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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16568

FusionGeneSummary for HNRNPD_SCD5

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPD_SCD5
Fusion gene ID: 16568
HgeneTgene
Gene symbol

HNRNPD

SCD5

Gene ID

3184

79966

Gene nameheterogeneous nuclear ribonucleoprotein Dstearoyl-CoA desaturase 5
SynonymsAUF1|AUF1A|HNRPD|P37|hnRNPD0ACOD4|FADS4|HSCD5|SCD2|SCD4
Cytomap

4q21.22

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4
Modification date2018052320180523
UniProtAcc

Q14103

Q86SK9

Ensembl transtripts involved in fusion geneENST00000313899, ENST00000353341, 
ENST00000543098, ENST00000352301, 
ENST00000508119, ENST00000541060, 
ENST00000319540, ENST00000273908, 
ENST00000282709, 
Fusion gene scores* DoF score8 X 7 X 4=2244 X 2 X 5=40
# samples 85
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HNRNPD [Title/Abstract] AND SCD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSCD5

GO:0006636

unsaturated fatty acid biosynthetic process

15907797


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-ZJ-A8QO-01AHNRNPDchr4

83294599

-SCD5chr4

83626566

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313899ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000313899ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
In-frameENST00000313899ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000353341ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000353341ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
In-frameENST00000353341ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000543098ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000543098ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
In-frameENST00000543098ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000352301ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
Frame-shiftENST00000352301ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
In-frameENST00000352301ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-
intron-3CDSENST00000508119ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
intron-3CDSENST00000508119ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
intron-3CDSENST00000508119ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-
5UTR-3CDSENST00000541060ENST00000319540HNRNPDchr4

83294599

-SCD5chr4

83626566

-
5UTR-3CDSENST00000541060ENST00000273908HNRNPDchr4

83294599

-SCD5chr4

83626566

-
5UTR-3CDSENST00000541060ENST00000282709HNRNPDchr4

83294599

-SCD5chr4

83626566

-

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FusionProtFeatures for HNRNPD_SCD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPD

Q14103

SCD5

Q86SK9

Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPD_SCD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa

>In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa

>In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_44aa

>In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_77aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt
ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG
GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC

>In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt
ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG
GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC

>In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_134nt
ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCG

>In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_233nt
ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATG
GTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_HNRNPD_ENST00000313899_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_901nt
AAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGGAGAGAGCGGGAGTGTGCGCCGCGCGAGAGT
GGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCCTTCCCTGTCTTGTGTGCTTCGCGAGGTAGA
GCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCGGGTGTAGTCTCGGCGGCAGCGGCGGAGACA
CTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGCGGCTCGGCGGGCGAGCAGGAGG
GAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAG
GGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCCTACTTCTGCTTCCTCCTGGCCGCTCTG
GGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCC
ATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTGTGATTTTGGAAGTTAACCCTTGAACAG
AATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCTGAGACAGCAAGATCAGCCCCTCCTCCT
CTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCACTTAATGAATAGTAAATATATTTTCTCTTCT

>In-frame_HNRNPD_ENST00000353341_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_931nt
CCATTTTAGGTGGTCCGCGGCGGCGCCATTAAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGG
AGAGAGCGGGAGTGTGCGCCGCGCGAGAGTGGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCC
TTCCCTGTCTTGTGTGCTTCGCGAGGTAGAGCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCG
GGTGTAGTCTCGGCGGCAGCGGCGGAGACACTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGG
CGGTAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCG
GGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAG
GCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCT
CTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTG
GTGTGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACC
TCTGAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCAC

>In-frame_HNRNPD_ENST00000543098_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_524nt
ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCG
GAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGC
CCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGC
AGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTGTGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCG
CAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCTGAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGC

>In-frame_HNRNPD_ENST00000352301_chr4_83294599_-_SCD5_ENST00000282709_chr4_83626566_-_928nt
TTTTAGGTGGTCCGCGGCGGCGCCATTAAAGCGAGGAGGAGGCGAGAGCGGCCGCCGCTGGTGCTTATTCTTTTTTAGTGCAGCGGGAGA
GAGCGGGAGTGTGCGCCGCGCGAGAGTGGGAGGCGAAGGGGGCAGGCCAGGGAGAGGCGCAGGAGCCTTTGCAGCCACGCGCGCGCCTTC
CCTGTCTTGTGTGCTTCGCGAGGTAGAGCGGGCGCGCGGCAGCGGCGGGGATTACTTTGCTGCTAGTTTCGGTTCGCGGCAGCGGCGGGT
GTAGTCTCGGCGGCAGCGGCGGAGACACTAGCACTATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGG
TAGGCGGCTCGGCGGGCGAGCAGGAGGGAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCGGCGGGAAGCGGAGCCGGGACCGGGG
GCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGCGCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCC
TACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTG
AGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGGCAGCAGCAGAAGTGGTCCTGACCCAGATGCCCTGACAGCTTTTCCTGGTG
TGATTTTGGAAGTTAACCCTTGAACAGAATGGGTTTGAACTGCGCAGCTTCACTTAAATGCATGGATTTTCTTCTGCCTCCACCACCTCT
GAGACAGCAAGATCAGCCCCTCCTCCTCTCAGCCTACTCAATGCAAAGAAGACAAGGATGAAGACCTTTATGATGATCCACTTCCACTTA


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FusionGenePPI for HNRNPD_SCD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPDLSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, CYLD, TRIM25, UBE2A, HEY1SCD5CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPD_SCD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for HNRNPD_SCD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource