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Fusion gene ID: 16550 |
FusionGeneSummary for HNRNPAB_SND1 |
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Fusion gene information | Fusion gene name: HNRNPAB_SND1 | Fusion gene ID: 16550 | Hgene | Tgene | Gene symbol | HNRNPAB | SND1 | Gene ID | 3182 | 27044 |
Gene name | heterogeneous nuclear ribonucleoprotein A/B | staphylococcal nuclease and tudor domain containing 1 | |
Synonyms | ABBP1|HNRPAB | TDRD11|Tudor-SN|p100 | |
Cytomap | 5q35.3 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein A/BABBP-1APOBEC1-binding protein 1apobec-1 binding protein 1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1hnRNP A/BhnRNP type A/B protein | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99729 | Q7KZF4 | |
Ensembl transtripts involved in fusion gene | ENST00000358344, ENST00000506339, ENST00000355836, ENST00000514633, ENST00000515193, ENST00000506259, ENST00000504898, | ENST00000354725, ENST00000467238, | |
Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 20 X 15 X 10=3000 |
# samples | 6 | 21 | |
** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/3000*10)=-3.83650126771712 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HNRNPAB [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF309478 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000358344 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000358344 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000506339 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000506339 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000355836 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000355836 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000514633 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000514633 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000515193 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000515193 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000506259 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000506259 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000504898 | ENST00000354725 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
5CDS-intron | ENST00000504898 | ENST00000467238 | HNRNPAB | chr5 | 177632936 | + | SND1 | chr7 | 127591552 | + |
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FusionProtFeatures for HNRNPAB_SND1 |
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Hgene | Tgene |
HNRNPAB | SND1 |
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNAtranscripts around the RNA editing site. | Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPAB_SND1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HNRNPAB_SND1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPAB_SND1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPAB_SND1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPAB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | SND1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SND1 | C0024121 | Lung Neoplasms | 1 | CTD_human |