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Fusion gene ID: 16744

FusionGeneSummary for HPGD_GUCY1A3

Fusion gene summary

Fusion gene information	Fusion gene name: HPGD_GUCY1A3
	Fusion gene ID: 16744
		Hgene	Tgene
	Gene symbol	HPGD	GUCY1A3
	Gene ID	3248
	Gene name	15-hydroxyprostaglandin dehydrogenase
	Synonyms	15-PGDH\|PGDH\|PGDH1\|PHOAR1\|SDR36C1
	Cytomap	4q34.1
	Type of gene	protein-coding
	Description	15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas
	Modification date	20180524
	UniProtAcc	P15428
	Ensembl transtripts involved in fusion gene	ENST00000296522, ENST00000296521, ENST00000510901, ENST00000422112, ENST00000541923, ENST00000542498, ENST00000504433,	ENST00000506455, ENST00000511108, ENST00000511507, ENST00000515602, ENST00000455639, ENST00000393832, ENST00000296518, ENST00000513574,
Fusion gene scores	* DoF score	2 X 2 X 2=8	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/8*10)=1.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: HPGD [Title/Abstract] AND GUCY1A3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HPGD	GO:0006693	prostaglandin metabolic process	16828555
Hgene	HPGD	GO:0007179	transforming growth factor beta receptor signaling pathway	15574495
Hgene	HPGD	GO:0007565	female pregnancy	15531523
Hgene	HPGD	GO:0007567	parturition	15531523
Hgene	HPGD	GO:0045786	negative regulation of cell cycle	15574495

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-K4-A3WU-01B	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000296522	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296522	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296522	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296522	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296522	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296522	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000296521	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296521	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000296521	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000296521	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000510901	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000510901	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000510901	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000510901	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000422112	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000422112	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000422112	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000422112	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3CDS	ENST00000541923	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000541923	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-3UTR	ENST00000541923	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5UTR-5UTR	ENST00000541923	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000542498	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000542498	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000542498	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000542498	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000506455	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000511108	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
Frame-shift	ENST00000504433	ENST00000511507	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000504433	ENST00000515602	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-3UTR	ENST00000504433	ENST00000455639	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000393832	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000296518	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+
5CDS-5UTR	ENST00000504433	ENST00000513574	HPGD	chr4	175443095	-	GUCY1A3	chr4	156629388	+

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FusionProtFeatures for HPGD_GUCY1A3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HPGD P15428	GUCY1A3
	Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for HPGD_GUCY1A3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HPGD_GUCY1A3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
HPGD	APP	GUCY1A3	STUB1, MAPK8, IKBKG, COPS4, TP53, COPS5, CSNK2A1, GUCY1B3, ANKMY2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for HPGD_GUCY1A3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HPGD_GUCY1A3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HPGD	C0029411	Osteoarthropathy, Primary Hypertrophic	2	CTD_human;ORPHANET;UNIPROT
Hgene	HPGD	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	HPGD	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	HPGD	C0206693	Medullary carcinoma	1	CTD_human
Hgene	HPGD	C0345408	Hereditary clubbing	1	ORPHANET;UNIPROT

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Fusion gene ID: 16744

FusionGeneSummary for HPGD_GUCY1A3

FusionProtFeatures for HPGD_GUCY1A3

FusionGeneSequence for HPGD_GUCY1A3

FusionGenePPI for HPGD_GUCY1A3

RelatedDrugs for HPGD_GUCY1A3

RelatedDiseases for HPGD_GUCY1A3