|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16784 |
FusionGeneSummary for HS3ST3B1_TMEM92 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HS3ST3B1_TMEM92 | Fusion gene ID: 16784 | Hgene | Tgene | Gene symbol | HS3ST3B1 | TMEM92 | Gene ID | 9953 | 162461 |
| Gene name | heparan sulfate-glucosamine 3-sulfotransferase 3B1 | transmembrane protein 92 | |
| Synonyms | 3-OST-3B|3OST3B1|h3-OST-3B | - | |
| Cytomap | 17p12 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan sulfate glucosamine 3-O-sulfotransferase 3B1heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1heparan sulfate 3-O-sulfotransferase 3B1heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1 | transmembrane protein 92 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y662 | Q6UXU6 | |
| Ensembl transtripts involved in fusion gene | ENST00000360954, | ENST00000300433, ENST00000507382, ENST00000511882, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: HS3ST3B1 [Title/Abstract] AND TMEM92 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A3TO-01A | HS3ST3B1 | chr17 | 14205389 | + | TMEM92 | chr17 | 48355917 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360954 | ENST00000300433 | HS3ST3B1 | chr17 | 14205389 | + | TMEM92 | chr17 | 48355917 | + |
| In-frame | ENST00000360954 | ENST00000507382 | HS3ST3B1 | chr17 | 14205389 | + | TMEM92 | chr17 | 48355917 | + |
| 5CDS-3UTR | ENST00000360954 | ENST00000511882 | HS3ST3B1 | chr17 | 14205389 | + | TMEM92 | chr17 | 48355917 | + |
Top |
FusionProtFeatures for HS3ST3B1_TMEM92 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HS3ST3B1 | TMEM92 |
| Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Catalyzes the O-sulfation of glucosamine inIdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specificO-sulfation generates an enzyme-modified heparan sulfate whichacts as a binding receptor to Herpes simplex virus-1 (HSV-1) andpermits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.{ECO:0000269|PubMed:10520990}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 147_151 | 184 | 391 | Nucleotide binding | PAPS |
| Hgene | HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 169_175 | 184 | 391 | Region | Substrate binding |
| Hgene | HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 1_32 | 184 | 391 | Topological domain | Cytoplasmic |
| Hgene | HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 33_53 | 184 | 391 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000300433 | + | 2 | 6 | 86_144 | 31 | 160 | Compositional bias | Note=Pro-rich |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000507382 | + | 1 | 5 | 86_144 | 31 | 160 | Compositional bias | Note=Pro-rich |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000300433 | + | 2 | 6 | 79_159 | 31 | 160 | Topological domain | Cytoplasmic |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000507382 | + | 1 | 5 | 79_159 | 31 | 160 | Topological domain | Cytoplasmic |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000300433 | + | 2 | 6 | 58_78 | 31 | 160 | Transmembrane | Helical |
| Tgene | >TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000507382 | + | 1 | 5 | 58_78 | 31 | 160 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 353_357 | 184 | 391 | Nucleotide binding | PAPS |
| Hgene | >HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 200_203 | 184 | 391 | Region | Substrate binding |
| Hgene | >HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 268_269 | 184 | 391 | Region | Substrate binding |
| Hgene | >HS3ST3B1 | chr17:14205389 | chr17:48355917 | ENST00000360954 | + | 1 | 2 | 54_390 | 184 | 391 | Topological domain | Lumenal |
| Tgene | TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000300433 | + | 2 | 6 | 27_57 | 31 | 160 | Topological domain | Extracellular |
| Tgene | TMEM92 | chr17:14205389 | chr17:48355917 | ENST00000507382 | + | 1 | 5 | 27_57 | 31 | 160 | Topological domain | Extracellular |
Top |
FusionGeneSequence for HS3ST3B1_TMEM92 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000300433_chr17_48355917_+_313aa MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPGLLLLGSGSRAAHDPPALATAPDGTPPRLPF RAPPATPLASGKEMAEGAASPEEQSPEVPDSPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKG LAWYRACPKGFKCCGDSCCQENELFPGPVRIFVIIFLVILSVFCICGLAKCFCRNCREPEPDSPVDCRGPLELPSIIPPERVRVSLSAPP >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000507382_chr17_48355917_+_313aa MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPGLLLLGSGSRAAHDPPALATAPDGTPPRLPF RAPPATPLASGKEMAEGAASPEEQSPEVPDSPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKG LAWYRACPKGFKCCGDSCCQENELFPGPVRIFVIIFLVILSVFCICGLAKCFCRNCREPEPDSPVDCRGPLELPSIIPPERVRVSLSAPP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000300433_chr17_48355917_+_939nt ATGGGGCAGCGCCTGAGTGGCGGCAGATCTTGCCTCGATGTCCCCGGCCGGCTCCTACCGCAGCCGCCGCCGCCCCCGCCGCCGGTGAGG AGGAAGCTCGCGCTGCTCTTCGCCATGCTCTGCGTCTGGCTCTATATGTTCCTGTACTCGTGCGCCGGCTCCTGCGCCGCCGCGCCGGGG CTGCTGCTCCTGGGCTCTGGGTCCCGCGCCGCACACGACCCGCCAGCCCTGGCCACAGCTCCGGACGGGACGCCCCCCAGGCTGCCGTTC CGGGCGCCGCCAGCCACCCCACTGGCTTCAGGCAAGGAGATGGCCGAGGGCGCTGCGAGCCCGGAGGAGCAGAGTCCCGAGGTGCCGGAC TCCCCAAGCCCCATCTCCAGCTTTTTCAGTGGGTCTGGGAGCAAGCAGCTGCCGCAGGCCATCATCATCGGCGTGAAGAAGGGCGGCACG CGGGCGCTGCTGGAGTTTCTGCGCGTGCACCCCGACGTGCGCGCCGTGGGCGCCGAGCCCCATTTCTTCGATCGCAGCTACGACAAGGGC CTCGCTTGGTACCGTGCCTGCCCCAAAGGATTCAAATGCTGTGGTGACAGCTGCTGCCAGGAGAACGAGCTCTTCCCTGGCCCCGTGAGG ATCTTCGTCATCATCTTCCTGGTCATCCTGTCCGTCTTTTGCATCTGTGGCCTGGCTAAGTGCTTCTGTCGCAACTGCAGAGAGCCGGAG CCAGACAGCCCAGTGGATTGCCGGGGGCCCCTGGAACTGCCCTCCATCATCCCCCCAGAGAGGGTCAGAGTATCCCTTTCTGCGCCCCCA CCCCCCTACAGTGAGGTGATTCTGAAGCCCAGCCTGGGCCCAACTCCCACAGAGCCACCCCCTCCCTACAGCTTCAGGCCTGAAGAATAT >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000507382_chr17_48355917_+_939nt ATGGGGCAGCGCCTGAGTGGCGGCAGATCTTGCCTCGATGTCCCCGGCCGGCTCCTACCGCAGCCGCCGCCGCCCCCGCCGCCGGTGAGG AGGAAGCTCGCGCTGCTCTTCGCCATGCTCTGCGTCTGGCTCTATATGTTCCTGTACTCGTGCGCCGGCTCCTGCGCCGCCGCGCCGGGG CTGCTGCTCCTGGGCTCTGGGTCCCGCGCCGCACACGACCCGCCAGCCCTGGCCACAGCTCCGGACGGGACGCCCCCCAGGCTGCCGTTC CGGGCGCCGCCAGCCACCCCACTGGCTTCAGGCAAGGAGATGGCCGAGGGCGCTGCGAGCCCGGAGGAGCAGAGTCCCGAGGTGCCGGAC TCCCCAAGCCCCATCTCCAGCTTTTTCAGTGGGTCTGGGAGCAAGCAGCTGCCGCAGGCCATCATCATCGGCGTGAAGAAGGGCGGCACG CGGGCGCTGCTGGAGTTTCTGCGCGTGCACCCCGACGTGCGCGCCGTGGGCGCCGAGCCCCATTTCTTCGATCGCAGCTACGACAAGGGC CTCGCTTGGTACCGTGCCTGCCCCAAAGGATTCAAATGCTGTGGTGACAGCTGCTGCCAGGAGAACGAGCTCTTCCCTGGCCCCGTGAGG ATCTTCGTCATCATCTTCCTGGTCATCCTGTCCGTCTTTTGCATCTGTGGCCTGGCTAAGTGCTTCTGTCGCAACTGCAGAGAGCCGGAG CCAGACAGCCCAGTGGATTGCCGGGGGCCCCTGGAACTGCCCTCCATCATCCCCCCAGAGAGGGTCAGAGTATCCCTTTCTGCGCCCCCA CCCCCCTACAGTGAGGTGATTCTGAAGCCCAGCCTGGGCCCAACTCCCACAGAGCCACCCCCTCCCTACAGCTTCAGGCCTGAAGAATAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000300433_chr17_48355917_+_3550nt AGTTCGCCTCTGCAGCCTCTGCGGGGAAGTGCCGGGGCTGCTCGAGGCTCAGTTCTTAGGACTGCAAGGAGGCAGCCCCGGCGTGCGGCG GTGCGCACAGTCTAGAGTGGCCAGGGCGCGAGAGTGCAACGTCCTCCTGGCCCCGAGCGCGTCGTCGCGCCCCGGGAGCAGACCCTCGCC CAGCAGTTACCGCCGTCCCGACTTTCCGTTCCAGTTGCAGCTCCTGCCGGGCAACATGTCAAGAGCCGCCGCCGCTACAGCTGCCGCCGC CACCTGGGGAAGAGCAGCAGCAGCAGCGGCGGCCGCGGGCACACGGGGGCAATAAACCGAGCCACCCGGGCGTCCAGCGTGCCGGGGAAC CCTCTCTGCGCTCACTGCCCGGCGGGACCCACGCCATGTGCTGAGCCATGTCCCTGGCCGCGCCCGCGGGCAGCGCATGGGGCAGCGCCT GAGTGGCGGCAGATCTTGCCTCGATGTCCCCGGCCGGCTCCTACCGCAGCCGCCGCCGCCCCCGCCGCCGGTGAGGAGGAAGCTCGCGCT GCTCTTCGCCATGCTCTGCGTCTGGCTCTATATGTTCCTGTACTCGTGCGCCGGCTCCTGCGCCGCCGCGCCGGGGCTGCTGCTCCTGGG CTCTGGGTCCCGCGCCGCACACGACCCGCCAGCCCTGGCCACAGCTCCGGACGGGACGCCCCCCAGGCTGCCGTTCCGGGCGCCGCCAGC CACCCCACTGGCTTCAGGCAAGGAGATGGCCGAGGGCGCTGCGAGCCCGGAGGAGCAGAGTCCCGAGGTGCCGGACTCCCCAAGCCCCAT CTCCAGCTTTTTCAGTGGGTCTGGGAGCAAGCAGCTGCCGCAGGCCATCATCATCGGCGTGAAGAAGGGCGGCACGCGGGCGCTGCTGGA GTTTCTGCGCGTGCACCCCGACGTGCGCGCCGTGGGCGCCGAGCCCCATTTCTTCGATCGCAGCTACGACAAGGGCCTCGCTTGGTACCG TGCCTGCCCCAAAGGATTCAAATGCTGTGGTGACAGCTGCTGCCAGGAGAACGAGCTCTTCCCTGGCCCCGTGAGGATCTTCGTCATCAT CTTCCTGGTCATCCTGTCCGTCTTTTGCATCTGTGGCCTGGCTAAGTGCTTCTGTCGCAACTGCAGAGAGCCGGAGCCAGACAGCCCAGT GGATTGCCGGGGGCCCCTGGAACTGCCCTCCATCATCCCCCCAGAGAGGGTCAGAGTATCCCTTTCTGCGCCCCCACCCCCCTACAGTGA GGTGATTCTGAAGCCCAGCCTGGGCCCAACTCCCACAGAGCCACCCCCTCCCTACAGCTTCAGGCCTGAAGAATATACCGGGGATCAGAG GGGCATTGACAACCCGGCCTTCTGAGTCACCTCCTGCCTGGAATCTTGCCATCAGCAACCTCCTCCCCAGTGCCTCCTGGATCAAGCTAG AGACTGCTGGCACCCCAGGAATGTCCCTGCCCATCCTGCCGTGTCTCTGTTCATTCTTGGATTTAACTTATTACTTTTTCTGCTTCTGTT TCCACCCCAGCTGCCTCTCTTGTCCTGAGGGTTAGGCTGGAGTGACAGTTTCCGCCCACCCCCCAGCCCAAGAAAGAGGCTGCCGGAAAG AAAATGCTGACCATTGGAGGTGCCCAACAGTAGAATGGGCTACTGTGAGGGGTAGTAAGAGCCCCATTTCTGGAGGTATGCAAATCTTGA CTGGACAGCCAGCTCTGAGATTTTATCAGGGCACTTCTATACCTGTGGGACATTGGACTGGATGAGCCCTGAGCCAGCTTCCACTCCTAC CTGAATAGAGAACTCACTGCACCCACCCACAACACATGATAAACACATGTCCTCACTGAATGTTACTGATTGCGGCTGAGGGCCTGCCTC TGGCTGTGTGGGGAGGTGGGTGGAGAGGTGAGCCCAGGCACTGCTGAGGGGTGCGGTGATGGGGTCGCTGCGCCGCAATCCCACCACTGA TGAGCCACCTGGGAGGTCTGGGAGGACAGTCCATCCATGGGCCGCCCTCGGAGAGAGGCTTGTTCTAGATGTATTGGCTGTCTGTTTTTT GATGTCTCTGTGTGCCAAACAGCCTGGAAATGGGGTACGCGTGTCCCTTGTGTGGGTTTCCCAATCCCTTCCGCCCAAGGCTTTCCTGGG ACACATGGAGCCCAGCTCTCTGGCTGTCTTACCATGAGAAGTTGGTAAGTTGGCTGTGAGGGGGTTGGATCCAGGAAGCAGCCCTGGGAC AGCCCATTCTGCTGTTGATAGCAGGAAACCACCTGCTGGGAGACAATGGGGGTGGGGAAAAGCCCAGGAGAGCAGTGGGTGGGGCTGGGC ATCCGTGGAGTGGGGCTTTAGGAGACCTTGAACGGCCCCACCCTGGAATCTCCTACAGGAAGGTGAGGAGGTGGCAGGTTCCACCCTTCT CTACCAGCCCCGCTCGCTCGTGGGAGTTAACCCCCTAGGGGAGAAGAGTCTTCACTGGGGTTCGACCCATGGGGGCCTGGCATAGTCATG CAGAATGGGGCGGGACAATGCCAATGCCTTGGGACTCAGACAGGGCTGAGTGCCTCCACCCTGATTTTTGCCTCTGCACTGCGCCCCCAC AGCCCACTCAATGCCAGCCTCCTTCTCCAGGCAGAGAGCCCCATGTCAATGCTGGCCAAAGCTCTCAGGAGGATTGGAGGTAGAACTGGC CCTGGTATGCCAACAGGGGTGCCTCTTTTAGTGCTCTCCCAATAATGCTCATCCTGGGGGCATCAGGACGCAGGCAGGTGGCAGAGCTGG GGGCAGCTTGATGGCACAGGCAGCCCCAAAGATGCCAGGAACAGGGACTGTCCGGGTGTGGGTTCCCAGTGAGATAGGGCCCTGGAAGGA GTGCAGCAGTTACTGACAATATAGTGCCAGGGTTGGCCATAGGAGAATGAGCCCAAGCGTAAGTGGAAGTTTCCCTTTACTTTCAGGGAT TGGTCAGGGGTGGCAGAAAACATGTGGGTTCTTTGTGTAGATGTGGCTAGTTCCAATTAGAGAAGTCCTGCAGCTGATGTTGCCCTCACC GTGATAGCAGGAGGATGTTGAGAAATGGGCTTGGGAGACCTGGAGGAGAAGTTACCCTCGGCCCAGACGTTGCCTTCCTTTCATCACAGG GCCTTTAACTCCTCCTAGGGAGTAGCAGAGTGGCCCTAGGGAAAGTGGCCATCCTGAAACCTAGTGTTGCTGTGACCTGGTGACAGAAAT GGAAACCTCTGTGGCTCTTCTGGTCATCCTTGGTGGGAGTGGGAATGGTGTCACCTTTCTAGAGGGCCATCTGGCACCATGTAATCACGC CACAGATCTTTACGAAGCTCCTGCTATGTAGGAAACACTATGCCTGGCACTGGGTATCCATTAAAATGTAAAATGCACGTGACCTGGCAA TTCCACTTCTAGAAATGAGCCTTCAGAAGTGCTCATACAAAAGAGCTCAATAAGTATCATGCACTAATTCATTGTGCCACCAGAGCTCCC >In-frame_HS3ST3B1_ENST00000360954_chr17_14205389_+_TMEM92_ENST00000507382_chr17_48355917_+_1393nt AGTTCGCCTCTGCAGCCTCTGCGGGGAAGTGCCGGGGCTGCTCGAGGCTCAGTTCTTAGGACTGCAAGGAGGCAGCCCCGGCGTGCGGCG GTGCGCACAGTCTAGAGTGGCCAGGGCGCGAGAGTGCAACGTCCTCCTGGCCCCGAGCGCGTCGTCGCGCCCCGGGAGCAGACCCTCGCC CAGCAGTTACCGCCGTCCCGACTTTCCGTTCCAGTTGCAGCTCCTGCCGGGCAACATGTCAAGAGCCGCCGCCGCTACAGCTGCCGCCGC CACCTGGGGAAGAGCAGCAGCAGCAGCGGCGGCCGCGGGCACACGGGGGCAATAAACCGAGCCACCCGGGCGTCCAGCGTGCCGGGGAAC CCTCTCTGCGCTCACTGCCCGGCGGGACCCACGCCATGTGCTGAGCCATGTCCCTGGCCGCGCCCGCGGGCAGCGCATGGGGCAGCGCCT GAGTGGCGGCAGATCTTGCCTCGATGTCCCCGGCCGGCTCCTACCGCAGCCGCCGCCGCCCCCGCCGCCGGTGAGGAGGAAGCTCGCGCT GCTCTTCGCCATGCTCTGCGTCTGGCTCTATATGTTCCTGTACTCGTGCGCCGGCTCCTGCGCCGCCGCGCCGGGGCTGCTGCTCCTGGG CTCTGGGTCCCGCGCCGCACACGACCCGCCAGCCCTGGCCACAGCTCCGGACGGGACGCCCCCCAGGCTGCCGTTCCGGGCGCCGCCAGC CACCCCACTGGCTTCAGGCAAGGAGATGGCCGAGGGCGCTGCGAGCCCGGAGGAGCAGAGTCCCGAGGTGCCGGACTCCCCAAGCCCCAT CTCCAGCTTTTTCAGTGGGTCTGGGAGCAAGCAGCTGCCGCAGGCCATCATCATCGGCGTGAAGAAGGGCGGCACGCGGGCGCTGCTGGA GTTTCTGCGCGTGCACCCCGACGTGCGCGCCGTGGGCGCCGAGCCCCATTTCTTCGATCGCAGCTACGACAAGGGCCTCGCTTGGTACCG TGCCTGCCCCAAAGGATTCAAATGCTGTGGTGACAGCTGCTGCCAGGAGAACGAGCTCTTCCCTGGCCCCGTGAGGATCTTCGTCATCAT CTTCCTGGTCATCCTGTCCGTCTTTTGCATCTGTGGCCTGGCTAAGTGCTTCTGTCGCAACTGCAGAGAGCCGGAGCCAGACAGCCCAGT GGATTGCCGGGGGCCCCTGGAACTGCCCTCCATCATCCCCCCAGAGAGGGTCAGAGTATCCCTTTCTGCGCCCCCACCCCCCTACAGTGA GGTGATTCTGAAGCCCAGCCTGGGCCCAACTCCCACAGAGCCACCCCCTCCCTACAGCTTCAGGCCTGAAGAATATACCGGGGATCAGAG |
Top |
FusionGenePPI for HS3ST3B1_TMEM92 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HS3ST3B1 | HLA-DPA1 | TMEM92 | BAG3, WWOX, NEDD4, ITCH, NEDD4L, POMT2, POMT1, NDFIP1, HBB, CUEDC1, CTDNEP1, MRPL9, PARD6B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HS3ST3B1_TMEM92 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HS3ST3B1_TMEM92 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HS3ST3B1 | C0014175 | Endometriosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|