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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16691

FusionGeneSummary for HOXA10_CSN1S1

check button Fusion gene summary
Fusion gene informationFusion gene name: HOXA10_CSN1S1
Fusion gene ID: 16691
HgeneTgene
Gene symbol

HOXA10

CSN1S1

Gene ID

3206

1446

Gene namehomeobox A10casein alpha s1
SynonymsHOX1|HOX1.8|HOX1H|PLCASA|CSN1
Cytomap

7p15.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Hox-A10homeo box A10homeobox protein 1Hhomeobox protein HOXA10homeobox protein Hox-1.8homeobox protein Hox-1Halpha-S1-caseincasein, alpha
Modification date2018051920180523
UniProtAcc

P31260

P47710

Ensembl transtripts involved in fusion geneENST00000283921, ENST00000396344, 
ENST00000521421, 
ENST00000444405, 
ENST00000246891, ENST00000507763, 
ENST00000507772, ENST00000505782, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: HOXA10 [Title/Abstract] AND CSN1S1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOXA10

GO:0045944

positive regulation of transcription by RNA polymerase II

21471217


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-2H-A9GG-01AHOXA10chr7

27212968

-CSN1S1chr4

70798262

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283921ENST00000444405HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
5CDS-5UTRENST00000283921ENST00000246891HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
5CDS-5UTRENST00000283921ENST00000507763HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
5CDS-intronENST00000283921ENST00000507772HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
5CDS-intronENST00000283921ENST00000505782HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000396344ENST00000444405HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000396344ENST00000246891HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000396344ENST00000507763HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-intronENST00000396344ENST00000507772HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-intronENST00000396344ENST00000505782HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000521421ENST00000444405HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000521421ENST00000246891HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-5UTRENST00000521421ENST00000507763HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-intronENST00000521421ENST00000507772HOXA10chr7

27212968

-CSN1S1chr4

70798262

+
intron-intronENST00000521421ENST00000505782HOXA10chr7

27212968

-CSN1S1chr4

70798262

+

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FusionProtFeatures for HOXA10_CSN1S1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOXA10

P31260

CSN1S1

P47710

Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis.Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Important role in the capacity of milk to transportcalcium phosphate. Casoxin D acts as opioid antagonist and has vasorelaxingactivity mediated by bradykinin B1 receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HOXA10_CSN1S1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HOXA10_CSN1S1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HOXA10PTPN6, POLR3D, EMX1, SNAPC1, PBX1, CREBBP, COPS5, SPI1, KAT2B, MAPK14, NFATC1, RBPJ, TEAD2, FOXB1, FOXE1, ARIH1, TRIM25CSN1S1TOLLIP, COPS5, CSNK2A1, CSNK2B, CUL1, CUL4A, COPS7A, PLK1, PARK7, PRSS2, PDE10A, B4GALNT4, LTBP1, EMILIN3, KLHL15, HSPA5, TIMP3, ERF, BCOR, CDKN2AIP, FAM120A, ETV3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HOXA10_CSN1S1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHOXA10P31260DB00136CalcitriolHomeobox protein Hox-A10small moleculeapproved|nutraceutical

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RelatedDiseases for HOXA10_CSN1S1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOXA10C0001418Adenocarcinoma1CTD_human
HgeneHOXA10C0014170Endometrial Neoplasms1CTD_human
HgeneHOXA10C1720887Female Urogenital Diseases1CTD_human