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Fusion gene ID: 16686 |
FusionGeneSummary for HOPX_IGFBP7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HOPX_IGFBP7 | Fusion gene ID: 16686 | Hgene | Tgene | Gene symbol | HOPX | IGFBP7 | Gene ID | 84525 | 3490 |
| Gene name | HOP homeobox | insulin like growth factor binding protein 7 | |
| Synonyms | CAMEO|HOD|HOP|LAGY|NECC1|OB1|SMAP31|TOTO | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1 | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9BPY8 | Q16270 | |
| Ensembl transtripts involved in fusion gene | ENST00000554144, ENST00000420433, ENST00000556376, ENST00000381260, ENST00000337881, ENST00000605395, ENST00000508121, ENST00000503639, ENST00000553379, ENST00000381255, ENST00000317745, ENST00000555760, ENST00000556614, | ENST00000295666, ENST00000537922, ENST00000512512, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 4 X 4 X 3=48 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HOPX [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HOPX | GO:0001829 | trophectodermal cell differentiation | 17576768 |
| Hgene | HOPX | GO:0045596 | negative regulation of cell differentiation | 17576768 |
| Hgene | HOPX | GO:0051131 | chaperone-mediated protein complex assembly | 10811660 |
| Tgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-28-5216-01A | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000554144 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000554144 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-5UTR | ENST00000554144 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000420433 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000420433 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-5UTR | ENST00000420433 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000556376 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000556376 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-5UTR | ENST00000556376 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000381260 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000381260 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000381260 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000337881 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000337881 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-5UTR | ENST00000337881 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000605395 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-3CDS | ENST00000605395 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| 5UTR-5UTR | ENST00000605395 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000508121 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000508121 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000508121 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000503639 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000503639 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000503639 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000553379 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000553379 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000553379 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000381255 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000381255 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000381255 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000317745 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000317745 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000317745 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000555760 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000555760 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000555760 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000556614 | ENST00000295666 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000556614 | ENST00000537922 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000556614 | ENST00000512512 | HOPX | chr4 | 57547421 | - | IGFBP7 | chr4 | 57907099 | - |
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FusionProtFeatures for HOPX_IGFBP7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HOPX | IGFBP7 |
| Atypical homeodomain protein which does not bind DNA andis required to modulate cardiac growth and development. Acts viaits interaction with SRF, thereby modulating the expression ofSRF-dependent cardiac-specific genes and cardiac development.Prevents SRF-dependent transcription either by inhibiting SRFbinding to DNA or by recruiting histone deacetylase (HDAC)proteins that prevent transcription by SRF. Overexpression causescardiac hypertrophy (By similarity). May act as a tumorsuppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperoneproteins and assists in chaperone-mediated protein refolding(PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0,ECO:0000269|PubMed:27708256}. | Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HOPX_IGFBP7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HOPX_IGFBP7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HOPX | HDAC2, HOXB9, TLX3, ZSCAN1, HSP90AA1, HSPA4, EPC1, TCF12, S100A2, ASUN | IGFBP7 | IGF1, IGF2, CHMP3, VEGFA, INS, DSTN, RTN4, HNF1A, RBBP8, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HOPX_IGFBP7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IGFBP7 | Q16270 | DB00071 | Insulin Pork | Insulin-like growth factor-binding protein 7 | biotech | approved |
| Tgene | IGFBP7 | Q16270 | DB00030 | Insulin Human | Insulin-like growth factor-binding protein 7 | biotech | approved|investigational |
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RelatedDiseases for HOPX_IGFBP7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HOPX | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGFBP7 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | IGFBP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGFBP7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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