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Fusion gene ID: 16608 |
FusionGeneSummary for HNRNPL_EMC8 |
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Fusion gene information | Fusion gene name: HNRNPL_EMC8 | Fusion gene ID: 16608 | Hgene | Tgene | Gene symbol | HNRNPL | EMC8 | Gene ID | 3191 | 10328 |
Gene name | heterogeneous nuclear ribonucleoprotein L | ER membrane protein complex subunit 8 | |
Synonyms | HNRPL|P/OKcl.14|hnRNP-L | C16orf2|C16orf4|COX4NB|FAM158B|NOC4 | |
Cytomap | 19q13.2 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein LhnRNP L | ER membrane protein complex subunit 8COX4 neighborfamily with sequence similarity 158, member Bneighbor of COX4 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P14866 | O43402 | |
Ensembl transtripts involved in fusion gene | ENST00000221419, ENST00000600873, | ENST00000253457, ENST00000435200, | |
Fusion gene scores | * DoF score | 9 X 10 X 5=450 | 6 X 6 X 5=180 |
# samples | 10 | 7 | |
** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HNRNPL [Title/Abstract] AND EMC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AL526231 | HNRNPL | chr19 | 39340408 | - | EMC8 | chr16 | 85833003 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000221419 | ENST00000253457 | HNRNPL | chr19 | 39340408 | - | EMC8 | chr16 | 85833003 | - |
intron-5UTR | ENST00000221419 | ENST00000435200 | HNRNPL | chr19 | 39340408 | - | EMC8 | chr16 | 85833003 | - |
intron-5UTR | ENST00000600873 | ENST00000253457 | HNRNPL | chr19 | 39340408 | - | EMC8 | chr16 | 85833003 | - |
intron-5UTR | ENST00000600873 | ENST00000435200 | HNRNPL | chr19 | 39340408 | - | EMC8 | chr16 | 85833003 | - |
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FusionProtFeatures for HNRNPL_EMC8 |
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Hgene | Tgene |
HNRNPL | EMC8 |
Splicing factor binding to exonic or intronic sites andacting as either an activator or repressor of exon inclusion.Exhibits a binding preference for CA-rich elements(PubMed:11809897, PubMed:22570490, PubMed:24164894,PubMed:25623890, PubMed:26051023). Component of the heterogeneousnuclear ribonucleoprotein (hnRNP) complexes and associated withmost nascent transcripts (PubMed:2687284). Associates, togetherwith APEX1, to the negative calcium responsive element (nCaRE) B2of the APEX2 promoter (PubMed:11809897).{ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490,ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023,ECO:0000269|PubMed:2687284}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPL_EMC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HNRNPL_EMC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPL_EMC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPL_EMC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPL | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | HNRNPL | C1458155 | Mammary Neoplasms | 1 | CTD_human |