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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16668

FusionGeneSummary for HOOK1_IVD

check button Fusion gene summary
Fusion gene informationFusion gene name: HOOK1_IVD
Fusion gene ID: 16668
HgeneTgene
Gene symbol

HOOK1

IVD

Gene ID

51361

3712

Gene namehook microtubule tethering protein 1isovaleryl-CoA dehydrogenase
SynonymsHK1ACAD2
Cytomap

1p32.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionprotein Hook homolog 1h-hook1hHK1hook homolog 1isovaleryl-CoA dehydrogenase, mitochondrialisovaleryl Coenzyme A dehydrogenase
Modification date2018052320180523
UniProtAcc

Q9UJC3

P26440

Ensembl transtripts involved in fusion geneENST00000371208, ENST00000465876, 
ENST00000395561, 
ENST00000249760, 
ENST00000490194, ENST00000487418, 
ENST00000479013, 
Fusion gene scores* DoF score4 X 6 X 4=963 X 3 X 3=27
# samples 64
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HOOK1 [Title/Abstract] AND IVD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIVD

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

3597357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-BG-A3PP-01AHOOK1chr1

60287615

+IVDchr15

40727616

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000371208ENST00000249760HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000371208ENST00000490194HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000371208ENST00000487418HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000371208ENST00000479013HOOK1chr1

60287615

+IVDchr15

40727616

+
3UTR-intronENST00000465876ENST00000249760HOOK1chr1

60287615

+IVDchr15

40727616

+
3UTR-intronENST00000465876ENST00000490194HOOK1chr1

60287615

+IVDchr15

40727616

+
3UTR-intronENST00000465876ENST00000487418HOOK1chr1

60287615

+IVDchr15

40727616

+
3UTR-intronENST00000465876ENST00000479013HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000395561ENST00000249760HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000395561ENST00000490194HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000395561ENST00000487418HOOK1chr1

60287615

+IVDchr15

40727616

+
5CDS-intronENST00000395561ENST00000479013HOOK1chr1

60287615

+IVDchr15

40727616

+

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FusionProtFeatures for HOOK1_IVD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HOOK1

Q9UJC3

IVD

P26440

Required for spermatid differentiation. Probablyinvolved in the positioning of the microtubules of the manchetteand the flagellum in relation to the membrane skeleton (Bysimilarity). Component of the FTS/Hook/FHIP complex (FHF complex).The FHF complex may function to promote vesicle trafficking and/orfusion via the homotypic vesicular protein sorting complex (theHOPS complex) (PubMed:18799622). {ECO:0000250|UniProtKB:Q8BIL5,ECO:0000269|PubMed:18799622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HOOK1_IVD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HOOK1_IVD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HOOK1ZNF250, AKTIP, CDC5L, HOOK2, HOOK3, HOOK1, FAM160A2, VPS16, VPS18, VPS39, VPS41, VCP, CDK4, LMO2, USP2, TFIP11, TBC1D7, SYCE1, ZNF785, LRRC29, TRAK2, TNFSF13B, RABGGTB, HERC2, AARSD1, SELENBP1, NCAPH2, CDC16, C6orf141, ALOXE3, CRYL1, TRIP11IVDTERF2, SLC25A41, NUDT13, ETFA, ETFB, IVD, PMPCB, PMPCA, KIR3DL2, STK11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HOOK1_IVD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HOOK1_IVD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIVDC0268575Isovaleryl-CoA dehydrogenase deficiency5CTD_human;ORPHANET;UNIPROT
TgeneIVDC0023893Liver Cirrhosis, Experimental1CTD_human