	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 16745

FusionGeneSummary for HPGD_HPGD

Fusion gene summary

Fusion gene information	Fusion gene name: HPGD_HPGD
	Fusion gene ID: 16745
		Hgene	Tgene
	Gene symbol	HPGD	HPGD
	Gene ID	3248	3248
	Gene name	15-hydroxyprostaglandin dehydrogenase	15-hydroxyprostaglandin dehydrogenase
	Synonyms	15-PGDH\|PGDH\|PGDH1\|PHOAR1\|SDR36C1	15-PGDH\|PGDH\|PGDH1\|PHOAR1\|SDR36C1
	Cytomap	4q34.1	4q34.1
	Type of gene	protein-coding	protein-coding
	Description	15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas	15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas
	Modification date	20180524	20180524
	UniProtAcc	P15428	P15428
	Ensembl transtripts involved in fusion gene	ENST00000296522, ENST00000296521, ENST00000510901, ENST00000422112, ENST00000541923, ENST00000542498, ENST00000504433,	ENST00000296522, ENST00000296521, ENST00000510901, ENST00000422112, ENST00000541923, ENST00000542498, ENST00000504433,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 3 X 2=18
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: HPGD [Title/Abstract] AND HPGD [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HPGD	GO:0006693	prostaglandin metabolic process	16828555
Hgene	HPGD	GO:0007179	transforming growth factor beta receptor signaling pathway	15574495
Hgene	HPGD	GO:0007565	female pregnancy	15531523
Hgene	HPGD	GO:0007567	parturition	15531523
Hgene	HPGD	GO:0045786	negative regulation of cell cycle	15574495
Tgene	HPGD	GO:0006693	prostaglandin metabolic process	16828555
Tgene	HPGD	GO:0007179	transforming growth factor beta receptor signaling pathway	15574495
Tgene	HPGD	GO:0007565	female pregnancy	15531523
Tgene	HPGD	GO:0007567	parturition	15531523
Tgene	HPGD	GO:0045786	negative regulation of cell cycle	15574495

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			J05594	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000296522	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296522	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000296521	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000296521	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000510901	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000510901	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000422112	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000422112	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000541923	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000541923	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000542498	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000542498	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-3UTR	ENST00000504433	ENST00000296522	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000296521	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000510901	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000422112	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000541923	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000542498	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+
intron-intron	ENST00000504433	ENST00000504433	HPGD	chr4	175411612	-	HPGD	chr4	175411745	+

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FusionProtFeatures for HPGD_HPGD

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HPGD P15428	HPGD P15428

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for HPGD_HPGD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HPGD_HPGD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for HPGD_HPGD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HPGD_HPGD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HPGD	C0029411	Osteoarthropathy, Primary Hypertrophic	2	CTD_human;ORPHANET;UNIPROT
Hgene	HPGD	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	HPGD	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	HPGD	C0206693	Medullary carcinoma	1	CTD_human
Hgene	HPGD	C0345408	Hereditary clubbing	1	ORPHANET;UNIPROT
Tgene	HPGD	C0029411	Osteoarthropathy, Primary Hypertrophic	2	CTD_human;ORPHANET;UNIPROT
Tgene	HPGD	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	HPGD	C0040136	Thyroid Neoplasm	1	CTD_human
Tgene	HPGD	C0206693	Medullary carcinoma	1	CTD_human
Tgene	HPGD	C0345408	Hereditary clubbing	1	ORPHANET;UNIPROT

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Fusion gene ID: 16745

FusionGeneSummary for HPGD_HPGD

FusionProtFeatures for HPGD_HPGD

FusionGeneSequence for HPGD_HPGD

FusionGenePPI for HPGD_HPGD

RelatedDrugs for HPGD_HPGD

RelatedDiseases for HPGD_HPGD