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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16791

FusionGeneSummary for HS6ST3_EFNA5

check button Fusion gene summary
Fusion gene informationFusion gene name: HS6ST3_EFNA5
Fusion gene ID: 16791
HgeneTgene
Gene symbol

HS6ST3

EFNA5

Gene ID

266722

1946

Gene nameheparan sulfate 6-O-sulfotransferase 3ephrin A5
SynonymsHS6ST-3AF1|EFL5|EPLG7|GLC1M|LERK7|RAGS
Cytomap

13q32.1

5q21.3

Type of geneprotein-codingprotein-coding
Descriptionheparan-sulfate 6-O-sulfotransferase 3ephrin-A5AL-1LERK-7eph-related receptor tyrosine kinase ligand 7
Modification date2018052320180523
UniProtAcc

Q8IZP7

P52803

Ensembl transtripts involved in fusion geneENST00000376705, ENST00000333274, 
ENST00000509503, ENST00000510359, 
Fusion gene scores* DoF score4 X 1 X 4=164 X 2 X 3=24
# samples 44
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HS6ST3 [Title/Abstract] AND EFNA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEFNA5

GO:0006915

apoptotic process

11870224

TgeneEFNA5

GO:0022407

regulation of cell-cell adhesion

11870224

TgeneEFNA5

GO:0022604

regulation of cell morphogenesis

23242526

TgeneEFNA5

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneEFNA5

GO:0043087

regulation of GTPase activity

11870224

TgeneEFNA5

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneEFNA5

GO:0051893

regulation of focal adhesion assembly

11870224

TgeneEFNA5

GO:0070507

regulation of microtubule cytoskeleton organization

11870224

TgeneEFNA5

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

23242526


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D9-A6EA-06AHS6ST3chr13

96743823

+EFNA5chr5

106763210

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000376705ENST00000333274HS6ST3chr13

96743823

+EFNA5chr5

106763210

-
In-frameENST00000376705ENST00000509503HS6ST3chr13

96743823

+EFNA5chr5

106763210

-
5CDS-intronENST00000376705ENST00000510359HS6ST3chr13

96743823

+EFNA5chr5

106763210

-

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FusionProtFeatures for HS6ST3_EFNA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HS6ST3

Q8IZP7

EFNA5

P52803

6-O-sulfation enzyme which catalyzes the transfer ofsulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) toposition 6 of the N-sulfoglucosamine residue (GlcNS) of heparansulfate. Cell surface GPI-bound ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while thesignaling pathway downstream of the ephrin ligand is referred toas reverse signaling. Induces compartmentalized signaling within acaveolae-like membrane microdomain when bound to the extracellulardomain of its cognate receptor. This signaling event requires theactivity of the Fyn tyrosine kinase. Activates the EPHA3 receptorto regulate cell-cell adhesion and cytoskeletal organization. Withthe receptor EPHA2 may regulate lens fiber cells shape andinteractions and be important for lens transparency maintenance.May function actively to stimulate axon fasciculation. Theinteraction of EFNA5 with EPHA5 also mediates communicationbetween pancreatic islet cells to regulate glucose-stimulatedinsulin secretion. Cognate/functional ligand for EPHA7, theirinteraction regulates brain development modulating cell-celladhesion and repulsion. {ECO:0000269|PubMed:10601038,ECO:0000269|PubMed:11870224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+12152_160235472RegionPAPS binding
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+12182_183235472RegionSubstrate binding
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+121_4235472Topological domainCytoplasmic
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+125_27235472TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+12377_379235472RegionPAPS binding
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+12383_384235472RegionPAPS binding
HgeneHS6ST3chr13:96743823chr5:106763210ENST00000376705+1228_471235472Topological domainLumenal
TgeneEFNA5chr13:96743823chr5:106763210ENST00000333274-0529_16241229DomainEphrin RBD


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FusionGeneSequence for HS6ST3_EFNA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_423aa
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEE
EDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTER
YVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMK

>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_396aa
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEE
EDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTER
YVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_1269nt
ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATGTACCAGTACGTGTCCCCCTCCTGC
ACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG
CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCGGAGGAG
GAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG
CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTC
CTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT
CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACCGGCTGGAGCTGCGGGCTGCACGCC
GACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGATTCCAGAGGGGT
GACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCCGTCCCAGAAGATAAGACTGAGCGC
TATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAGAGATGGGAATGTAACCGGCCTCAC
TCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTTGAATTCAGGCCAGGCCGAGAATAT
TTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTGAGACCAACAAATAGCTGTATGAAA
ACTATAGGTGTTCATGATCGTGTTTTCGATGTTAACGACAAAGTAGAAAATTCATTAGAACCAGCAGATGACACCGTACATGAGTCAGCC
GAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCGATGCTTTTG

>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_1188nt
ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATGTACCAGTACGTGTCCCCCTCCTGC
ACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG
CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCGGAGGAG
GAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG
CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTC
CTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT
CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACCGGCTGGAGCTGCGGGCTGCACGCC
GACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGATTCCAGAGGGGT
GACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCCGTCCCAGAAGATAAGACTGAGCGC
TATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAGAGATGGGAATGTAACCGGCCTCAC
TCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTTGAATTCAGGCCAGGCCGAGAATAT
TTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTGAGACCAACAAATGACACCGTACAT
GAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000333274_chr5_106763210_-_5659nt
GCCTGCCGGCCTGAGAGCGGGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATG
TACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCG
GGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCT
CGGGGGGCCGCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCC
GAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATC
AAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAG
CAGCCTTGTAGCTGCAAAGCGGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACC
GGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCAC
AGCCACACCAGATTCCAGAGGGGTGACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCC
GTCCCAGAAGATAAGACTGAGCGCTATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAG
AGATGGGAATGTAACCGGCCTCACTCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTT
GAATTCAGGCCAGGCCGAGAATATTTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTG
AGACCAACAAATAGCTGTATGAAAACTATAGGTGTTCATGATCGTGTTTTCGATGTTAACGACAAAGTAGAAAATTCATTAGAACCAGCA
GATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTA
CTGTTCCTCCTGGCGATGCTTTTGACATTATAGCACAGTCTCCTCCCATCACTTGTCACAGAAAACATCAGGGTCTTGGAACACCAGAGA
TCCACCTAACTGCTCATCCTAAGAAGGGACTTGTTATTGGGTTTTGGCAGATGTCAGATTTTTGTTTTCTTTCTTTCAGCCTGAATTCTA
AGCAACAACTTCAGGTTGGGGGCCTAAACTTGTTCCTGCCTCCCTCACCCCACCCCGCCCCACCCCCAGCCCTGGCCCTTGGCTTCTCTC
ACCCCTCCCAAATTAAATGGACTCCAGATGAAAATGCCAAATTGTCATAGTGACACCAGTGGTTCGTCAGCTCCTGTGCATTCTCCTCTA
AGAACTCACCTCCGTTAGCGCACTGTGTCAGCGGGCTATGGACAAGGAAGAATAGTGGCAGATGCAGCCAGCGCTGGCTAGGGCTGGGAG
GGTTTTGCTCTCCTATGCAATATTTATGCCTTCTCATTCAGAACTGTAAGATGATCGCGCAGGGCATCATGTCACCATGTCAGGTCCGGA
GGGGAGGTATTAAGAATAGATACGATATTACACCATTTCCTATAGGAGTATGTAAATGAACAGGCTTCTAAAAGGTTGAGACACTGGTTT
TTTTTTTTAATATGACTGTCTTAAAGCATTCTTGACAGCAAAACTTGTGCTCTCTAAAAGAAGCCTTTTTTTTTTTTCTAGGAGGCAGGT
TGGGTGTGGAATGCTAATACAGAGCAGGTGTGAAAACAGAGAAAACTACAGGTTTGCTGGGGGTGTGTATGTGTGAGTGCCTCTAATTTT
TTTGGTGACTGGGCAGTGCACACCAGATATTTTTTCTTTGAATACAGATCACCATGGTGCTACAACTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTAAGAAACTCAAAGAGGCATTTTTATGAATAAAGTGACCTTCCCCAAGGCTGACAAGCCAGGGTTGATGAGTGCATAG
TGGAATAGCTTTGGATACTCCTCTGGGGGATGACATGTACCAAGGAGAGGACCGCAGTGGCCAGAGGAGACATGATTTGGCTTTGCTGGA
GCGCCAGTGTGCTGTGGCCTTTCCCCGCCTCCCACCCTAGTACCCACGTTTTGCTCCACACTCCTTGACCGCAGGGGCTCGGACACAAAC
CCCTGTCACCAGGAGAGTCAGTCAGCACTACTTGGGAGGGCTAAAGGGAAATTTGGAAATAAAATTCCAAAGTTTGGAGTAAAAAAATTC
AAGTGTTGATTTTATATTCTTTCCCTTTCTGACACAGCCTAAAGCGTAGGGGGAACATGTGTTTATCTGTGGGAGATAAACAAGATGGAG
TCCCAAAGACTTTAACAAAATATTTTTTTAAAAATCCACTAGAATAGAAAATACATTATTTAGATATACTTTATGCTGAGAGTGAGTATA
TATGCTTGTCCTATTTAAACTTGTGAGAAAAAGTGGTATCCCTTGATACATTTAGAAATATGGGGGCTATCTTGTTTCATTGTGGGGGTG
GGGCAGAAGGAGAATAAATGCAGGATGACCCTGTTGAAGGAATCTTAGCATGGCCAACAGGGGACGTTTCCAGTCGATTACCAGGAAATG
CAAGCCTTGGGGTTTCTACTGGTGGTGGGGCTGTCATGAACTTTAAAATCCAAAGCCTAGACAAGGAAAAGTGTTAGACCAATTGAAAAG
CAATCCAGCCCTTTTTTTTTTTTTTTTTTTGGCTTTGCACGACATGTCAACAGAAACCATGCCTTTCAATATAAGAAATAAATGTGATGA
TCATGTAAAATGTGAAAAATTGAAAGCATTCCAGCAAAATAAGAATTTTTTATATATTTGTTTTTTAAGATGTATATGTTAAAAAAAGAG
AAGGTCGCATTATGGACAGACTTCGTGAATGGGAATTTGCTTAGAATTGTGAGTAGTTCTGAATTAGAAAAGTATGTGAAGGAAAGGCAG
CTGTAAACGTATTGTGCCCTGGAGAGTTGTACACATGTTGAAATGTAATCTGGGCTTACCTGATCCATTTGGAGTGGATGTCACTGCCGA
GTCTGTTCTCACATGGAACCATGTGTGTGGGGTTGCCAGCCTCACAGATACAATCAATCCTATTCCCCTCTGACATAAGGAACTCCTCTG
GAGTGGCAGAGTCTTATCACAGAAGGCAGCCACCATTTCACCAAAACAAAAGTTCACGGCATTCAATTCCTTTTTCCTTTAGCTATTTAT
ATATGCAGTACTCTCAGTCATATGCAGAAATACTTTTTTTTTTTTAATTAATAGTTACAGGCTTGTTGGTCCAGTGGGATTTGGGTAGGG
GGAGAAAGATACCTTCTAAAATGGATCAATAGAACCAAAATAATACAGCATGTTCTATAACCACAAGGAAATCAAATGATCCTGTCATGA
TTCCAGTTAGTCATAACTATGTTAGCAGTGCTAAATGCATTTTAGAAATGGTGACTTCTGTGGTTTTCCTAGCATTTGTCTCTAACAAAT
GGTGAAATAATTACTCATGGCCCTCTCTGCCATTGTCTTTCATTTTTTCACAGTGAAATTAGACCCCTTTACTTCACCATTCTGCCACTG
CAAATTAAGTATAAAGAAAATAGCAAGAGTGTCCACACCAGTAGACAGTAAGCTTCTCTACCTGTAAGTGATGAAATCATAGCTAATGCA
CTTGCCATGGAGTTTTCAAGATGATTGGTGTCAGACAGTTTTCACTTTGTTTAAAAAGTGTTGGTGGCCTTTTGTGGTGGTGTTACAATC
CTCTGGGGGCTTAGGAGGATGTTGATGCAACTTTTAGAAGCTTTTAATTTCAAAAACAACTCAAAAATCTGAAGGACAGTCATAGCTGCC
ACTCAGCCCCAGTTAGTCAAACCCCAGTGACCTTTGCCCCTGGTTGCCAAGGGCTTTGCAACATCAAGCAGGGAAATAAGGATCTGTCTG
TTTAGTGGATACCGTGTATCCTTTAATAGACCAGGTAACAGTTCGTGTTAGTTTAGACTATTGTTTTGTACTGTACTTTCTTGGGTGGCA
GAGGAAAGAAAAGTAAAACATTAAAAAAAAAAAAAAAACTGCGTTCTTTAAATTCTGTATTATTAGCAACCTCTGTTGTACATAGTGTTT
GATAATAAAGTATTAATTTGATTCTTATGTCTTTTGTAAGTGAGAACAATAGACTTTCAGGATACAAAACATGCATTGAGGCTTTGAAAC
ATCCAATGTGTACCATGGCTGAAAAAAAGAGTCACAAGTGGCTGAGACACTGCTCCATACAGGACTCATGTGTGGTCATTGCCCACCCAA
TCTTATGACTCCATCATCTTGGGACCTGGAACAACATGACTTTTTTGATCGATATTTTGTCCTCGGTGTTTTCAAGGTCTGATGTTGGAG
CCCTGTGGCCCACCCTCCCTTCTCCACCAGCATGTTGGTTTGAAAAGGATAGGGAATTTAGAAACAGTTCTGTACTTTGGTTTGGTTTGG
TTTTCTGTTTGTGATTGTTTTCATGGACTGTTTTATTTTTTCCCAGGAAGAGTCTTTATCAATATCATGTGCAGCTCACTCATGGAAATG
GTTGCAAACCAATCAGTGTAGGAAGCTTAAATGGGGCTGTTTCCCTCTCTGTGTCGTTGTGAAAGGAAGAGTCACACAGTACCTGTGGAT
TTTCAGGGACTCTGTTTTTCTCCGGTGCCTTAGCAACGGCAGCAGCCATTTGTATTATTTTCAAATAATTAGAAAAACAGTTTTCAACTC
CTCCTTTCCATTCATTGCTCTCAGAGTTGTGGTCACTGACTTTTCTTTTGAAAACCGCCTCCACCAACACCCCCGTTTGCCTACACCACC
CCCCTTTTACTTAGTATGTTTATTTTTTGTGTGTCTCTTGCCTTCCTCCCACGTTTTATTTCCCCTCAGAGCTGTGAATGGGCAGGTCTG
TCTCTGGTTTGGCATCACTGAGTTTTTCCCATGCATTGGCCCCAGGGCTGCTAGGATGTGAGACAAATCTCCCTACAATGGGCTTGCTCC
CATTGTCTGTACAGTTTAATAGATGCTGGCATGTCGGAGGTTACCCATGAGTCAAAATCCGCTCTCCATGCTTACTCTTGACACCCCATT
GAAGCCACTCATTGTGTGTGCGTCTGGGTGTGAAGTCCAGCTCCGTGTGGTCCTGTGCTTGTACTGCCCTGCTTTGCAGTTCCTTTGCAC
TTACTCATCGAGTGCTGTTTTGAAATGCTGACATTATATAAACGTAAAAGAAAATGTAAAAAAAAAAAACCCACACACAAACAAACCCAT

>In-frame_HS6ST3_ENST00000376705_chr13_96743823_+_EFNA5_ENST00000509503_chr5_106763210_-_1229nt
GCCTGCCGGCCTGAGAGCGGGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATCATG
TACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCG
GGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCT
CGGGGGGCCGCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCC
GAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTCAACATC
AAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAG
CAGCCTTGTAGCTGCAAAGCGGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCACC
GGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAGAAGAAGGACTGTCCCCGCAACCAC
AGCCACACCAGATTCCAGAGGGGTGACTACCATATTGATGTCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCC
GTCCCAGAAGATAAGACTGAGCGCTATGTCCTCTACATGGTGAACTTTGATGGCTACAGTGCCTGCGACCACACTTCCAAAGGGTTCAAG
AGATGGGAATGTAACCGGCCTCACTCTCCAAATGGACCGCTGAAGTTCTCTGAAAAATTCCAGCTCTTCACTCCCTTTTCTCTAGGATTT
GAATTCAGGCCAGGCCGAGAATATTTCTACATCTCCTCTGCAATCCCAGATAATGGAAGAAGGTCCTGTCTAAAGCTCAAAGTCTTTGTG
AGACCAACAAATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTG


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FusionGenePPI for HS6ST3_EFNA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HS6ST3EFNA5EPHA7, EPHA3, EPHB1, SRC, GRIP1, MYC, EPHA8, GJB7, CYP2S1, MED21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HS6ST3_EFNA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HS6ST3_EFNA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEFNA5C0035126Reperfusion Injury1CTD_human