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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16560

FusionGeneSummary for HNRNPDL_HNRNPDL

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPDL_HNRNPDL
Fusion gene ID: 16560
HgeneTgene
Gene symbol

HNRNPDL

HNRNPDL

Gene ID

9987

9987

Gene nameheterogeneous nuclear ribonucleoprotein D likeheterogeneous nuclear ribonucleoprotein D like
SynonymsHNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1
Cytomap

4q21.22

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1
Modification date2018052320180523
UniProtAcc

O14979

O14979

Ensembl transtripts involved in fusion geneENST00000295470, ENST00000349655, 
ENST00000602300, ENST00000502762, 
ENST00000514511, 
ENST00000295470, 
ENST00000349655, ENST00000602300, 
ENST00000502762, ENST00000514511, 
Fusion gene scores* DoF score5 X 6 X 1=307 X 7 X 3=147
# samples 69
** MAII scorelog2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPDL [Title/Abstract] AND HNRNPDL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X52767HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
ChiTaRS3.1BU607354HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000295470ENST00000295470HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000295470ENST00000349655HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000295470ENST00000602300HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000295470ENST00000502762HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000295470ENST00000514511HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-3CDSENST00000349655ENST00000295470HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000349655ENST00000349655HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000349655ENST00000602300HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000349655ENST00000502762HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000349655ENST00000514511HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-3CDSENST00000602300ENST00000295470HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000602300ENST00000349655HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000602300ENST00000602300HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000602300ENST00000502762HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000602300ENST00000514511HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-3CDSENST00000502762ENST00000295470HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000502762ENST00000349655HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000502762ENST00000602300HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000502762ENST00000502762HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000502762ENST00000514511HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-3CDSENST00000514511ENST00000295470HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000514511ENST00000349655HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000514511ENST00000602300HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000514511ENST00000502762HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-5UTRENST00000514511ENST00000514511HNRNPDLchr4

83349587

+HNRNPDLchr4

83350565

-
intron-3UTRENST00000295470ENST00000295470HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000295470ENST00000349655HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000295470ENST00000602300HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000295470ENST00000502762HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-intronENST00000295470ENST00000514511HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000349655ENST00000295470HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000349655ENST00000349655HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000349655ENST00000602300HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000349655ENST00000502762HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-intronENST00000349655ENST00000514511HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000602300ENST00000295470HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000602300ENST00000349655HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000602300ENST00000602300HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000602300ENST00000502762HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-intronENST00000602300ENST00000514511HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000502762ENST00000295470HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000502762ENST00000349655HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000502762ENST00000602300HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000502762ENST00000502762HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-intronENST00000502762ENST00000514511HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000514511ENST00000295470HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000514511ENST00000349655HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000514511ENST00000602300HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-3UTRENST00000514511ENST00000502762HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-
intron-intronENST00000514511ENST00000514511HNRNPDLchr4

83345864

+HNRNPDLchr4

83346021

-

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FusionProtFeatures for HNRNPDL_HNRNPDL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPDL

O14979

HNRNPDL

O14979

Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPDL_HNRNPDL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPDL_HNRNPDL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPDL_HNRNPDL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPDL_HNRNPDL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHNRNPDLC1836765LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder)1ORPHANET;UNIPROT
TgeneHNRNPDLC1836765LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder)1ORPHANET;UNIPROT