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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16649

FusionGeneSummary for HNRNPUL2_YY1AP1

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPUL2_YY1AP1
Fusion gene ID: 16649
HgeneTgene
Gene symbol

HNRNPUL2

YY1AP1

Gene ID

221092

55249

Gene nameheterogeneous nuclear ribonucleoprotein U like 2YY1 associated protein 1
SynonymsHNRPUL2|SAF-A2GRNG|HCCA1|HCCA2|YY1AP
Cytomap

11q12.3

1q22

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 2scaffold-attachment factor A2YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2
Modification date2018051920180523
UniProtAcc

Q1KMD3

Q9H869

Ensembl transtripts involved in fusion geneENST00000301785, ENST00000311573, 
ENST00000368340, ENST00000347088, 
ENST00000361831, ENST00000355499, 
ENST00000404643, ENST00000407221, 
ENST00000359205, ENST00000295566, 
ENST00000368330, ENST00000368339, 
ENST00000535662, ENST00000405763, 
ENST00000438245, ENST00000476093, 
Fusion gene scores* DoF score6 X 6 X 3=1085 X 5 X 1=25
# samples 76
** MAII scorelog2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPUL2 [Title/Abstract] AND YY1AP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYY1AP1

GO:0051726

regulation of cell cycle

17541814


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW249049HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
ChiTaRS3.1AW247583HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000301785ENST00000311573HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000368340HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000347088HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000361831HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000355499HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000404643HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000407221HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-5UTRENST00000301785ENST00000359205HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000295566HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000368330HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000368339HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000535662HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000405763HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000438245HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-
intron-intronENST00000301785ENST00000476093HNRNPUL2chr11

62482596

+YY1AP1chr1

155658475

-

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FusionProtFeatures for HNRNPUL2_YY1AP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL2

Q1KMD3

YY1AP1

Q9H869


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPUL2_YY1AP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPUL2_YY1AP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPUL2_YY1AP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPUL2_YY1AP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource