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Fusion gene ID: 16791 |
FusionGeneSummary for HS6ST3_EFNA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HS6ST3_EFNA5 | Fusion gene ID: 16791 | Hgene | Tgene | Gene symbol | HS6ST3 | EFNA5 | Gene ID | 266722 | 1946 |
| Gene name | heparan sulfate 6-O-sulfotransferase 3 | ephrin A5 | |
| Synonyms | HS6ST-3 | AF1|EFL5|EPLG7|GLC1M|LERK7|RAGS | |
| Cytomap | 13q32.1 | 5q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan-sulfate 6-O-sulfotransferase 3 | ephrin-A5AL-1LERK-7eph-related receptor tyrosine kinase ligand 7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IZP7 | P52803 | |
| Ensembl transtripts involved in fusion gene | ENST00000376705, | ENST00000333274, ENST00000509503, ENST00000510359, | |
| Fusion gene scores | * DoF score | 4 X 1 X 4=16 | 4 X 2 X 3=24 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HS6ST3 [Title/Abstract] AND EFNA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EFNA5 | GO:0006915 | apoptotic process | 11870224 |
| Tgene | EFNA5 | GO:0022407 | regulation of cell-cell adhesion | 11870224 |
| Tgene | EFNA5 | GO:0022604 | regulation of cell morphogenesis | 23242526 |
| Tgene | EFNA5 | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 |
| Tgene | EFNA5 | GO:0043087 | regulation of GTPase activity | 11870224 |
| Tgene | EFNA5 | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
| Tgene | EFNA5 | GO:0051893 | regulation of focal adhesion assembly | 11870224 |
| Tgene | EFNA5 | GO:0070507 | regulation of microtubule cytoskeleton organization | 11870224 |
| Tgene | EFNA5 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 23242526 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D9-A6EA-06A | HS6ST3 | chr13 | 96743823 | + | EFNA5 | chr5 | 106763210 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000376705 | ENST00000333274 | HS6ST3 | chr13 | 96743823 | + | EFNA5 | chr5 | 106763210 | - |
| In-frame | ENST00000376705 | ENST00000509503 | HS6ST3 | chr13 | 96743823 | + | EFNA5 | chr5 | 106763210 | - |
| 5CDS-intron | ENST00000376705 | ENST00000510359 | HS6ST3 | chr13 | 96743823 | + | EFNA5 | chr5 | 106763210 | - |
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FusionProtFeatures for HS6ST3_EFNA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HS6ST3 | EFNA5 |
| 6-O-sulfation enzyme which catalyzes the transfer ofsulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) toposition 6 of the N-sulfoglucosamine residue (GlcNS) of heparansulfate. | Cell surface GPI-bound ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while thesignaling pathway downstream of the ephrin ligand is referred toas reverse signaling. Induces compartmentalized signaling within acaveolae-like membrane microdomain when bound to the extracellulardomain of its cognate receptor. This signaling event requires theactivity of the Fyn tyrosine kinase. Activates the EPHA3 receptorto regulate cell-cell adhesion and cytoskeletal organization. Withthe receptor EPHA2 may regulate lens fiber cells shape andinteractions and be important for lens transparency maintenance.May function actively to stimulate axon fasciculation. Theinteraction of EFNA5 with EPHA5 also mediates communicationbetween pancreatic islet cells to regulate glucose-stimulatedinsulin secretion. Cognate/functional ligand for EPHA7, theirinteraction regulates brain development modulating cell-celladhesion and repulsion. {ECO:0000269|PubMed:10601038,ECO:0000269|PubMed:11870224}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 152_160 | 235 | 472 | Region | PAPS binding |
| Hgene | HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 182_183 | 235 | 472 | Region | Substrate binding |
| Hgene | HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 1_4 | 235 | 472 | Topological domain | Cytoplasmic |
| Hgene | HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 5_27 | 235 | 472 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 377_379 | 235 | 472 | Region | PAPS binding |
| Hgene | >HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 383_384 | 235 | 472 | Region | PAPS binding |
| Hgene | >HS6ST3 | chr13:96743823 | chr5:106763210 | ENST00000376705 | + | 1 | 2 | 28_471 | 235 | 472 | Topological domain | Lumenal |
| Tgene | EFNA5 | chr13:96743823 | chr5:106763210 | ENST00000333274 | - | 0 | 5 | 29_162 | 41 | 229 | Domain | Ephrin RBD |
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FusionGeneSequence for HS6ST3_EFNA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_423aa MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEE EDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTER YVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMK >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_396aa MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEE EDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTER YVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_1269nt ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATGTACCAGTACGTGTCCCCCTCCTGC ACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCGGAGGAG GAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTC CTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACCGGCTGGAGCTGCGGGCTGCACGCC GACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGATTCCAGAGGGGT GACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCCGTCCCAGAAGATAAGACTGAGCGC TATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAGAGATGGGAATGTAACCGGCCTCAC TCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTTGAATTCAGGCCAGGCCGAGAATAT TTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTGAGACCAACAAATAGCTGTATGAAA ACTATAGGTGTTCATGATCGTGTTTTCGATGTTAACGACAAAGTAGAAAATTCATTAGAACCAGCAGATGACACCGTACATGAGTCAGCC GAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCGATGCTTTTG >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_1188nt ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATGTACCAGTACGTGTCCCCCTCCTGC ACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCGGAGGAG GAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTC CTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACCGGCTGGAGCTGCGGGCTGCACGCC GACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGATTCCAGAGGGGT GACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCCGTCCCAGAAGATAAGACTGAGCGC TATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAGAGATGGGAATGTAACCGGCCTCAC TCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTTGAATTCAGGCCAGGCCGAGAATAT TTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTGAGACCAACAAATGACACCGTACAT GAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_5659nt GCCTGCCGGCCTGAGAGCGGGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATG TACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCG GGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCT CGGGGGGCCGCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCC GAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATC AAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAG CAGCCTTGTAGCTGCAAAGCGGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACC GGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCAC AGCCACACCAGATTCCAGAGGGGTGACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCC GTCCCAGAAGATAAGACTGAGCGCTATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAG AGATGGGAATGTAACCGGCCTCACTCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTT GAATTCAGGCCAGGCCGAGAATATTTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTG AGACCAACAAATAGCTGTATGAAAACTATAGGTGTTCATGATCGTGTTTTCGATGTTAACGACAAAGTAGAAAATTCATTAGAACCAGCA GATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTA CTGTTCCTCCTGGCGATGCTTTTGACATTATAGCACAGTCTCCTCCCATCACTTGTCACAGAAAACATCAGGGTCTTGGAACACCAGAGA TCCACCTAACTGCTCATCCTAAGAAGGGACTTGTTATTGGGTTTTGGCAGATGTCAGATTTTTGTTTTCTTTCTTTCAGCCTGAATTCTA AGCAACAACTTCAGGTTGGGGGCCTAAACTTGTTCCTGCCTCCCTCACCCCACCCCGCCCCACCCCCAGCCCTGGCCCTTGGCTTCTCTC ACCCCTCCCAAATTAAATGGACTCCAGATGAAAATGCCAAATTGTCATAGTGACACCAGTGGTTCGTCAGCTCCTGTGCATTCTCCTCTA AGAACTCACCTCCGTTAGCGCACTGTGTCAGCGGGCTATGGACAAGGAAGAATAGTGGCAGATGCAGCCAGCGCTGGCTAGGGCTGGGAG GGTTTTGCTCTCCTATGCAATATTTATGCCTTCTCATTCAGAACTGTAAGATGATCGCGCAGGGCATCATGTCACCATGTCAGGTCCGGA GGGGAGGTATTAAGAATAGATACGATATTACACCATTTCCTATAGGAGTATGTAAATGAACAGGCTTCTAAAAGGTTGAGACACTGGTTT TTTTTTTTAATATGACTGTCTTAAAGCATTCTTGACAGCAAAACTTGTGCTCTCTAAAAGAAGCCTTTTTTTTTTTTCTAGGAGGCAGGT TGGGTGTGGAATGCTAATACAGAGCAGGTGTGAAAACAGAGAAAACTACAGGTTTGCTGGGGGTGTGTATGTGTGAGTGCCTCTAATTTT TTTGGTGACTGGGCAGTGCACACCAGATATTTTTTCTTTGAATACAGATCACCATGGTGCTACAACTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTAAGAAACTCAAAGAGGCATTTTTATGAATAAAGTGACCTTCCCCAAGGCTGACAAGCCAGGGTTGATGAGTGCATAG TGGAATAGCTTTGGATACTCCTCTGGGGGATGACATGTACCAAGGAGAGGACCGCAGTGGCCAGAGGAGACATGATTTGGCTTTGCTGGA GCGCCAGTGTGCTGTGGCCTTTCCCCGCCTCCCACCCTAGTACCCACGTTTTGCTCCACACTCCTTGACCGCAGGGGCTCGGACACAAAC CCCTGTCACCAGGAGAGTCAGTCAGCACTACTTGGGAGGGCTAAAGGGAAATTTGGAAATAAAATTCCAAAGTTTGGAGTAAAAAAATTC AAGTGTTGATTTTATATTCTTTCCCTTTCTGACACAGCCTAAAGCGTAGGGGGAACATGTGTTTATCTGTGGGAGATAAACAAGATGGAG TCCCAAAGACTTTAACAAAATATTTTTTTAAAAATCCACTAGAATAGAAAATACATTATTTAGATATACTTTATGCTGAGAGTGAGTATA TATGCTTGTCCTATTTAAACTTGTGAGAAAAAGTGGTATCCCTTGATACATTTAGAAATATGGGGGCTATCTTGTTTCATTGTGGGGGTG GGGCAGAAGGAGAATAAATGCAGGATGACCCTGTTGAAGGAATCTTAGCATGGCCAACAGGGGACGTTTCCAGTCGATTACCAGGAAATG CAAGCCTTGGGGTTTCTACTGGTGGTGGGGCTGTCATGAACTTTAAAATCCAAAGCCTAGACAAGGAAAAGTGTTAGACCAATTGAAAAG CAATCCAGCCCTTTTTTTTTTTTTTTTTTTGGCTTTGCACGACATGTCAACAGAAACCATGCCTTTCAATATAAGAAATAAATGTGATGA TCATGTAAAATGTGAAAAATTGAAAGCATTCCAGCAAAATAAGAATTTTTTATATATTTGTTTTTTAAGATGTATATGTTAAAAAAAGAG AAGGTCGCATTATGGACAGACTTCGTGAATGGGAATTTGCTTAGAATTGTGAGTAGTTCTGAATTAGAAAAGTATGTGAAGGAAAGGCAG CTGTAAACGTATTGTGCCCTGGAGAGTTGTACACATGTTGAAATGTAATCTGGGCTTACCTGATCCATTTGGAGTGGATGTCACTGCCGA GTCTGTTCTCACATGGAACCATGTGTGTGGGGTTGCCAGCCTCACAGATACAATCAATCCTATTCCCCTCTGACATAAGGAACTCCTCTG GAGTGGCAGAGTCTTATCACAGAAGGCAGCCACCATTTCACCAAAACAAAAGTTCACGGCATTCAATTCCTTTTTCCTTTAGCTATTTAT ATATGCAGTACTCTCAGTCATATGCAGAAATACTTTTTTTTTTTTAATTAATAGTTACAGGCTTGTTGGTCCAGTGGGATTTGGGTAGGG GGAGAAAGATACCTTCTAAAATGGATCAATAGAACCAAAATAATACAGCATGTTCTATAACCACAAGGAAATCAAATGATCCTGTCATGA TTCCAGTTAGTCATAACTATGTTAGCAGTGCTAAATGCATTTTAGAAATGGTGACTTCTGTGGTTTTCCTAGCATTTGTCTCTAACAAAT GGTGAAATAATTACTCATGGCCCTCTCTGCCATTGTCTTTCATTTTTTCACAGTGAAATTAGACCCCTTTACTTCACCATTCTGCCACTG CAAATTAAGTATAAAGAAAATAGCAAGAGTGTCCACACCAGTAGACAGTAAGCTTCTCTACCTGTAAGTGATGAAATCATAGCTAATGCA CTTGCCATGGAGTTTTCAAGATGATTGGTGTCAGACAGTTTTCACTTTGTTTAAAAAGTGTTGGTGGCCTTTTGTGGTGGTGTTACAATC CTCTGGGGGCTTAGGAGGATGTTGATGCAACTTTTAGAAGCTTTTAATTTCAAAAACAACTCAAAAATCTGAAGGACAGTCATAGCTGCC ACTCAGCCCCAGTTAGTCAAACCCCAGTGACCTTTGCCCCTGGTTGCCAAGGGCTTTGCAACATCAAGCAGGGAAATAAGGATCTGTCTG TTTAGTGGATACCGTGTATCCTTTAATAGACCAGGTAACAGTTCGTGTTAGTTTAGACTATTGTTTTGTACTGTACTTTCTTGGGTGGCA GAGGAAAGAAAAGTAAAACATTAAAAAAAAAAAAAAAACTGCGTTCTTTAAATTCTGTATTATTAGCAACCTCTGTTGTACATAGTGTTT GATAATAAAGTATTAATTTGATTCTTATGTCTTTTGTAAGTGAGAACAATAGACTTTCAGGATACAAAACATGCATTGAGGCTTTGAAAC ATCCAATGTGTACCATGGCTGAAAAAAAGAGTCACAAGTGGCTGAGACACTGCTCCATACAGGACTCATGTGTGGTCATTGCCCACCCAA TCTTATGACTCCATCATCTTGGGACCTGGAACAACATGACTTTTTTGATCGATATTTTGTCCTCGGTGTTTTCAAGGTCTGATGTTGGAG CCCTGTGGCCCACCCTCCCTTCTCCACCAGCATGTTGGTTTGAAAAGGATAGGGAATTTAGAAACAGTTCTGTACTTTGGTTTGGTTTGG TTTTCTGTTTGTGATTGTTTTCATGGACTGTTTTATTTTTTCCCAGGAAGAGTCTTTATCAATATCATGTGCAGCTCACTCATGGAAATG GTTGCAAACCAATCAGTGTAGGAAGCTTAAATGGGGCTGTTTCCCTCTCTGTGTCGTTGTGAAAGGAAGAGTCACACAGTACCTGTGGAT TTTCAGGGACTCTGTTTTTCTCCGGTGCCTTAGCAACGGCAGCAGCCATTTGTATTATTTTCAAATAATTAGAAAAACAGTTTTCAACTC CTCCTTTCCATTCATTGCTCTCAGAGTTGTGGTCACTGACTTTTCTTTTGAAAACCGCCTCCACCAACACCCCCGTTTGCCTACACCACC CCCCTTTTACTTAGTATGTTTATTTTTTGTGTGTCTCTTGCCTTCCTCCCACGTTTTATTTCCCCTCAGAGCTGTGAATGGGCAGGTCTG TCTCTGGTTTGGCATCACTGAGTTTTTCCCATGCATTGGCCCCAGGGCTGCTAGGATGTGAGACAAATCTCCCTACAATGGGCTTGCTCC CATTGTCTGTACAGTTTAATAGATGCTGGCATGTCGGAGGTTACCCATGAGTCAAAATCCGCTCTCCATGCTTACTCTTGACACCCCATT GAAGCCACTCATTGTGTGTGCGTCTGGGTGTGAAGTCCAGCTCCGTGTGGTCCTGTGCTTGTACTGCCCTGCTTTGCAGTTCCTTTGCAC TTACTCATCGAGTGCTGTTTTGAAATGCTGACATTATATAAACGTAAAAGAAAATGTAAAAAAAAAAAACCCACACACAAACAAACCCAT >In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_1229nt GCCTGCCGGCCTGAGAGCGGGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATG TACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCG GGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCT CGGGGGGCCGCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCC GAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATC AAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAG CAGCCTTGTAGCTGCAAAGCGGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACC GGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCAC AGCCACACCAGATTCCAGAGGGGTGACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCC GTCCCAGAAGATAAGACTGAGCGCTATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAG AGATGGGAATGTAACCGGCCTCACTCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTT GAATTCAGGCCAGGCCGAGAATATTTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTG AGACCAACAAATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTG |
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FusionGenePPI for HS6ST3_EFNA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HS6ST3 | EFNA5 | EPHA7, EPHA3, EPHB1, SRC, GRIP1, MYC, EPHA8, GJB7, CYP2S1, MED21 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HS6ST3_EFNA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HS6ST3_EFNA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EFNA5 | C0035126 | Reperfusion Injury | 1 | CTD_human |
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