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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16521

FusionGeneSummary for HNRNPA1_CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPA1_CSN2
Fusion gene ID: 16521
HgeneTgene
Gene symbol

HNRNPA1

CSN2

Gene ID

3178

9318

Gene nameheterogeneous nuclear ribonucleoprotein A1COP9 signalosome subunit 2
SynonymsALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1ALIEN|CSN2|SGN2|TRIP15
Cytomap

12q13.13

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-likCOP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15
Modification date2018052320180523
UniProtAcc

P09651

P05814

Ensembl transtripts involved in fusion geneENST00000546500, ENST00000340913, 
ENST00000330752, ENST00000547276, 
ENST00000551803, 
ENST00000353151, 
Fusion gene scores* DoF score2 X 2 X 2=814 X 11 X 2=308
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/308*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPA1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPA1

GO:0032212

positive regulation of telomere maintenance via telomerase

23935072

HgeneHNRNPA1

GO:0051168

nuclear export

8521471

HgeneHNRNPA1

GO:0051170

import into nucleus

8521471

HgeneHNRNPA1

GO:1903936

cellular response to sodium arsenite

27694260

TgeneCSN2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A1KO-01AHNRNPA1chr12

54678888

+CSN2chr4

70823333

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000546500ENST00000353151HNRNPA1chr12

54678888

+CSN2chr4

70823333

-
3UTR-3CDSENST00000340913ENST00000353151HNRNPA1chr12

54678888

+CSN2chr4

70823333

-
intron-3CDSENST00000330752ENST00000353151HNRNPA1chr12

54678888

+CSN2chr4

70823333

-
3UTR-3CDSENST00000547276ENST00000353151HNRNPA1chr12

54678888

+CSN2chr4

70823333

-
intron-3CDSENST00000551803ENST00000353151HNRNPA1chr12

54678888

+CSN2chr4

70823333

-

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FusionProtFeatures for HNRNPA1_CSN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPA1

P09651

CSN2

P05814

Involved in the packaging of pre-mRNA into hnRNPparticles, transport of poly(A) mRNA from the nucleus to thecytoplasm and may modulate splice site selection(PubMed:17371836). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:17371836,ECO:0000269|PubMed:28431233}. (Microbial infection) May play a role in HCV RNAreplication. {ECO:0000269|PubMed:17229681}. Important role in determination of the surfaceproperties of the casein micelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPA1_CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HNRNPA1_CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPA1PRRC2A, FEN1, PRMT1, KHSRP, HNRNPA1, NFKBIA, SAFB, RRP1B, MEPCE, CDK9, DDX17, DDX5, HSP90AB1, IGF2BP1, IGF2BP3, UBR2, HNRNPA2B1, HNRNPH1, HNRNPK, HNRNPR, ILF2, ILF3, SYNCRIP, KHDRBS2, RPAP1, HNRNPUL2, IGF2BP2, LARP7, HNRNPM, RBMX, HNRNPC, HSPA9, SRP72, MRPS27, PABPC1, CCNT1, ZFR, YTHDF2, RBM39, HSPA2, GTF2E2, KIAA0368, ARHGAP23, SYTL2, ARID2, HNRNPAB, PABPC4, PRMT8, HNRNPCL2, TARDBP, UBR1, GTF2A1, PLOD3, PURA, MOV10, HNRNPA1P70, HNRNPDL, PLOD2, ROCK1, CENPC, CAPN2, HNRNPL, MRPL37, FRMD4A, NNT, SAP25, SRRM2, TOPORS, H2AFX, SMN1, CD4, HDAC5, NOP56, NR3C1, TOP1, PSMA3, VHL, SREK1, ELAVL1, SF3A2, ARRB1, ARRB2, XRN2, PTBP1, FIP1L1, NONO, CPSF2, NUDT21, SFPQ, CPSF6, CSTF3, CSTF1, SNRNP200, PUF60, PRPF8, SUGP2, SRSF4, PRPF4, SRSF1, CDC5L, PNN, SRSF6, PRPF19, SNRPD1, SNRPD2, SNRPD3, AQR, XAB2, HNRNPD, HNRNPH2, HNRNPF, HNRNPH3, DDX1, DHX15, DDX21, DDX28, DDX23, DHX30, DHX9, EWSR1, RBM26, ADAR, RBM12, RBM7, RBM14, AKAP8, LMNB1, NUP205, NCBP1, ALYREF, MLLT4, WDR82, NFATC1, NFATC2, NKRF, MEF2A, RAD50, G3BP1, BRINP1, WDR33, PTCD1, PTCD3, GADD45GIP1, ZNF326, ACIN1, CARF, XRCC6, PPIA, LRPPRC, XRCC5, SRRT, PRKDC, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, RN7SK, BRCA1, RNF14, XIAP, HIPK3, SRSF7, APP, HNRNPU, SF3B6, PHF5A, RPS8, RPS3A, RPS6, RPSA, CPSF7, RPLP2, RPS5, RPS21, RPS3, HSP90AA1, CLIC4, RBM3, PPP5C, ESR1, LIG4, SMURF1, CTNNB1, VCP, FN1, VCAM1, PPIL1, TRA2B, IFIT2, IFIT3, NOS2, ITGA4, PRMT2, PRMT3, CARM1, PAN2, CD81, IGSF8, ICAM1, HMGA1, LMNA, CSF2, NR0B2, TFEC, XRN1, SRPK1, YWHAQ, FBXO6, PARK2, AIMP2, HIST1H2AB, CCAR2, QARS, RPL27A, RPL38, IQGAP1, ZC3HC1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, PSMD9, CHUK, TNF, PSMB4, IVNS1ABP, STAU1, AURKA, AURKB, NEDD1, TP53, TUBGCP3, HIST3H3, CUL7, OBSL1, CCDC8, EED, RNF2, FBXW11, MRPL16, MRPL28, MRPS18A, MRPL4, RPL26, RPS27A, MTERF3, FAM120A, STRBP, NGRN, UPF1, PDCD11, YARS2, RPS7, MRPS23, HNRNPA1L2, TRUB2, MRPL9, MRPL32, MRPL3, ZCCHC3, MRPS10, DAP3, MRPL1, LARP1, LARP1B, FASTKD2, MRPS5, MRPS7, MRPS22, MRPL10, RPS15, MRPL44, MRPS9, PAIP2, PAIP2B, PRKRIR, MRPL27, MALSU1, DHX36, MRPL47, DUSP11, MRPS24, YTHDC1, RALY, RBMS1, MRPL15, MRPL21, MRPL13, MCAT, FARS2, ICT1, DNTTIP2, MRPS18C, RPUSD3, MRPL57, SUPV3L1, MRPL52, RPS6KB2, PDCD4, BCL2L1, YWHAE, YWHAZ, A2ML1, ACTB, ADA, AKR1B10, ALB, ALDOA, ANGEL2, ANXA1, ANXA2, ARF3, ARG1, ASPRV1, ATP5A1, ATP5B, STRAP, C14orf166, C1orf68, RTCB, C3, CALML3, CALML5, CANX, CAPRIN1, CDKN2AIP, CFL1, CKMT1A, CLTC, YBX3, CTSD, DCD, DDX3X, DDX6, DIMT1, DNAJC10, DSG1, DSP, EEF1A1, EEF1G, EEF2, EIF2B1, EIF2B3, EIF3H, EIF4A2, EIF4A3, ENO1, EPPK1, FAM120C, FAM35A, FAM98B, FLG, FLG2, FLNA, FUS, G3BP2, GADD45A, GAPDH, GDE1, GM2A, GNB2L1, GSN, GSTP1, GTF2I, H1FX, H3F3A, HAL, HIST1H1E, HNRNPA0, HNRNPA3, HNRNPUL1, HRNR, HSPA1A, HSPA8, HSPB1, HSPD1, IL36G, IVL, JUP, KPRP, KRT1, KRT10, KRT14, KRT15, KRT16, KRT17, KRT2, KRT33A, KRT34, KRT5, KRT6A, KRT6B, KRT6C, KRT78, KRT79, KRT80, KRT83, KRT9, LAMP1, SSB, LCN2, LDHA, LGALS7, LTV1, MARK2, MATR3, MRPL11, MRPL18, MRPL19, MRPL22, MRPL24, MRPL38, MRPL39, MRPL43, MRPL45, MRPL46, MRPL48, MRPS15, MRPS18B, MRPS2, MRPS28, MRPS30, MRPS31, MRPS35, MX1, MYH9, MYL12A, NAMPT, NCCRP1, NCL, NSUN5, NXF1, P4HB, PCBP2, PFN1, PGK1, PHB2, PICALM, PKM, PKP1, PLOD1, PNO1, PNP, POF1B, POLDIP3, PPL, PPP2R1A, PRDX1, PRPF31, PRSS3, MAEL, AASDHPPT, ACAA2, ANXA5, CARS, CDC42, CYB5B, EIF4EBP1, FDPS, HMBS, ATP5F1, CRIP1, DUT, GART, GLO1, KAT8, MSN, PAPOLA, PHGDH, PROSC, PRRC1, RAB1A, UBE2I, UBE2K, ITPA, MSI2, SEC31A, NTRK1, SCARNA22, SRPK2, CLK1, XPO1, AHSA1, ADARB1, CIRBP, GTF2F1, SEC16A, ZWINT, EXOSC4, PARD6B, TAF15, TNK1, FUBP3, APOBEC3B, SAFB2, RBM6, KHDRBS1, ZNF638, YLPM1, NCOA5, NBEAL1, SCAI, RBM12B, GAN, UBQLN2, MCM2, MCM5, SNW1, U2AF2, MRPL35, RPS15A, C17orf89, CYLD, COX15, PDHA1, SDHA, TRIM25, HEY1, MTF1, HIST1H3ACSN2CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPA1_CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPA1_CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHNRNPA1C3715156AMYOTROPHIC LATERAL SCLEROSIS 202UNIPROT
HgeneHNRNPA1C3809469INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 32UNIPROT
HgeneHNRNPA1C0024667Animal Mammary Neoplasms1CTD_human
HgeneHNRNPA1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCSN2C0024667Animal Mammary Neoplasms2CTD_human
TgeneCSN2C0024668Mammary Neoplasms, Experimental2CTD_human