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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1651

FusionGeneSummary for ANAPC4_RTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC4_RTN4
Fusion gene ID: 1651
HgeneTgene
Gene symbol

ANAPC4

RTN4

Gene ID

29945

57142

Gene nameanaphase promoting complex subunit 4reticulon 4
SynonymsAPC4ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

4p15.2

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 4cyclosome subunit 4reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2018052320180523
UniProtAcc

Q9UJX5

Q9NQC3

Ensembl transtripts involved in fusion geneENST00000315368, ENST00000510092, 
ENST00000394609, ENST00000405240, 
ENST00000357376, ENST00000317610, 
ENST00000357732, ENST00000337526, 
ENST00000394611, ENST00000404909, 
ENST00000486085, ENST00000354474, 
ENST00000402434, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 19 X 5=1235
# samples 223
** MAII scorelog2(2/8*10)=1.32192809488736log2(23/1235*10)=-2.42480527552766
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC4 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC4

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W68688ANAPC4chr4

25419961

-RTN4chr2

55209717

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000315368ENST00000394609ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000405240ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000357376ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000317610ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000357732ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000337526ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000394611ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000404909ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000315368ENST00000486085ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000315368ENST00000354474ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000315368ENST00000402434ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000394609ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000405240ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000357376ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000317610ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000357732ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000337526ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000394611ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000404909ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000486085ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000354474ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000402434ANAPC4chr4

25419961

-RTN4chr2

55209717

+

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FusionProtFeatures for ANAPC4_RTN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC4

Q9UJX5

RTN4

Q9NQC3

Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-07143_148-82374Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-0730_47-82374Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-09143_148-821193Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-0930_47-821193Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-09143_148-61987Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-0930_47-61987Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-08143_148-82393Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-0830_47-82393Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-07143_148-110200Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-0730_47-110200Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-09143_148-78987Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-0930_47-78987Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-09143_148-58987Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-0930_47-58987Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-09143_148-45987Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-0930_47-45987Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071005_1192-82374DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091005_1192-821193DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091005_1192-61987DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081005_1192-82393DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071005_1192-110200DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091005_1192-78987DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091005_1192-58987DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091005_1192-45987DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071040_1133-82374Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071155_1192-82374Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071_1018-82374Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091040_1133-821193Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091155_1192-821193Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091_1018-821193Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091040_1133-61987Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091155_1192-61987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091_1018-61987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081040_1133-82393Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081155_1192-82393Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081_1018-82393Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071040_1133-110200Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071155_1192-110200Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071_1018-110200Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091040_1133-78987Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091155_1192-78987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091_1018-78987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091040_1133-58987Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091155_1192-58987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091_1018-58987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091040_1133-45987Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091155_1192-45987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091_1018-45987Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071019_1039-82374TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610-071134_1154-82374TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091019_1039-821193TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526-091134_1154-821193TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091019_1039-61987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376-091134_1154-61987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081019_1039-82393TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732-081134_1154-82393TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071019_1039-110200TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609-071134_1154-110200TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091019_1039-78987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611-091134_1154-78987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091019_1039-58987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909-091134_1154-58987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091019_1039-45987TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240-091134_1154-45987TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANAPC4_RTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0aa

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000315368_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394609_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000405240_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357376_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000317610_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000357732_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000337526_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000394611_chr2_55209717_+_0nt

>In-frame_ANAPC4_ENST00000510092_chr4_25419961_-_RTN4_ENST00000404909_chr2_55209717_+_0nt


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FusionGenePPI for ANAPC4_RTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANAPC4_RTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANAPC4_RTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRTN4C0005586Bipolar Disorder1PSYGENET
TgeneRTN4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRTN4C0036341Schizophrenia1CTD_human