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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 1672

FusionGeneSummary for ANK2_ARHGAP10

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK2_ARHGAP10
Fusion gene ID: 1672
HgeneTgene
Gene symbol

ANK2

ARHGAP10

Gene ID

287

79658

Gene nameankyrin 2Rho GTPase activating protein 10
SynonymsANK-2|LQT4|brank-2GRAF2|PS-GAP|PSGAP
Cytomap

4q25-q26

4q31.23

Type of geneprotein-codingprotein-coding
Descriptionankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrinrho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10
Modification date2018052320180523
UniProtAcc

Q01484

A1A4S6

Ensembl transtripts involved in fusion geneENST00000506722, ENST00000394537, 
ENST00000357077, ENST00000264366, 
ENST00000509550, ENST00000510275, 
ENST00000504887, 
ENST00000336498, 
ENST00000414545, ENST00000510076, 
Fusion gene scores* DoF score8 X 9 X 4=2886 X 6 X 3=108
# samples 116
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANK2 [Title/Abstract] AND ARHGAP10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-27-1830-01AANK2chr4

113970968

+ARHGAP10chr4

148944414

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000506722ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000506722ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-intronENST00000506722ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000394537ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000394537ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
5CDS-intronENST00000394537ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000357077ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000357077ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
5CDS-intronENST00000357077ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000264366ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
In-frameENST00000264366ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
5CDS-intronENST00000264366ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000509550ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000509550ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-intronENST00000509550ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000510275ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000510275ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-intronENST00000510275ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000504887ENST00000336498ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-3CDSENST00000504887ENST00000414545ANK2chr4

113970968

+ARHGAP10chr4

148944414

+
intron-intronENST00000504887ENST00000510076ANK2chr4

113970968

+ARHGAP10chr4

148944414

+

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FusionProtFeatures for ANK2_ARHGAP10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK2

Q01484

ARHGAP10

A1A4S6

In skeletal muscle, required for proper localization ofDMD and DCTN4 and for the formation and/or stability of a specialsubset of microtubules associated with costameres andneuromuscular junctions. Attaches integral membrane proteins tocytoskeletal elements. Also binds to cytoskeletal proteins.Required for coordinate assembly of Na/Ca exchanger, Na/K ATPaseand InsP3 receptor at sarcoplasmic reticulum sites incardiomyocytes. Required for the coordinated expression of theNa/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in theinner segment of rod photoreceptors (By similarity). Required forexpression and targeting of SPTBN1 in neonatal cardiomyocytes andfor the regulation of neonatal cardiomyocyte contraction rate(PubMed:12571597). Plays a role in endocytosis and intracellularprotein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promotelong-range motility of cells. Recruits RABGAP1L to (PI3P)-positiveearly endosomes, where RABGAP1L inactivates RAB22A, and promotespolarized trafficking to the leading edge of the migrating cells.Part of the ANK2/RABGAP1L complex which is required for thepolarized recycling of fibronectin receptor ITGA5 ITGB1 to theplasma membrane that enables continuous directional cell migration(By similarity). {ECO:0000250|UniProtKB:Q8C8R3,ECO:0000269|PubMed:12571597}. GTPase activator for the small GTPases RhoA and Cdc42 byconverting them to an inactive GDP-bound state. Essential forPTKB2 regulation of cytoskeletal organization via Rho familyGTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinaseactivity and changes its localization from the nucleus to theperinuclear region. Stabilizes PAK-2p34 thereby increasingstimulation of cell death (By similarity). {ECO:0000250,ECO:0000269|PubMed:11432776}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANK2_ARHGAP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_243aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKP

>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_192aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKR

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_243aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKP

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_192aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKR

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_243aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKP

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_192aa
MMNEDAAQKSDSGEKFNGSSQRRKRPKKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTP
TSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_729nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCCCAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACC
ACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCACCCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCA
CCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATT
TTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAG

>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_576nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCG
GAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGG

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_729nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCCCAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACC
ACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCACCCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCA
CCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATT
TTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAG

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_576nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCG
GAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGG

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_729nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCCCAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACC
ACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCACCCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCA
CCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATT
TTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAG

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_576nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCG
GAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_1481nt
GTACAGGCGGCACGGTTTGATGGCAGAGATATTTTCTTTCCAAACTGTTCAAAATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTG
GAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTTCGGACGCCGCCCGATACTACATTCCCTGAGCCCACCT
GCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGCCAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTT
GTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCTACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCG
TGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCAGATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCC
CAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACCACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCAC
CCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCACCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGT
ATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGC
TAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAGCTGCTGTAGCTCCTGGCCTCAGAGCCCCTGCTGACCC
TGGCACCCAGGGACCTGCCTGGGGGCAGAGAGCTGTCTTCCTCCTCCGAGGCTCTGGGCTGCACCCACAGGTACCTCCACACTTGGGAGT
TACCATCATCACAGTCAGCCCTGGGGGTGGGGGGTGGTGGGCAGGGATGGGACGCACCACACAGAACTGTGATTGTGGATCAGGAGGGGA
ATGTCAGGATTCGCAAAATGGACTTTTCATTTGTCAAGTATTGGGACTTGTGATTTTTAATTATCCAGCATATAGAATGAGAGGGAGGGC
AGCCTTCTGCCACCTGTGTCGCCTCCACTGGCAGTCACGCCACCAGAGCCACCCTGGCTCCCTCTCCTCCCTGAGCACCTGCTGCTGCGA
TTTTAAAGGGAACTGTACTACTCGCAGTGATAGGTTTGCAGAGTGTGTGCTTGGCTGTGGCAGCCTAGCTTGGAGAAGCTGCTGTTGGTG
CAAGGGAGATGGTCTCAAGTCAGAGGGAAGCAGAGACGCGCGTCTCAAGCCTGCCCTTCCTAGACGGCCACCTGCAGGACCCCACACTCA
CTGCACTGGCAGCGTGCACTGGCGTATTTGTAACAGGCTTCTCGGTGCTCCTCACCCGTGTGCTGTTTTCCAAACACCACCTTTTTGCCT

>In-frame_ANK2_ENST00000394537_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_1323nt
GTACAGGCGGCACGGTTTGATGGCAGAGATATTTTCTTTCCAAACTGTTCAAAATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTG
GAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTTCGGACGCCGCCCGATACTACATTCCCTGAGCCCACCT
GCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGCCAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTT
GTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCTACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCG
TGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCAGATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCA
TCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATG
TACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAGCTGCTGTAGC
TCCTGGCCTCAGAGCCCCTGCTGACCCTGGCACCCAGGGACCTGCCTGGGGGCAGAGAGCTGTCTTCCTCCTCCGAGGCTCTGGGCTGCA
CCCACAGGTACCTCCACACTTGGGAGTTACCATCATCACAGTCAGCCCTGGGGGTGGGGGGTGGTGGGCAGGGATGGGACGCACCACACA
GAACTGTGATTGTGGATCAGGAGGGGAATGTCAGGATTCGCAAAATGGACTTTTCATTTGTCAAGTATTGGGACTTGTGATTTTTAATTA
TCCAGCATATAGAATGAGAGGGAGGGCAGCCTTCTGCCACCTGTGTCGCCTCCACTGGCAGTCACGCCACCAGAGCCACCCTGGCTCCCT
CTCCTCCCTGAGCACCTGCTGCTGCGATTTTAAAGGGAACTGTACTACTCGCAGTGATAGGTTTGCAGAGTGTGTGCTTGGCTGTGGCAG
CCTAGCTTGGAGAAGCTGCTGTTGGTGCAAGGGAGATGGTCTCAAGTCAGAGGGAAGCAGAGACGCGCGTCTCAAGCCTGCCCTTCCTAG
ACGGCCACCTGCAGGACCCCACACTCACTGCACTGGCAGCGTGCACTGGCGTATTTGTAACAGGCTTCTCGGTGCTCCTCACCCGTGTGC

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_1481nt
GTACAGGCGGCACGGTTTGATGGCAGAGATATTTTCTTTCCAAACTGTTCAAAATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTG
GAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTTCGGACGCCGCCCGATACTACATTCCCTGAGCCCACCT
GCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGCCAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTT
GTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCTACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCG
TGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCAGATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCC
CAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACCACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCAC
CCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCACCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGT
ATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGC
TAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAGCTGCTGTAGCTCCTGGCCTCAGAGCCCCTGCTGACCC
TGGCACCCAGGGACCTGCCTGGGGGCAGAGAGCTGTCTTCCTCCTCCGAGGCTCTGGGCTGCACCCACAGGTACCTCCACACTTGGGAGT
TACCATCATCACAGTCAGCCCTGGGGGTGGGGGGTGGTGGGCAGGGATGGGACGCACCACACAGAACTGTGATTGTGGATCAGGAGGGGA
ATGTCAGGATTCGCAAAATGGACTTTTCATTTGTCAAGTATTGGGACTTGTGATTTTTAATTATCCAGCATATAGAATGAGAGGGAGGGC
AGCCTTCTGCCACCTGTGTCGCCTCCACTGGCAGTCACGCCACCAGAGCCACCCTGGCTCCCTCTCCTCCCTGAGCACCTGCTGCTGCGA
TTTTAAAGGGAACTGTACTACTCGCAGTGATAGGTTTGCAGAGTGTGTGCTTGGCTGTGGCAGCCTAGCTTGGAGAAGCTGCTGTTGGTG
CAAGGGAGATGGTCTCAAGTCAGAGGGAAGCAGAGACGCGCGTCTCAAGCCTGCCCTTCCTAGACGGCCACCTGCAGGACCCCACACTCA
CTGCACTGGCAGCGTGCACTGGCGTATTTGTAACAGGCTTCTCGGTGCTCCTCACCCGTGTGCTGTTTTCCAAACACCACCTTTTTGCCT

>In-frame_ANK2_ENST00000357077_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_1323nt
GTACAGGCGGCACGGTTTGATGGCAGAGATATTTTCTTTCCAAACTGTTCAAAATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTG
GAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTTCGGACGCCGCCCGATACTACATTCCCTGAGCCCACCT
GCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGCCAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTT
GTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCTACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCG
TGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCAGATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCA
TCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATG
TACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAGCTGCTGTAGC
TCCTGGCCTCAGAGCCCCTGCTGACCCTGGCACCCAGGGACCTGCCTGGGGGCAGAGAGCTGTCTTCCTCCTCCGAGGCTCTGGGCTGCA
CCCACAGGTACCTCCACACTTGGGAGTTACCATCATCACAGTCAGCCCTGGGGGTGGGGGGTGGTGGGCAGGGATGGGACGCACCACACA
GAACTGTGATTGTGGATCAGGAGGGGAATGTCAGGATTCGCAAAATGGACTTTTCATTTGTCAAGTATTGGGACTTGTGATTTTTAATTA
TCCAGCATATAGAATGAGAGGGAGGGCAGCCTTCTGCCACCTGTGTCGCCTCCACTGGCAGTCACGCCACCAGAGCCACCCTGGCTCCCT
CTCCTCCCTGAGCACCTGCTGCTGCGATTTTAAAGGGAACTGTACTACTCGCAGTGATAGGTTTGCAGAGTGTGTGCTTGGCTGTGGCAG
CCTAGCTTGGAGAAGCTGCTGTTGGTGCAAGGGAGATGGTCTCAAGTCAGAGGGAAGCAGAGACGCGCGTCTCAAGCCTGCCCTTCCTAG
ACGGCCACCTGCAGGACCCCACACTCACTGCACTGGCAGCGTGCACTGGCGTATTTGTAACAGGCTTCTCGGTGCTCCTCACCCGTGTGC

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000336498_chr4_148944414_+_1428nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCCCAGGCCAGACCCGATCGTCTATGGTCCAGTGGCTTAACCCACAGTCTCCAACC
ACAACAAGCTCCAACTCAGCTGTGACACCTCTTTCACCCGGGTCGTCCCCTTTCCCCTTTTCTCCTCCTGCTACTGTAGCGGACAAGCCA
CCTGAAAGCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCGGAATTATCTTTTGAAATAGGAGCAATT
TTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGGGGGCTGATTCCACAGAACTACGTCAAG
CTGCTGTAGCTCCTGGCCTCAGAGCCCCTGCTGACCCTGGCACCCAGGGACCTGCCTGGGGGCAGAGAGCTGTCTTCCTCCTCCGAGGCT
CTGGGCTGCACCCACAGGTACCTCCACACTTGGGAGTTACCATCATCACAGTCAGCCCTGGGGGTGGGGGGTGGTGGGCAGGGATGGGAC
GCACCACACAGAACTGTGATTGTGGATCAGGAGGGGAATGTCAGGATTCGCAAAATGGACTTTTCATTTGTCAAGTATTGGGACTTGTGA
TTTTTAATTATCCAGCATATAGAATGAGAGGGAGGGCAGCCTTCTGCCACCTGTGTCGCCTCCACTGGCAGTCACGCCACCAGAGCCACC
CTGGCTCCCTCTCCTCCCTGAGCACCTGCTGCTGCGATTTTAAAGGGAACTGTACTACTCGCAGTGATAGGTTTGCAGAGTGTGTGCTTG
GCTGTGGCAGCCTAGCTTGGAGAAGCTGCTGTTGGTGCAAGGGAGATGGTCTCAAGTCAGAGGGAAGCAGAGACGCGCGTCTCAAGCCTG
CCCTTCCTAGACGGCCACCTGCAGGACCCCACACTCACTGCACTGGCAGCGTGCACTGGCGTATTTGTAACAGGCTTCTCGGTGCTCCTC

>In-frame_ANK2_ENST00000264366_chr4_113970968_+_ARHGAP10_ENST00000414545_chr4_148944414_+_1270nt
ATGATGAACGAAGATGCAGCTCAGAAAAGCGACAGTGGAGAGAAGTTCAACGGCAGTAGTCAGAGGAGAAAAAGACCCAAGAAGATTTTT
CGGACGCCGCCCGATACTACATTCCCTGAGCCCACCTGCCTGTCAGCATCACCCCCAAATGCGCCACCAAGGCAGTCGAAGAGACAAGGC
CAGAGAACCAAGAGGCCCGTGGCCGTCTACAATCTTTGTCTGGAGCTGGAAGATGGTGACAATCCTTACCCTTCCAAGGAGGACACCCCT
ACCAGCAGTCTGGACTCACTTTCCTCCCCGTCTCCCGTGACTACAGCTGTCCCTGGGCCTCCTGGACCAGACAAAAACCACCTTCTGGCA
GATGGAGGGAGCTTTGGAGACTGGGCATCCACTATCATCCGCAGTCGGAAGGCTCGAGCCGTGTATCCGTGTGAAGCAGAACACAGCTCG
GAATTATCTTTTGAAATAGGAGCAATTTTTGAGGATGTACAAACCTCCAGGGAACCTGGCTGGCTAGAAGGGACTCTGAACGGCAAGAGG
GGGCTGATTCCACAGAACTACGTCAAGCTGCTGTAGCTCCTGGCCTCAGAGCCCCTGCTGACCCTGGCACCCAGGGACCTGCCTGGGGGC
AGAGAGCTGTCTTCCTCCTCCGAGGCTCTGGGCTGCACCCACAGGTACCTCCACACTTGGGAGTTACCATCATCACAGTCAGCCCTGGGG
GTGGGGGGTGGTGGGCAGGGATGGGACGCACCACACAGAACTGTGATTGTGGATCAGGAGGGGAATGTCAGGATTCGCAAAATGGACTTT
TCATTTGTCAAGTATTGGGACTTGTGATTTTTAATTATCCAGCATATAGAATGAGAGGGAGGGCAGCCTTCTGCCACCTGTGTCGCCTCC
ACTGGCAGTCACGCCACCAGAGCCACCCTGGCTCCCTCTCCTCCCTGAGCACCTGCTGCTGCGATTTTAAAGGGAACTGTACTACTCGCA
GTGATAGGTTTGCAGAGTGTGTGCTTGGCTGTGGCAGCCTAGCTTGGAGAAGCTGCTGTTGGTGCAAGGGAGATGGTCTCAAGTCAGAGG
GAAGCAGAGACGCGCGTCTCAAGCCTGCCCTTCCTAGACGGCCACCTGCAGGACCCCACACTCACTGCACTGGCAGCGTGCACTGGCGTA
TTTGTAACAGGCTTCTCGGTGCTCCTCACCCGTGTGCTGTTTTCCAAACACCACCTTTTTGCCTCAAGGTCTCTGTAAATGAAATAAACT


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FusionGenePPI for ANK2_ARHGAP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANK2SIGMAR1, EPB42, NDEL1, TNIK, KIAA0368, TAF9, TP53, UBAC2, ABCE1, POPDC2, HAX1, NUFIP1, DGUOK, DNAAF2, PALM2, NTRK1, CEP120, RAPGEF5, CHL1, MAPK8IP1, HIF1ANARHGAP10PKN3, RHOA, CDC42, YWHAQ, C2CD2, SH3BP2, ANKS1A, FOXQ1, PTPN12, ARHGAP26, NRXN1, ARF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANK2_ARHGAP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANK2_ARHGAP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK2C1970119CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED1CTD_human;UNIPROT