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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16686

FusionGeneSummary for HOPX_IGFBP7

check button Fusion gene summary
Fusion gene informationFusion gene name: HOPX_IGFBP7
Fusion gene ID: 16686
HgeneTgene
Gene symbol

HOPX

IGFBP7

Gene ID

84525

3490

Gene nameHOP homeoboxinsulin like growth factor binding protein 7
SynonymsCAMEO|HOD|HOP|LAGY|NECC1|OB1|SMAP31|TOTOAGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionhomeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor
Modification date2018052320180522
UniProtAcc

Q9BPY8

Q16270

Ensembl transtripts involved in fusion geneENST00000554144, ENST00000420433, 
ENST00000556376, ENST00000381260, 
ENST00000337881, ENST00000605395, 
ENST00000508121, ENST00000503639, 
ENST00000553379, ENST00000381255, 
ENST00000317745, ENST00000555760, 
ENST00000556614, 
ENST00000295666, 
ENST00000537922, ENST00000512512, 
Fusion gene scores* DoF score2 X 1 X 1=24 X 4 X 3=48
# samples 25
** MAII scorelog2(2/2*10)=3.32192809488736log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HOPX [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOPX

GO:0001829

trophectodermal cell differentiation

17576768

HgeneHOPX

GO:0045596

negative regulation of cell differentiation

17576768

HgeneHOPX

GO:0051131

chaperone-mediated protein complex assembly

10811660

TgeneIGFBP7

GO:0007155

cell adhesion

8117260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-28-5216-01AHOPXchr4

57547421

-IGFBP7chr4

57907099

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000554144ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000554144ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-5UTRENST00000554144ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000420433ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000420433ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-5UTRENST00000420433ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000556376ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000556376ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-5UTRENST00000556376ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000381260ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000381260ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000381260ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000337881ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000337881ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-5UTRENST00000337881ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000605395ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-3CDSENST00000605395ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
5UTR-5UTRENST00000605395ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000508121ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000508121ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000508121ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000503639ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000503639ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000503639ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000553379ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000553379ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000553379ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000381255ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000381255ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000381255ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000317745ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000317745ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000317745ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000555760ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000555760ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000555760ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000556614ENST00000295666HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-3CDSENST00000556614ENST00000537922HOPXchr4

57547421

-IGFBP7chr4

57907099

-
intron-5UTRENST00000556614ENST00000512512HOPXchr4

57547421

-IGFBP7chr4

57907099

-

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FusionProtFeatures for HOPX_IGFBP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOPX

Q9BPY8

IGFBP7

Q16270

Atypical homeodomain protein which does not bind DNA andis required to modulate cardiac growth and development. Acts viaits interaction with SRF, thereby modulating the expression ofSRF-dependent cardiac-specific genes and cardiac development.Prevents SRF-dependent transcription either by inhibiting SRFbinding to DNA or by recruiting histone deacetylase (HDAC)proteins that prevent transcription by SRF. Overexpression causescardiac hypertrophy (By similarity). May act as a tumorsuppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperoneproteins and assists in chaperone-mediated protein refolding(PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0,ECO:0000269|PubMed:27708256}. Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HOPX_IGFBP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HOPX_IGFBP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HOPXHDAC2, HOXB9, TLX3, ZSCAN1, HSP90AA1, HSPA4, EPC1, TCF12, S100A2, ASUNIGFBP7IGF1, IGF2, CHMP3, VEGFA, INS, DSTN, RTN4, HNF1A, RBBP8, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HOPX_IGFBP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIGFBP7Q16270DB00071Insulin PorkInsulin-like growth factor-binding protein 7biotechapproved
TgeneIGFBP7Q16270DB00030Insulin HumanInsulin-like growth factor-binding protein 7biotechapproved|investigational

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RelatedDiseases for HOPX_IGFBP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOPXC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIGFBP7C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneIGFBP7C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIGFBP7C0033578Prostatic Neoplasms1CTD_human
TgeneIGFBP7C0038356Stomach Neoplasms1CTD_human
TgeneIGFBP7C1458155Mammary Neoplasms1CTD_human