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Fusion gene ID: 16691 |
FusionGeneSummary for HOXA10_CSN1S1 |
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Fusion gene information | Fusion gene name: HOXA10_CSN1S1 | Fusion gene ID: 16691 | Hgene | Tgene | Gene symbol | HOXA10 | CSN1S1 | Gene ID | 3206 | 1446 |
Gene name | homeobox A10 | casein alpha s1 | |
Synonyms | HOX1|HOX1.8|HOX1H|PL | CASA|CSN1 | |
Cytomap | 7p15.2 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | homeobox protein Hox-A10homeo box A10homeobox protein 1Hhomeobox protein HOXA10homeobox protein Hox-1.8homeobox protein Hox-1H | alpha-S1-caseincasein, alpha | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P31260 | P47710 | |
Ensembl transtripts involved in fusion gene | ENST00000283921, ENST00000396344, ENST00000521421, | ENST00000444405, ENST00000246891, ENST00000507763, ENST00000507772, ENST00000505782, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: HOXA10 [Title/Abstract] AND CSN1S1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HOXA10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21471217 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-2H-A9GG-01A | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000283921 | ENST00000444405 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
5CDS-5UTR | ENST00000283921 | ENST00000246891 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
5CDS-5UTR | ENST00000283921 | ENST00000507763 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
5CDS-intron | ENST00000283921 | ENST00000507772 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
5CDS-intron | ENST00000283921 | ENST00000505782 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000396344 | ENST00000444405 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000396344 | ENST00000246891 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000396344 | ENST00000507763 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-intron | ENST00000396344 | ENST00000507772 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-intron | ENST00000396344 | ENST00000505782 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000521421 | ENST00000444405 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000521421 | ENST00000246891 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-5UTR | ENST00000521421 | ENST00000507763 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-intron | ENST00000521421 | ENST00000507772 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
intron-intron | ENST00000521421 | ENST00000505782 | HOXA10 | chr7 | 27212968 | - | CSN1S1 | chr4 | 70798262 | + |
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FusionProtFeatures for HOXA10_CSN1S1 |
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Hgene | Tgene |
HOXA10 | CSN1S1 |
Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis.Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. | Important role in the capacity of milk to transportcalcium phosphate. Casoxin D acts as opioid antagonist and has vasorelaxingactivity mediated by bradykinin B1 receptors. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HOXA10_CSN1S1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HOXA10_CSN1S1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HOXA10 | PTPN6, POLR3D, EMX1, SNAPC1, PBX1, CREBBP, COPS5, SPI1, KAT2B, MAPK14, NFATC1, RBPJ, TEAD2, FOXB1, FOXE1, ARIH1, TRIM25 | CSN1S1 | TOLLIP, COPS5, CSNK2A1, CSNK2B, CUL1, CUL4A, COPS7A, PLK1, PARK7, PRSS2, PDE10A, B4GALNT4, LTBP1, EMILIN3, KLHL15, HSPA5, TIMP3, ERF, BCOR, CDKN2AIP, FAM120A, ETV3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HOXA10_CSN1S1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HOXA10 | P31260 | DB00136 | Calcitriol | Homeobox protein Hox-A10 | small molecule | approved|nutraceutical |
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RelatedDiseases for HOXA10_CSN1S1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HOXA10 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | HOXA10 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | HOXA10 | C1720887 | Female Urogenital Diseases | 1 | CTD_human |