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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16598

FusionGeneSummary for HNRNPK_MYOM2

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPK_MYOM2
Fusion gene ID: 16598
HgeneTgene
Gene symbol

HNRNPK

MYOM2

Gene ID

3190

9172

Gene nameheterogeneous nuclear ribonucleoprotein Kmyomesin 2
SynonymsAUKS|CSBP|HNRPK|TUNPTTNAP
Cytomap

9q21.32

8p23.3

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein KdC-stretch binding proteintransformation upregulated nuclear proteinmyomesin-2165 kDa connectin-associated protein165 kDa titin-associated proteinM-band proteinM-proteinmyomesin (M-protein) 2, 165kDamyomesin family member 2titin-associated protein, 165 kD
Modification date2018052220180523
UniProtAcc

P61978

P54296

Ensembl transtripts involved in fusion geneENST00000376281, ENST00000376263, 
ENST00000376264, ENST00000351839, 
ENST00000360384, 
ENST00000262113, 
ENST00000523438, ENST00000520298, 
Fusion gene scores* DoF score6 X 6 X 4=1443 X 3 X 3=27
# samples 63
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPK [Title/Abstract] AND MYOM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF930538HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000376281ENST00000262113HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376281ENST00000523438HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376281ENST00000520298HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376263ENST00000262113HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376263ENST00000523438HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376263ENST00000520298HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376264ENST00000262113HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376264ENST00000523438HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000376264ENST00000520298HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000351839ENST00000262113HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000351839ENST00000523438HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000351839ENST00000520298HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000360384ENST00000262113HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000360384ENST00000523438HNRNPKchr9

86592673

+MYOM2chr8

2092964

+
intron-3UTRENST00000360384ENST00000520298HNRNPKchr9

86592673

+MYOM2chr8

2092964

+

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FusionProtFeatures for HNRNPK_MYOM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPK

P61978

MYOM2

P54296

Major component of the vertebrate myofibrillar M band.Binds myosin, titin, and light meromyosin. This binding is dosedependent.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPK_MYOM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPK_MYOM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPK_MYOM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHNRNPKP61978DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein Ksmall moleculeapproved|investigational

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RelatedDiseases for HNRNPK_MYOM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHNRNPKC1458155Mammary Neoplasms1CTD_human