![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 16559 |
FusionGeneSummary for HNRNPDL_HAUS5 |
![]() |
Fusion gene information | Fusion gene name: HNRNPDL_HAUS5 | Fusion gene ID: 16559 | Hgene | Tgene | Gene symbol | HNRNPDL | HAUS5 | Gene ID | 9987 | 23354 |
Gene name | heterogeneous nuclear ribonucleoprotein D like | HAUS augmin like complex subunit 5 | |
Synonyms | HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1 | KIAA0841|dgt5 | |
Cytomap | 4q21.22 | 19q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1 | HAUS augmin-like complex subunit 5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O14979 | O94927 | |
Ensembl transtripts involved in fusion gene | ENST00000295470, ENST00000349655, ENST00000602300, ENST00000502762, ENST00000514511, | ENST00000203166, ENST00000379045, | |
Fusion gene scores | * DoF score | 5 X 6 X 1=30 | 2 X 2 X 1=4 |
# samples | 6 | 2 | |
** MAII score | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: HNRNPDL [Title/Abstract] AND HAUS5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | D20017 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000295470 | ENST00000203166 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-intron | ENST00000295470 | ENST00000379045 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-3UTR | ENST00000349655 | ENST00000203166 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-intron | ENST00000349655 | ENST00000379045 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-3UTR | ENST00000602300 | ENST00000203166 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-intron | ENST00000602300 | ENST00000379045 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-3UTR | ENST00000502762 | ENST00000203166 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-intron | ENST00000502762 | ENST00000379045 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-3UTR | ENST00000514511 | ENST00000203166 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
intron-intron | ENST00000514511 | ENST00000379045 | HNRNPDL | chr4 | 83347219 | - | HAUS5 | chr19 | 36115879 | + |
Top |
FusionProtFeatures for HNRNPDL_HAUS5 |
![]() |
Hgene | Tgene |
HNRNPDL | HAUS5 |
Acts as a transcriptional regulator. Promotestranscription repression. Promotes transcription activation indifferentiated myotubes (By similarity). Binds to double- andsingle-stranded DNA sequences. Binds to the transcriptionsuppressor CATR sequence of the COX5B promoter (By similarity).Binds with high affinity to RNA molecules that contain AU-richelements (AREs) found within the 3'-UTR of many proto-oncogenesand cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A)mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C)RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensussequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. | Contributes to mitotic spindle assembly, maintenance ofcentrosome integrity and completion of cytokinesis as part of theHAUS augmin-like complex. {ECO:0000269|PubMed:19369198,ECO:0000269|PubMed:19427217}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HNRNPDL_HAUS5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HNRNPDL_HAUS5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HNRNPDL_HAUS5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HNRNPDL_HAUS5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPDL | C1836765 | LIMB-GIRDLE MUSCULAR DYSTROPHY, TYPE 1G (disorder) | 1 | ORPHANET;UNIPROT |