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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16800

FusionGeneSummary for HSD17B11_HSD17B11

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD17B11_HSD17B11
Fusion gene ID: 16800
HgeneTgene
Gene symbol

HSD17B11

HSD17B11

Gene ID

51170

51170

Gene namehydroxysteroid 17-beta dehydrogenase 11hydroxysteroid 17-beta dehydrogenase 11
Synonyms17-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C217-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C2
Cytomap

4q22.1

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionestradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-chestradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-ch
Modification date2018052320180523
UniProtAcc

Q8NBQ5

Q8NBQ5

Ensembl transtripts involved in fusion geneENST00000358290, ENST00000507518, 
ENST00000507286, 
ENST00000358290, 
ENST00000507518, ENST00000507286, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HSD17B11 [Title/Abstract] AND HSD17B11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSD17B11

GO:0006710

androgen catabolic process

12697717

TgeneHSD17B11

GO:0006710

androgen catabolic process

12697717


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW022407HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000358290ENST00000358290HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000358290ENST00000507518HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000358290ENST00000507286HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-3UTRENST00000507518ENST00000358290HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000507518ENST00000507518HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000507518ENST00000507286HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-3UTRENST00000507286ENST00000358290HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000507286ENST00000507518HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-
intron-intronENST00000507286ENST00000507286HSD17B11chr4

88257946

+HSD17B11chr4

88257839

-

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FusionProtFeatures for HSD17B11_HSD17B11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD17B11

Q8NBQ5

HSD17B11

Q8NBQ5

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participatein androgen metabolism during steroidogenesis. May act bymetabolizing compounds that stimulate steroid synthesis and/or bygenerating metabolites that inhibit it. Has no activity towardDHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participatein androgen metabolism during steroidogenesis. May act bymetabolizing compounds that stimulate steroid synthesis and/or bygenerating metabolites that inhibit it. Has no activity towardDHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HSD17B11_HSD17B11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSD17B11_HSD17B11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSD17B11_HSD17B11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSD17B11_HSD17B11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource