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Fusion gene ID: 16481 |
FusionGeneSummary for HMGN2_WDTC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGN2_WDTC1 | Fusion gene ID: 16481 | Hgene | Tgene | Gene symbol | HMGN2 | WDTC1 | Gene ID | 3151 | 23038 |
| Gene name | high mobility group nucleosomal binding domain 2 | WD and tetratricopeptide repeats 1 | |
| Synonyms | HMG17 | ADP|DCAF9 | |
| Cytomap | 1p36.11 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | non-histone chromosomal protein HMG-17high mobility group nucleosome-binding domain-containing protein 2high mobility group protein N2high-mobility group (nonhistone chromosomal) protein 17nonhistone chromosomal protein HMG-17 | WD and tetratricopeptide repeats protein 1DDB1 and CUL4 associated factor 9adipose homolog | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P05204 | Q8N5D0 | |
| Ensembl transtripts involved in fusion gene | ENST00000361427, ENST00000493418, | ENST00000319394, ENST00000361771, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 7 X 9=567 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/567*10)=-2.36584521141757 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HMGN2 [Title/Abstract] AND WDTC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-04-1337-01A | HMGN2 | chr1 | 26801158 | + | WDTC1 | chr1 | 27614165 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361427 | ENST00000319394 | HMGN2 | chr1 | 26801158 | + | WDTC1 | chr1 | 27614165 | + |
| In-frame | ENST00000361427 | ENST00000361771 | HMGN2 | chr1 | 26801158 | + | WDTC1 | chr1 | 27614165 | + |
| 3UTR-3CDS | ENST00000493418 | ENST00000319394 | HMGN2 | chr1 | 26801158 | + | WDTC1 | chr1 | 27614165 | + |
| 3UTR-3CDS | ENST00000493418 | ENST00000361771 | HMGN2 | chr1 | 26801158 | + | WDTC1 | chr1 | 27614165 | + |
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FusionProtFeatures for HMGN2_WDTC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGN2 | WDTC1 |
| Binds to the inner side of the nucleosomal DNA thusaltering the interaction between the DNA and the histone octamer.May be involved in the process which maintains transcribable genesin a unique chromatin conformation (By similarity). {ECO:0000250}. | May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 132_172 | 97 | 678 | Repeat | Note=WD 3 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 182_222 | 97 | 678 | Repeat | Note=WD 4 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 265_305 | 97 | 678 | Repeat | Note=WD 5 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 362_395 | 97 | 678 | Repeat | Note=TPR 1 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 397_432 | 97 | 678 | Repeat | Note=TPR 2 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 535_575 | 97 | 678 | Repeat | Note=WD 6 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 578_617 | 97 | 678 | Repeat | Note=WD 7 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 132_172 | 97 | 677 | Repeat | Note=WD 3 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 182_222 | 97 | 677 | Repeat | Note=WD 4 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 265_305 | 97 | 677 | Repeat | Note=WD 5 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 362_395 | 97 | 677 | Repeat | Note=TPR 1 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 397_432 | 97 | 677 | Repeat | Note=TPR 2 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 535_575 | 97 | 677 | Repeat | Note=WD 6 |
| Tgene | >WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 578_617 | 97 | 677 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 45_84 | 97 | 678 | Repeat | Note=WD 1 |
| Tgene | WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000319394 | + | 4 | 16 | 88_129 | 97 | 678 | Repeat | Note=WD 2 |
| Tgene | WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 45_84 | 97 | 677 | Repeat | Note=WD 1 |
| Tgene | WDTC1 | chr1:26801158 | chr1:27614165 | ENST00000361771 | + | 4 | 16 | 88_129 | 97 | 677 | Repeat | Note=WD 2 |
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FusionGeneSequence for HMGN2_WDTC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000319394_chr1_27614165_+_660aa MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQFLPHAGDRILI TGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNN CLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTFSPNGTELLVNMG GEQVYLFDLTYKQRPYTFLLPRKCHSSGEVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQW TQAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAH SSACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSRKDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSD DGSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNADPLEVMLLNMG >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000361771_chr1_27614165_+_659aa MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQFLPHAGDRILI TGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNN CLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTFSPNGTELLVNMG GEQVYLFDLTYKQRPYTFLLPRKCHSSGVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQWT QAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHS SACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSRKDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDD GSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNADPLEVMLLNMGY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000319394_chr1_27614165_+_1980nt ATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAGGGAGATAAAGCAAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTCTGCT AAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAAAGCT GATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAATGGAGATGCCAAAACAGACCAGTTCCTGCCTCACGCTGGGGACCGCATCTTGATC ACGGGGGCAGCCGACTCTAAGGTGCATGTGCACGACCTGACAGTAAAGGAGACCATCCACATGTTTGGAGACCACACAAACCGGGTGAAG CGCATCGCCACAGCGCCCATGTGGCCCAACACATTCTGGAGTGCTGCTGAGGATGGGCTTATCCGCCAGTATGACCTTCGAGAGAACAGC AAACACTCGGAGGTGCTGATTGACCTGACAGAGTACTGTGGCCAGCTGGTGGAGGCCAAGTGCCTCACTGTCAACCCCCAGGACAACAAC TGCCTGGCAGTTGGGGCCAGCGGGCCCTTCGTGAGGCTCTATGACATCCGCATGATCCATAACCACAGAAAGAGCATGAAGCAGAGCCCT TCAGCGGGTGTGCACACCTTCTGTGACCGGCAGAAACCCCTTCCGGACGGTGCAGCCCAGTATTACGTAGCAGGTCACCTGCCAGTGAAG CTTCCTGACTACAACAACCGTTTGAGAGTGCTGGTTGCCACCTATGTGACCTTCAGCCCCAATGGCACAGAGCTACTAGTCAACATGGGG GGGGAACAGGTCTATTTGTTTGACTTGACTTACAAGCAGCGGCCGTACACCTTCCTCTTGCCTAGAAAATGCCACTCCTCGGGGGAAGTC CAGAATGGCAAGATGTCCACCAACGGTGTGTCCAACGGTGTGTCCAATGGCCTGCACCTTCATAGCAATGGCTTCCGGCTGCCGGAGAGT AGGGGACATGTCAGCCCCCAAGTAGAGCTACCACCATACCTGGAGCGTGTGAAACAGCAAGCCAATGAGGCTTTTGCCTGCCAGCAGTGG ACCCAAGCCATTCAGCTTTACAGCAAGGCTGTGCAGAGGGCCCCTCACAATGCCATGCTTTATGGAAACCGAGCAGCAGCCTACATGAAG CGCAAGTGGGATGGTGACCACTATGATGCCCTGAGGGACTGCCTCAAGGCCATCTCCCTAAACCCATGCCACCTGAAGGCACACTTTCGC CTGGCCCGCTGCCTCTTTGAGCTCAAGTATGTGGCTGAAGCCCTGGAGTGCCTGGACGACTTCAAAGGGAAATTTCCGGAGCAGGCCCAC AGCAGCGCTTGTGATGCATTGGGCCGCGACATCACAGCTGCCCTCTTCTCTAAAAATGATGGTGAGGAGAAGAAGGGACCTGGTGGCGGC GCCCCAGTCCGCCTCCGCAGCACGAGCCGCAAGGACTCCATCTCAGAGGATGAAATGGTGCTGCGGGAGCGAAGCTACGACTATCAGTTC CGCTACTGCGGCCACTGCAACACCACCACGGATATCAAAGAGGCCAATTTCTTTGGCAGCAACGCTCAGTATATCGTCAGTGGCTCTGAC GATGGCTCCTTCTTCATCTGGGAAAAGGAGACCACCAACCTGGTCCGTGTGCTCCAAGGGGATGAGTCCATTGTCAACTGCCTGCAGCCA CACCCCAGCTACTGCTTCCTGGCCACCAGTGGCATCGATCCTGTTGTGCGGCTCTGGAACCCCCGACCAGAGAGTGAAGACCTCACAGGC CGAGTCGTGGAAGATATGGAGGGTGCTTCACAGGCCAACCAGCGGCGCATGAATGCAGACCCGTTGGAGGTGATGCTGCTCAACATGGGC TACCGGATCACGGGCCTGAGCAGTGGGGGTGCCGGGGCCTCTGATGATGAGGACAGCTCTGAGGGCCAGGTGCAGTGCCGGCCCAGCTAG >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000361771_chr1_27614165_+_1977nt ATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAGGGAGATAAAGCAAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTCTGCT AAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAAAGCT GATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAATGGAGATGCCAAAACAGACCAGTTCCTGCCTCACGCTGGGGACCGCATCTTGATC ACGGGGGCAGCCGACTCTAAGGTGCATGTGCACGACCTGACAGTAAAGGAGACCATCCACATGTTTGGAGACCACACAAACCGGGTGAAG CGCATCGCCACAGCGCCCATGTGGCCCAACACATTCTGGAGTGCTGCTGAGGATGGGCTTATCCGCCAGTATGACCTTCGAGAGAACAGC AAACACTCGGAGGTGCTGATTGACCTGACAGAGTACTGTGGCCAGCTGGTGGAGGCCAAGTGCCTCACTGTCAACCCCCAGGACAACAAC TGCCTGGCAGTTGGGGCCAGCGGGCCCTTCGTGAGGCTCTATGACATCCGCATGATCCATAACCACAGAAAGAGCATGAAGCAGAGCCCT TCAGCGGGTGTGCACACCTTCTGTGACCGGCAGAAACCCCTTCCGGACGGTGCAGCCCAGTATTACGTAGCAGGTCACCTGCCAGTGAAG CTTCCTGACTACAACAACCGTTTGAGAGTGCTGGTTGCCACCTATGTGACCTTCAGCCCCAATGGCACAGAGCTACTAGTCAACATGGGG GGGGAACAGGTCTATTTGTTTGACTTGACTTACAAGCAGCGGCCGTACACCTTCCTCTTGCCTAGAAAATGCCACTCCTCGGGGGTCCAG AATGGCAAGATGTCCACCAACGGTGTGTCCAACGGTGTGTCCAATGGCCTGCACCTTCATAGCAATGGCTTCCGGCTGCCGGAGAGTAGG GGACATGTCAGCCCCCAAGTAGAGCTACCACCATACCTGGAGCGTGTGAAACAGCAAGCCAATGAGGCTTTTGCCTGCCAGCAGTGGACC CAAGCCATTCAGCTTTACAGCAAGGCTGTGCAGAGGGCCCCTCACAATGCCATGCTTTATGGAAACCGAGCAGCAGCCTACATGAAGCGC AAGTGGGATGGTGACCACTATGATGCCCTGAGGGACTGCCTCAAGGCCATCTCCCTAAACCCATGCCACCTGAAGGCACACTTTCGCCTG GCCCGCTGCCTCTTTGAGCTCAAGTATGTGGCTGAAGCCCTGGAGTGCCTGGACGACTTCAAAGGGAAATTTCCGGAGCAGGCCCACAGC AGCGCTTGTGATGCATTGGGCCGCGACATCACAGCTGCCCTCTTCTCTAAAAATGATGGTGAGGAGAAGAAGGGACCTGGTGGCGGCGCC CCAGTCCGCCTCCGCAGCACGAGCCGCAAGGACTCCATCTCAGAGGATGAAATGGTGCTGCGGGAGCGAAGCTACGACTATCAGTTCCGC TACTGCGGCCACTGCAACACCACCACGGATATCAAAGAGGCCAATTTCTTTGGCAGCAACGCTCAGTATATCGTCAGTGGCTCTGACGAT GGCTCCTTCTTCATCTGGGAAAAGGAGACCACCAACCTGGTCCGTGTGCTCCAAGGGGATGAGTCCATTGTCAACTGCCTGCAGCCACAC CCCAGCTACTGCTTCCTGGCCACCAGTGGCATCGATCCTGTTGTGCGGCTCTGGAACCCCCGACCAGAGAGTGAAGACCTCACAGGCCGA GTCGTGGAAGATATGGAGGGTGCTTCACAGGCCAACCAGCGGCGCATGAATGCAGACCCGTTGGAGGTGATGCTGCTCAACATGGGCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000319394_chr1_27614165_+_4310nt AAGAGGCGAGAACGACCCCCGGACCGACCAAAGCCCGCGCGCCGCTGCATCCCGCGTCCAGCACCTACGTCCCGCTGCCGTCGCCGCCGC CACCATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAGGGAGATAAAGCAAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTC TGCTAAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAA AGCTGATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAATGGAGATGCCAAAACAGACCAGTTCCTGCCTCACGCTGGGGACCGCATCTT GATCACGGGGGCAGCCGACTCTAAGGTGCATGTGCACGACCTGACAGTAAAGGAGACCATCCACATGTTTGGAGACCACACAAACCGGGT GAAGCGCATCGCCACAGCGCCCATGTGGCCCAACACATTCTGGAGTGCTGCTGAGGATGGGCTTATCCGCCAGTATGACCTTCGAGAGAA CAGCAAACACTCGGAGGTGCTGATTGACCTGACAGAGTACTGTGGCCAGCTGGTGGAGGCCAAGTGCCTCACTGTCAACCCCCAGGACAA CAACTGCCTGGCAGTTGGGGCCAGCGGGCCCTTCGTGAGGCTCTATGACATCCGCATGATCCATAACCACAGAAAGAGCATGAAGCAGAG CCCTTCAGCGGGTGTGCACACCTTCTGTGACCGGCAGAAACCCCTTCCGGACGGTGCAGCCCAGTATTACGTAGCAGGTCACCTGCCAGT GAAGCTTCCTGACTACAACAACCGTTTGAGAGTGCTGGTTGCCACCTATGTGACCTTCAGCCCCAATGGCACAGAGCTACTAGTCAACAT GGGGGGGGAACAGGTCTATTTGTTTGACTTGACTTACAAGCAGCGGCCGTACACCTTCCTCTTGCCTAGAAAATGCCACTCCTCGGGGGA AGTCCAGAATGGCAAGATGTCCACCAACGGTGTGTCCAACGGTGTGTCCAATGGCCTGCACCTTCATAGCAATGGCTTCCGGCTGCCGGA GAGTAGGGGACATGTCAGCCCCCAAGTAGAGCTACCACCATACCTGGAGCGTGTGAAACAGCAAGCCAATGAGGCTTTTGCCTGCCAGCA GTGGACCCAAGCCATTCAGCTTTACAGCAAGGCTGTGCAGAGGGCCCCTCACAATGCCATGCTTTATGGAAACCGAGCAGCAGCCTACAT GAAGCGCAAGTGGGATGGTGACCACTATGATGCCCTGAGGGACTGCCTCAAGGCCATCTCCCTAAACCCATGCCACCTGAAGGCACACTT TCGCCTGGCCCGCTGCCTCTTTGAGCTCAAGTATGTGGCTGAAGCCCTGGAGTGCCTGGACGACTTCAAAGGGAAATTTCCGGAGCAGGC CCACAGCAGCGCTTGTGATGCATTGGGCCGCGACATCACAGCTGCCCTCTTCTCTAAAAATGATGGTGAGGAGAAGAAGGGACCTGGTGG CGGCGCCCCAGTCCGCCTCCGCAGCACGAGCCGCAAGGACTCCATCTCAGAGGATGAAATGGTGCTGCGGGAGCGAAGCTACGACTATCA GTTCCGCTACTGCGGCCACTGCAACACCACCACGGATATCAAAGAGGCCAATTTCTTTGGCAGCAACGCTCAGTATATCGTCAGTGGCTC TGACGATGGCTCCTTCTTCATCTGGGAAAAGGAGACCACCAACCTGGTCCGTGTGCTCCAAGGGGATGAGTCCATTGTCAACTGCCTGCA GCCACACCCCAGCTACTGCTTCCTGGCCACCAGTGGCATCGATCCTGTTGTGCGGCTCTGGAACCCCCGACCAGAGAGTGAAGACCTCAC AGGCCGAGTCGTGGAAGATATGGAGGGTGCTTCACAGGCCAACCAGCGGCGCATGAATGCAGACCCGTTGGAGGTGATGCTGCTCAACAT GGGCTACCGGATCACGGGCCTGAGCAGTGGGGGTGCCGGGGCCTCTGATGATGAGGACAGCTCTGAGGGCCAGGTGCAGTGCCGGCCCAG CTAGACCCTCCAGCCCTGGTCCCCAGCCCCTGCTACTGGCTGGACCCTCTGCCCTGGGCAGGAGGTCAGGGGATTCTGTTTTGGTTTGTC TTCCCCACCACCCTTTTTTTTCATTTCCCCTGTTTTGTTTGTTAGTTTGGCGTTAGGGGTGGAGGTTGCTACAACTTGCTGGCTTTCGGA CTCTGGGCTGATTGTCCCCTGACTATCCCCAGCCCTGAAAAAAAGAGCAGGAGGGGACACCCCTCCATATGCCCCCCCCCATCTCCTGCT TTCATGTCCCTGGAGGGCTCTGGCCTGCCTCAAAACCCCTTCTGCCTCAGGTGGGGAGGAACAAGCTGAACTGTCTTCAGGGACTGTCCT GCCCTTTAGCTGGCAGCAGCAGGAGGAGTGGGATTCCCAATTGGTAAGGGCTCGCCTTGGCCTGTTGCCACTCTTGCTCCCTAGCCTGCA AGGCTAGCTCCCCTGTGGTCTTCAGGAAAGGTTTTGAAAAAGGATGGGTCCCACCCTCCCTCCAGAGCCACCAGTGTTAGAGCGGAGCCC AAAGGAAGGATGGGAGCCCTGGAGTGGGCAAGACCAGGCCACCTGCTGAGGTCGCTGTGGAGCACCCTCGCTCCTCTCCTGGCTACTAGC TCTGGCCCTGCACCTACTCTCACTGGCCACCTCTGGAGGCTCTGCCTTTCCCAAGGGCCCTGGCAGAGGGTGGGGCACTGCACCTTACCC CACCCATCCATGCCAGCACTTCTGCACTACGGCCATTCTCCTCTTGGGCGCTCCTCAGCCTCACTGTGACCTTTCTGCCAGAGCTCCCAG CCAGGCCTACTCTGCTGAGGTGGCGCTTCCTGCTAAGGGCCCTTCTCTGCCCTTTCTGCCCTCCTTCCCATCCCACATGCTGAGCCGCCA CAAAGACCAAAGAAGTGATGGCTTTTCTCTGTCCCCTGCTGCTCTGAGGGGAGAGGGGTGGGTCTCCTGAGCCACTCAGATGGGAAAGTC CCTTACTCGGCCCCTCCCTCCCCAGCAGCCCCAAGCTTTACACTGGATGCAGCGATCAACCCACCACTCACCAGGCCTCTCCTCCCCTCT GCCCCCGGCTCTTAGCTCCAGCTGCTCCAGGTAGTTGGTTCATCCTTCCCCCTCTCTCCCTCCCTGCTTCCCCTTCAGTGCTTACTTGGC TCCAGCCCTCCAGCTGCAGCCCCTGGGGAAAAGCAGCCTCCCTTCTCCTCTCCCTCCACTCCCTCGCTCCCTCCCTCAGCCCCTGTCTCT GCCAGGTGCCTCCTCTCAGTCAGGCTTCAGAGCAGCCCTGGAGACAGGAGGGCCATGTTAAAAGCTTTTTCACAGTTTTAAGAAGACAAG TGGAGGGTGAGGATAGTGGTGGGGGGTCTGGCACCATCTCATTGCTTTAATCCCAGCAACACAGGTGGCAGCTTCTCCCCCTTCCTTCCC ACCCCAGTCCCTCTTCCCACCCCTCTCTTCTAGCTTGGTAATGAAGTATATTTATTGGTGAAGGAAACAGCTGCTGCTGCTTCTCCTGCT GCTGGGACCTGCTCCCCTGTCTCTTCTCCGTGACCTTTCTCTAGCCAGGGAGAAGGGAGAGCAGGAGTATTGGGGCTGGGCCCTGGGGCC CAAGGACCAGCTGGGTCCCCTTTGCTTTCTTGTGTTCCAGCCACCTGCCATTTCCTCCCTGCCTCCCACCCTCCCTCCCTGCCCCCTGTC CTGCTTCCCACCCCCTGCCTGCCCAGCCTGGGCCCTGCAGTGTGGAGAGACACATAAGCCTTACTGTCCTCTGGGGGCAGGAGCCGAGCC TTTTTGTTGCTCCGCTCCCAGGAGAGTGAGGGTGACGCAATTGATTAAAACCATTTTGTTCTAGGTGTGGCTGGTGGCATTTGTGGGGTG CAGATGGGTCTTGGAACCAAAGTGAGGGCACCTGGTCCCTCACCTCTGTAGCTCTATGACTTAGTAACCACACCTCTACTGGACAGAATG AGGCCTGCCTTGAAGGGTCACCGTGAGCAGCGGCCACCCAGCCCAGCAGGGCTGAGTGCAGAGCCCAGCTCTCATGGCTGTGATTTGTAA TCATCAGCTTTCACTCTCTGGCTGTTTTCTCATCAGTAAAATAAGGGACTTGGAATCTTAGTGGTTTTTCAAACCATTTTACATTGTGAC >In-frame_HMGN2_ENST00000361427_chr1_26801158_+_WDTC1_ENST00000361771_chr1_27614165_+_3932nt AAGAGGCGAGAACGACCCCCGGACCGACCAAAGCCCGCGCGCCGCTGCATCCCGCGTCCAGCACCTACGTCCCGCTGCCGTCGCCGCCGC CACCATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAGGGAGATAAAGCAAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTC TGCTAAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAA AGCTGATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAATGGAGATGCCAAAACAGACCAGTTCCTGCCTCACGCTGGGGACCGCATCTT GATCACGGGGGCAGCCGACTCTAAGGTGCATGTGCACGACCTGACAGTAAAGGAGACCATCCACATGTTTGGAGACCACACAAACCGGGT GAAGCGCATCGCCACAGCGCCCATGTGGCCCAACACATTCTGGAGTGCTGCTGAGGATGGGCTTATCCGCCAGTATGACCTTCGAGAGAA CAGCAAACACTCGGAGGTGCTGATTGACCTGACAGAGTACTGTGGCCAGCTGGTGGAGGCCAAGTGCCTCACTGTCAACCCCCAGGACAA CAACTGCCTGGCAGTTGGGGCCAGCGGGCCCTTCGTGAGGCTCTATGACATCCGCATGATCCATAACCACAGAAAGAGCATGAAGCAGAG CCCTTCAGCGGGTGTGCACACCTTCTGTGACCGGCAGAAACCCCTTCCGGACGGTGCAGCCCAGTATTACGTAGCAGGTCACCTGCCAGT GAAGCTTCCTGACTACAACAACCGTTTGAGAGTGCTGGTTGCCACCTATGTGACCTTCAGCCCCAATGGCACAGAGCTACTAGTCAACAT GGGGGGGGAACAGGTCTATTTGTTTGACTTGACTTACAAGCAGCGGCCGTACACCTTCCTCTTGCCTAGAAAATGCCACTCCTCGGGGGT CCAGAATGGCAAGATGTCCACCAACGGTGTGTCCAACGGTGTGTCCAATGGCCTGCACCTTCATAGCAATGGCTTCCGGCTGCCGGAGAG TAGGGGACATGTCAGCCCCCAAGTAGAGCTACCACCATACCTGGAGCGTGTGAAACAGCAAGCCAATGAGGCTTTTGCCTGCCAGCAGTG GACCCAAGCCATTCAGCTTTACAGCAAGGCTGTGCAGAGGGCCCCTCACAATGCCATGCTTTATGGAAACCGAGCAGCAGCCTACATGAA GCGCAAGTGGGATGGTGACCACTATGATGCCCTGAGGGACTGCCTCAAGGCCATCTCCCTAAACCCATGCCACCTGAAGGCACACTTTCG CCTGGCCCGCTGCCTCTTTGAGCTCAAGTATGTGGCTGAAGCCCTGGAGTGCCTGGACGACTTCAAAGGGAAATTTCCGGAGCAGGCCCA CAGCAGCGCTTGTGATGCATTGGGCCGCGACATCACAGCTGCCCTCTTCTCTAAAAATGATGGTGAGGAGAAGAAGGGACCTGGTGGCGG CGCCCCAGTCCGCCTCCGCAGCACGAGCCGCAAGGACTCCATCTCAGAGGATGAAATGGTGCTGCGGGAGCGAAGCTACGACTATCAGTT CCGCTACTGCGGCCACTGCAACACCACCACGGATATCAAAGAGGCCAATTTCTTTGGCAGCAACGCTCAGTATATCGTCAGTGGCTCTGA CGATGGCTCCTTCTTCATCTGGGAAAAGGAGACCACCAACCTGGTCCGTGTGCTCCAAGGGGATGAGTCCATTGTCAACTGCCTGCAGCC ACACCCCAGCTACTGCTTCCTGGCCACCAGTGGCATCGATCCTGTTGTGCGGCTCTGGAACCCCCGACCAGAGAGTGAAGACCTCACAGG CCGAGTCGTGGAAGATATGGAGGGTGCTTCACAGGCCAACCAGCGGCGCATGAATGCAGACCCGTTGGAGGTGATGCTGCTCAACATGGG CTACCGGATCACGGGCCTGAGCAGTGGGGGTGCCGGGGCCTCTGATGATGAGGACAGCTCTGAGGGCCAGGTGCAGTGCCGGCCCAGCTA GACCCTCCAGCCCTGGTCCCCAGCCCCTGCTACTGGCTGGACCCTCTGCCCTGGGCAGGAGGTCAGGGGATTCTGTTTTGGTTTGTCTTC CCCACCACCCTTTTTTTTCATTTCCCCTGTTTTGTTTGTTAGTTTGGCGTTAGGGGTGGAGGTTGCTACAACTTGCTGGCTTTCGGACTC TGGGCTGATTGTCCCCTGACTATCCCCAGCCCTGAAAAAAAGAGCAGGAGGGGACACCCCTCCATATGCCCCCCCCCATCTCCTGCTTTC ATGTCCCTGGAGGGCTCTGGCCTGCCTCAAAACCCCTTCTGCCTCAGGTGGGGAGGAACAAGCTGAACTGTCTTCAGGGACTGTCCTGCC CTTTAGCTGGCAGCAGCAGGAGGAGTGGGATTCCCAATTGGTAAGGGCTCGCCTTGGCCTGTTGCCACTCTTGCTCCCTAGCCTGCAAGG CTAGCTCCCCTGTGGTCTTCAGGAAAGGTTTTGAAAAAGGATGGGTCCCACCCTCCCTCCAGAGCCACCAGTGTTAGAGCGGAGCCCAAA GGAAGGATGGGAGCCCTGGAGTGGGCAAGACCAGGCCACCTGCTGAGGTCGCTGTGGAGCACCCTCGCTCCTCTCCTGGCTACTAGCTCT GGCCCTGCACCTACTCTCACTGGCCACCTCTGGAGGCTCTGCCTTTCCCAAGGGCCCTGGCAGAGGGTGGGGCACTGCACCTTACCCCAC CCATCCATGCCAGCACTTCTGCACTACGGCCATTCTCCTCTTGGGCGCTCCTCAGCCTCACTGTGACCTTTCTGCCAGAGCTCCCAGCCA GGCCTACTCTGCTGAGGTGGCGCTTCCTGCTAAGGGCCCTTCTCTGCCCTTTCTGCCCTCCTTCCCATCCCACATGCTGAGCCGCCACAA AGACCAAAGAAGTGATGGCTTTTCTCTGTCCCCTGCTGCTCTGAGGGGAGAGGGGTGGGTCTCCTGAGCCACTCAGATGGGAAAGTCCCT TACTCGGCCCCTCCCTCCCCAGCAGCCCCAAGCTTTACACTGGATGCAGCGATCAACCCACCACTCACCAGGCCTCTCCTCCCCTCTGCC CCCGGCTCTTAGCTCCAGCTGCTCCAGGTAGTTGGTTCATCCTTCCCCCTCTCTCCCTCCCTGCTTCCCCTTCAGTGCTTACTTGGCTCC AGCCCTCCAGCTGCAGCCCCTGGGGAAAAGCAGCCTCCCTTCTCCTCTCCCTCCACTCCCTCGCTCCCTCCCTCAGCCCCTGTCTCTGCC AGGTGCCTCCTCTCAGTCAGGCTTCAGAGCAGCCCTGGAGACAGGAGGGCCATGTTAAAAGCTTTTTCACAGTTTTAAGAAGACAAGTGG AGGGTGAGGATAGTGGTGGGGGGTCTGGCACCATCTCATTGCTTTAATCCCAGCAACACAGGTGGCAGCTTCTCCCCCTTCCTTCCCACC CCAGTCCCTCTTCCCACCCCTCTCTTCTAGCTTGGTAATGAAGTATATTTATTGGTGAAGGAAACAGCTGCTGCTGCTTCTCCTGCTGCT GGGACCTGCTCCCCTGTCTCTTCTCCGTGACCTTTCTCTAGCCAGGGAGAAGGGAGAGCAGGAGTATTGGGGCTGGGCCCTGGGGCCCAA GGACCAGCTGGGTCCCCTTTGCTTTCTTGTGTTCCAGCCACCTGCCATTTCCTCCCTGCCTCCCACCCTCCCTCCCTGCCCCCTGTCCTG CTTCCCACCCCCTGCCTGCCCAGCCTGGGCCCTGCAGTGTGGAGAGACACATAAGCCTTACTGTCCTCTGGGGGCAGGAGCCGAGCCTTT |
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FusionGenePPI for HMGN2_WDTC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HMGN2 | HMGN2, KAT2B, EP300, UBE2I, TERF2, CDK2, UBC, PRKCA, KRAS, SRPK2, PARP1, C4orf27, EGFR, KLHL36, PARP2, CHMP1A, H2AFY, PYGB, GBE1, HIST1H2AG, MTNR1A | WDTC1 | USP3, DDB1, CUL4A, DDA1, TADA2A, MED4, CUL3, SLC25A22, BCKDK, MRPS11, FBXW11, XPO1, STXBP4, CUL4B, MIPEP, ETNK1, PPP1R21, CCT6A, CCT3, CCT2, TCP1, CCT4, PDCL, ARHGAP44, SEPT3, CCT7, CCT5, CCT6B, DFNB31 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HMGN2_WDTC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HMGN2_WDTC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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