD17B11_SPARCL1 |
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Hgene | Tgene |
HSD17B11 | SPARCL1 |
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participatein androgen metabolism during steroidogenesis. May act bymetabolizing compounds that stimulate steroid synthesis and/or bygenerating metabolites that inhibit it. Has no activity towardDHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HSD17B11_SPARCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HSD17B11_SPARCL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HSD17B11 | ELAVL1, FBXO6, PEX19, NTRK1, IL13RA2, UBC | SPARCL1 | EGFR, DISC1, SKIL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HSD17B11_SPARCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HSD17B11_SPARCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |