FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 16516

FusionGeneSummary for HNF4G_AFM

check button Fusion gene summary
Fusion gene informationFusion gene name: HNF4G_AFM
Fusion gene ID: 16516
HgeneTgene
Gene symbol

HNF4G

AFM

Gene ID

3174

173

Gene namehepatocyte nuclear factor 4 gammaafamin
SynonymsNR2A2|NR2A3ALB2|ALBA|ALF
Cytomap

8q21.13

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionhepatocyte nuclear factor 4-gammaHNF-4-gammanuclear receptor subfamily 2 group A member 2afaminalpha-Albalpha-albumin
Modification date2018051920180519
UniProtAcc

Q14541

P43652

Ensembl transtripts involved in fusion geneENST00000494318, ENST00000354370, 
ENST00000396423, 
ENST00000226355, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: HNF4G [Title/Abstract] AND AFM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNF4G

GO:0045944

positive regulation of transcription by RNA polymerase II

23896584

TgeneAFM

GO:0050821

protein stabilization

26902720

TgeneAFM

GO:0051180

vitamin transport

12463752|19046407


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1L32140HNF4Gchr8

76327636

-AFMchr4

74347463

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000494318ENST00000226355HNF4Gchr8

76327636

-AFMchr4

74347463

+
intron-5UTRENST00000354370ENST00000226355HNF4Gchr8

76327636

-AFMchr4

74347463

+
intron-5UTRENST00000396423ENST00000226355HNF4Gchr8

76327636

-AFMchr4

74347463

+

Top

FusionProtFeatures for HNF4G_AFM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNF4G

Q14541

AFM

P43652

Transcription factor. Has a lower transcriptionactivation potential than HNF4-alpha. Functions as carrier for hydrophobic molecules in bodyfluids (Probable). Essential for the solubility and activity oflipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A,WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B(PubMed:26902720). Binds vitamin E (PubMed:15952736,PubMed:12463752). May transport vitamin E in body fluids underconditions where the lipoprotein system is not sufficient(PubMed:15952736). May be involved in the transport of vitamin Eacross the blood-brain barrier (PubMed:19046407).{ECO:0000269|PubMed:12463752, ECO:0000269|PubMed:15952736,ECO:0000269|PubMed:19046407, ECO:0000269|PubMed:26902720,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HNF4G_AFM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HNF4G_AFM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HNF4G_AFM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HNF4G_AFM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAFMC0023893Liver Cirrhosis, Experimental1CTD_human