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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 16778

FusionGeneSummary for HS2ST1_SH3GLB1

check button Fusion gene summary
Fusion gene informationFusion gene name: HS2ST1_SH3GLB1
Fusion gene ID: 16778
HgeneTgene
Gene symbol

HS2ST1

SH3GLB1

Gene ID

9653

51100

Gene nameheparan sulfate 2-O-sulfotransferase 1SH3 domain containing GRB2 like, endophilin B1
SynonymsdJ604K5.2Bif-1|CGI-61|PPP1R70|dJ612B15.2
Cytomap

1p22.3

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionheparan sulfate 2-O-sulfotransferase 12-O-sulfotransferase2OSTendophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172
Modification date2018052320180522
UniProtAcc

Q7LGA3

Q9Y371

Ensembl transtripts involved in fusion geneENST00000370551, ENST00000370550, 
ENST00000356813, 
ENST00000370558, 
ENST00000535010, ENST00000482504, 
Fusion gene scores* DoF score9 X 5 X 5=2253 X 3 X 2=18
# samples 94
** MAII scorelog2(9/225*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HS2ST1 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSH3GLB1

GO:0032461

positive regulation of protein oligomerization

19074440

TgeneSH3GLB1

GO:0051259

protein complex oligomerization

19805544


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-AAEG-01AHS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000370551ENST00000370558HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
5CDS-5UTRENST00000370551ENST00000535010HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
5CDS-5UTRENST00000370551ENST00000482504HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
In-frameENST00000370550ENST00000370558HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
5CDS-5UTRENST00000370550ENST00000535010HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
5CDS-5UTRENST00000370550ENST00000482504HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
intron-3CDSENST00000356813ENST00000370558HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
intron-5UTRENST00000356813ENST00000535010HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+
intron-5UTRENST00000356813ENST00000482504HS2ST1chr1

87380843

+SH3GLB1chr1

87185190

+

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FusionProtFeatures for HS2ST1_SH3GLB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HS2ST1

Q7LGA3

SH3GLB1

Q9Y371

Catalyzes the transfer of sulfate to the C2-position ofselected hexuronic acid residues within the maturing heparansulfate (HS). 2-O-sulfation within HS, particularly of iduronateresidues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.Mediates 2-O-sulfation of both L-iduronyl and D-glucuronylresidues (By similarity). {ECO:0000250}. May be required for normal outer mitochondrial membranedynamics (PubMed:15452144). Required for coatomer-mediatedretrograde transport in certain cells (By similarity). May recruitother proteins to membranes with high curvature. May promotemembrane fusion (PubMed:11604418). Involved in activation ofcaspase-dependent apoptosis by promoting BAX/BAK1 activation(PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (Bysimilarity). Involved in caspase-independent apoptosis duringnutrition starvation and involved in the regulation of autophagy.Activates lipid kinase activity of PIK3C3 during autophagyprobably by associating with the PI3K complex II (PI3KC3-C2)(PubMed:17891140). Associated with PI3KC3-C2 during autophagy mayregulate the trafficking of ATG9A from the Golgi complex to theperipheral cytoplasm for the formation of autophagosomes byinducing Golgi membrane tubulation and fragmentation(PubMed:21068542). Involved in regulation of degradative endocytictrafficking and cytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells;involved in maintenance of mitochondrial morphology and promotesneuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48,ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144,ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:21068542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370550+171_1141357Topological domainCytoplasmic
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370551+151_1141230Topological domainCytoplasmic
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370550+1712_2841357TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370551+1512_2841230TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000370558+19155_19571366Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000482504+111155_19571387Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000535010+08155_195-29266Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000370558+19305_36571366DomainSH3
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000482504+111305_36571387DomainSH3
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000535010+0827_261-29266DomainBAR
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000535010+08305_365-29266DomainSH3
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000535010+081_30-29266RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000535010+081_37-29266RegionRequired for membrane binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370550+1729_35641357Topological domainLumenal
HgeneHS2ST1chr1:87380843chr1:87185190ENST00000370551+1529_35641230Topological domainLumenal
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000370558+1927_26171366DomainBAR
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000482504+11127_26171387DomainBAR
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000370558+191_3071366RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000370558+191_3771366RegionRequired for membrane binding
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000482504+1111_3071387RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:87380843chr1:87185190ENST00000482504+1111_3771387RegionRequired for membrane binding


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FusionGeneSequence for HS2ST1_SH3GLB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_336aa
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK
CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR
LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD

>In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_336aa
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK
CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR
LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_1008nt
ATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAACCAG
ATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGTCGT
ATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATTAAA
TGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAACTTT
ATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTAAAA
AAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACCAGA
CTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCACAG
TGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACACCT
GTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGTGAC
CTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGATGAG
GTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACCTAC

>In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_1008nt
ATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAACCAG
ATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGTCGT
ATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATTAAA
TGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAACTTT
ATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTAAAA
AAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACCAGA
CTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCACAG
TGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACACCT
GTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGTGAC
CTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGATGAG
GTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACCTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_6346nt
CGGTGGAGGGGCGCGCGGCCGCGAGCAAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGA
CTGAGGCAGTAGAGGGAGGCGAGAGCCCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTG
AGGAGAAGCGGACACCAGCGGCGTTGGTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTC
GCTGTCGCTCTCTCTTTGCCTCGCTCCCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCG
GTATGTCTTGATCCCGAGCAGCGGGTTTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCG
CGGTGGCGATGCTCTTCTTGGAAAACCAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATG
AGAAACTGGATAGAAAAGCTCCAAGTCGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAG
GAACAGCTTATGGTAATGCCCTTATTAAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCT
TAAATTTTCTTACTCCTTTAAGAAACTTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGG
ATTTGGATGCTGCAAAAACGAGACTAAAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTG
AATTTGATCGTCAAGCAGAGATTACCAGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTG
TAGAAGCCCAGATGACTTACTATGCACAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTA
GTAACAACAATCAGACTTCTGTGACACCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAG
TAATCACCTCTCCTTCCAACCTCAGTGACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACA
GTACTGAATTATCACTTCTGGCAGATGAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAA
ACCAGAAGGGCAAGGTGCCAATTACCTACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTT
ATATACAATTAACTCTAAATAAAGCAGGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCT
TTCTGCCAATAAAGTTGCATGGTAAATATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTT
TTTATTGAGGTTTCACTAATAAGCAGCTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAA
GCTTTTTCTTTTATGTAAAATAAATCTATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAA
AATTTATTTTAAACTTTCGGTCTTAAAAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACA
AAAACGCATTTAAACTATGTTTACCTGGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTT
TGGTTTTTTAAACACTACTGAATGGTTTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGT
AGTTAAGGTTCTAGAAAATCTAGGACAAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATT
GGGATTGGATCCATTTACTGTACTGTGGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCA
ACTACATTATAAATTGTATACGAACAAAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCT
ATCTTGATGAGGATCTCTGCTTATGAAACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTG
CTATAAATCATTGTTTCCATGTTAAGACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAAC
TGGGGATACTGTCCTGAACAATATGCACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATC
CTATAGTAGGATTCGTGGTGTGATGGGGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCT
GGGGAAGAACTGTTCCAGATAAAAAGATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATG
AAGTACAAAAGTATAGTTCATTTATTGAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACA
CCGTTTTAAAATTTTGTGTTAAGAGCTCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTA
GTTACCCTTTTATTTCTGTGCCATGAGACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATT
CTTAAAGAAACCCTGAAAAGCTGCTCAAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTC
TACAGCCTAGAGTACCATCTATTGTGTTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCA
ACTATGAATTAGGTTTATGGGAAATGTAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTT
CCTCACATATTGTGCTCTTTAAGCTTCAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATA
GGGTGGTTGTGAGGATTAGCAAATGTTATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATA
TCAGTTTCCCCTTGTTAGCCCCTGTAGCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTAC
ATCTGGGCTCTGTTTTCTCTCTATCAATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATC
ATTTTTCAGAACTTTCAGCTTTCCATCAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAA
AGGCTTCTGGTACGTTTGTCTACCACAGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGT
TGTTTGGGTTTTATTTTGGTTTTGGCTTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGA
AAAAGCTTGGGAAGCCTATTAATTCATGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGA
CATGTGAAGGATGCACATATGAATGAAAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCT
TTTTCCTCAAAGTAATCTAACCTAAACGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGT
CTCAAAAATGGGAATGTGCCTCCTCACTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCAT
AGTCTCCTGTTATCCTCCCCCTGAACAAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTG
GAGAAGACAATGGAGGGCAAGGCAAAAACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAA
ATTCCTTCCCTATCTCCCAAACACCTGAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGA
GATAGCTTCATAGTTTAGCCTATAGCCAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGC
TGGAGAGAGAGTTCCACAACCACCCCTGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGC
CTGTAATCCCAGCACTTTGGAGGCTGAGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGT
CTCTACTGAAAATATAAAAATTAGCCGGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGA
ACCCCAGAGGCAGAGGCTACAGTGAGCCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAA
AAAATGTCTACTCAGTAGAGCAGTGATTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCT
GATTACTATTTTCAAGAACTTTCTACCTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTT
TTAAATATTTTAAGACAAAAACTGAGTCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATT
TGTTTAGTGTATATCTGTCACTCTAGAATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAG
CACAAGATCTAGGACATAGTATGAACTCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGA
ATCAAACTCTGAGAGTGGAGCCCAGCAATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAG
AACTAAGAGAACATTCATTTCACCTTCAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAAC
AGTGCCCTGTCCATGTAGGGGAAACTTCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGA
ATGCCAGTACTTGTTTGCTGTGGAAGGTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACA
CAGTGCCTTTTAATTGGTGACTAACATCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTT
AGATTGCTAAGTTCTGCTCTCATTCTTACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGT
TGGCAAAAAGAAAAAAGATTCAGTGAGAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCT
TCCAGACTTTTCTGTGCATTTATAGATATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATG
ACTGTCTTGCTGTGTCAAGTATATTTCTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTC

>In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_6320nt
AAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGACTGAGGCAGTAGAGGGAGGCGAGAGC
CCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTGAGGAGAAGCGGACACCAGCGGCGTTG
GTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTCGCTGTCGCTCTCTCTTTGCCTCGCTC
CCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCGGTATGTCTTGATCCCGAGCAGCGGGT
TTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAAC
CAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGT
CGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATT
AAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAAC
TTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTA
AAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACC
AGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCA
CAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACA
CCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGT
GACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGAT
GAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACC
TACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTTATATACAATTAACTCTAAATAAAGCA
GGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCTTTCTGCCAATAAAGTTGCATGGTAAA
TATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTTTTTATTGAGGTTTCACTAATAAGCAG
CTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAAGCTTTTTCTTTTATGTAAAATAAATC
TATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAAAATTTATTTTAAACTTTCGGTCTTAA
AAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACAAAAACGCATTTAAACTATGTTTACCT
GGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTTTGGTTTTTTAAACACTACTGAATGGT
TTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGTAGTTAAGGTTCTAGAAAATCTAGGAC
AAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATTGGGATTGGATCCATTTACTGTACTGT
GGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCAACTACATTATAAATTGTATACGAACA
AAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCTATCTTGATGAGGATCTCTGCTTATGA
AACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTGCTATAAATCATTGTTTCCATGTTAAG
ACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAACTGGGGATACTGTCCTGAACAATATGC
ACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATCCTATAGTAGGATTCGTGGTGTGATGG
GGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCTGGGGAAGAACTGTTCCAGATAAAAAG
ATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATGAAGTACAAAAGTATAGTTCATTTATT
GAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACACCGTTTTAAAATTTTGTGTTAAGAGC
TCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTAGTTACCCTTTTATTTCTGTGCCATGA
GACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATTCTTAAAGAAACCCTGAAAAGCTGCTC
AAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTCTACAGCCTAGAGTACCATCTATTGTG
TTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCAACTATGAATTAGGTTTATGGGAAATG
TAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTTCCTCACATATTGTGCTCTTTAAGCTT
CAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATAGGGTGGTTGTGAGGATTAGCAAATGT
TATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATATCAGTTTCCCCTTGTTAGCCCCTGTA
GCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTACATCTGGGCTCTGTTTTCTCTCTATCA
ATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATCATTTTTCAGAACTTTCAGCTTTCCAT
CAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAAAGGCTTCTGGTACGTTTGTCTACCAC
AGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGTTGTTTGGGTTTTATTTTGGTTTTGGC
TTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGAAAAAGCTTGGGAAGCCTATTAATTCA
TGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGACATGTGAAGGATGCACATATGAATGA
AAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCTTTTTCCTCAAAGTAATCTAACCTAAA
CGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGTCTCAAAAATGGGAATGTGCCTCCTCA
CTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCATAGTCTCCTGTTATCCTCCCCCTGAAC
AAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTGGAGAAGACAATGGAGGGCAAGGCAAA
AACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAAATTCCTTCCCTATCTCCCAAACACCT
GAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGAGATAGCTTCATAGTTTAGCCTATAGC
CAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGCTGGAGAGAGAGTTCCACAACCACCCC
TGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCTG
AGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGTCTCTACTGAAAATATAAAAATTAGCC
GGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCCAGAGGCAGAGGCTACAGTGAG
CCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAAAAAATGTCTACTCAGTAGAGCAGTGA
TTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCTGATTACTATTTTCAAGAACTTTCTAC
CTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTTTTAAATATTTTAAGACAAAAACTGAG
TCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATTTGTTTAGTGTATATCTGTCACTCTAG
AATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAGCACAAGATCTAGGACATAGTATGAAC
TCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGAATCAAACTCTGAGAGTGGAGCCCAGC
AATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAGAACTAAGAGAACATTCATTTCACCTT
CAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAACAGTGCCCTGTCCATGTAGGGGAAACT
TCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGAATGCCAGTACTTGTTTGCTGTGGAAG
GTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACACAGTGCCTTTTAATTGGTGACTAACA
TCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTTAGATTGCTAAGTTCTGCTCTCATTCT
TACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGTTGGCAAAAAGAAAAAAGATTCAGTGA
GAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCTTCCAGACTTTTCTGTGCATTTATAGA
TATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATGACTGTCTTGCTGTGTCAAGTATATTT
CTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTCAATTTTTAGGTTTCCAACTTTCATTA


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FusionGenePPI for HS2ST1_SH3GLB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HS2ST1ATP12A, NMNAT3, DIAPH3, CKAP4, HLA-A, TBC1D23, DYM, PIGU, PEX19, TSPAN17, P2RX4, TGOLN2, CHRNA9, TMEM258, SOGA3, P2RX2, USP9Y, UXS1, SLC7A1, APP, TRIM25SH3GLB1SH3KBP1, BAX, SH3GLB2, ARHGAP17, USP7, CUL2, KLHDC10, ITCH, ADAM15, APP, GADD45A, GADD45G, AARSD1, ARPC1A, ARPC4, CALR, KIAA1279, NSUN2, PRKACA, RANGAP1, ACTR2, ACTR3, AGFG1, ARPC2, CALU, HSPBP1, LAP3, P3H1, LPP, NIF3L1, PPP2R5D, RPA2, SH3GL1, THG1L, TPD52L2, TPRKB, PSMA1, TFIP11, SH3GLB1, ZNF576, CMTM5, FUNDC1, SERPINB3, CCDC22, COMMD3, DSCR3, FLAD1, RPRD1A, UBE2I, USP14, WARS, XPO7, CEP128, CDK2AP1, HTATIP2, RAB5A, ACSL4, CDH1, FCGRT, SERPINB13, SCYL2, CDK5, PRCC, SEPT7, DIS3, CHORDC1, SUB1, SARNP, COPZ1, GORASP2, SEPT11, DRG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HS2ST1_SH3GLB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HS2ST1_SH3GLB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource