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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16570

FusionGeneSummary for HNRNPD_VAMP2

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPD_VAMP2
Fusion gene ID: 16570
HgeneTgene
Gene symbol

HNRNPD

VAMP2

Gene ID

3184

6844

Gene nameheterogeneous nuclear ribonucleoprotein Dvesicle associated membrane protein 2
SynonymsAUF1|AUF1A|HNRPD|P37|hnRNPD0SYB2|VAMP-2
Cytomap

4q21.22

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0vesicle-associated membrane protein 2synaptobrevin 2
Modification date2018052320180523
UniProtAcc

Q14103

P63027

Ensembl transtripts involved in fusion geneENST00000313899, ENST00000353341, 
ENST00000543098, ENST00000352301, 
ENST00000508119, ENST00000541060, 
ENST00000316509, ENST00000404970, 
ENST00000488857, ENST00000481878, 
Fusion gene scores* DoF score8 X 7 X 4=2243 X 3 X 1=9
# samples 83
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPD [Title/Abstract] AND VAMP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE646088HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000313899ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000313899ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000313899ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000313899ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-3UTRENST00000353341ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000353341ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000353341ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000353341ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-3UTRENST00000543098ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000543098ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000543098ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000543098ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-3UTRENST00000352301ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000352301ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000352301ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000352301ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-3UTRENST00000508119ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000508119ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000508119ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000508119ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-3UTRENST00000541060ENST00000316509HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000541060ENST00000404970HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000541060ENST00000488857HNRNPDchr4

83275258

+VAMP2chr17

8063452

+
intron-intronENST00000541060ENST00000481878HNRNPDchr4

83275258

+VAMP2chr17

8063452

+

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FusionProtFeatures for HNRNPD_VAMP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPD

Q14103

VAMP2

P63027

Involved in the targeting and/or fusion of transportvesicles to their target membrane. Modulates the gatingcharacteristics of the delayed rectifier voltage-dependentpotassium channel KCNB1. {ECO:0000250|UniProtKB:P63045}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPD_VAMP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPD_VAMP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPD_VAMP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational
TgeneVAMP2P63027DB00042Botulinum Toxin Type BVesicle-associated membrane protein 2biotechapproved|investigational

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RelatedDiseases for HNRNPD_VAMP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVAMP2C0005586Bipolar Disorder1PSYGENET
TgeneVAMP2C0036341Schizophrenia1PSYGENET
TgeneVAMP2C0041696Unipolar Depression1PSYGENET
TgeneVAMP2C1269683Major Depressive Disorder1PSYGENET
TgeneVAMP2C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET