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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16744

FusionGeneSummary for HPGD_GUCY1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: HPGD_GUCY1A3
Fusion gene ID: 16744
HgeneTgene
Gene symbol

HPGD

GUCY1A3

Gene ID

3248

Gene name15-hydroxyprostaglandin dehydrogenase
Synonyms15-PGDH|PGDH|PGDH1|PHOAR1|SDR36C1
Cytomap

4q34.1

Type of geneprotein-coding
Description15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas
Modification date20180524
UniProtAcc

P15428

Ensembl transtripts involved in fusion geneENST00000296522, ENST00000296521, 
ENST00000510901, ENST00000422112, 
ENST00000541923, ENST00000542498, 
ENST00000504433, 
ENST00000506455, 
ENST00000511108, ENST00000511507, 
ENST00000515602, ENST00000455639, 
ENST00000393832, ENST00000296518, 
ENST00000513574, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: HPGD [Title/Abstract] AND GUCY1A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHPGD

GO:0006693

prostaglandin metabolic process

16828555

HgeneHPGD

GO:0007179

transforming growth factor beta receptor signaling pathway

15574495

HgeneHPGD

GO:0007565

female pregnancy

15531523

HgeneHPGD

GO:0007567

parturition

15531523

HgeneHPGD

GO:0045786

negative regulation of cell cycle

15574495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-K4-A3WU-01BHPGDchr4

175443095

-GUCY1A3chr4

156629388

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296522ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000296522ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000296522ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000296522ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000296522ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296522ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296522ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296522ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000296521ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000296521ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000296521ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000296521ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000296521ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296521ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296521ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000296521ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000510901ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000510901ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000510901ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3UTRENST00000510901ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3UTRENST00000510901ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000510901ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000510901ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000510901ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000422112ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000422112ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000422112ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000422112ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000422112ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000422112ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000422112ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000422112ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000541923ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000541923ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3CDSENST00000541923ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3UTRENST00000541923ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-3UTRENST00000541923ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000541923ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000541923ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5UTR-5UTRENST00000541923ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000542498ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000542498ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000542498ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000542498ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000542498ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000542498ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000542498ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000542498ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000504433ENST00000506455HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000504433ENST00000511108HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
Frame-shiftENST00000504433ENST00000511507HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000504433ENST00000515602HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-3UTRENST00000504433ENST00000455639HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000504433ENST00000393832HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000504433ENST00000296518HPGDchr4

175443095

-GUCY1A3chr4

156629388

+
5CDS-5UTRENST00000504433ENST00000513574HPGDchr4

175443095

-GUCY1A3chr4

156629388

+

Top

FusionProtFeatures for HPGD_GUCY1A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HPGD

P15428

GUCY1A3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HPGD_GUCY1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HPGD_GUCY1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HPGDAPPGUCY1A3STUB1, MAPK8, IKBKG, COPS4, TP53, COPS5, CSNK2A1, GUCY1B3, ANKMY2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HPGD_GUCY1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HPGD_GUCY1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHPGDC0029411Osteoarthropathy, Primary Hypertrophic2CTD_human;ORPHANET;UNIPROT
HgeneHPGDC0033578Prostatic Neoplasms1CTD_human
HgeneHPGDC0040136Thyroid Neoplasm1CTD_human
HgeneHPGDC0206693Medullary carcinoma1CTD_human
HgeneHPGDC0345408Hereditary clubbing1ORPHANET;UNIPROT