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Fusion gene ID: 16779 |
FusionGeneSummary for HS2ST1_SSX2IP |
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Fusion gene information | Fusion gene name: HS2ST1_SSX2IP | Fusion gene ID: 16779 | Hgene | Tgene | Gene symbol | HS2ST1 | SSX2IP | Gene ID | 9653 | 117178 |
Gene name | heparan sulfate 2-O-sulfotransferase 1 | SSX family member 2 interacting protein | |
Synonyms | dJ604K5.2 | ADIP|hMsd1 | |
Cytomap | 1p22.3 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | heparan sulfate 2-O-sulfotransferase 12-O-sulfotransferase2OST | afadin- and alpha-actinin-binding proteinSSX2-interacting proteinafadin DIL domain-interacting proteinsynovial sarcoma, X breakpoint 2 interacting protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q7LGA3 | Q9Y2D8 | |
Ensembl transtripts involved in fusion gene | ENST00000370551, ENST00000370550, ENST00000356813, | ENST00000437941, ENST00000342203, ENST00000605755, ENST00000603677, ENST00000370612, | |
Fusion gene scores | * DoF score | 9 X 5 X 5=225 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/225*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: HS2ST1 [Title/Abstract] AND SSX2IP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF223279 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000370551 | ENST00000437941 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-3UTR | ENST00000370551 | ENST00000342203 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370551 | ENST00000605755 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370551 | ENST00000603677 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370551 | ENST00000370612 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-3UTR | ENST00000370550 | ENST00000437941 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-3UTR | ENST00000370550 | ENST00000342203 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370550 | ENST00000605755 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370550 | ENST00000603677 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000370550 | ENST00000370612 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-3UTR | ENST00000356813 | ENST00000437941 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-3UTR | ENST00000356813 | ENST00000342203 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000356813 | ENST00000605755 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000356813 | ENST00000603677 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
intron-intron | ENST00000356813 | ENST00000370612 | HS2ST1 | chr1 | 87512716 | + | SSX2IP | chr1 | 85112268 | - |
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FusionProtFeatures for HS2ST1_SSX2IP |
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Hgene | Tgene |
HS2ST1 | SSX2IP |
Catalyzes the transfer of sulfate to the C2-position ofselected hexuronic acid residues within the maturing heparansulfate (HS). 2-O-sulfation within HS, particularly of iduronateresidues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.Mediates 2-O-sulfation of both L-iduronyl and D-glucuronylresidues (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HS2ST1_SSX2IP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HS2ST1_SSX2IP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HS2ST1_SSX2IP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HS2ST1_SSX2IP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |