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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 1673

FusionGeneSummary for ANK2_ARHGAP31

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK2_ARHGAP31
Fusion gene ID: 1673
HgeneTgene
Gene symbol

ANK2

ARHGAP31

Gene ID

287

57514

Gene nameankyrin 2Rho GTPase activating protein 31
SynonymsANK-2|LQT4|brank-2AOS1|CDGAP
Cytomap

4q25-q26

3q13.32-q13.33

Type of geneprotein-codingprotein-coding
Descriptionankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrinrho GTPase-activating protein 31Cdc42 GTPase-activating protein
Modification date2018052320180523
UniProtAcc

Q01484

Q2M1Z3

Ensembl transtripts involved in fusion geneENST00000506722, ENST00000394537, 
ENST00000357077, ENST00000264366, 
ENST00000509550, ENST00000510275, 
ENST00000504887, 		ENST00000264245, 
Fusion gene scores* DoF score8 X 9 X 4=2882 X 2 X 2=8
# samples 112
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ANK2 [Title/Abstract] AND ARHGAP31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DB-A75P-01AANK2chr4

114304891

+ARHGAP31chr3

119013220

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000506722ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
intron-3CDSENST00000394537ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
Frame-shiftENST00000357077ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
intron-3CDSENST00000264366ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
intron-3CDSENST00000509550ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
intron-3CDSENST00000510275ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+
intron-3CDSENST00000504887ENST00000264245ANK2chr4

114304891

+ARHGAP31chr3

119013220

+

Top

FusionProtFeatures for ANK2_ARHGAP31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK2

Q01484

ARHGAP31

Q2M1Z3

In skeletal muscle, required for proper localization ofDMD and DCTN4 and for the formation and/or stability of a specialsubset of microtubules associated with costameres andneuromuscular junctions. Attaches integral membrane proteins tocytoskeletal elements. Also binds to cytoskeletal proteins.Required for coordinate assembly of Na/Ca exchanger, Na/K ATPaseand InsP3 receptor at sarcoplasmic reticulum sites incardiomyocytes. Required for the coordinated expression of theNa/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in theinner segment of rod photoreceptors (By similarity). Required forexpression and targeting of SPTBN1 in neonatal cardiomyocytes andfor the regulation of neonatal cardiomyocyte contraction rate(PubMed:12571597). Plays a role in endocytosis and intracellularprotein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promotelong-range motility of cells. Recruits RABGAP1L to (PI3P)-positiveearly endosomes, where RABGAP1L inactivates RAB22A, and promotespolarized trafficking to the leading edge of the migrating cells.Part of the ANK2/RABGAP1L complex which is required for thepolarized recycling of fibronectin receptor ITGA5 ITGB1 to theplasma membrane that enables continuous directional cell migration(By similarity). {ECO:0000250|UniProtKB:Q8C8R3,ECO:0000269|PubMed:12571597}. Functions as a GTPase-activating protein (GAP) for RAC1and CDC42. Required for cell spreading, polarized lamellipodiaformation and cell migration. {ECO:0000269|PubMed:12192056,ECO:0000269|PubMed:16519628}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461158_130447143958DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461450_153547143958DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46463569_365347143958DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646968_115647143958DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471158_130426181864DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471450_153526181864DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47473569_365326181864DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747968_115626181864DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461289_142347143958RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461806_198347143958RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471289_142326181864RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471806_198326181864RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646129_15847143958RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646162_19147143958RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461806_181747143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461818_182947143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461830_184147143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461842_185347143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461854_186547143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461866_187747143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461878_188947143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461890_190047143958RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461901_191247143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461913_192447143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461925_193547143958RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461936_194747143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646193_22047143958RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461948_195947143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461960_197147143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+46461972_198347143958RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646232_26147143958RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646265_29447143958RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646298_32747143958RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+464630_6247143958RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646331_36047143958RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646364_39347143958RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646397_42647143958RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646430_45947143958RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646463_49247143958RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646496_52547143958RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646529_55847143958RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646562_59147143958RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646595_62447143958RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646628_65747143958RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+464663_9247143958RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646661_69047143958RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646694_72347143958RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646727_75647143958RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646760_78947143958RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646793_82247143958RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+464696_12547143958RepeatNote=ANK 3
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747129_15826181864RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747162_19126181864RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471806_181726181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471818_182926181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471830_184126181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471842_185326181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471854_186526181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471866_187726181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471878_188926181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471890_190026181864RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471901_191226181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471913_192426181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471925_193526181864RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471936_194726181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747193_22026181864RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471948_195926181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471960_197126181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+47471972_198326181864RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747232_26126181864RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747265_29426181864RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747298_32726181864RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+474730_6226181864RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747331_36026181864RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747364_39326181864RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747397_42626181864RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747430_45926181864RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747463_49226181864RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747496_52526181864RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747529_55826181864RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747562_59126181864RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747595_62426181864RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747628_65726181864RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+474763_9226181864RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747661_69026181864RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747694_72326181864RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747727_75626181864RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747760_78926181864RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747793_82226181864RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+474796_12526181864RepeatNote=ANK 3
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245+-112673_790331445Compositional biasNote=Pro-rich
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245+-112971_974331445Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451158_1304-181873DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451450_1535-181873DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1453569_3653-181873DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145968_1156-181873DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141158_1304-2556DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141450_1535-2556DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1143569_3653-2556DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114968_1156-2556DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451289_1423-181873RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451806_1983-181873RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141289_1423-2556RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141806_1983-2556RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145129_158-181873RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145162_191-181873RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451806_1817-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451818_1829-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451830_1841-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451842_1853-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451854_1865-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451866_1877-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451878_1889-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451890_1900-181873RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451901_1912-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451913_1924-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451925_1935-181873RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451936_1947-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145193_220-181873RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451948_1959-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451960_1971-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+1451972_1983-181873RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145232_261-181873RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145265_294-181873RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145298_327-181873RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+14530_62-181873RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145331_360-181873RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145364_393-181873RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145397_426-181873RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145430_459-181873RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145463_492-181873RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145496_525-181873RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145529_558-181873RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145562_591-181873RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145595_624-181873RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145628_657-181873RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+14563_92-181873RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145661_690-181873RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145694_723-181873RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145727_756-181873RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145760_789-181873RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145793_822-181873RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+14596_125-181873RepeatNote=ANK 3
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114129_158-2556RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114162_191-2556RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141806_1817-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141818_1829-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141830_1841-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141842_1853-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141854_1865-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141866_1877-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141878_1889-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141890_1900-2556RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141901_1912-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141913_1924-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141925_1935-2556RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141936_1947-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114193_220-2556RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141948_1959-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141960_1971-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+1141972_1983-2556RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114232_261-2556RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114265_294-2556RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114298_327-2556RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+11430_62-2556RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114331_360-2556RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114364_393-2556RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114397_426-2556RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114430_459-2556RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114463_492-2556RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114496_525-2556RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114529_558-2556RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114562_591-2556RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114595_624-2556RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114628_657-2556RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+11463_92-2556RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114661_690-2556RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114694_723-2556RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114727_756-2556RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114760_789-2556RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114793_822-2556RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+11496_125-2556RepeatNote=ANK 3
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245+-11221_216331445DomainRho-GAP


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FusionGeneSequence for ANK2_ARHGAP31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ANK2_ENST00000506722_chr4_114304891_+_ARHGAP31_ENST00000264245_chr3_119013220_+_4241aa
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAE
VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAAR
KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ
IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT
KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA
ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK
KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY
GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV
KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH
KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAV
MDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCT
APTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRG
KERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQV
QAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTT
PAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLE
QQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLN
ITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERD
GKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSE
EDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTP
AEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHT
VVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNEXSHHTEEGCGEGPAWKTHXLGAPGGCT
RSTRPGRPPARSPAAPSAFLQGGLEARGQVRGCPVLTPETTHSLNMQLPVSVGEXPNWPNXWDTPTFPLLANIRHFALVFPHPLXLXSXF
VTKDGILHTGCCIQYFVVSVLTWELATSIVLCFCTRSMKIHXSEELHLQTSSSDTMXESFQGISMYNVYSXNAQMNNILKLKPLPIVTTL
GIRIKGLXKLLNNGXLRYCXHNRVIIQFYCKRSTSNLLCPXNFQSSHCSQLKVGQXPCRTVLRSYCWCWPAMAXDSNSHSEGGEKGAEAT
QNEPMGYSVAGSYIVWHSSIFRSLDLGQVGRVFXKLXLLXFSSFHCCFSKPRCLTVVLSSGHCTVDNSLETRFTHYIKGXTPSVCWSGFF
FFFFLSFFSSGLYLLXYLHVAFKNQDHGQTPLLITLIVSILFTLSEHFSLSSXVCFSACRQDXEILENLVLVKIFGLFIXNPHSLGNSXV
HLCTSVCLSQRRDCNNLSNFHVLFLIPLVVEAVXHFNIYIFTNIFIXTVYILNQSFVKEKYIQXRXNLNKKGQSLSSRDXTFSNYLVFSC
CAKMTHCSECQKQMRQTMALHHLKXCCQEKKFPGREVSHKPNLLSLKCXHFLAVGXEMRHSLAAKIREADGETFXDTLWPSCQNLHWSSR
KAFLLCYLQCRXCLCNNIMVIHLFLILIFAVLSKTXILXEEVNFQLTNQHLVPMVITLIEYIYEGMYXLMEKKIQHXQYIAAMCTMADLI
KXNVQVLNVEKKEGVRAGSSDRMLVFRSTKVVXRRDSGPRAQDPPQPPGQSPRPASASSPGHLVRGGESLPSLLSXGETPEDTAGACESP
XDSKXGSDTPRRAGPRLPVCTASARRPRSGAGWISGSAGPRPAGSMRRAPSPSSSIFRCGPPEPRGSRXSSPGAHLTAVPSRGAAETEGQ
PLWDXLMKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVY
LQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVW
APNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPA
RKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVP
VEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESE
QTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGG
WPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESS
TLQESPRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTP
LEVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPPPTPLEESTPVLLSKGGP
EREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTV
TDIAQHGLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSSSSCANLETERNS
DPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPPNQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPS
VQDSTSPGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMTSSYCKADPWRVYSQDPQD
LDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSS
LESSKEEKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLERPSGGSKPFHRSRPGRP
QSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ANK2_ENST00000506722_chr4_114304891_+_ARHGAP31_ENST00000264245_chr3_119013220_+_12723nt
ATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCAGGCAACCTGGACAAAGTTGTGGAATATCTG
AAGGGGGGCATAGACATCAATACCTGCAATCAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCACGTGGGGCTGGTGCAG
GAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTTCACATTGCATCTTTGGCTGGACAAGCAGAA
GTTGTCAAAGTTCTTGTTAAGGAAGGAGCCAATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATGGCTGCCCAAGAGAAT
CACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAGGATGGCTTTACTCCTCTAGCTGTGGCACTC
CAGCAAGGACACAACCAGGCGGTGGCCATCCTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTGCATATTGCCGCTAGG
AAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAATCCAAGATGATGGTGAATAGGACAACTGAG
AGTGGTTTTACCCCTTTGCACATAGCTGCACATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGAGCTGCTGTGGACTTC
ACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATGGTGAAGCTCTTACTGGATCGAGGCGGTCAG
ATCGATGCCAAAACTAGGGATGGGTTGACACCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAACTTCTGTTGGAACGG
GGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAGGGAGACCACGTGGAATGTGTGAAGCACCTG
TTACAGCACAAGGCACCTGTTGATGATGTCACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGCCACTACCGTGTAACC
AAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCACTGCACATTGCCTGCAAGAAAAACCGCATC
AAAGTCATGGAACTGCTGGTGAAATATGGGGCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACATGTGGCTGCCTTCATG
GGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAACATTCGTGGTGAGACGGCACTACACATGGCA
GCCCGAGCCGGGCAGGTGGAAGTGGTCCGATGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAGGAACAGACACCTTTA
CATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCTCATCCAGATGCGGCCACTACAAATGGGTAC
ACACCACTGCACATCTCTGCCCGGGAGGGCCAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCACTCCTTAGCTACCAAG
AAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGTGCTGCCGCAGATTCT
GCAGGGAAGAACGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTGGAGAAGGGTGCTTCC
CCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAAATGCAGATAGCTTCCACACTCCTGAACTAT
GGAGCAGAGACAAACATTGTGACAAAGCAAGGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGATATGGTTACCTTGCTT
CTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTTGCAGCCCAGGAAGATAAAGTGAATGTTGCT
GATATTCTCACCAAGCATGGAGCTGATCAGGATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGTCACTATGGAAATGTG
AAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGCTACACGCCTTTGCACCAGGCCGCTCAGCAG
GGTCACACGCACATCATCAACGTCCTGCTCCAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACTGCCTTGGCGATTGCT
AAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACCACCACCACCACAACTATTACAGAAAAACAC
AAACTAAATGTACCTGAGACGATGACTGAGGTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGTGATGGGGGAGAATAC
CTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTGGATGGTATGAATTACCTGCGATACAGCTTG
GAGGGAGGACGATCTGACAGCCTTCGATCCTTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTGAGGGACAGTGCCGTG
ATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAAAGGAATTCTTATCGCCTAAGCTGGGGCACT
GAGAACTTAGACAACGTGGCTCTTTCTTCTAGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGACAACAGCAGTTTCCTG
GTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTCCGAATCATTATTCCACCTCGGAAATGTACT
GCTCCAACGCGAGTCACCTGCCGACTGGTCAAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAAGGCCTGGCCAGTCGC
CTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCTCCTCCCCCACTTAATGAGGGAGAAAGTTTG
GTCAGCCGCATTCTTCAGCTGGGGCCTCCTGGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTTGCGGCCCTTCGAGGA
AAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTCTGTGACTACACTGAAGATGAATTGAATGAA
ATTCTTAACGGCATGGATGAAGTACTGGATAGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACCCGAGACTTCCCACAG
TACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGTGTACTGAGCAGCACAGTGGTGCCCCAGGTG
CAGGCCGTCTTCCCAGAGGGGGCACTCACCAAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAGCTGGTTAAGAAGATC
CTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTCCACAAACCAATTACCATGACCATTCCTGTC
CCCAAAGCTTCAAGTGATGTCATGTTGAATGGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATAACAGGTGGAACCACC
CCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTTTCCTTTACAACAAACGTGTCTGCCAGGTTC
TGGCTGATAGATTGTCGACAGATCCAGGAATCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTACCTTATATGGCCAAA
TTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATGACTGATGATAAAGTGGATAAGACCCTTGAA
CAACAAGAAAATTTTGCTGAGGTGGCCAGAAGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGATTGTTTCGGCAACTTG
GTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAATAGACTTCCTCTATTTGTCAAGGTACGCGAT
ACGACTCAGGAACCTTGCGGACGACTATCATTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCTATTTGCAACTTAAAC
ATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATCGATATGACATCAGAAAAAAATCCACAGGAT
GAGCAGGAACGGATCGAGGAAAGGCTGGCTTATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGAGAACTGGATTTCACT
GAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCATGCACTGTTGAAGTACTGGCTAGAGAGGGAT
GGGAAACATGCTACAGATACCAACCTCGTTGAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATGGAGACCAACACAGAA
CCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGATCATAGTGAAGGGTTCTCGGTACTTCAAGAG
GAGTTATGCACTGCACAGCACAAGCAGAAAGAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCTCCTATCGTCTCAGAG
GAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGACAGCTCAGCAACAGCACTCTTTCCCCAAACT
CACAAGGAGCAAGTTCAACAGGATTTCTCAGGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAGCAGGAATATTTTGTG
ACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCCAGCAAGACACCTGAGGAAGTTAGCACCCCT
GCAGAGGAGGAGAAGCTGTACCTCCAGACCCCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCCGAAGAGCCCTCAGAG
CACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAACCAGCCTGAGACCTGTGAAAGACTCGATGAA
GATGCAGCTTTTGAAAAGGGAGACGATATGCCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGATGAGCATGGACACACC
GTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAGAAAGAAGAGATTATGGTGCAGGGAATGCCA
CAGGAACCTGTCAACATCGAGGAAGGGGATGGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACCGAGCAGTCAGAGGAC
AACAATGAGTAAAGCCATCACACAGAAGAGGGCTGTGGTGAAGGACCAGCATGGAAAACGCATTGACTTGGAGCACCTGGAGGATGTACC
AGAAGCACTAGACCAGGACGACCTCCAGCGCGATCTCCAGCAGCTCCTTCGGCATTTCTGCAAGGAGGACTTGAAGCAAGAGGCCAAGTG
AGGGGCTGCCCAGTTCTCACACCAGAAACCACACATTCACTCAATATGCAGCTTCCTGTTTCAGTAGGGGAGTGACCTAACTGGCCTAAT
TAATGGGATACCCCGACATTTCCACTGTTAGCAAATATACGGCATTTTGCTTTAGTTTTCCCCCATCCTCTTTAACTATAAAGCTAATTT
GTGACCAAAGATGGCATCCTTCATACTGGATGCTGTATCCAATACTTTGTTGTGTCTGTGCTAACCTGGGAACTGGCCACCTCCATTGTT
CTTTGCTTCTGCACAAGATCCATGAAAATCCATTGATCAGAAGAACTTCACCTGCAGACCTCTTCAAGTGACACTATGTAGGAATCCTTC
CAAGGAATATCTATGTACAATGTATATAGCTGAAATGCTCAGATGAACAACATATTAAAATTAAAACCACTGCCTATTGTAACTACACTG
GGCATCAGAATAAAAGGCCTCTAGAAATTGCTGAACAATGGTTAATTAAGATATTGCTAACACAATCGAGTGATAATACAGTTTTACTGC
AAAAGAAGCACTTCAAACCTATTATGTCCTTAGAACTTCCAGAGTAGCCACTGCTCCCAGTTAAAGGTGGGTCAGTAGCCTTGCAGAACT
GTCCTGAGAAGTTATTGCTGGTGCTGGCCAGCCATGGCTTAGGACTCCAACAGCCACTCTGAGGGAGGGGAGAAGGGAGCAGAGGCCACG
CAGAATGAACCGATGGGGTATTCAGTTGCTGGCAGCTACATTGTGTGGCATTCTAGCATCTTCAGGTCTTTAGATCTTGGACAAGTTGGC
AGGGTATTTTAAAAGCTATAACTACTGTAGTTTTCCAGTTTTCATTGCTGCTTTAGCAAACCACGCTGTCTTACAGTGGTACTTTCTTCT
GGCCACTGCACTGTAGATAATTCATTGGAAACAAGATTTACCCACTACATAAAAGGTTAAACTCCTTCAGTATGTTGGAGTGGTTTCTTT
TTTTTTTTCTTTCTTTCTTTTTTTTCTTCAGGTTTATATCTTCTCTAATACCTGCATGTGGCGTTTAAAAATCAAGACCACGGTCAAACC
CCTCTTCTAATCACATTAATTGTTTCCATTCTTTTTACCCTGAGTGAGCACTTTTCACTTTCCAGCTAGGTCTGTTTTTCAGCTTGCAGA
CAAGATTGAGAAATCCTTGAAAATTTGGTTTTGGTTAAAATTTTTGGTTTATTTATTTGAAATCCACACTCCCTTGGAAACTCTTAAGTG
CATTTGTGCACTTCTGTTTGTTTGTCTCAAAGAAGGGACTGTAACAATCTGAGTAATTTCCATGTCCTCTTCCTTATTCCTCTAGTGGTT
GAAGCTGTGTAGCATTTTAACATATATATATTCACAAATATATTCATATAAACAGTATACATTTTGAATCAGTCATTTGTTAAAGAAAAG
TATATTCAATGAAGATGAAATTTAAATAAAAAAGGACAGAGTCTATCCTCCAGGGATTGAACATTTTCCAATTATCTGGTCTTTTCCTGT
TGTGCAAAAATGACTCATTGCTCCGAATGTCAAAAACAAATGCGACAAACAATGGCACTTCATCATTTAAAGTAATGTTGCCAAGAGAAA
AAATTTCCTGGGAGGGAGGTTTCCCACAAGCCAAATCTCCTAAGCCTCAAATGCTAGCACTTTTTGGCAGTTGGATAGGAAATGAGACAT
TCTTTGGCAGCCAAAATAAGAGAGGCCGATGGTGAAACTTTTTGAGACACCCTATGGCCTTCTTGTCAAAACCTTCACTGGAGCTCAAGA
AAAGCATTTCTGTTGTGTTATTTGCAGTGCAGATGATGTCTGTGTAACAACATAATGGTTATTCACCTTTTTTTGATTTTGATTTTTGCT
GTGTTATCAAAAACTTGAATACTGTGAGAAGAAGTGAATTTTCAGTTGACGAATCAGCATCTTGTTCCCATGGTGATAACACTAATTGAA
TATATCTATGAGGGCATGTATTAGTTAATGGAAAAAAAAATACAACACTAACAATACATAGCTGCAATGTGTACAATGGCTGATTTAATT
AAATAAAATGTACAAGTGTTAAATGTGGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTTTTTCGCTCTACCAAA
GTCGTCTGAAGGCGAGACAGCGGGCCCAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCGTCCGCGTCGTCTCCG
GGGCACTTAGTAAGGGGTGGGGAGAGCTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGAGCCTGTGAAAGTCCC
TAGGACTCCAAGTGAGGAAGTGACACTCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGGCGGCCCCGGAGCGGC
GCGGGGTGGATCTCAGGCTCTGCCGGCCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCCATCTTCCGATGCGGC
CCCCCAGAGCCGCGGGGCAGCCGGTGATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCAGAGACGGAGGGGCAG
CCTCTTTGGGACTAACTCATGAAGAACAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTTGGCTGTGACCTGACG
GAGTATCTGGAAAGCTCGGGACAGGATGTTCCATACGTTTTGAAGAGCTGTGCAGAATTTATAGAGACTCACGGCATCGTGGATGGAATC
TATCGGCTTTCAGGAGTCACCTCAAACATACAACGGCTAAGGCAAGAGTTTGGCTCAGATCAATGTCCAGATCTGACAAGGGAAGTGTAC
CTCCAGGACATCCACTGTGTGGGCTCGCTTTGCAAGCTCTACTTTAGGGAGCTGCCCAACCCCCTCCTGACTTATGAGCTCTATGAGAAA
TTCACGGAGGCAGTGTCGCATTGCCCTGAAGAAGGCCAACTGGCCCGAATCCAAAATGTTATCCAGGAGCTTCCTCCATCCCACTATAGG
ACCTTGGAATACCTGATTCGACACCTGGCCCATATCGCCTCCTTCAGCAGCAAGACCAACATGCACGCCCGGAACCTGGCCCTGGTGTGG
GCGCCAAACCTCCTCAGGTCTAAAGAAATTGAAGCCACTGGTTGCAATGGAGATGCAGCCTTCCTTGCAGTCCGGGTCCAGCAGGTGGTG
ATTGAGTTCATATTGAATCATGTAGATCAAATCTTTAACAACGGTGCACCTGGGTCTCTGGAGAATGATGAAAACCGGCCCATCATGAAG
AGCCTGACCTTGCCAGCCCTCTCCCTGCCCATGAAGCTGGTGAGCCTTGAGGAAGCTCAAGCCCGCAGCCTGGCCACTAACCATCCTGCT
CGCAAGGAAAGGAGGGAGAACAGCCTGCCTGAGATTGTCCCTCCCATGGGCACCCTCTTCCACACTGTCCTTGAGTTACCAGACAACAAG
CGAAAGCTCTCCAGTAAATCAAAGAAGTGGAAATCAATATTTAACCTGGGACGTTCTGGATCAGACTCCAAATCAAAACTGAGTAGAAAT
GGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGTGGAAAAGGCTACTATCCGACCAGCTAAAAGCATGGACTCACTATGTTCAGTGCCT
GTAGAAGGAAAAGAAACCAAGGGAAATTTCAATCGAACAGTTACCACCGGTGGATTTTTCATTCCAGCAACAAAGATGCACTCCACCGGC
ACCGGCAGCTCATGTGACCTCACCAAGCAGGAGGGCGAATGGGGCCAGGAGGGGATGCCTCCCGGGGCTGAGGGTGGCTTTGATGTGAGC
AGTGATCGCAGCCATCTCCAGGGCGCTCAGGCCCGGCCCCCACCGGAACAGCTGAAGGTTTTCCGGCCTGTTGAGGATCCGGAGAGCGAG
CAAACAGCCCCAAAGATGTTGGGTATGTTCTACACTTCGAACGACAGCCCTAGCAAATCCGTCTTCACCAGCAGCCTCTTCCAGATGGAG
CCCTCGCCGCGTAACCAGCGCAAGGCGCTGAACATCTCCGAGCCCTTTGCGGTATCTGTGCCGCTCCGCGTGTCCGCAGTCATCAGCACC
AACAGCACGCCGTGCAGAACACCCCCGAAGGAGCTGCAGTCTCTTTCCAGCCTGGAAGAGTTTTCTTTTCATGGATCAGAGAGCGGAGGC
TGGCCAGAAGAAGAGAAACCGCTGGGAGCTGAGACTTCTGCAGCTTCTGTACCTAAGAAGGCAGGTCTTGAGGATGCCAAGGCAGTACCT
GAAGCACCGGGGACAGTGGAATGCAGCAAAGGCCTGTCCCAGGAGCCAGGCGCCCACCTGGAGGAGAAGAAAACCCCAGAAAGCTCCTTG
AGCTCTCAACATTTAAATGAATTAGAGAAGAGGCCAAATCCGGAGAAGGTGGTGGAGGAGGGACGAGAGGCTGGTGAGATGGAGTCCAGC
ACCCTGCAGGAGAGCCCCAGGGCCAGAGCCGAAGCTGTGCTTCTCCATGAGATGGATGAAGATGATCTGGCCAATGCCCTGATCTGGCCT
GAGATTCAACAGGAGCTGAAAATCATTGAATCTGAGGAGGAGCTCTCATCGTTGCCACCTCCTGCTCTGAAGACCAGCCCAATTCAGCCT
ATTCTCGAGTCGAGTCTGGGGCCCTTTATTCCCTCAGAGCCTCCTGGGAGCTTGCCTTGTGGCTCCTTCCCTGCTCCAGTCTCCACCCCT
CTGGAGGTGTGGACTAGGGATCCAGCCAATCAGAGCACACAGGGGGCTTCCACAGCAGCCAGCAGAGAGAAGCCGGAACCTGAGCAGGGC
CTGCACCCAGACCTCGCCAGCCTGGCTCCTCTGGAAATAGTTCCTTTTGAGAAGGCATCTCCACAAGCAACAGTGGAAGTAGGAGGCCCA
GGCAATCTGTCTCCTCCACTCCCACCTGCTCCTCCCCCTCCAACTCCTCTGGAGGAGTCAACTCCAGTCCTGCTTTCAAAGGGCGGCCCG
GAAAGAGAAGACTCATCCAGGAAATTGAGGACAGATCTCTACATAGACCAGCTGAAGTCCCAAGACAGCCCTGAGATCTCTAGCCTCTGT
CAGGGAGAGGAGGCAACCCCAAGACACAGTGACAAGCAAAATTCAAAGAATGCTGCTTCTGAGGGGAAAGGCTGTGGTTTTCCAAGCCCA
ACCAGGGAGGTTGAGATCGTCTCACAAGAAGAGGAGGATGTAACCCATTCAGTACAGGAGCCTTCAGACTGTGACGAAGATGACACTGTG
ACAGACATTGCCCAGCATGGCCTGGAGATGGTGGAGCCCTGGGAGGAACCCCAGTGGGTGACGAGTCCCCTTCACTCTCCCACCCTGAAA
GACGCGCACAAGGCCCAGGTACAGGGCCTTCAGGGTCACCAGTTGGAGAAGAGGCTTTCCCACAGGCCCAGCCTTCGCCAGAGCCATTCT
CTAGATAGCAAACCCACGGTTAAAAGCCAGTGGACTCTCGAGGTTCCCTCCTCCAGCAGCTGTGCTAATCTTGAAACAGAGAGGAATTCT
GACCCTCTTCAGCCCCAGGCACCCAGGAGAGAGATTACTGGATGGGATGAGAAAGCCCTGAGGTCCTTCAGAGAGTTCTCTGGCCTGAAA
GGGGCAGAGGCTCCTCCCAACCAGAAGGGACCAAGTGGTGTGCAACCCAACCCAGCAGAAACCAGCCCCATCAGCCTAGCAGAGGGAAAG
GAGCTAGGGACACACCTGGGGCACAGCAGTCCACAGATTAGGCAAGGTGGTGTTCCTGGGCCAGAGAGCAGCAAGGAGAGTTCACCCAGC
GTGCAGGACAGCACTTCGCCTGGAGAGCACCCCGCAAAGTTACAGCTAAAGAGCACAGAGTGTGGGCCCCCAAAAGGGAAAAACAGGCCT
TCTTCCCTCAACTTGGACCCTGCCATTCCCATTGCTGACCTCTTCTGGTTTGAGAATGTGGCCTCATTTAGTTCACCTGGAATGCAGGTC
TCTGAGCCAGGAGACCCAAAGGTCACATGGATGACCTCATCTTACTGTAAAGCAGACCCCTGGAGGGTTTACTCCCAGGACCCCCAGGAC
CTGGACATTGTTGCTCATGCACTGACAGGCCGCCGTAACTCAGCTCCTGTGAGTGTGTCAGCTGTGAGAACCTCCTTCATGGTCAAAATG
TGCCAGGCCAGGGCGGTCCCAGTCATCCCTCCCAAGATTCAGTACACCCAGATCCCACAGCCCCTGCCCTCTCAGAGCTCAGGGGAGAAT
GGGGTTCAGCCTCTGGAGAGGAGCCAGGAGGGACCCAGCTCAACCAGTGGGACCACTCAGAAACCTGCCAAAGATGATTCTCCCTCCTCC
CTGGAAAGCTCAAAGGAAGAAAAACCAAAGCAAGATCCCGGAGCCATTAAGTCCTCACCAGTGGATGCCACTGCACCCTGCATGTGCGAG
GGACCTACCCTTTCTCCAGAACCAGGCTCGTCTAACCTGCTCTCCACCCAGGATGCAGTAGTGCAATGCAGAAAGCGCATGTCAGAGACA
GAGCCATCTGGGGACAACCTTCTTTCTTCAAAACTAGAGCGACCATCTGGGGGTTCTAAGCCTTTCCACAGGTCAAGGCCAGGAAGACCT
CAGAGCCTAATCTTATTCAGTCCTCCTTTCCCCATTATGGACCACCTGCCCCCTTCATCCACAGTGACAGATTCCAAGGTCCTGCTGTCC
CCTATCAGAAGTCCCACCCAGACAGTTTCCCCTGGCCTTCTTTGTGGAGAGTTGGCAGAAAACACATGGGTCACACCAGAAGGGGTTACA
CTTAGGAATAAAATGACCATCCCTAAGAATGGCCAGAGACTAGAGACCTCAACCAGCTGTTTTTACCAGCCTCAGCGGAGATCAGTAATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ANK2_ENST00000506722_chr4_114304891_+_ARHGAP31_ENST00000264245_chr3_119013220_+_17368nt
ACAGTCTGAGGCTGTAATGGGAAAGTCGGTTCCTGGGCTGCTGTCTCATAGACATCAGCTTGCAGGGAAGCTGGGGGCTCTCCGAATTGC
CCTGCTCCGGGGCCCCTCCTGCTGCGTGACTCACAGGCACATTGCAGAGAGAAGCTGCCGCTCCCAGTAAGTAATGAAAAGAGACATGAA
GAATTGGTATTTCAAATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCAGGCAACCTGGACAAA
GTTGTGGAATATCTGAAGGGGGGCATAGACATCAATACCTGCAATCAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCAC
GTGGGGCTGGTGCAGGAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTTCACATTGCATCTTTG
GCTGGACAAGCAGAAGTTGTCAAAGTTCTTGTTAAGGAAGGAGCCAATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATG
GCTGCCCAAGAGAATCACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAGGATGGCTTTACTCCT
CTAGCTGTGGCACTCCAGCAAGGACACAACCAGGCGGTGGCCATCCTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTG
CATATTGCCGCTAGGAAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAATCCAAGATGATGGTG
AATAGGACAACTGAGAGTGGTTTTACCCCTTTGCACATAGCTGCACATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGA
GCTGCTGTGGACTTCACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATGGTGAAGCTCTTACTG
GATCGAGGCGGTCAGATCGATGCCAAAACTAGGGATGGGTTGACACCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAA
CTTCTGTTGGAACGGGGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAGGGAGACCACGTGGAA
TGTGTGAAGCACCTGTTACAGCACAAGGCACCTGTTGATGATGTCACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGC
CACTACCGTGTAACCAAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCACTGCACATTGCCTGC
AAGAAAAACCGCATCAAAGTCATGGAACTGCTGGTGAAATATGGGGCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACAT
GTGGCTGCCTTCATGGGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAACATTCGTGGTGAGACG
GCACTACACATGGCAGCCCGAGCCGGGCAGGTGGAAGTGGTCCGATGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAG
GAACAGACACCTTTACATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCTCATCCAGATGCGGCC
ACTACAAATGGGTACACACCACTGCACATCTCTGCCCGGGAGGGCCAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCAC
TCCTTAGCTACCAAGAAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGT
GCTGCCGCAGATTCTGCAGGGAAGAACGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTG
GAGAAGGGTGCTTCCCCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAAATGCAGATAGCTTCC
ACACTCCTGAACTATGGAGCAGAGACAAACATTGTGACAAAGCAAGGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGAT
ATGGTTACCTTGCTTCTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTTGCAGCCCAGGAAGAT
AAAGTGAATGTTGCTGATATTCTCACCAAGCATGGAGCTGATCAGGATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGT
CACTATGGAAATGTGAAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGCTACACGCCTTTGCAC
CAGGCCGCTCAGCAGGGTCACACGCACATCATCAACGTCCTGCTCCAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACT
GCCTTGGCGATTGCTAAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACCACCACCACCACAACT
ATTACAGAAAAACACAAACTAAATGTACCTGAGACGATGACTGAGGTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGT
GATGGGGGAGAATACCTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTGGATGGTATGAATTAC
CTGCGATACAGCTTGGAGGGAGGACGATCTGACAGCCTTCGATCCTTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTG
AGGGACAGTGCCGTGATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAAAGGAATTCTTATCGC
CTAAGCTGGGGCACTGAGAACTTAGACAACGTGGCTCTTTCTTCTAGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGAC
AACAGCAGTTTCCTGGTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTCCGAATCATTATTCCA
CCTCGGAAATGTACTGCTCCAACGCGAGTCACCTGCCGACTGGTCAAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAA
GGCCTGGCCAGTCGCCTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCTCCTCCCCCACTTAAT
GAGGGAGAAAGTTTGGTCAGCCGCATTCTTCAGCTGGGGCCTCCTGGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTT
GCGGCCCTTCGAGGAAAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTCTGTGACTACACTGAA
GATGAATTGAATGAAATTCTTAACGGCATGGATGAAGTACTGGATAGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACC
CGAGACTTCCCACAGTACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGTGTACTGAGCAGCACA
GTGGTGCCCCAGGTGCAGGCCGTCTTCCCAGAGGGGGCACTCACCAAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAG
CTGGTTAAGAAGATCCTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTCCACAAACCAATTACC
ATGACCATTCCTGTCCCCAAAGCTTCAAGTGATGTCATGTTGAATGGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATA
ACAGGTGGAACCACCCCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTTTCCTTTACAACAAAC
GTGTCTGCCAGGTTCTGGCTGATAGATTGTCGACAGATCCAGGAATCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTA
CCTTATATGGCCAAATTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATGACTGATGATAAAGTG
GATAAGACCCTTGAACAACAAGAAAATTTTGCTGAGGTGGCCAGAAGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGAT
TGTTTCGGCAACTTGGTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAATAGACTTCCTCTATTT
GTCAAGGTACGCGATACGACTCAGGAACCTTGCGGACGACTATCATTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCT
ATTTGCAACTTAAACATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATCGATATGACATCAGAA
AAAAATCCACAGGATGAGCAGGAACGGATCGAGGAAAGGCTGGCTTATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGA
GAACTGGATTTCACTGAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCATGCACTGTTGAAGTAC
TGGCTAGAGAGGGATGGGAAACATGCTACAGATACCAACCTCGTTGAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATG
GAGACCAACACAGAACCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGATCATAGTGAAGGGTTC
TCGGTACTTCAAGAGGAGTTATGCACTGCACAGCACAAGCAGAAAGAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCT
CCTATCGTCTCAGAGGAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGACAGCTCAGCAACAGCA
CTCTTTCCCCAAACTCACAAGGAGCAAGTTCAACAGGATTTCTCAGGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAG
CAGGAATATTTTGTGACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCCAGCAAGACACCTGAG
GAAGTTAGCACCCCTGCAGAGGAGGAGAAGCTGTACCTCCAGACCCCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCC
GAAGAGCCCTCAGAGCACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAACCAGCCTGAGACCTGT
GAAAGACTCGATGAAGATGCAGCTTTTGAAAAGGGAGACGATATGCCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGAT
GAGCATGGACACACCGTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAGAAAGAAGAGATTATG
GTGCAGGGAATGCCACAGGAACCTGTCAACATCGAGGAAGGGGATGGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACC
GAGCAGTCAGAGGACAACAATGAGTAAAGCCATCACACAGAAGAGGGCTGTGGTGAAGGACCAGCATGGAAAACGCATTGACTTGGAGCA
CCTGGAGGATGTACCAGAAGCACTAGACCAGGACGACCTCCAGCGCGATCTCCAGCAGCTCCTTCGGCATTTCTGCAAGGAGGACTTGAA
GCAAGAGGCCAAGTGAGGGGCTGCCCAGTTCTCACACCAGAAACCACACATTCACTCAATATGCAGCTTCCTGTTTCAGTAGGGGAGTGA
CCTAACTGGCCTAATTAATGGGATACCCCGACATTTCCACTGTTAGCAAATATACGGCATTTTGCTTTAGTTTTCCCCCATCCTCTTTAA
CTATAAAGCTAATTTGTGACCAAAGATGGCATCCTTCATACTGGATGCTGTATCCAATACTTTGTTGTGTCTGTGCTAACCTGGGAACTG
GCCACCTCCATTGTTCTTTGCTTCTGCACAAGATCCATGAAAATCCATTGATCAGAAGAACTTCACCTGCAGACCTCTTCAAGTGACACT
ATGTAGGAATCCTTCCAAGGAATATCTATGTACAATGTATATAGCTGAAATGCTCAGATGAACAACATATTAAAATTAAAACCACTGCCT
ATTGTAACTACACTGGGCATCAGAATAAAAGGCCTCTAGAAATTGCTGAACAATGGTTAATTAAGATATTGCTAACACAATCGAGTGATA
ATACAGTTTTACTGCAAAAGAAGCACTTCAAACCTATTATGTCCTTAGAACTTCCAGAGTAGCCACTGCTCCCAGTTAAAGGTGGGTCAG
TAGCCTTGCAGAACTGTCCTGAGAAGTTATTGCTGGTGCTGGCCAGCCATGGCTTAGGACTCCAACAGCCACTCTGAGGGAGGGGAGAAG
GGAGCAGAGGCCACGCAGAATGAACCGATGGGGTATTCAGTTGCTGGCAGCTACATTGTGTGGCATTCTAGCATCTTCAGGTCTTTAGAT
CTTGGACAAGTTGGCAGGGTATTTTAAAAGCTATAACTACTGTAGTTTTCCAGTTTTCATTGCTGCTTTAGCAAACCACGCTGTCTTACA
GTGGTACTTTCTTCTGGCCACTGCACTGTAGATAATTCATTGGAAACAAGATTTACCCACTACATAAAAGGTTAAACTCCTTCAGTATGT
TGGAGTGGTTTCTTTTTTTTTTTCTTTCTTTCTTTTTTTTCTTCAGGTTTATATCTTCTCTAATACCTGCATGTGGCGTTTAAAAATCAA
GACCACGGTCAAACCCCTCTTCTAATCACATTAATTGTTTCCATTCTTTTTACCCTGAGTGAGCACTTTTCACTTTCCAGCTAGGTCTGT
TTTTCAGCTTGCAGACAAGATTGAGAAATCCTTGAAAATTTGGTTTTGGTTAAAATTTTTGGTTTATTTATTTGAAATCCACACTCCCTT
GGAAACTCTTAAGTGCATTTGTGCACTTCTGTTTGTTTGTCTCAAAGAAGGGACTGTAACAATCTGAGTAATTTCCATGTCCTCTTCCTT
ATTCCTCTAGTGGTTGAAGCTGTGTAGCATTTTAACATATATATATTCACAAATATATTCATATAAACAGTATACATTTTGAATCAGTCA
TTTGTTAAAGAAAAGTATATTCAATGAAGATGAAATTTAAATAAAAAAGGACAGAGTCTATCCTCCAGGGATTGAACATTTTCCAATTAT
CTGGTCTTTTCCTGTTGTGCAAAAATGACTCATTGCTCCGAATGTCAAAAACAAATGCGACAAACAATGGCACTTCATCATTTAAAGTAA
TGTTGCCAAGAGAAAAAATTTCCTGGGAGGGAGGTTTCCCACAAGCCAAATCTCCTAAGCCTCAAATGCTAGCACTTTTTGGCAGTTGGA
TAGGAAATGAGACATTCTTTGGCAGCCAAAATAAGAGAGGCCGATGGTGAAACTTTTTGAGACACCCTATGGCCTTCTTGTCAAAACCTT
CACTGGAGCTCAAGAAAAGCATTTCTGTTGTGTTATTTGCAGTGCAGATGATGTCTGTGTAACAACATAATGGTTATTCACCTTTTTTTG
ATTTTGATTTTTGCTGTGTTATCAAAAACTTGAATACTGTGAGAAGAAGTGAATTTTCAGTTGACGAATCAGCATCTTGTTCCCATGGTG
ATAACACTAATTGAATATATCTATGAGGGCATGTATTAGTTAATGGAAAAAAAAATACAACACTAACAATACATAGCTGCAATGTGTACA
ATGGCTGATTTAATTAAATAAAATGTACAAGTGTTAAATGTGGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTT
TTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCCCAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCG
TCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAGCTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGA
GCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACACTCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGG
CGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGGCCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCC
ATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTGATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCA
GAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAACAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTT
GGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGATGTTCCATACGTTTTGAAGAGCTGTGCAGAATTTATAGAGACTCACGGC
ATCGTGGATGGAATCTATCGGCTTTCAGGAGTCACCTCAAACATACAACGGCTAAGGCAAGAGTTTGGCTCAGATCAATGTCCAGATCTG
ACAAGGGAAGTGTACCTCCAGGACATCCACTGTGTGGGCTCGCTTTGCAAGCTCTACTTTAGGGAGCTGCCCAACCCCCTCCTGACTTAT
GAGCTCTATGAGAAATTCACGGAGGCAGTGTCGCATTGCCCTGAAGAAGGCCAACTGGCCCGAATCCAAAATGTTATCCAGGAGCTTCCT
CCATCCCACTATAGGACCTTGGAATACCTGATTCGACACCTGGCCCATATCGCCTCCTTCAGCAGCAAGACCAACATGCACGCCCGGAAC
CTGGCCCTGGTGTGGGCGCCAAACCTCCTCAGGTCTAAAGAAATTGAAGCCACTGGTTGCAATGGAGATGCAGCCTTCCTTGCAGTCCGG
GTCCAGCAGGTGGTGATTGAGTTCATATTGAATCATGTAGATCAAATCTTTAACAACGGTGCACCTGGGTCTCTGGAGAATGATGAAAAC
CGGCCCATCATGAAGAGCCTGACCTTGCCAGCCCTCTCCCTGCCCATGAAGCTGGTGAGCCTTGAGGAAGCTCAAGCCCGCAGCCTGGCC
ACTAACCATCCTGCTCGCAAGGAAAGGAGGGAGAACAGCCTGCCTGAGATTGTCCCTCCCATGGGCACCCTCTTCCACACTGTCCTTGAG
TTACCAGACAACAAGCGAAAGCTCTCCAGTAAATCAAAGAAGTGGAAATCAATATTTAACCTGGGACGTTCTGGATCAGACTCCAAATCA
AAACTGAGTAGAAATGGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGTGGAAAAGGCTACTATCCGACCAGCTAAAAGCATGGACTCA
CTATGTTCAGTGCCTGTAGAAGGAAAAGAAACCAAGGGAAATTTCAATCGAACAGTTACCACCGGTGGATTTTTCATTCCAGCAACAAAG
ATGCACTCCACCGGCACCGGCAGCTCATGTGACCTCACCAAGCAGGAGGGCGAATGGGGCCAGGAGGGGATGCCTCCCGGGGCTGAGGGT
GGCTTTGATGTGAGCAGTGATCGCAGCCATCTCCAGGGCGCTCAGGCCCGGCCCCCACCGGAACAGCTGAAGGTTTTCCGGCCTGTTGAG
GATCCGGAGAGCGAGCAAACAGCCCCAAAGATGTTGGGTATGTTCTACACTTCGAACGACAGCCCTAGCAAATCCGTCTTCACCAGCAGC
CTCTTCCAGATGGAGCCCTCGCCGCGTAACCAGCGCAAGGCGCTGAACATCTCCGAGCCCTTTGCGGTATCTGTGCCGCTCCGCGTGTCC
GCAGTCATCAGCACCAACAGCACGCCGTGCAGAACACCCCCGAAGGAGCTGCAGTCTCTTTCCAGCCTGGAAGAGTTTTCTTTTCATGGA
TCAGAGAGCGGAGGCTGGCCAGAAGAAGAGAAACCGCTGGGAGCTGAGACTTCTGCAGCTTCTGTACCTAAGAAGGCAGGTCTTGAGGAT
GCCAAGGCAGTACCTGAAGCACCGGGGACAGTGGAATGCAGCAAAGGCCTGTCCCAGGAGCCAGGCGCCCACCTGGAGGAGAAGAAAACC
CCAGAAAGCTCCTTGAGCTCTCAACATTTAAATGAATTAGAGAAGAGGCCAAATCCGGAGAAGGTGGTGGAGGAGGGACGAGAGGCTGGT
GAGATGGAGTCCAGCACCCTGCAGGAGAGCCCCAGGGCCAGAGCCGAAGCTGTGCTTCTCCATGAGATGGATGAAGATGATCTGGCCAAT
GCCCTGATCTGGCCTGAGATTCAACAGGAGCTGAAAATCATTGAATCTGAGGAGGAGCTCTCATCGTTGCCACCTCCTGCTCTGAAGACC
AGCCCAATTCAGCCTATTCTCGAGTCGAGTCTGGGGCCCTTTATTCCCTCAGAGCCTCCTGGGAGCTTGCCTTGTGGCTCCTTCCCTGCT
CCAGTCTCCACCCCTCTGGAGGTGTGGACTAGGGATCCAGCCAATCAGAGCACACAGGGGGCTTCCACAGCAGCCAGCAGAGAGAAGCCG
GAACCTGAGCAGGGCCTGCACCCAGACCTCGCCAGCCTGGCTCCTCTGGAAATAGTTCCTTTTGAGAAGGCATCTCCACAAGCAACAGTG
GAAGTAGGAGGCCCAGGCAATCTGTCTCCTCCACTCCCACCTGCTCCTCCCCCTCCAACTCCTCTGGAGGAGTCAACTCCAGTCCTGCTT
TCAAAGGGCGGCCCGGAAAGAGAAGACTCATCCAGGAAATTGAGGACAGATCTCTACATAGACCAGCTGAAGTCCCAAGACAGCCCTGAG
ATCTCTAGCCTCTGTCAGGGAGAGGAGGCAACCCCAAGACACAGTGACAAGCAAAATTCAAAGAATGCTGCTTCTGAGGGGAAAGGCTGT
GGTTTTCCAAGCCCAACCAGGGAGGTTGAGATCGTCTCACAAGAAGAGGAGGATGTAACCCATTCAGTACAGGAGCCTTCAGACTGTGAC
GAAGATGACACTGTGACAGACATTGCCCAGCATGGCCTGGAGATGGTGGAGCCCTGGGAGGAACCCCAGTGGGTGACGAGTCCCCTTCAC
TCTCCCACCCTGAAAGACGCGCACAAGGCCCAGGTACAGGGCCTTCAGGGTCACCAGTTGGAGAAGAGGCTTTCCCACAGGCCCAGCCTT
CGCCAGAGCCATTCTCTAGATAGCAAACCCACGGTTAAAAGCCAGTGGACTCTCGAGGTTCCCTCCTCCAGCAGCTGTGCTAATCTTGAA
ACAGAGAGGAATTCTGACCCTCTTCAGCCCCAGGCACCCAGGAGAGAGATTACTGGATGGGATGAGAAAGCCCTGAGGTCCTTCAGAGAG
TTCTCTGGCCTGAAAGGGGCAGAGGCTCCTCCCAACCAGAAGGGACCAAGTGGTGTGCAACCCAACCCAGCAGAAACCAGCCCCATCAGC
CTAGCAGAGGGAAAGGAGCTAGGGACACACCTGGGGCACAGCAGTCCACAGATTAGGCAAGGTGGTGTTCCTGGGCCAGAGAGCAGCAAG
GAGAGTTCACCCAGCGTGCAGGACAGCACTTCGCCTGGAGAGCACCCCGCAAAGTTACAGCTAAAGAGCACAGAGTGTGGGCCCCCAAAA
GGGAAAAACAGGCCTTCTTCCCTCAACTTGGACCCTGCCATTCCCATTGCTGACCTCTTCTGGTTTGAGAATGTGGCCTCATTTAGTTCA
CCTGGAATGCAGGTCTCTGAGCCAGGAGACCCAAAGGTCACATGGATGACCTCATCTTACTGTAAAGCAGACCCCTGGAGGGTTTACTCC
CAGGACCCCCAGGACCTGGACATTGTTGCTCATGCACTGACAGGCCGCCGTAACTCAGCTCCTGTGAGTGTGTCAGCTGTGAGAACCTCC
TTCATGGTCAAAATGTGCCAGGCCAGGGCGGTCCCAGTCATCCCTCCCAAGATTCAGTACACCCAGATCCCACAGCCCCTGCCCTCTCAG
AGCTCAGGGGAGAATGGGGTTCAGCCTCTGGAGAGGAGCCAGGAGGGACCCAGCTCAACCAGTGGGACCACTCAGAAACCTGCCAAAGAT
GATTCTCCCTCCTCCCTGGAAAGCTCAAAGGAAGAAAAACCAAAGCAAGATCCCGGAGCCATTAAGTCCTCACCAGTGGATGCCACTGCA
CCCTGCATGTGCGAGGGACCTACCCTTTCTCCAGAACCAGGCTCGTCTAACCTGCTCTCCACCCAGGATGCAGTAGTGCAATGCAGAAAG
CGCATGTCAGAGACAGAGCCATCTGGGGACAACCTTCTTTCTTCAAAACTAGAGCGACCATCTGGGGGTTCTAAGCCTTTCCACAGGTCA
AGGCCAGGAAGACCTCAGAGCCTAATCTTATTCAGTCCTCCTTTCCCCATTATGGACCACCTGCCCCCTTCATCCACAGTGACAGATTCC
AAGGTCCTGCTGTCCCCTATCAGAAGTCCCACCCAGACAGTTTCCCCTGGCCTTCTTTGTGGAGAGTTGGCAGAAAACACATGGGTCACA
CCAGAAGGGGTTACACTTAGGAATAAAATGACCATCCCTAAGAATGGCCAGAGACTAGAGACCTCAACCAGCTGTTTTTACCAGCCTCAG
CGGAGATCAGTAATTCTGGATGGAAGAAGTGGGAGGCAAATAGAATGATTTCGGTTCACCTGCTGGTGTCTGAAAAAAACCGTGATTCAT
CTGGAAGTTATTACAGGGCCAGCTTGCCATATTCCAGGCACACGTTATCAAGTTTGGGCCTATTGTGGCCTCTGACTTCTCTTTCTTCAG
CCTTTTGACCACTTATTAATTAGTCCATTTGCTAGAAGAGTGGTCAAGGGAAAAACGAGAGATGAAATTTAGTTAAGTCTATGTGAGCAA
GTGAGAGAAGGTTAGGTAAGGGGAGAGGATGGAATGCTTGCCTCCAATGAACTTTGGAGCTTGTATGTGAGTCAGATTGCTCCCCTATTG
CTATTATCTATTACTCTTGAGAGCTGGCTGTCCTTTGAAAGAAAGAAGTAATGTTCTTTGAAAGAAAGAAAAATCTCTTGCTGTGTCAAA
CCTCAAAATGTTGCTATTGGGGTTAGAAGGCCTCCTCTTTATGCTTTTTAATGCTCTTTCAAACGTGTTCTTTTAGACCAGTTTTCTAAT
AAGCTTTGTAAAATGTACTATCCAAATTAGAAGCGGATTTGGAAATGCAAACTAACGTGCACTTAGATATCCAAGTGGGTGAGCTTAGCC
ACTCTTACCCATGCTCTTTCCCTGGAATCCCTGGAGACCTGTCCAAGATGATTTCCATATACCAGCATAGAAAATCAGAATCAAGAGCAA
ACTCTGAGACTGGCACAATCCAAGAAGATTTCCTGGCTCTGGCTTTTAGTAATTTGGGACTCCAACTGCCACTGTACTGGACTGTAATTT
ATAAATCCAGTAGCTACGCAGGGTGGAGGCTGGGCTGAGGATTACCATAATGAAATGTACTAAATCTTCATTTAGGTATGCAATTGTGAA
GTGAAGGCATCTGCTTTCTTTACAGTATCAGAGTCCAAGAACAGGATGTCACCATAGATAAAAGCCTCATACAAAGGCAGAACTACACTC
CAAATTTAATGTGTTTAAATTGGTGGGGCACCAGCAGAAAATATTCTAGCTCAGCTTTACTCTTCTTCCACACTAGGCTGGGCCCAGCAA
TACAGGAGAGGATGAAGGGAGGAGCTCCAGGAGGCGAGGGAAGAGCCCTAGCAGGGCGGCCATCACAACCACTCACTGAGAGTTGCCCTT
CTTAAAAATGTATTTTATTTTAGCCAGTGGGTCCCTTCCTTTCTCCTTTCCTCTCTACTGCTCAAGAACAGATTTGAGGCCAGGTGCGGT
GCCTCACATCTGTAATCCCAACACTTTGGGAGGCTGAGATGGGTGGATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGC
GAGACCCCATCTCTTAAAAAATAACAGACTTGAGGAACCCCTCTCCCTTCCATAATTCCCCTCATCCACCGCCCACTCCAGGCACTCACT
CAAACTTGCTCTTCAACTCTGTATACAAGCAGAAGCAATAAACCAATCTGATTTTCTTTTCAATTATTTATAACTTTCAATGGTTCTTTC
CTTTCCAGCTGGCGAGAGAAAGGAGAACTAATATACCTGCTGGCAGATTTTTGGTGCTGCCCAAAAAAGGACTTCACAGGGCATCTCTTC
TCAGGTTCAAGCCTGGCTGAATTCTGCCCAGAAGCTCAGTCATTGCAGAAATTTCTCTAAGGGCTGATAGTACCTCTGGGTAGGCGTCAC
AACCAAGGCTGGTTCTGGGCTTAGTGGGGGCTGAGATGAAGTTACCTCCTCCAATGAGAAATTGGGAGCTGATGCCCTGCAACAGATATA
TATTCCTCTCTCTCTCTGTCTCTCTATCTCTCTCCTCCCTCTCCCTCCCTCCCTCCCCGCCAATAAGCCTTACAAACAGTTTTGAAATCT
TGTTCTGTACCTTTTAAGCCAGTGTCTGTGGCGAGGGTGACTGGCAAGTCAGCTGATGAGTTCTGCCTTCTGAGAGCACTGAGTGAGCAA
GGCCTTTCATCAGTGTTTTGGCCTTCTCATTGGGTGAGGAAGACATTGAACCAACAGCCAACGAGATATGAACCTGTAAGAAAAAAGTCC
TAGAATATAGTATTTTTCCCCAGGCCAGCAAAGTGAAGAAATACAGTGGTGACAGATGAGAAAGGCCATGTTCAAGAGATCTGAAAAGTA
CATTCCTGCCTTATCAGAAAATGTGTCAGACAGGTTTTATGTCAGCCTCAGTGCTCCTGCGGTGTCGACGCTCTGATAAGGACCATGTTC
CAGTTAGAATGCGAGGGAGGGAAAGAGCTGCACTTTGCTTCACCATCAGAACTCTGAGCCAAATAATGAATATGTAAACTATTTTATGAT
TATTTTAAATGTTTGTTTGGTAACATTTATAAGATCTATTTTTATTTGGGGATAGACTGAGAAGCCACCATTTACATATTAACAAGTGAC
TTCAGTTCTAAGGGTTGAGATGCCTGTGTGGATTTATAAAATGGTTGCAAGATCTTTTAGACTCTGACATTTATAGCATCACCTTCAGGA
ACACAGTTCTGGGGATGTCATCATGAGACACACTGACAGCTGTGGAGATAGTCCCTACTCTCAGCTTTCCTTGCTAGTCAAGTCCAAAAG
GCCTTAGAAGCTGACTCACCTTCTCAGCCAGAGTCCTGCTGCTCAAGTGTGGACCTCCACTTTGACTCTCACCCAGCCTGCCAGCCATCA
CAAAGGCTTTCATAAACTTCCTGTGGTCTGGGCTAGCCTGGCACTGATGAAATTCCATTCTAAAGAAAGAAAACTCATATTCCTCCCCCC
CACAAATTGTTCCCCCAAATGCTCTGGGATTACCTATTTCACCACTCATTTGAGTCTCCGAAAAATGAACTCCCTGAGAATGGCTGGATG
GGAATCAGATAGTCTGCTTCCATTCAGGAGAGGGACAGAACAGGAGCTGCTGTGTTTAGGAGGATTTACCTGGTGCCCTAGAAAGGGCTA
TGCAATCAAATTCTCAAGGGCTCCTTCAAATCAGCTATCAGTCCTCAAAATGGGGGTTGCTGATGTTAAATGATGGATTTGCAGTGAAAC
GCATGCATGTACTGACGTTTTCTTTCAGCATTAGTGGTTGCTTAAGAAAATAGTAACCTATATTTTCTGCTACACTTGGAATATGAAGAA
ATCTGAACAAGAACCCCATTAAGACACCTAACCTAATCTAAACCCTAAAATTCAAAATATTGTCCAAGTCAAAAGTCTAGACTCTGAGGA
CATTAAAAATGTAAATATCATCATCCTTAGCAAATATTTATTGGGAGCTTAGTAATAGTGCACTGGGTACCTTAGCACTCCCAAATCATT
CAAGAGTCTAGTGAAAAAGGGGGAGGGATGGCAGCAAATAAAACACCCCCATAAACAACCAGGAGCAAGGTTGAGAACCATTAAGTTGCC
AAACAAAAGCAGAAGGGGAAAAAGTGTGGCAACAAGCATCTTTTAATAGGATAGTTGACGGTATTCAAGTGACCTACTGACTCCAAATAA
TCAAATTGAACACAATTGCAAATCCAATAGAACATCCCAGTGAGACACTCGGGTATTTGAGAACTTTGCTTGATTTAGAAAACTGGAAAG
TGGCAACTAGGCTAGAATAGTGGCAACTAGGTTCGGAGGTTTCGTGTGGTCATAATTGGTTTGGTGAAGTGTGAGATCTCTGCAAATGAG
CCAGGTAAGATCAGTATTCCATAGTGCTTGAAAAGGGGATTTTAGAGACTTCTGTCATCACAAAGCAGATTAACTCCTAGTTAATGATGA
AGCAGTAGGCCCAAGATAAACTGTTCAATTCAAGATAAATTGTTCTTGTCAGTGTTTGGCATATGATAATCACATTTGGCTAAAATTGGA
TGGGACAGTCATTTGTCTACACAGGCCTTCCATTCCTGCATGAAGAGATACTGGGGAGCATACAATTATTTTGTCCAGTATTAGAGTGGG
AGAAGTTCTCAGTAAGTCCAGTCCCACCAGGATTTATTTGGGCCACATTCTACCACGGCCAGTCCAATCTGATGACCACATGAATTGGGG
TTAAGTGTTGCTAAGACTATGATTTTAGACATGTCTGGCAGGAAGGTCAGCTCAAAATGTGGCATGACAAAGAATATGTGCTCTACTACC
AAAACCTTTCCTAGCAAAACAAGGCCAGAAGAGGGAGCAAGCATCTTTCCAAGCATGGAGAGGAGGGGGCAATGGTGGAAGGGTGATTGC
CTGAAATCAGTGCCAGTACAGATAGCATAAAATTGGGGGCCACCACAGATTGGCTGGCTACTGTGTAGATCATTTAGTAATCTTGAGGTA
CATTAATAATGCAGAGATTACTTTTCTGTGAGGGTAAGGGGGACGTAGCTAAATATAAGAAGCTTACAAGGTCCATAGCCATGTATTTTA


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FusionGenePPI for ANK2_ARHGAP31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANK2SIGMAR1, EPB42, NDEL1, TNIK, KIAA0368, TAF9, TP53, UBAC2, ABCE1, POPDC2, HAX1, NUFIP1, DGUOK, DNAAF2, PALM2, NTRK1, CEP120, RAPGEF5, CHL1, MAPK8IP1, HIF1ANARHGAP31RAC1, ITSN1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneANK2chr4:114304891chr3:119013220ENST00000357077+4646966_112547143958SPTBN1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722+4747966_112526181864SPTBN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANK2chr4:114304891chr3:119013220ENST00000394537+145966_1125-181873SPTBN1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275+114966_1125-2556SPTBN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANK2_ARHGAP31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANK2_ARHGAP31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK2C1970119CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED1CTD_human;UNIPROT