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Fusion gene ID: 16568 |
FusionGeneSummary for HNRNPD_SCD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPD_SCD5 | Fusion gene ID: 16568 | Hgene | Tgene | Gene symbol | HNRNPD | SCD5 | Gene ID | 3184 | 79966 |
| Gene name | heterogeneous nuclear ribonucleoprotein D | stearoyl-CoA desaturase 5 | |
| Synonyms | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | ACOD4|FADS4|HSCD5|SCD2|SCD4 | |
| Cytomap | 4q21.22 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14103 | Q86SK9 | |
| Ensembl transtripts involved in fusion gene | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | ENST00000319540, ENST00000273908, ENST00000282709, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 4 X 2 X 5=40 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HNRNPD [Title/Abstract] AND SCD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SCD5 | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-ZJ-A8QO-01A | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000313899 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000313899 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| In-frame | ENST00000313899 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000353341 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000353341 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| In-frame | ENST00000353341 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000543098 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000543098 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| In-frame | ENST00000543098 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000352301 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| Frame-shift | ENST00000352301 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| In-frame | ENST00000352301 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| intron-3CDS | ENST00000508119 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| intron-3CDS | ENST00000508119 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| intron-3CDS | ENST00000508119 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| 5UTR-3CDS | ENST00000541060 | ENST00000319540 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| 5UTR-3CDS | ENST00000541060 | ENST00000273908 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
| 5UTR-3CDS | ENST00000541060 | ENST00000282709 | HNRNPD | chr4 | 83294599 | - | SCD5 | chr4 | 83626566 | - |
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FusionProtFeatures for HNRNPD_SCD5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPD | SCD5 |
| Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPD_SCD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa >In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa >In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_44aa >In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC >In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC >In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_134nt ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCG >In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_901nt AAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGGAGAGAGCGGGAGTGTGCGCCGCGCGAGAGT GGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCCTTCCCTGTCTTGTGTGCTTCGCGAGGTAGA GCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCGGGTGTAGTCTCGGCGGCAGCGGCGGAGACA CTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGG GAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAG GGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCCTACTTCTGCTTCCTCCTGGCCGCTCTG GGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCC ATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTGTGATTTTGGAAGTTAACCCTTGAACAG AATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCTGAGACAGCAAGATCAGCCCCTCCTCCT CTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCACTTAATGAATAGTAAATATATTTTCTCTTCT >In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_931nt CCATTTTAGGTGGTCCGCGGCGGCGCCATTAAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGG AGAGAGCGGGAGTGTGCGCCGCGCGAGAGTGGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCC TTCCCTGTCTTGTGTGCTTCGCGAGGTAGAGCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCG GGTGTAGTCTCGGCGGCAGCGGCGGAGACACTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGG CGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCG GGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAG GCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCT CTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTG GTGTGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACC TCTGAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCAC >In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_524nt ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCG GAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGC CCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGC AGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTGTGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCG CAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCTGAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGC >In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_928nt TTTTAGGTGGTCCGCGGCGGCGCCATTAAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGGAGA GAGCGGGAGTGTGCGCCGCGCGAGAGTGGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCCTTC CCTGTCTTGTGTGCTTCGCGAGGTAGAGCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCGGGT GTAGTCTCGGCGGCAGCGGCGGAGACACTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGG TAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGG GCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCC TACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTG AGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTG TGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCT GAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCACTTA |
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FusionGenePPI for HNRNPD_SCD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HNRNPD | LSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, CYLD, TRIM25, UBE2A, HEY1 | SCD5 | CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPD_SCD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
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RelatedDiseases for HNRNPD_SCD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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