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Fusion gene ID: 16783 |
FusionGeneSummary for HS3ST3A1_GSTO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HS3ST3A1_GSTO1 | Fusion gene ID: 16783 | Hgene | Tgene | Gene symbol | HS3ST3A1 | GSTO1 | Gene ID | 9955 | 9446 |
| Gene name | heparan sulfate-glucosamine 3-sulfotransferase 3A1 | glutathione S-transferase omega 1 | |
| Synonyms | 3-OST-3A|3OST3A1 | GSTO 1-1|GSTTLp28|HEL-S-21|P28|SPG-R | |
| Cytomap | 17p12 | 10q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan sulfate glucosamine 3-O-sulfotransferase 3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1heparan sulfate 3-O-sulfotransferase 3A1heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1heparin-glucosamine 3-O-sulfotransferase | glutathione S-transferase omega-1MMA(V) reductaseS-(Phenacyl)glutathione reductaseepididymis secretory protein Li 21glutathione S-transferase omega 1-1glutathione-S-transferase likeglutathione-dependent dehydroascorbate reductasemonomethylarsonic a | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y663 | P78417 | |
| Ensembl transtripts involved in fusion gene | ENST00000284110, ENST00000578576, | ENST00000493946, ENST00000539281, ENST00000369710, ENST00000369713, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: HS3ST3A1 [Title/Abstract] AND GSTO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GSTO1 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 11035031 |
| Tgene | GSTO1 | GO:0019852 | L-ascorbic acid metabolic process | 11511179 |
| Tgene | GSTO1 | GO:0042178 | xenobiotic catabolic process | 12928150 |
| Tgene | GSTO1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 11035031 |
| Tgene | GSTO1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 11035031 |
| Tgene | GSTO1 | GO:0071243 | cellular response to arsenic-containing substance | 11511179 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC082963 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000284110 | ENST00000493946 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-intron | ENST00000284110 | ENST00000539281 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-5UTR | ENST00000284110 | ENST00000369710 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-5UTR | ENST00000284110 | ENST00000369713 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-intron | ENST00000578576 | ENST00000493946 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-intron | ENST00000578576 | ENST00000539281 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-5UTR | ENST00000578576 | ENST00000369710 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
| intron-5UTR | ENST00000578576 | ENST00000369713 | HS3ST3A1 | chr17 | 13505235 | + | GSTO1 | chr10 | 106014662 | + |
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FusionProtFeatures for HS3ST3A1_GSTO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HS3ST3A1 | GSTO1 |
| Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Catalyzes the O-sulfation of glucosamine inIdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specificO-sulfation generates an enzyme-modified heparan sulfate whichacts as a binding receptor to Herpes simplex virus-1 (HSV-1) andpermits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.{ECO:0000269|PubMed:10520990}. | Exhibits glutathione-dependent thiol transferase anddehydroascorbate reductase activities. Has S-(phenacyl)glutathionereductase activity. Has also glutathione S-transferase activity.Participates in the biotransformation of inorganic arsenic andreduces monomethylarsonic acid (MMA) and dimethylarsonic acid.{ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179,ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863,ECO:0000269|PubMed:21106529}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HS3ST3A1_GSTO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HS3ST3A1_GSTO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HS3ST3A1_GSTO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HS3ST3A1 | Q9Y663 | DB04272 | Citric Acid | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | small molecule | approved|nutraceutical|vet_approved |
| Tgene | GSTO1 | P78417 | DB00143 | Glutathione | Glutathione S-transferase omega-1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for HS3ST3A1_GSTO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GSTO1 | C0023418 | leukemia | 1 | CTD_human |
| Tgene | GSTO1 | C0024115 | Lung diseases | 1 | CTD_human |
| Tgene | GSTO1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | GSTO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | GSTO1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Tgene | GSTO1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | GSTO1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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