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Fusion gene ID: 16597 |
FusionGeneSummary for HNRNPH3_SLC29A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPH3_SLC29A3 | Fusion gene ID: 16597 | Hgene | Tgene | Gene symbol | HNRNPH3 | SLC29A3 | Gene ID | 3189 | 55315 |
| Gene name | heterogeneous nuclear ribonucleoprotein H3 | solute carrier family 29 member 3 | |
| Synonyms | 2H9|HNRPH3 | ENT3|HCLAP|HJCD|PHID | |
| Cytomap | 10q21.3 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein H3heterogeneous nuclear ribonucleoprotein 2H9hnRNP 2H9hnRNP H3 | equilibrative nucleoside transporter 3solute carrier family 29 (equilibrative nucleoside transporter), member 3solute carrier family 29 (nucleoside transporters), member 3 | |
| Modification date | 20180519 | 20180525 | |
| UniProtAcc | P31942 | Q9BZD2 | |
| Ensembl transtripts involved in fusion gene | ENST00000469172, ENST00000265866, ENST00000441000, ENST00000354695, | ENST00000373189, ENST00000469204, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 3 X 2 X 3=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HNRNPH3 [Title/Abstract] AND SLC29A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-FP-8631-01A | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000469172 | ENST00000373189 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| 3UTR-3UTR | ENST00000469172 | ENST00000469204 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| In-frame | ENST00000265866 | ENST00000373189 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| 5CDS-3UTR | ENST00000265866 | ENST00000469204 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| In-frame | ENST00000441000 | ENST00000373189 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| 5CDS-3UTR | ENST00000441000 | ENST00000469204 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| In-frame | ENST00000354695 | ENST00000373189 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
| 5CDS-3UTR | ENST00000354695 | ENST00000469204 | HNRNPH3 | chr10 | 70099312 | + | SLC29A3 | chr10 | 73121711 | + |
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FusionProtFeatures for HNRNPH3_SLC29A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPH3 | SLC29A3 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPH3_SLC29A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HNRNPH3_ENST00000265866_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_431aa MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPNGITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFR SSRSEIKGFYDPPRRLLGQRPGPYDRPIGGRGGYYGAGRGSMYDRMRRGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDRMRDGRGMGGHG YGGAGDASSGFHGGHFVHMRGLPFRATENDIANVLHEACSCGPCVFWXRGASPGLPQCPFGGLQIHXFPHTPSPPHPEEDGQPGLLCHLR LLHHQPHLPRHLHQHRVPQQGFGLTVDHQVFHPPHYLPPVQLCXPMWPAAHRLDPGARAQXQGAPRVRAPPDLPHPPLRALXLPAPRPPE >In-frame_HNRNPH3_ENST00000441000_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_323aa MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGYGGFDDYGGYNNYGYGNDGFDDRMRDGRGMGGHGYGGAGDASSGFHGGHFVH MRGLPFRATENDIANVLHEACSCGPCVFWXRGASPGLPQCPFGGLQIHXFPHTPSPPHPEEDGQPGLLCHLRLLHHQPHLPRHLHQHRVP QQGFGLTVDHQVFHPPHYLPPVQLCXPMWPAAHRLDPGARAQXQGAPRVRAPPDLPHPPLRALXLPAPRPPEDCGLPVRCVPRTPQLPAG >In-frame_HNRNPH3_ENST00000354695_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_416aa MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPNGITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFR SSRSEIKGFYDPPRRLLGQRPGPYDRPIGGRGGYYGAGRGSYGGFDDYGGYNNYGYGNDGFDDRMRDGRGMGGHGYGGAGDASSGFHGGH FVHMRGLPFRATENDIANVLHEACSCGPCVFWXRGASPGLPQCPFGGLQIHXFPHTPSPPHPEEDGQPGLLCHLRLLHHQPHLPRHLHQH RVPQQGFGLTVDHQVFHPPHYLPPVQLCXPMWPAAHRLDPGARAQXQGAPRVRAPPDLPHPPLRALXLPAPRPPEDCGLPVRCVPRTPQL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HNRNPH3_ENST00000265866_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_1294nt ATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAG GAAATAGTTCAGTTCTTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGACTACCAGGGGAGAAGCACAGGGGAGGCC TTCGTGCAGTTTGCTTCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAGATCTTCAGA AGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACCGGGACCATATGATAGACCAATAGGAGGA AGAGGGGGTTATTATGGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGATATGATGGTGGTTATGGAGGTTTT GATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGC TATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGAC ATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTC GGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGT CTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTT TTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAA TAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAA GACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCT CTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTC >In-frame_HNRNPH3_ENST00000441000_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_970nt ATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAG GAAATAGTTCAGTTCTTTCAAGGTTATGGAGGTTTTGATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGCTTTGATGAC AGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACAT ATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGA AGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAA GAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCT CAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCG GCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTT CGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGG GCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGAT >In-frame_HNRNPH3_ENST00000354695_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_1249nt ATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAG GAAATAGTTCAGTTCTTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGACTACCAGGGGAGAAGCACAGGGGAGGCC TTCGTGCAGTTTGCTTCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAGATCTTCAGA AGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACCGGGACCATATGATAGACCAATAGGAGGA AGAGGGGGTTATTATGGAGCTGGGCGTGGAAGTTATGGAGGTTTTGATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGC TTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCAT TTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTT TTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCC CATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACAT CGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCT ATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCAT CCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTC CCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HNRNPH3_ENST00000265866_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_2236nt TGCGCAGCTCCCTAAGCGGTTGTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTC TTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATG AAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTC TTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGACTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCT TCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAA ATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACCGGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTAT GGAGCTGGGCGTGGAAGTATGTATGACAGAATGCGACGAGGAGGTGATGGATATGATGGTGGTTATGGAGGTTTTGATGACTATGGTGGC TATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGT GATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTA CATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATT CATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAG CCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCAC TACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCC AGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCA GTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGAT TGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCT CCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGG CCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTC CATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTA CTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCA GTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCT TACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCT GTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCT CCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATG >In-frame_HNRNPH3_ENST00000441000_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_1891nt GTCACCGCTGGAGACGGTTGGGAGAACCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGC ACCAGAGTCGGCGTAACTATCGCCTGACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGAC GCTAGTGATGGGACAGTACGACTTCGTGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGTTATGGAGGTTTT GATGACTATGGTGGCTATAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGC TATGGTGGAGCTGGTGATGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGAC ATTGCTAATGTACTACATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTC GGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGT CTTCTTCATCACCAGCCTCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTT TTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAA TAGCAAGGCGCTCCCAGGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAA GACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCT CTACGGGCCTAAGATTGTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTC AGCCTGCTCTACCCTCCTGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTG CAGGAGGGCTGGGGGCCATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATG CCAGTGAGCCACGTCCATGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAG CACAAATCAGGGGTACTCCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGA GTTATTACAAAGCCAGTGCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAA ATGCTCAGCTCTCCTTACCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCAC AGACCCCTGTGTTCTGTGGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGA GGGACCAGAGGGCCTCCCTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATG GCCTGGGTCAAGATGAGGGTCTTTCAGTGTTCCTGTTTACAACATGTCAAAGCCATTGGTTCAAGGGCGTAATAAATACTTGCGTATTCA >In-frame_HNRNPH3_ENST00000354695_chr10_70099312_+_SLC29A3_ENST00000373189_chr10_73121711_+_2144nt CCGTTGTGGCGAGCGCTACACGAGGCAAACGACTTCTCCCTTCTTTGAACTGGACCCCGCGAGCACCAGAGTCGGCGTAACTATCGCCTG ACAGGCATTTAAATCAAACGGTATTGAGATGGATTGGGTTATGAAACATAATGGTCCAAATGACGCTAGTGATGGGACAGTACGACTTCG TGGACTACCATTTGGTTGCAGCAAAGAGGAAATAGTTCAGTTCTTTCAAGGGTTGGAAATCGTGCCAAATGGGATAACATTGACGATGGA CTACCAGGGGAGAAGCACAGGGGAGGCCTTCGTGCAGTTTGCTTCAAAGGAGATAGCAGAAAATGCTCTGGGGAAACACAAGGAAAGAAT AGGGCACAGGTATATTGAGATCTTCAGAAGTAGCAGGAGTGAAATCAAAGGATTTTATGATCCACCAAGAAGATTGCTGGGACAGCGACC GGGACCATATGATAGACCAATAGGAGGAAGAGGGGGTTATTATGGAGCTGGGCGTGGAAGTTATGGAGGTTTTGATGACTATGGTGGCTA TAATAATTACGGCTATGGGAATGATGGCTTTGATGACAGAATGAGAGATGGAAGAGGTATGGGAGGACATGGCTATGGTGGAGCTGGTGA TGCAAGTTCAGGTTTTCATGGTGGTCATTTCGTACATATGAGAGGGTTGCCTTTTCGTGCAACTGAAAATGACATTGCTAATGTACTACA TGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCCCTCAGTGCCCCTTCGGTGGCCTCCAGATTCA TTGATTCCCACACACCCCCTCTCCGCCCCATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGCC TCATCTACCCCGCCATCTGCACCAACATCGAGTCCCTCAACAAGGGTTCGGGCTCACTGTGGACCACCAAGTTTTTCATCCCCCTCACTA CCTTCCTCCTGTACAACTTTGCTGACCTATGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCAG GGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCCCGCGTCCACCTGAAGACTGTGGTCTTCCAGT CCGATGTGTACCCCGCACTCCTCAGCTCCCTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATTG TGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGCTTAACACTGGGCTCAGCCTGCTCTACCCTCC TGGTGCACCTCATCTAGAAGGGAGGACACAAGGACATTGGTGCTTCAGAGCCTTTGAAGATGAGAAGAGAGTGCAGGAGGGCTGGGGGCC ATGGAGGAAAGGCCTAAAGTTTCACTTGGGGACAGAGAGCAGAGCACACTCGGGCCTCATCCCTCCCAAGATGCCAGTGAGCCACGTCCA TGCCCATTCCGTGCAAGGCAGATATTCCAGTCATATTAACAGAACACTCCTGAGACAGTTGAAGAAGAAATAGCACAAATCAGGGGTACT CCCTTCACAGCTGATGGTTAACATTCCACCTTCTTTCTAGCCCTTCAAAGATGCTGCCAGTGTTCGCCCTAGAGTTATTACAAAGCCAGT GCCAAAACCCAGCCATGGGCTCTTTGCAACCTCCCAGCTGCGCTCATTCCAGCTGACAGCGAGATGCAAGCAAATGCTCAGCTCTCCTTA CCCTGAAGGGGTCTCCCTGGAATGGAAGTCCCCTGGCATGGTCAGTCCTCAGGCCCAAGACTCAAGTGTGCACAGACCCCTGTGTTCTGT GGGTGAACAACTGCCCACTAACCAGACTGGAAAACCCAGAAAGATGGGCCTTCCATGAATGCTTCATTCCAGAGGGACCAGAGGGCCTCC CTGTGCAAGGGATCAAGCATGTCTGGCCTGGGTTTTCAAAAAAAGAGGGATCCTCATGACCTGGTGGTCTATGGCCTGGGTCAAGATGAG |
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FusionGenePPI for HNRNPH3_SLC29A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HNRNPH3 | STK24, ANXA11, PIM2, RPS4X, TTR, C14orf1, KAT5, UTP14A, CRMP1, EEF1G, ZMYM2, KHDRBS2, SRRM2, H2AFX, SMN1, MAPK6, MBNL1, HNRNPA1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HNRNPDL, HNRNPH1, HNRNPA2B1, HNRNPR, SRSF1, HNRNPF, SF3A3, HNRNPUL1, SNRPA, SSBP1, PUF60, VCP, FN1, VCAM1, CHERP, HNRNPA0, C17orf85, DDX17, DDX5, HNRNPU, RBM4, HNRNPD, HNRNPH3, IL7R, ITGA4, PARK2, WWOX, ERG, HSPA5, STAU1, ENO1, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, EED, RNF2, FBXW11, DDX43, HNRNPA1L2, HNRNPA3, IARS2, MCM3, NLE1, PLD3, HSPB1, PDCD6, SEC16A, STIP1, NTRK1, EWSR1, XPO1, HNRNPH2, PPP1CB, PPP1CC, MATR3, ERBB3, RNGTT, NR3C1, COX15, DLST, DNM1L, HSD17B10, PDHA1, SDHA, TRIM25, BRCA1 | SLC29A3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPH3_SLC29A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPH3_SLC29A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC29A3 | C1864445 | Histiocytosis with joint contractures and sensorineural deafness | 7 | CTD_human;ORPHANET;UNIPROT |
| Tgene | SLC29A3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | CTD_human |
| Tgene | SLC29A3 | C0020555 | Hypertrichosis | 2 | CTD_human;HPO |
| Tgene | SLC29A3 | C0162834 | Hyperpigmentation | 2 | CTD_human;HPO |
| Tgene | SLC29A3 | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | SLC29A3 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Tgene | SLC29A3 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Tgene | SLC29A3 | C0019209 | Hepatomegaly | 1 | CTD_human;HPO |
| Tgene | SLC29A3 | C0019618 | Histiocytosis | 1 | CTD_human;HPO |
| Tgene | SLC29A3 | C0019625 | Sinus histiocytosis | 1 | CTD_human |
| Tgene | SLC29A3 | C0020619 | Hypogonadism | 1 | CTD_human |
| Tgene | SLC29A3 | C1384666 | hearing impairment | 1 | CTD_human;HPO |
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