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Fusion gene ID: 16607 |
FusionGeneSummary for HNRNPL_ACTN4 |
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Fusion gene information | Fusion gene name: HNRNPL_ACTN4 | Fusion gene ID: 16607 | Hgene | Tgene | Gene symbol | HNRNPL | ACTN4 | Gene ID | 3191 | 81 |
Gene name | heterogeneous nuclear ribonucleoprotein L | actinin alpha 4 | |
Synonyms | HNRPL|P/OKcl.14|hnRNP-L | ACTININ-4|FSGS|FSGS1 | |
Cytomap | 19q13.2 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein LhnRNP L | alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P14866 | O43707 | |
Ensembl transtripts involved in fusion gene | ENST00000221419, ENST00000600873, | ENST00000252699, ENST00000424234, ENST00000390009, ENST00000497637, | |
Fusion gene scores | * DoF score | 9 X 10 X 5=450 | 19 X 14 X 7=1862 |
# samples | 10 | 20 | |
** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1862*10)=-3.21878116778407 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HNRNPL [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACTN4 | GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 22351778 |
Tgene | ACTN4 | GO:0048384 | retinoic acid receptor signaling pathway | 22351778 |
Tgene | ACTN4 | GO:0051272 | positive regulation of cellular component movement | 9508771 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-23-1107-01A | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000221419 | ENST00000252699 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
5CDS-intron | ENST00000221419 | ENST00000424234 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
5CDS-intron | ENST00000221419 | ENST00000390009 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
5CDS-intron | ENST00000221419 | ENST00000497637 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
intron-3CDS | ENST00000600873 | ENST00000252699 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
intron-intron | ENST00000600873 | ENST00000424234 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
intron-intron | ENST00000600873 | ENST00000390009 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
intron-intron | ENST00000600873 | ENST00000497637 | HNRNPL | chr19 | 39340340 | - | ACTN4 | chr19 | 39205109 | + |
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FusionProtFeatures for HNRNPL_ACTN4 |
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Hgene | Tgene |
HNRNPL | ACTN4 |
Splicing factor binding to exonic or intronic sites andacting as either an activator or repressor of exon inclusion.Exhibits a binding preference for CA-rich elements(PubMed:11809897, PubMed:22570490, PubMed:24164894,PubMed:25623890, PubMed:26051023). Component of the heterogeneousnuclear ribonucleoprotein (hnRNP) complexes and associated withmost nascent transcripts (PubMed:2687284). Associates, togetherwith APEX1, to the negative calcium responsive element (nCaRE) B2of the APEX2 promoter (PubMed:11809897).{ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490,ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023,ECO:0000269|PubMed:2687284}. | F-actin cross-linking protein which is thought to anchoractin to a variety of intracellular structures. This is a bundlingprotein (Probable). Probably involved in vesicular trafficking viaits association with the CART complex. The CART complex isnecessary for efficient transferrin receptor recycling but not forEGFR degradation (PubMed:15772161). Involved in tight junctionassembly in epithelial cells probably through interaction withMICALL2. Links MICALL2 to the actin cytoskeleton and recruits itto the tight junctions (By similarity). May also function as atranscriptional coactivator, stimulating transcription mediated bythe nuclear hormone receptors PPARG and RARA (PubMed:22351778).{ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161,ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 39_89 | 89 | 590 | Compositional bias | Note=Gly-rich |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 778_789 | 273 | 912 | Calcium binding | 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 819_830 | 273 | 912 | Calcium binding | 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 778_789 | 54 | 693 | Calcium binding | 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 819_830 | 54 | 693 | Calcium binding | 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 765_800 | 273 | 912 | Domain | EF-hand 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 806_841 | 273 | 912 | Domain | EF-hand 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 163_269 | 54 | 693 | Domain | Calponin-homology (CH) 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 765_800 | 54 | 693 | Domain | EF-hand 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 806_841 | 54 | 693 | Domain | EF-hand 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 84_88 | 54 | 693 | Motif | LXXLL motif |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 177_192 | 54 | 693 | Region | Polyphosphoinositide (PIP2)-binding |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 293_403 | 273 | 912 | Repeat | Spectrin 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 413_518 | 273 | 912 | Repeat | Spectrin 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 528_639 | 273 | 912 | Repeat | Spectrin 3 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 649_752 | 273 | 912 | Repeat | Spectrin 4 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 293_403 | 54 | 693 | Repeat | Spectrin 1 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 413_518 | 54 | 693 | Repeat | Spectrin 2 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 528_639 | 54 | 693 | Repeat | Spectrin 3 |
Tgene | >ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 649_752 | 54 | 693 | Repeat | Spectrin 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 335_382 | 89 | 590 | Compositional bias | Note=Pro-rich |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 335_382 | -59 | 457 | Compositional bias | Note=Pro-rich |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 39_89 | -59 | 457 | Compositional bias | Note=Gly-rich |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 102_176 | 89 | 590 | Domain | RRM 1 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 193_270 | 89 | 590 | Domain | RRM 2 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 382_478 | 89 | 590 | Domain | RRM 3 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000221419 | - | 1 | 13 | 495_583 | 89 | 590 | Domain | RRM 4 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 102_176 | -59 | 457 | Domain | RRM 1 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 193_270 | -59 | 457 | Domain | RRM 2 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 382_478 | -59 | 457 | Domain | RRM 3 |
Hgene | >HNRNPL | chr19:39340340 | chr19:39205109 | ENST00000600873 | - | 1 | 13 | 495_583 | -59 | 457 | Domain | RRM 4 |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 19_26 | 273 | 912 | Compositional bias | Poly-Gly |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 19_26 | 54 | 693 | Compositional bias | Poly-Gly |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 163_269 | 273 | 912 | Domain | Calponin-homology (CH) 2 |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 50_154 | 273 | 912 | Domain | Calponin-homology (CH) 1 |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 50_154 | 54 | 693 | Domain | Calponin-homology (CH) 1 |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 84_88 | 273 | 912 | Motif | LXXLL motif |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 177_192 | 273 | 912 | Region | Polyphosphoinositide (PIP2)-binding |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 1_269 | 273 | 912 | Region | Note=Actin-binding |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 1_269 | 54 | 693 | Region | Note=Actin-binding |
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FusionGeneSequence for HNRNPL_ACTN4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_HNRNPL_ENST00000221419_chr19_39340340_-_ACTN4_ENST00000252699_chr19_39205109_+_728aa MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGA ETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKL RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRD HALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKH TNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRI MSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_HNRNPL_ENST00000221419_chr19_39340340_-_ACTN4_ENST00000252699_chr19_39205109_+_2184nt ATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAGCAGCCGGACGAGCAGCGGAGGCGGTCGGGA GCGATGGTGAAGATGGCGGCGGCGGGCGGCGGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCCTAAGCGG CTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCCGGGGCGGCGGGCGGCGGCGGCGGTGGGGCT GAAACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGAC CTCCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGAC TTCCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTG CGCCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGACATCAACAATGGCTGGCAGCACTTGGAGCAGGCTGAG AAGGGCTACGAGGAGTGGCTGCTGAATGAGATCCGCAGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATC CACGAGGCCTGGACTGACGGGAAGGAAGCCATGCTGAAGCACCGGGACTACGAGACGGCCACACTATCGGACATCAAAGCCCTCATTCGC AAGCACGAGGCCTTCGAGAGCGACCTGGCTGCGCACCAGGACCGCGTGGAGCAGATCGCCGCCATTGCCCAGGAGCTCAACGAGCTGGAT TACTACGACTCCCACAATGTCAACACCCGGTGCCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCGCAGGGAA GCCCTGGAGAAAACAGAGAAGCAGCTGGAGGCCATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAACTGGATG GAGAGCGCCATGGAGGACCTCCAGGACATGTTCATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCAGTTCAAG TCCACCCTGCCGGACGCCGATAGGGAGCGCGAGGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCACATCAAG CTGTCGGGCAGCAACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAAACGGGAC CATGCCCTCCTGGAGGAGCAGAGCAAGCAGCAGTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGGGCCCTGG ATCCAGACCAAGATGGAGGAGATCGGGCGCATCTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCAGTATGAA CGCAGCATCGTGGACTACAAGCCCAACCTGGACCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAACAAGCAC ACCAACTATACCATGGAGCACATCCGCGTGGGCTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAACCAGATC CTCACCCGCGACGCCAAGGGCATCAGCCAGGAGCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGGCGGGGCG CTGGGGCCCGAGGAGTTCAAGGCCTGCCTCATCAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAACCGCATC ATGAGCCTGGTCGACCCCAACCATAGCGGCCTTGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACACGGACACG GCTGACCAGGTCATCGCTTCCTTCAAGGTCTTAGCAGGGGACAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCGAC CAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTCCACGGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_HNRNPL_ENST00000221419_chr19_39340340_-_ACTN4_ENST00000252699_chr19_39205109_+_4702nt GGAGACCAATGAAAGTGGGAGGGAGGCGGAGATTCTTGGGAGGTTTAGAGCGCCGTTCCTATCAGGTGCTTTTAGGGAGGCCAGCAGCGC CAGAAATCCGACCTATCAAATTGGATTTTATTTTAAGGCGGCGGGGTCGACGGAAAGACTGGCAGAAAGCGACCACCTATAAGGAGTGTC TCAGACAAACAAGGGCGGGCCCTCCTGCAGAACGGCGTGGGCAATGTCCAATAAGCGCGCAAGGCGTGTGGCGGCCTACCCTCCCCCCGC GGCGGGACCAGTGGCTCCCCCTATCGGGTGGGGGCGGCGGGTGACGGGCGTGTCCCTCCCCCAATGAGAGGCGGGGGGAGGCGGGTTCTG CGCCGCCATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAGCAGCCGGACGAGCAGCGGAGGCG GTCGGGAGCGATGGTGAAGATGGCGGCGGCGGGCGGCGGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCC TAAGCGGCTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCCGGGGCGGCGGGCGGCGGCGGCGG TGGGGCTGAAACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGC CAGCGACCTCCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCT GGAGGACTTCCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGAC CAAGCTGCGCCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGACATCAACAATGGCTGGCAGCACTTGGAGCA GGCTGAGAAGGGCTACGAGGAGTGGCTGCTGAATGAGATCCGCAGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGC CTCCATCCACGAGGCCTGGACTGACGGGAAGGAAGCCATGCTGAAGCACCGGGACTACGAGACGGCCACACTATCGGACATCAAAGCCCT CATTCGCAAGCACGAGGCCTTCGAGAGCGACCTGGCTGCGCACCAGGACCGCGTGGAGCAGATCGCCGCCATTGCCCAGGAGCTCAACGA GCTGGATTACTACGACTCCCACAATGTCAACACCCGGTGCCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCG CAGGGAAGCCCTGGAGAAAACAGAGAAGCAGCTGGAGGCCATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAA CTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTTCATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCA GTTCAAGTCCACCCTGCCGGACGCCGATAGGGAGCGCGAGGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCA CATCAAGCTGTCGGGCAGCAACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAA ACGGGACCATGCCCTCCTGGAGGAGCAGAGCAAGCAGCAGTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGG GCCCTGGATCCAGACCAAGATGGAGGAGATCGGGCGCATCTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCA GTATGAACGCAGCATCGTGGACTACAAGCCCAACCTGGACCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAA CAAGCACACCAACTATACCATGGAGCACATCCGCGTGGGCTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAA CCAGATCCTCACCCGCGACGCCAAGGGCATCAGCCAGGAGCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGG CGGGGCGCTGGGGCCCGAGGAGTTCAAGGCCTGCCTCATCAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAA CCGCATCATGAGCCTGGTCGACCCCAACCATAGCGGCCTTGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACAC GGACACGGCTGACCAGGTCATCGCTTCCTTCAAGGTCTTAGCAGGGGACAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCC CCCCGACCAGGCCGAGTACTGCATCGCCCGCATGGCGCCATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTC CACGGCCTTGTATGGCGAGAGCGACCTGTGAGGCCCCAGAGACCTGACCCAACACCCCCGACGGCCTCCAGGAGGGGCCTGGGCAGCCCC ACAGTCCCATTCCTCCACTCTGTATCTATGCAAAGCACTCTCTGCAGTCCTCCGGGGTGGGTGGGTGGGCAGGGAGGGGCTGGGGCAGGC TCTCTCCTCTCTCTCTTTGTGGGTTGGCCAGGAGGTTCCCCCGACCAGGTTGGGGAGACTTGGGGCCAGCGCTTCTGGTCTGGTAAATAT GTATGATGTGTTGTGCTTTTTTAACCAAGGAGGGGCCAGTGGATTCCCACAGCACAACCGGTCCCTTCCATGCCCTGGGATGCCTCACCA CACCCAGGTCTCTTCCTTTGCTCTGAGGTCCCTTCAAGGCCTCCCCAATCCAGGCCAAAGCCCCATGTGCCTTGTCCAGGAACTGCCTGG GCCATGCGAGGGGCCAGCAGAGGGCGCCACCACCACCTGACGGCTGGGGACCCACCCAGCCCCTCTCCCCTCTCTGCTCCAGACTCACTT GCCATTGCCAGGAGATGGCCCCAACAAGCACCCCGCTTTTGCAGCAGAGGAGCTGAGTTGGCAGACCGGGCCCCCCTGAACCGCACCCCA TCCCACCAGCCCCGGCCTTGCTTTGTCTGGCCTCACGTGTCTCAGATTTTCTAAGAACCAAAAAAAAAAAAGGAAAAAAAACACAAAACA ACAAAAACCAAAAAAAAAAAAAATCACAAAAACAAAAAAACTATAAAAAAGAAAGAATTAAAAACTTTCAGAGAATTACTATTTACTTTA TTAACTTACGGATTTATTATATAAATATATATTCACCTAGCAACATATCTCTGCCGTCTCTCCTGCTCTCATAATGAAGACATAGCCGAT TCTCTGCCCGGGCCCCTTGCTGATGCTCCTCCGGGTCTGCGTCGGGCGTGGGTCTCTGGGGACCCTCCAGAGGTGGAGGTGGGCTGATGG CCTGGCTGCCTGGTGGTTGATGGTTTTGCTCCCCCTACCTTTTTTTTTTGAGTTTATTCTGATTGATTTTTTTTCTTGGTTTCTGGATAA ACCACCCTCTGGGGACAGGATAATAAAACATGTAATATTTTTAAGAAGGATTCCTGCAGCATCATCTTTTTTTATTTCTCCTGTGTCTGT CCTCCACCTTCTAGGAGAGCCAGGGCAGAGCTAGCACTGTCTTAAGCTGTCAACGTGGACTAGCTCGTGTCATCTGCTCGAGAAGGGCTG TCGCTGTTCTTGTTTCTGAGTGAGGAGTACGCAGGCCAGAGTGGTCACCCGGCCGTGAGCAGTGAGGGCCAGAGACTAGCCCCAGACAGG TGGATGCCAGAGAGAGTGGCACCCATGCCAGGCAAGGCCTAGGGAGGTGGTCTTGCTCAGCAACCCTGCCCTGAGCAGCAGGTGCGCCCA TCCGGAGATCCTAGGAGAAGGTGGCCACCTCCATCCACTAAGGAAGAGAAGGAAGACAGTGGCTTGAGGCAGGGAGCTCGCAGGACAGAG CCTGAGCCACCCTGTCCCTCCCACCTGGCTCACCTGTCTGTGGGTCAGGCAGATGACCCCCTCACCCCCATCCAGGTGCTGGCTGCAGTG GCCTGTGCAGAGAGGGGCAGGGTGAGTGCCCACCAGTCCCCGTACCCCTTCCCCCCATGCCCCACCATGCCGGGGTGGTACTCACAGAAG ATGCAGGTGAGGTGGGCCACACAGGACACGAACCGCTCGAAGTCCACACGCAGACGGCTATCCCGGTAGCGGCTGGTGAGGGTCTGGGTC AGCTGGTTGTTCAGGTGGAAGCCTAGGGGGAGGCTGCTTCTGAGCCCAGTGGCCCACAGGGAACCCACCTTGGCATTGCATCCCCACCCC ACCTCCTCAGGGAGGACATGAATGCCACAGGGTGTCACACCCCAACTCTGCCCCATCCCGGCAGGGTGAGTACAGGCTGATCCCTTCAAT CCTCTGGGCCTGTTTCCTCATCCATCAAACGGACTAAGACAGCCCCGACCCCATAGGGTGTGTGAAGACAGAACGCTCAGGACAGCGTCT GACACGTGACTCGATGTGTGGGTACTGTTACTCCTTAAATCCTGTGGGGCTTTCTCCTTGCCAGTGGGCACTGGAGGATATTTCTGTGCA |
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FusionGenePPI for HNRNPL_ACTN4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HNRNPL | PTBP1, PUF60, DOCK4, EIF2B1, YWHAZ, CSE1L, FGFR3, HMG20B, PCBP2, HNRNPK, HNRNPL, HNRNPA2B1, APEX1, KHDRBS2, HNRNPA1, SRRM2, TOPORS, UBC, HDAC5, TOP1, VHL, SMARCAD1, MBNL1, ELAVL1, ISG15, CUL3, CUL1, COPS5, CAND1, HNRNPR, HNRNPA3, HNRNPA0, HNRNPD, HNRNPH1, HNRNPM, EEF1A1, SFPQ, HNRNPDL, ATP6V1F, NPLOC4, LPP, MPV17, HSPA5, DYNC1H1, GCN1L1, EEF2, PLEC, LSM14A, MAGOH, EIF4A3, FN1, VCAM1, CSNK2A1, TP63, IFIT2, IFIT3, DAB2, IL7R, UBL4A, ITGA4, HMGA1, FBXO6, ITCH, NEDD4, ILF3, VEGFA, RPA1, RPA2, RPA3, IVNS1ABP, TRIM68, TP53, FUS, HIST3H3, CUL7, OBSL1, CCDC8, EED, RNF2, UNK, ACTR3, DHX15, DPH5, EIF4H, ABCC1, DDX17, LGALS1, HSPA9, HSPBP1, MRPL41, NAA50, NARS, NHP2L1, PDHA1, SF1, SYNCRIP, TUFM, YWHAE, NTRK1, SCARNA22, HIST1H3E, HNRNPU, MATR3, FOXE1, CRY1, MCM2, U2AF2, CRBN, SSU72, ELAVL2, APOBEC3D, CYLD, TRIM25, BRCA1, LMNA | ACTN4 | MYOZ2, MYOZ1, PDLIM1, USP6NL, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, CTNNB1, MCM2, NFYA, CDC73, DDIAS, SSH1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 108_126 | 54 | 693 | VCL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 108_126 | 273 | 912 | VCL |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 12_26 | 273 | 912 | VCL |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000252699 | + | 7 | 21 | 40_61 | 273 | 912 | VCL |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 12_26 | 54 | 693 | VCL |
Tgene | ACTN4 | chr19:39340340 | chr19:39205109 | ENST00000390009 | + | 0 | 14 | 40_61 | 54 | 693 | VCL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPL_ACTN4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPL_ACTN4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPL | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | HNRNPL | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ACTN4 | C0333497 | Segmental glomerulosclerosis | 3 | UNIPROT |
Tgene | ACTN4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ACTN4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |