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Fusion gene ID: 16544 |
FusionGeneSummary for HNRNPA3_PTPN1 |
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Fusion gene information | Fusion gene name: HNRNPA3_PTPN1 | Fusion gene ID: 16544 | Hgene | Tgene | Gene symbol | HNRNPA3 | PTPN1 | Gene ID | 220988 | 5770 |
Gene name | heterogeneous nuclear ribonucleoprotein A3 | protein tyrosine phosphatase, non-receptor type 1 | |
Synonyms | 2610510D13Rik|D10S102|FBRNP|HNRPA3 | PTP1B | |
Cytomap | 2q31.2 | 20q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein A3 | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P51991 | P18031 | |
Ensembl transtripts involved in fusion gene | ENST00000392524, ENST00000411529, ENST00000435711, | ENST00000371621, ENST00000541713, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 5 X 5=175 |
# samples | 3 | 10 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(10/175*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HNRNPA3 [Title/Abstract] AND PTPN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
Tgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
Tgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
Tgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
Tgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF877638 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + | ||
ChiTaRS3.1 | BF877639 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000392524 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
intron-intron | ENST00000392524 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
3UTR-intron | ENST00000411529 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
3UTR-intron | ENST00000411529 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
intron-intron | ENST00000435711 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
intron-intron | ENST00000435711 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
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FusionProtFeatures for HNRNPA3_PTPN1 |
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Hgene | Tgene |
HNRNPA3 | PTPN1 |
Plays a role in cytoplasmic trafficking of RNA. Binds tothe cis-acting response element, A2RE. May be involved in pre-mRNAsplicing. {ECO:0000269|PubMed:11886857}. | Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPA3_PTPN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HNRNPA3_PTPN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPA3_PTPN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PTPN1 | P18031 | DB01133 | Tiludronic acid | Tyrosine-protein phosphatase non-receptor type 1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for HNRNPA3_PTPN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPA3 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | PTPN1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | PTPN1 | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | PTPN1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PTPN1 | C0025063 | Mediastinal Neoplasms | 1 | CTD_human |
Tgene | PTPN1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PTPN1 | C0035372 | Rett Syndrome | 1 | CTD_human |
Tgene | PTPN1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PTPN1 | C0079731 | B-Cell Lymphomas | 1 | CTD_human |