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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16775

FusionGeneSummary for HS2ST1_PCGF3

check button Fusion gene summary
Fusion gene informationFusion gene name: HS2ST1_PCGF3
Fusion gene ID: 16775
HgeneTgene
Gene symbol

HS2ST1

PCGF3

Gene ID

9653

10336

Gene nameheparan sulfate 2-O-sulfotransferase 1polycomb group ring finger 3
SynonymsdJ604K5.2DONG1|RNF3|RNF3A
Cytomap

1p22.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionheparan sulfate 2-O-sulfotransferase 12-O-sulfotransferase2OSTpolycomb group RING finger protein 3RING finger protein 3Aring finger protein 3
Modification date2018052320180523
UniProtAcc

Q7LGA3

Q3KNV8

Ensembl transtripts involved in fusion geneENST00000370551, ENST00000370550, 
ENST00000356813, 		ENST00000362003, 
ENST00000400151, ENST00000482726, 
ENST00000470161, ENST00000521023, 
ENST00000505655, 
Fusion gene scores* DoF score9 X 5 X 5=2254 X 4 X 3=48
# samples 94
** MAII scorelog2(9/225*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HS2ST1 [Title/Abstract] AND PCGF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW086208HS2ST1chr1

87483849

-PCGF3chr4

763719

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000370551ENST00000362003HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370551ENST00000400151HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370551ENST00000482726HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370551ENST00000470161HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370551ENST00000521023HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370551ENST00000505655HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-3UTRENST00000370550ENST00000362003HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370550ENST00000400151HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370550ENST00000482726HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370550ENST00000470161HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370550ENST00000521023HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000370550ENST00000505655HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-3UTRENST00000356813ENST00000362003HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000356813ENST00000400151HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000356813ENST00000482726HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000356813ENST00000470161HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000356813ENST00000521023HS2ST1chr1

87483849

-PCGF3chr4

763719

+
intron-intronENST00000356813ENST00000505655HS2ST1chr1

87483849

-PCGF3chr4

763719

+

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FusionProtFeatures for HS2ST1_PCGF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HS2ST1

Q7LGA3

PCGF3

Q3KNV8

Catalyzes the transfer of sulfate to the C2-position ofselected hexuronic acid residues within the maturing heparansulfate (HS). 2-O-sulfation within HS, particularly of iduronateresidues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.Mediates 2-O-sulfation of both L-iduronyl and D-glucuronylresidues (By similarity). {ECO:0000250}. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Within the PRC1-likecomplex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). Plays a redundant role with PCGF5 as part of aPRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencingof one copy of the X chromosome in XX females (By similarity).{ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HS2ST1_PCGF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HS2ST1_PCGF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HS2ST1_PCGF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HS2ST1_PCGF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource