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Fusion gene ID: 16521 |
FusionGeneSummary for HNRNPA1_CSN2 |
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Fusion gene information | Fusion gene name: HNRNPA1_CSN2 | Fusion gene ID: 16521 | Hgene | Tgene | Gene symbol | HNRNPA1 | CSN2 | Gene ID | 3178 | 9318 |
Gene name | heterogeneous nuclear ribonucleoprotein A1 | COP9 signalosome subunit 2 | |
Synonyms | ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1 | ALIEN|CSN2|SGN2|TRIP15 | |
Cytomap | 12q13.13 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | heterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-lik | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P09651 | P05814 | |
Ensembl transtripts involved in fusion gene | ENST00000546500, ENST00000340913, ENST00000330752, ENST00000547276, ENST00000551803, | ENST00000353151, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 14 X 11 X 2=308 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/308*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HNRNPA1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HNRNPA1 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 23935072 |
Hgene | HNRNPA1 | GO:0051168 | nuclear export | 8521471 |
Hgene | HNRNPA1 | GO:0051170 | import into nucleus | 8521471 |
Hgene | HNRNPA1 | GO:1903936 | cellular response to sodium arsenite | 27694260 |
Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A1KO-01A | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000546500 | ENST00000353151 | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
3UTR-3CDS | ENST00000340913 | ENST00000353151 | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
intron-3CDS | ENST00000330752 | ENST00000353151 | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
3UTR-3CDS | ENST00000547276 | ENST00000353151 | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
intron-3CDS | ENST00000551803 | ENST00000353151 | HNRNPA1 | chr12 | 54678888 | + | CSN2 | chr4 | 70823333 | - |
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FusionProtFeatures for HNRNPA1_CSN2 |
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Hgene | Tgene |
HNRNPA1 | CSN2 |
Involved in the packaging of pre-mRNA into hnRNPparticles, transport of poly(A) mRNA from the nucleus to thecytoplasm and may modulate splice site selection(PubMed:17371836). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:17371836,ECO:0000269|PubMed:28431233}. (Microbial infection) May play a role in HCV RNAreplication. {ECO:0000269|PubMed:17229681}. | Important role in determination of the surfaceproperties of the casein micelles. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HNRNPA1_CSN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HNRNPA1_CSN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HNRNPA1 | PRRC2A, FEN1, PRMT1, KHSRP, HNRNPA1, NFKBIA, SAFB, RRP1B, MEPCE, CDK9, DDX17, DDX5, HSP90AB1, IGF2BP1, IGF2BP3, UBR2, HNRNPA2B1, HNRNPH1, HNRNPK, HNRNPR, ILF2, ILF3, SYNCRIP, KHDRBS2, RPAP1, HNRNPUL2, IGF2BP2, LARP7, HNRNPM, RBMX, HNRNPC, HSPA9, SRP72, MRPS27, PABPC1, CCNT1, ZFR, YTHDF2, RBM39, HSPA2, GTF2E2, KIAA0368, ARHGAP23, SYTL2, ARID2, HNRNPAB, PABPC4, PRMT8, HNRNPCL2, TARDBP, UBR1, GTF2A1, PLOD3, PURA, MOV10, HNRNPA1P70, HNRNPDL, PLOD2, ROCK1, CENPC, CAPN2, HNRNPL, MRPL37, FRMD4A, NNT, SAP25, SRRM2, TOPORS, H2AFX, SMN1, CD4, HDAC5, NOP56, NR3C1, TOP1, PSMA3, VHL, SREK1, ELAVL1, SF3A2, ARRB1, ARRB2, XRN2, PTBP1, FIP1L1, NONO, CPSF2, NUDT21, SFPQ, CPSF6, CSTF3, CSTF1, SNRNP200, PUF60, PRPF8, SUGP2, SRSF4, PRPF4, SRSF1, CDC5L, PNN, SRSF6, PRPF19, SNRPD1, SNRPD2, SNRPD3, AQR, XAB2, HNRNPD, HNRNPH2, HNRNPF, HNRNPH3, DDX1, DHX15, DDX21, DDX28, DDX23, DHX30, DHX9, EWSR1, RBM26, ADAR, RBM12, RBM7, RBM14, AKAP8, LMNB1, NUP205, NCBP1, ALYREF, MLLT4, WDR82, NFATC1, NFATC2, NKRF, MEF2A, RAD50, G3BP1, BRINP1, WDR33, PTCD1, PTCD3, GADD45GIP1, ZNF326, ACIN1, CARF, XRCC6, PPIA, LRPPRC, XRCC5, SRRT, PRKDC, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, RN7SK, BRCA1, RNF14, XIAP, HIPK3, SRSF7, APP, HNRNPU, SF3B6, PHF5A, RPS8, RPS3A, RPS6, RPSA, CPSF7, RPLP2, RPS5, RPS21, RPS3, HSP90AA1, CLIC4, RBM3, PPP5C, ESR1, LIG4, SMURF1, CTNNB1, VCP, FN1, VCAM1, PPIL1, TRA2B, IFIT2, IFIT3, NOS2, ITGA4, PRMT2, PRMT3, CARM1, PAN2, CD81, IGSF8, ICAM1, HMGA1, LMNA, CSF2, NR0B2, TFEC, XRN1, SRPK1, YWHAQ, FBXO6, PARK2, AIMP2, HIST1H2AB, CCAR2, QARS, RPL27A, RPL38, IQGAP1, ZC3HC1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, PSMD9, CHUK, TNF, PSMB4, IVNS1ABP, STAU1, AURKA, AURKB, NEDD1, TP53, TUBGCP3, HIST3H3, CUL7, OBSL1, CCDC8, EED, RNF2, FBXW11, MRPL16, MRPL28, MRPS18A, MRPL4, RPL26, RPS27A, MTERF3, FAM120A, STRBP, NGRN, UPF1, PDCD11, YARS2, RPS7, MRPS23, HNRNPA1L2, TRUB2, MRPL9, MRPL32, MRPL3, ZCCHC3, MRPS10, DAP3, MRPL1, LARP1, LARP1B, FASTKD2, MRPS5, MRPS7, MRPS22, MRPL10, RPS15, MRPL44, MRPS9, PAIP2, PAIP2B, PRKRIR, MRPL27, MALSU1, DHX36, MRPL47, DUSP11, MRPS24, YTHDC1, RALY, RBMS1, MRPL15, MRPL21, MRPL13, MCAT, FARS2, ICT1, DNTTIP2, MRPS18C, RPUSD3, MRPL57, SUPV3L1, MRPL52, RPS6KB2, PDCD4, BCL2L1, YWHAE, YWHAZ, A2ML1, ACTB, ADA, AKR1B10, ALB, ALDOA, ANGEL2, ANXA1, ANXA2, ARF3, ARG1, ASPRV1, ATP5A1, ATP5B, STRAP, C14orf166, C1orf68, RTCB, C3, CALML3, CALML5, CANX, CAPRIN1, CDKN2AIP, CFL1, CKMT1A, CLTC, YBX3, CTSD, DCD, DDX3X, DDX6, DIMT1, DNAJC10, DSG1, DSP, EEF1A1, EEF1G, EEF2, EIF2B1, EIF2B3, EIF3H, EIF4A2, EIF4A3, ENO1, EPPK1, FAM120C, FAM35A, FAM98B, FLG, FLG2, FLNA, FUS, G3BP2, GADD45A, GAPDH, GDE1, GM2A, GNB2L1, GSN, GSTP1, GTF2I, H1FX, H3F3A, HAL, HIST1H1E, HNRNPA0, HNRNPA3, HNRNPUL1, HRNR, HSPA1A, HSPA8, HSPB1, HSPD1, IL36G, IVL, JUP, KPRP, KRT1, KRT10, KRT14, KRT15, KRT16, KRT17, KRT2, KRT33A, KRT34, KRT5, KRT6A, KRT6B, KRT6C, KRT78, KRT79, KRT80, KRT83, KRT9, LAMP1, SSB, LCN2, LDHA, LGALS7, LTV1, MARK2, MATR3, MRPL11, MRPL18, MRPL19, MRPL22, MRPL24, MRPL38, MRPL39, MRPL43, MRPL45, MRPL46, MRPL48, MRPS15, MRPS18B, MRPS2, MRPS28, MRPS30, MRPS31, MRPS35, MX1, MYH9, MYL12A, NAMPT, NCCRP1, NCL, NSUN5, NXF1, P4HB, PCBP2, PFN1, PGK1, PHB2, PICALM, PKM, PKP1, PLOD1, PNO1, PNP, POF1B, POLDIP3, PPL, PPP2R1A, PRDX1, PRPF31, PRSS3, MAEL, AASDHPPT, ACAA2, ANXA5, CARS, CDC42, CYB5B, EIF4EBP1, FDPS, HMBS, ATP5F1, CRIP1, DUT, GART, GLO1, KAT8, MSN, PAPOLA, PHGDH, PROSC, PRRC1, RAB1A, UBE2I, UBE2K, ITPA, MSI2, SEC31A, NTRK1, SCARNA22, SRPK2, CLK1, XPO1, AHSA1, ADARB1, CIRBP, GTF2F1, SEC16A, ZWINT, EXOSC4, PARD6B, TAF15, TNK1, FUBP3, APOBEC3B, SAFB2, RBM6, KHDRBS1, ZNF638, YLPM1, NCOA5, NBEAL1, SCAI, RBM12B, GAN, UBQLN2, MCM2, MCM5, SNW1, U2AF2, MRPL35, RPS15A, C17orf89, CYLD, COX15, PDHA1, SDHA, TRIM25, HEY1, MTF1, HIST1H3A | CSN2 | CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HNRNPA1_CSN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPA1_CSN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HNRNPA1 | C3715156 | AMYOTROPHIC LATERAL SCLEROSIS 20 | 2 | UNIPROT |
Hgene | HNRNPA1 | C3809469 | INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 3 | 2 | UNIPROT |
Hgene | HNRNPA1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | HNRNPA1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |