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Fusion gene ID: 16778 |
FusionGeneSummary for HS2ST1_SH3GLB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HS2ST1_SH3GLB1 | Fusion gene ID: 16778 | Hgene | Tgene | Gene symbol | HS2ST1 | SH3GLB1 | Gene ID | 9653 | 51100 |
| Gene name | heparan sulfate 2-O-sulfotransferase 1 | SH3 domain containing GRB2 like, endophilin B1 | |
| Synonyms | dJ604K5.2 | Bif-1|CGI-61|PPP1R70|dJ612B15.2 | |
| Cytomap | 1p22.3 | 1p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan sulfate 2-O-sulfotransferase 12-O-sulfotransferase2OST | endophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q7LGA3 | Q9Y371 | |
| Ensembl transtripts involved in fusion gene | ENST00000370551, ENST00000370550, ENST00000356813, | ENST00000370558, ENST00000535010, ENST00000482504, | |
| Fusion gene scores | * DoF score | 9 X 5 X 5=225 | 3 X 3 X 2=18 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/225*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HS2ST1 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SH3GLB1 | GO:0032461 | positive regulation of protein oligomerization | 19074440 |
| Tgene | SH3GLB1 | GO:0051259 | protein complex oligomerization | 19805544 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-AAEG-01A | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370551 | ENST00000370558 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| 5CDS-5UTR | ENST00000370551 | ENST00000535010 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| 5CDS-5UTR | ENST00000370551 | ENST00000482504 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| In-frame | ENST00000370550 | ENST00000370558 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| 5CDS-5UTR | ENST00000370550 | ENST00000535010 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| 5CDS-5UTR | ENST00000370550 | ENST00000482504 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| intron-3CDS | ENST00000356813 | ENST00000370558 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| intron-5UTR | ENST00000356813 | ENST00000535010 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
| intron-5UTR | ENST00000356813 | ENST00000482504 | HS2ST1 | chr1 | 87380843 | + | SH3GLB1 | chr1 | 87185190 | + |
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FusionProtFeatures for HS2ST1_SH3GLB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HS2ST1 | SH3GLB1 |
| Catalyzes the transfer of sulfate to the C2-position ofselected hexuronic acid residues within the maturing heparansulfate (HS). 2-O-sulfation within HS, particularly of iduronateresidues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.Mediates 2-O-sulfation of both L-iduronyl and D-glucuronylresidues (By similarity). {ECO:0000250}. | May be required for normal outer mitochondrial membranedynamics (PubMed:15452144). Required for coatomer-mediatedretrograde transport in certain cells (By similarity). May recruitother proteins to membranes with high curvature. May promotemembrane fusion (PubMed:11604418). Involved in activation ofcaspase-dependent apoptosis by promoting BAX/BAK1 activation(PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (Bysimilarity). Involved in caspase-independent apoptosis duringnutrition starvation and involved in the regulation of autophagy.Activates lipid kinase activity of PIK3C3 during autophagyprobably by associating with the PI3K complex II (PI3KC3-C2)(PubMed:17891140). Associated with PI3KC3-C2 during autophagy mayregulate the trafficking of ATG9A from the Golgi complex to theperipheral cytoplasm for the formation of autophagosomes byinducing Golgi membrane tubulation and fragmentation(PubMed:21068542). Involved in regulation of degradative endocytictrafficking and cytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells;involved in maintenance of mitochondrial morphology and promotesneuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48,ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144,ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:21068542}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370550 | + | 1 | 7 | 1_11 | 41 | 357 | Topological domain | Cytoplasmic |
| Hgene | HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370551 | + | 1 | 5 | 1_11 | 41 | 230 | Topological domain | Cytoplasmic |
| Hgene | HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370550 | + | 1 | 7 | 12_28 | 41 | 357 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370551 | + | 1 | 5 | 12_28 | 41 | 230 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000370558 | + | 1 | 9 | 155_195 | 71 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000482504 | + | 1 | 11 | 155_195 | 71 | 387 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000535010 | + | 0 | 8 | 155_195 | -29 | 266 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000370558 | + | 1 | 9 | 305_365 | 71 | 366 | Domain | SH3 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000482504 | + | 1 | 11 | 305_365 | 71 | 387 | Domain | SH3 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000535010 | + | 0 | 8 | 27_261 | -29 | 266 | Domain | BAR |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000535010 | + | 0 | 8 | 305_365 | -29 | 266 | Domain | SH3 |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000535010 | + | 0 | 8 | 1_30 | -29 | 266 | Region | Note=Membrane-binding amphipathic helix |
| Tgene | >SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000535010 | + | 0 | 8 | 1_37 | -29 | 266 | Region | Required for membrane binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370550 | + | 1 | 7 | 29_356 | 41 | 357 | Topological domain | Lumenal |
| Hgene | >HS2ST1 | chr1:87380843 | chr1:87185190 | ENST00000370551 | + | 1 | 5 | 29_356 | 41 | 230 | Topological domain | Lumenal |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000370558 | + | 1 | 9 | 27_261 | 71 | 366 | Domain | BAR |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000482504 | + | 1 | 11 | 27_261 | 71 | 387 | Domain | BAR |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000370558 | + | 1 | 9 | 1_30 | 71 | 366 | Region | Note=Membrane-binding amphipathic helix |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000370558 | + | 1 | 9 | 1_37 | 71 | 366 | Region | Required for membrane binding |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000482504 | + | 1 | 11 | 1_30 | 71 | 387 | Region | Note=Membrane-binding amphipathic helix |
| Tgene | SH3GLB1 | chr1:87380843 | chr1:87185190 | ENST00000482504 | + | 1 | 11 | 1_37 | 71 | 387 | Region | Required for membrane binding |
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FusionGeneSequence for HS2ST1_SH3GLB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_336aa MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD >In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_336aa MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLDARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIK CGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITR LLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_1008nt ATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAACCAG ATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGTCGT ATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATTAAA TGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAACTTT ATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTAAAA AAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACCAGA CTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCACAG TGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACACCT GTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGTGAC CTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGATGAG GTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACCTAC >In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_1008nt ATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAACCAG ATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGTCGT ATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATTAAA TGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAACTTT ATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTAAAA AAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACCAGA CTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCACAG TGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACACCT GTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGTGAC CTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGATGAG GTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HS2ST1_ENST00000370551_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_6346nt CGGTGGAGGGGCGCGCGGCCGCGAGCAAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGA CTGAGGCAGTAGAGGGAGGCGAGAGCCCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTG AGGAGAAGCGGACACCAGCGGCGTTGGTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTC GCTGTCGCTCTCTCTTTGCCTCGCTCCCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCG GTATGTCTTGATCCCGAGCAGCGGGTTTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCG CGGTGGCGATGCTCTTCTTGGAAAACCAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATG AGAAACTGGATAGAAAAGCTCCAAGTCGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAG GAACAGCTTATGGTAATGCCCTTATTAAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCT TAAATTTTCTTACTCCTTTAAGAAACTTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGG ATTTGGATGCTGCAAAAACGAGACTAAAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTG AATTTGATCGTCAAGCAGAGATTACCAGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTG TAGAAGCCCAGATGACTTACTATGCACAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTA GTAACAACAATCAGACTTCTGTGACACCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAG TAATCACCTCTCCTTCCAACCTCAGTGACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACA GTACTGAATTATCACTTCTGGCAGATGAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAA ACCAGAAGGGCAAGGTGCCAATTACCTACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTT ATATACAATTAACTCTAAATAAAGCAGGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCT TTCTGCCAATAAAGTTGCATGGTAAATATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTT TTTATTGAGGTTTCACTAATAAGCAGCTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAA GCTTTTTCTTTTATGTAAAATAAATCTATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAA AATTTATTTTAAACTTTCGGTCTTAAAAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACA AAAACGCATTTAAACTATGTTTACCTGGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTT TGGTTTTTTAAACACTACTGAATGGTTTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGT AGTTAAGGTTCTAGAAAATCTAGGACAAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATT GGGATTGGATCCATTTACTGTACTGTGGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCA ACTACATTATAAATTGTATACGAACAAAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCT ATCTTGATGAGGATCTCTGCTTATGAAACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTG CTATAAATCATTGTTTCCATGTTAAGACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAAC TGGGGATACTGTCCTGAACAATATGCACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATC CTATAGTAGGATTCGTGGTGTGATGGGGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCT GGGGAAGAACTGTTCCAGATAAAAAGATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATG AAGTACAAAAGTATAGTTCATTTATTGAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACA CCGTTTTAAAATTTTGTGTTAAGAGCTCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTA GTTACCCTTTTATTTCTGTGCCATGAGACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATT CTTAAAGAAACCCTGAAAAGCTGCTCAAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTC TACAGCCTAGAGTACCATCTATTGTGTTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCA ACTATGAATTAGGTTTATGGGAAATGTAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTT CCTCACATATTGTGCTCTTTAAGCTTCAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATA GGGTGGTTGTGAGGATTAGCAAATGTTATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATA TCAGTTTCCCCTTGTTAGCCCCTGTAGCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTAC ATCTGGGCTCTGTTTTCTCTCTATCAATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATC ATTTTTCAGAACTTTCAGCTTTCCATCAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAA AGGCTTCTGGTACGTTTGTCTACCACAGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGT TGTTTGGGTTTTATTTTGGTTTTGGCTTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGA AAAAGCTTGGGAAGCCTATTAATTCATGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGA CATGTGAAGGATGCACATATGAATGAAAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCT TTTTCCTCAAAGTAATCTAACCTAAACGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGT CTCAAAAATGGGAATGTGCCTCCTCACTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCAT AGTCTCCTGTTATCCTCCCCCTGAACAAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTG GAGAAGACAATGGAGGGCAAGGCAAAAACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAA ATTCCTTCCCTATCTCCCAAACACCTGAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGA GATAGCTTCATAGTTTAGCCTATAGCCAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGC TGGAGAGAGAGTTCCACAACCACCCCTGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGC CTGTAATCCCAGCACTTTGGAGGCTGAGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGT CTCTACTGAAAATATAAAAATTAGCCGGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGA ACCCCAGAGGCAGAGGCTACAGTGAGCCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAA AAAATGTCTACTCAGTAGAGCAGTGATTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCT GATTACTATTTTCAAGAACTTTCTACCTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTT TTAAATATTTTAAGACAAAAACTGAGTCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATT TGTTTAGTGTATATCTGTCACTCTAGAATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAG CACAAGATCTAGGACATAGTATGAACTCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGA ATCAAACTCTGAGAGTGGAGCCCAGCAATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAG AACTAAGAGAACATTCATTTCACCTTCAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAAC AGTGCCCTGTCCATGTAGGGGAAACTTCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGA ATGCCAGTACTTGTTTGCTGTGGAAGGTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACA CAGTGCCTTTTAATTGGTGACTAACATCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTT AGATTGCTAAGTTCTGCTCTCATTCTTACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGT TGGCAAAAAGAAAAAAGATTCAGTGAGAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCT TCCAGACTTTTCTGTGCATTTATAGATATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATG ACTGTCTTGCTGTGTCAAGTATATTTCTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTC >In-frame_HS2ST1_ENST00000370550_chr1_87380843_+_SH3GLB1_ENST00000370558_chr1_87185190_+_6320nt AAAGGAGGGAGGGAAGGAAGGAAGAGAGGGAGGCGGGCAAGCAGGCGGGCGCGGGGGTCGGGGACTGAGGCAGTAGAGGGAGGCGAGAGC CCGGCAGCCGCTTCGCGCTGTTTGCTGCGCGGGCTTTTGGAGGGGGCGGCCGTTTAGTCGGCTGAGGAGAAGCGGACACCAGCGGCGTTG GTGATAGCGCCTGGGGGAGGGGGACTGGAGAGGCGAGAAGGGGGGTCGCTGCGGTGGTTCTCTCGCTGTCGCTCTCTCTTTGCCTCGCTC CCGGCTCGGCGGGCTCCTCCCGGCGTCTCTCTCGCCTCCGGGGTCCCGCTCCCCGCCCCCCGCGGTATGTCTTGATCCCGAGCAGCGGGT TTCATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTCGCGGTGGCGATGCTCTTCTTGGAAAAC CAGATCCAGAAACTGGAGGAGTCCCGCTCGAAGCTAGATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGT CGTATAAACAACCCAGAACTTTTGGGACAATATATGATTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATT AAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAGACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAAC TTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAAGGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTA AAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTGAACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACC AGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCCATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCA CAGTGTTACCAGTATATGTTGGACCTCCAGAAACAACTGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACA CCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTTCTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGT GACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGGTTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGAT GAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATTCAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACC TACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGAAAGGTTGCCCATCATGACTTTGTATTTATATACAATTAACTCTAAATAAAGCA GGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTGAAAATACCAGCCATCAGAAACTGGCCTTTCTGCCAATAAAGTTGCATGGTAAA TATTTCATTACAGAATTTATGTTAGAGCTTTCATGCCAAGAATGTTTTCTTACAAAATTCTCTTTTTATTGAGGTTTCACTAATAAGCAG CTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTTTTCTACTGGATTTTTCATTAACAGCAAGCTTTTTCTTTTATGTAAAATAAATC TATTGTGAATTGATATCAGCGACTCATTTATTAGGTATAAATAATAGCCAAAGAATAAAATTAAAATTTATTTTAAACTTTCGGTCTTAA AAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGTAGAATTTTCTGAATGCTTTCATAGACAAAAACGCATTTAAACTATGTTTACCT GGTTTTCCAACAGAAATCAAATGATTTTAATATTATGTTTTGATGGGTTATTTTCAGAGTTGTTTGGTTTTTTAAACACTACTGAATGGT TTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGCAATACCGTATTTCTCTGATAAATTTGTAGTTAAGGTTCTAGAAAATCTAGGAC AAATTTACTTCATTAAACATAAAGTTTTTAAGATTATTCAGTTGGCACAATTTAATGCATAATTGGGATTGGATCCATTTACTGTACTGT GGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAGATTTGTATACAAATACGGAATAATGCAACTACATTATAAATTGTATACGAACA AAATAAATTGGGTCACTCTGAGCTTACTATTAAAACATTGAAAATTTATTAATGAACACAGGCTATCTTGATGAGGATCTCTGCTTATGA AACACATACTAATGAAATTATTAGTGACACATTGGAAGCTAGAAAATTGCTGTTGGGGCCATTGCTATAAATCATTGTTTCCATGTTAAG ACTTCTGTTCTAATTCATTCATTCAACAAACATTTGTTGAGGGCCAGATACTGTGCTGGTCAACTGGGGATACTGTCCTGAACAATATGC ACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTAAAGGATACAGAAAATTAAGCAATTATCCTATAGTAGGATTCGTGGTGTGATGG GGAAAATACAAGGTACTGTATTTGGGAGTCATGTAACTCCAGTTTTGGGAGTGAGAGAGGGTCTGGGGAAGAACTGTTCCAGATAAAAAG ATGTGTAACCAAGATAGCATAGCACATTCTGACAACTAAAGCAATTTACTCTAACTTAAGCATGAAGTACAAAAGTATAGTTCATTTATT GAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGTACTTTTAAAAAAATGAATACTTAAACACCGTTTTAAAATTTTGTGTTAAGAGC TCCTAATAAGAACTTGGTAAACATGTTGACAATTTAACTCACAGTCTAAACTTTAAAAGTAGTAGTTACCCTTTTATTTCTGTGCCATGA GACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATGTTTTGACTCACTCTCAATTGCCATATTCTTAAAGAAACCCTGAAAAGCTGCTC AAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAATTTTCTCTCCCCTCAGAAAGGAAGTTCTACAGCCTAGAGTACCATCTATTGTG TTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATACCAAAACTTCAGATCGACTTAAACAGCAACTATGAATTAGGTTTATGGGAAATG TAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGAAATGGTCCTGGGTTCAAATCCAGTCTTCCTCACATATTGTGCTCTTTAAGCTT CAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAAAATGAGGACAATAATTATGACACCATAGGGTGGTTGTGAGGATTAGCAAATGT TATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTGGCACATAGTAAACACATCCTGTAAATATCAGTTTCCCCTTGTTAGCCCCTGTA GCATCCTGACCTACCAAGTCTATAGGCCTTGCATATCACTGTGCACCAGAGATACCTCTTTTACATCTGGGCTCTGTTTTCTCTCTATCA ATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGTTTAACCTTCCCACAGTCAGTATAAATCATTTTTCAGAACTTTCAGCTTTCCAT CAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACAGAAACCTTCAATAATGTTAAGCTTCAAAGGCTTCTGGTACGTTTGTCTACCAC AGAACCACCACAATATATATGCTTGTTCTTAGGTTTATTGCTTTTTATTTTAATGGGGTTTGGTTGTTTGGGTTTTATTTTGGTTTTGGC TTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAAGGCCTGAAGTTTCTTGGGCGTGGAAGAAAAAGCTTGGGAAGCCTATTAATTCA TGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCCACTGAGCTTAATCTGAAAGTATAGTGACATGTGAAGGATGCACATATGAATGA AAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAAAAAAAAGTGATTGGATTGTGTCTACCTTTTTCCTCAAAGTAATCTAACCTAAA CGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAGAAAAATTGATGTTGCAAGAAATGAGGTCTCAAAAATGGGAATGTGCCTCCTCA CTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGATCACCAGTGGGGTAGAGTCATCTTCATAGTCTCCTGTTATCCTCCCCCTGAAC AAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGAAACATTTCTGGGATAAACTGTGGAGTGGAGAAGACAATGGAGGGCAAGGCAAA AACCCACAGACTTGTTTACCCATAGAGGCCCCACTCACCTCCATGCTGACAGAATTCCAGAAAAATTCCTTCCCTATCTCCCAAACACCT GAAATTCTGAAATATTGCCCTACTATTTAGCACTTTAAGCTTCAGTGAGGTGCTGTAATGGAGAGATAGCTTCATAGTTTAGCCTATAGC CAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGGCTTTTACCTCATGTGAGTCTCAAACGCTGGAGAGAGAGTTCCACAACCACCCC TGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTACTCAGGGCTGGGTGCCGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCTG AGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGGAAACCCTGTCTCTACTGAAAATATAAAAATTAGCC GGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCCAGAGGCAGAGGCTACAGTGAG CCAAGATTGCACCACTGCACTCCAACCTGGGTGATAGAATAAGACTCTTGTCTCAAGGAAAGAAAAAATGTCTACTCAGTAGAGCAGTGA TTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGCATCTCCTGGAGACTTGTTTAAAATGCTGATTACTATTTTCAAGAACTTTCTAC CTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCATGGAATCAGTCTTCCATGTGACAGCTTTTTAAATATTTTAAGACAAAAACTGAG TCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTGTAATTATAGTTATTTTTATAATTTATTTGTTTAGTGTATATCTGTCACTCTAG AATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTTGATGGCAGTTACATTCCCAACTCTTAGCACAAGATCTAGGACATAGTATGAAC TCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAATTTATAAGCCTTTTCAGAGACCTACTGAATCAAACTCTGAGAGTGGAGCCCAGC AATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCACTCTAAGCTTGAGAACCACTGCAATAGAACTAAGAGAACATTCATTTCACCTT CAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTCTGCCTTCTGTAACCCTTAACCAACAACAGTGCCCTGTCCATGTAGGGGAAACT TCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGGATATCATAGTGGGAAGTATTGCTTAGAATGCCAGTACTTGTTTGCTGTGGAAG GTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCACTACCACCATCCACGTTTTCACTCAACACAGTGCCTTTTAATTGGTGACTAACA TCAAAACACCTTGACAAACCGTTAAAACAGTATCAGAAACCATGTGTACATCCCTGTGCCTCTTAGATTGCTAAGTTCTGCTCTCATTCT TACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCTTTTTTATAATACAAGTCATAGCCCTGTTGGCAAAAAGAAAAAAGATTCAGTGA GAAAGAAAAATCACTGATAATTCCATCATCCAGGGAGAACCACTGTTATTTAAGTATATGGCCTTCCAGACTTTTCTGTGCATTTATAGA TATTTTTAATGGGATCAAAGTGTACATACTGTTTTGTAACTTTTTTTCACTCAACAATACCATGACTGTCTTGCTGTGTCAAGTATATTT CTACATCTCTTAATGGCTGCATGATATTCCATCATATGTGCCACATTTTATTAAACTACTGTTCAATTTTTAGGTTTCCAACTTTCATTA |
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FusionGenePPI for HS2ST1_SH3GLB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HS2ST1 | ATP12A, NMNAT3, DIAPH3, CKAP4, HLA-A, TBC1D23, DYM, PIGU, PEX19, TSPAN17, P2RX4, TGOLN2, CHRNA9, TMEM258, SOGA3, P2RX2, USP9Y, UXS1, SLC7A1, APP, TRIM25 | SH3GLB1 | SH3KBP1, BAX, SH3GLB2, ARHGAP17, USP7, CUL2, KLHDC10, ITCH, ADAM15, APP, GADD45A, GADD45G, AARSD1, ARPC1A, ARPC4, CALR, KIAA1279, NSUN2, PRKACA, RANGAP1, ACTR2, ACTR3, AGFG1, ARPC2, CALU, HSPBP1, LAP3, P3H1, LPP, NIF3L1, PPP2R5D, RPA2, SH3GL1, THG1L, TPD52L2, TPRKB, PSMA1, TFIP11, SH3GLB1, ZNF576, CMTM5, FUNDC1, SERPINB3, CCDC22, COMMD3, DSCR3, FLAD1, RPRD1A, UBE2I, USP14, WARS, XPO7, CEP128, CDK2AP1, HTATIP2, RAB5A, ACSL4, CDH1, FCGRT, SERPINB13, SCYL2, CDK5, PRCC, SEPT7, DIS3, CHORDC1, SUB1, SARNP, COPZ1, GORASP2, SEPT11, DRG1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HS2ST1_SH3GLB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HS2ST1_SH3GLB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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