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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16563

FusionGeneSummary for HNRNPD_C4orf22

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPD_C4orf22
Fusion gene ID: 16563
HgeneTgene
Gene symbol

HNRNPD

C4orf22

Gene ID

3184

Gene nameheterogeneous nuclear ribonucleoprotein D
SynonymsAUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

4q21.22

Type of geneprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date20180523
UniProtAcc

Q14103

Q6V702

Ensembl transtripts involved in fusion geneENST00000313899, ENST00000353341, 
ENST00000543098, ENST00000352301, 
ENST00000508119, ENST00000541060, 
ENST00000358105, ENST00000508675, 
ENST00000512931, 
Fusion gene scores* DoF score8 X 7 X 4=2245 X 5 X 3=75
# samples 85
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPD [Title/Abstract] AND C4orf22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7820-01AHNRNPDchr4

83292681

-C4orf22chr4

81865964

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313899ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
Frame-shiftENST00000313899ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
5CDS-intronENST00000313899ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
Frame-shiftENST00000353341ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
Frame-shiftENST00000353341ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
5CDS-intronENST00000353341ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000543098ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000543098ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-intronENST00000543098ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000352301ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000352301ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-intronENST00000352301ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000508119ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000508119ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-intronENST00000508119ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000541060ENST00000358105HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-3CDSENST00000541060ENST00000508675HNRNPDchr4

83292681

-C4orf22chr4

81865964

+
intron-intronENST00000541060ENST00000512931HNRNPDchr4

83292681

-C4orf22chr4

81865964

+

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FusionProtFeatures for HNRNPD_C4orf22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPD

Q14103

C4orf22

Q6V702


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPD_C4orf22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPD_C4orf22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPDLSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, CYLD, TRIM25, UBE2A, HEY1C4orf22APP, BAG3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPD_C4orf22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for HNRNPD_C4orf22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource