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Fusion gene ID: 16598 |
FusionGeneSummary for HNRNPK_MYOM2 |
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Fusion gene information | Fusion gene name: HNRNPK_MYOM2 | Fusion gene ID: 16598 | Hgene | Tgene | Gene symbol | HNRNPK | MYOM2 | Gene ID | 3190 | 9172 |
Gene name | heterogeneous nuclear ribonucleoprotein K | myomesin 2 | |
Synonyms | AUKS|CSBP|HNRPK|TUNP | TTNAP | |
Cytomap | 9q21.32 | 8p23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein KdC-stretch binding proteintransformation upregulated nuclear protein | myomesin-2165 kDa connectin-associated protein165 kDa titin-associated proteinM-band proteinM-proteinmyomesin (M-protein) 2, 165kDamyomesin family member 2titin-associated protein, 165 kD | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P61978 | P54296 | |
Ensembl transtripts involved in fusion gene | ENST00000376281, ENST00000376263, ENST00000376264, ENST00000351839, ENST00000360384, | ENST00000262113, ENST00000523438, ENST00000520298, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 3 X 3 X 3=27 |
# samples | 6 | 3 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: HNRNPK [Title/Abstract] AND MYOM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF930538 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000376281 | ENST00000262113 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376281 | ENST00000523438 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376281 | ENST00000520298 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376263 | ENST00000262113 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376263 | ENST00000523438 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376263 | ENST00000520298 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376264 | ENST00000262113 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376264 | ENST00000523438 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000376264 | ENST00000520298 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000351839 | ENST00000262113 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000351839 | ENST00000523438 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000351839 | ENST00000520298 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000360384 | ENST00000262113 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000360384 | ENST00000523438 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
intron-3UTR | ENST00000360384 | ENST00000520298 | HNRNPK | chr9 | 86592673 | + | MYOM2 | chr8 | 2092964 | + |
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FusionProtFeatures for HNRNPK_MYOM2 |
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Hgene | Tgene |
HNRNPK | MYOM2 |
Major component of the vertebrate myofibrillar M band.Binds myosin, titin, and light meromyosin. This binding is dosedependent. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPK_MYOM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HNRNPK_MYOM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPK_MYOM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HNRNPK | P61978 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein K | small molecule | approved|investigational |
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RelatedDiseases for HNRNPK_MYOM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPK | C1458155 | Mammary Neoplasms | 1 | CTD_human |