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Fusion gene ID: 16668 |
FusionGeneSummary for HOOK1_IVD |
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Fusion gene information | Fusion gene name: HOOK1_IVD | Fusion gene ID: 16668 | Hgene | Tgene | Gene symbol | HOOK1 | IVD | Gene ID | 51361 | 3712 |
Gene name | hook microtubule tethering protein 1 | isovaleryl-CoA dehydrogenase | |
Synonyms | HK1 | ACAD2 | |
Cytomap | 1p32.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Hook homolog 1h-hook1hHK1hook homolog 1 | isovaleryl-CoA dehydrogenase, mitochondrialisovaleryl Coenzyme A dehydrogenase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UJC3 | P26440 | |
Ensembl transtripts involved in fusion gene | ENST00000371208, ENST00000465876, ENST00000395561, | ENST00000249760, ENST00000490194, ENST00000487418, ENST00000479013, | |
Fusion gene scores | * DoF score | 4 X 6 X 4=96 | 3 X 3 X 3=27 |
# samples | 6 | 4 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HOOK1 [Title/Abstract] AND IVD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IVD | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 3597357 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-BG-A3PP-01A | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000371208 | ENST00000249760 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000371208 | ENST00000490194 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000371208 | ENST00000487418 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000371208 | ENST00000479013 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
3UTR-intron | ENST00000465876 | ENST00000249760 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
3UTR-intron | ENST00000465876 | ENST00000490194 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
3UTR-intron | ENST00000465876 | ENST00000487418 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
3UTR-intron | ENST00000465876 | ENST00000479013 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000395561 | ENST00000249760 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000395561 | ENST00000490194 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000395561 | ENST00000487418 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
5CDS-intron | ENST00000395561 | ENST00000479013 | HOOK1 | chr1 | 60287615 | + | IVD | chr15 | 40727616 | + |
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FusionProtFeatures for HOOK1_IVD |
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Hgene | Tgene |
HOOK1 | IVD |
Required for spermatid differentiation. Probablyinvolved in the positioning of the microtubules of the manchetteand the flagellum in relation to the membrane skeleton (Bysimilarity). Component of the FTS/Hook/FHIP complex (FHF complex).The FHF complex may function to promote vesicle trafficking and/orfusion via the homotypic vesicular protein sorting complex (theHOPS complex) (PubMed:18799622). {ECO:0000250|UniProtKB:Q8BIL5,ECO:0000269|PubMed:18799622}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HOOK1_IVD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HOOK1_IVD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HOOK1 | ZNF250, AKTIP, CDC5L, HOOK2, HOOK3, HOOK1, FAM160A2, VPS16, VPS18, VPS39, VPS41, VCP, CDK4, LMO2, USP2, TFIP11, TBC1D7, SYCE1, ZNF785, LRRC29, TRAK2, TNFSF13B, RABGGTB, HERC2, AARSD1, SELENBP1, NCAPH2, CDC16, C6orf141, ALOXE3, CRYL1, TRIP11 | IVD | TERF2, SLC25A41, NUDT13, ETFA, ETFB, IVD, PMPCB, PMPCA, KIR3DL2, STK11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HOOK1_IVD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HOOK1_IVD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IVD | C0268575 | Isovaleryl-CoA dehydrogenase deficiency | 5 | CTD_human;ORPHANET;UNIPROT |
Tgene | IVD | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |