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Fusion gene ID: 16474 |
FusionGeneSummary for HMGN1_UBE2G2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGN1_UBE2G2 | Fusion gene ID: 16474 | Hgene | Tgene | Gene symbol | HMGN1 | UBE2G2 | Gene ID | 3150 | 7327 |
| Gene name | high mobility group nucleosome binding domain 1 | ubiquitin conjugating enzyme E2 G2 | |
| Synonyms | HMG14 | UBC7 | |
| Cytomap | 21q22.2 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | non-histone chromosomal protein HMG-14high mobility group nucleosome-binding domain-containing protein 1high-mobility group (nonhistone chromosomal) protein 14high-mobility group nucleosome binding 1nonhistone chromosomal protein HMG-14 | ubiquitin-conjugating enzyme E2 G2E2 ubiquitin-conjugating enzyme G2ubiquitin carrier protein G2ubiquitin conjugating enzyme 7ubiquitin conjugating enzyme G2ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)ubiquitin-conjugating enzyme E2G 2 ( | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P05114 | P60604 | |
| Ensembl transtripts involved in fusion gene | ENST00000380749, ENST00000361263, ENST00000380748, ENST00000489072, ENST00000380747, | ENST00000345496, ENST00000477954, ENST00000330942, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HMGN1 [Title/Abstract] AND UBE2G2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBE2G2 | GO:0044257 | cellular protein catabolic process | 21628527 |
| Tgene | UBE2G2 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-RP-A693-06A | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380749 | ENST00000345496 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380749 | ENST00000477954 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380749 | ENST00000330942 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| In-frame | ENST00000361263 | ENST00000345496 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000361263 | ENST00000477954 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000361263 | ENST00000330942 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| Frame-shift | ENST00000380748 | ENST00000345496 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380748 | ENST00000477954 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380748 | ENST00000330942 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5UTR-3CDS | ENST00000489072 | ENST00000345496 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5UTR-5UTR | ENST00000489072 | ENST00000477954 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5UTR-5UTR | ENST00000489072 | ENST00000330942 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| Frame-shift | ENST00000380747 | ENST00000345496 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380747 | ENST00000477954 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
| 5CDS-5UTR | ENST00000380747 | ENST00000330942 | HMGN1 | chr21 | 40717072 | - | UBE2G2 | chr21 | 46197332 | - |
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FusionProtFeatures for HMGN1_UBE2G2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGN1 | UBE2G2 |
| Binds to the inner side of the nucleosomal DNA thusaltering the interaction between the DNA and the histone octamer.May be involved in the process which maintains transcribable genesin a unique chromatin conformation. Inhibits the phosphorylationof nucleosomal histones H3 and H2A by RPS6KA5/MSK1 andRPS6KA3/RSK2 (By similarity). {ECO:0000250}. | Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). {ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:22607976}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HMGN1_UBE2G2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HMGN1_ENST00000361263_chr21_40717072_-_UBE2G2_ENST00000345496_chr21_46197332_-_173aa MVLFFRINLQTKKCKQKGKGEQRENRPKWLTKKLKKTYLRKTGKRRLRRGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HMGN1_ENST00000361263_chr21_40717072_-_UBE2G2_ENST00000345496_chr21_46197332_-_519nt ATGGTGCTTTTTTTCAGGATAAATCTTCAGACAAAAAAGTGCAAACAAAAGGGAAAAGGGGAGCAAAGGGAAAACAGGCCGAAGTGGCTA ACCAAGAAACTAAAGAAGACTTACCTGCGGAAAACGGGGAAACGAAGACTGAGGAGGGGCCCAGAAGACACCTGCTTTGAGTTTGGTGTT TTTCCTGCCATCCTGAGTTTCCCACTTGATTACCCGTTAAGTCCCCCAAAGATGAGATTTACCTGTGAGATGTTTCATCCCAACATCTAC CCTGATGGGAGAGTCTGCATTTCCATCCTCCACGCGCCAGGCGATGACCCCATGGGCTACGAGAGCAGCGCGGAGCGGTGGAGTCCTGTG CAGAGTGTGGAGAAGATCCTGCTGTCGGTGGTGAGCATGCTGGCAGAGCCCAATGACGAAAGTGGAGCTAACGTGGATGCGTCCAAAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HMGN1_ENST00000361263_chr21_40717072_-_UBE2G2_ENST00000345496_chr21_46197332_-_3538nt ATTTCAAGTCCAAGATATTATGTATTCTATTTTAACTGTTTCCCAGTTTTGTATTTTTTGTATTGGAATGATTATGAAATTAATGAGAAA TCTTTAGAAACAGACTACAAAAGAGTAGTTCTTAAATACAGAAGTGATTGTGAAACTTTGTGATAGCAATGTGTGTAGTAGCAGTTTTGT CTCAAATACATTTATCATTTGTTACTCAAAGGATGTTGAAGTATTAAAAGTCATTATGCTGTCTGTGGAATCCTACTATTAGTACAGAAC ACCCTGCAGTGATTTTTCCGCCCGTGTTAGCATTGAAGTTGTGAGCTCTACTTGCTTGTCTTTATGGCCCTTTAATTCAAGTAATTGGTC AGTATCCGTATGGGTCTTTTATACCACCCGCTGGGGGCTAAACTAATTTAGCTGCTGCTGTATACTTACTAACAAGGAATAAATGTTAAG CTTTCTTCTCAGTATTGATGGATGGTATCTAAAAGTATTTTTATGTTTCTTTAACATGGCTTAAATTTTGAACTTAATGTATCAAGTTAG TATGGTCATATTAATACCTGTGCTTTTCAGATTCTTCAAACACCTAAATGAAAGTGATAAATTCAAAACTGATCCTTTTAGTTCCTCATT ATATGATATGAAGGGATTAACTGTAGCAGGATAGTCAACCTGACCGTACGGCATGGTGCTTTTTTTCAGGATAAATCTTCAGACAAAAAA GTGCAAACAAAAGGGAAAAGGGGAGCAAAGGGAAAACAGGCCGAAGTGGCTAACCAAGAAACTAAAGAAGACTTACCTGCGGAAAACGGG GAAACGAAGACTGAGGAGGGGCCCAGAAGACACCTGCTTTGAGTTTGGTGTTTTTCCTGCCATCCTGAGTTTCCCACTTGATTACCCGTT AAGTCCCCCAAAGATGAGATTTACCTGTGAGATGTTTCATCCCAACATCTACCCTGATGGGAGAGTCTGCATTTCCATCCTCCACGCGCC AGGCGATGACCCCATGGGCTACGAGAGCAGCGCGGAGCGGTGGAGTCCTGTGCAGAGTGTGGAGAAGATCCTGCTGTCGGTGGTGAGCAT GCTGGCAGAGCCCAATGACGAAAGTGGAGCTAACGTGGATGCGTCCAAAATGTGGCGCGATGACCGGGAGCAGTTCTATAAGATTGCCAA GCAGATCGTCCAGAAGTCTCTGGGACTGTGAGACCTGGCCTCGCACAGGCGCGCACACACCGCCAAGCAGCTCAGCATTCTCCCCCGGCA CACTTAGTGACAGTGATGCTCTGTGCTGGTACCAAACAAGGCAGACTTGCAAGAACCATGGCATCTTTTTTTTTTTTCAAACCTTTCCTA CTTCAAACAGGCTTCTCTTCTGAAATGATGACTTAATGTCGAATATTGACAGCTTACTGCAGTTTTACAGTATTCCTCACAAAGGGCTTC AGGTAGATTATCAGAGCTGTCAGCACTACCTCTCCCCGCTGAAACCAGCAGTTCATGGCTTCCTGTGGATTCCCTCCCTCCCTGGAGTGT TGAGGGGGTTGTACCTGCCAGACTTCCAGGGGACGATGGAATACCCAGAACGCTCCTTCTGAAGAAATGGGGCCCTGTAGCTGCAGCACA GGGGAAGGGCCCGGCACCCTTTCTGGGTCCTTCCTGGTTCCCTGTGGGCCCCATGAGGAGTCCATTACTTCCTTTCTTCCTTCATATTTT ACAGGCAGATGCTTTTCTTATAATCTAATTACATCTTTTCATTTGTTATATATTACAAACCATCACACTTAGAAATACTTCCAGGAAATG CTTTTTTGAAGTGTGAATTAATAAGAAATGGGGTAAATAGAAAAGAAATTTATTGCTGATTGGCCAGGTGCGGTGGTTCGTGCCTGTAAT CCCAGCTCTTTGGGAGGCCAAGGCAGGTAGATCACAAGGTCAGGAAATTGAGACCATCCTGGCTAATACAGTGAAACCCCATGTCTGCTA AAATTACAAAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAGTCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG AGGCAGAGGTAGCAGTGAGCTGAAGTCCCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCAGTCTCAAAAAGAAAAAAGAAATT TATTGCTGATCACAAGGACAGACAGTTTTTTCCCGACCATACTCATCAAAGATTTACGTTTGTATATTAGTAACTAGTGCATTACTAGAG CAGGTGCAGGTGAGGTCTTTAAAGTTTCAATGAAAGTTTCTTCTGGATCTACAGAAAAAATTTTTTTTTTTCAATCTAAAAACTGGAAAT TCTAGGGTTTTTGTACATTTTGGATGCACTGGGAATTTATTAGCACAAAATCATTCTTTGCAACTCAAAATTCAGAAGGGACTCTACCAT ATCTTAGCTCAGAGCACAGAGGAGTGCCTTATCCCCACACTTGACTGGGCTGTGGAGGTGGGCATGTGGGCCCCTGGGCCCAGGCTGGGG ACAGAGCCCTTGTTTTGTGACTTAGGATTTTGATGTGGTTCCCATGTTCTCTAACAGGGCCAGCTGAGCAGCACAGGCCAGGAGGCCACA GTGTAAGCAATAACAGATCTGCCACATGCAGAAGCAAATATCAGGCCTGTCGCACACGGGCGGCATTTAAATAGGAATTTCTATTTTTGA AATAAGGGATGGTCTATGAGGCATACAGTAGATTTGATGTGATCCTTTTCTCCCTCCCTTCCATAATGGATCGTGGTCTGTGTGACTGAA CCCACACAGAGTGTCATGGGTGACAGTTTCTGGTTGAAGTAGCTCCACGCCTGGCTTCTGTGGACAGCAGATTCTTTTCCTTCTCACAAG GGGCTCATTTAAAATTTGGAGGCTGGGTGCTGTGGCTCACGCCTGCAATCCCAGCACTTTGGGAGACTGAGGCGGGCGGATCATGAGGTC AGGAGATCGCGACCATCCTGGCTAACAGTGAAACCCTGTCTCCACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAG TCCCAGCTACTCTGAAGACTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATCACGCCACTGCACTCCA GCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATGGAACGCAGGGCAAGAACTCGTATTTGGAAGGAGATGGGG GAAAGGAGCGGTATTATACCTATGTTGTATTTGCAGGCAAATGAGATGGAGCCCTCTCTGTAAAGAAGAGTCATTTGTGCAAGTAGACGG GGTCTGTGGGTGCAGGCCCTGGAGGGGCACACAATTGCCTGGAGGCTTCTGTGAGATCGGGAGAGGGAGGAGAGGCAGTCTCTTGACAAA ATAAAGTATTTTTATTCATTTGTATTTATTAAATGAAAAAACAATCCCATGGTGTCCCTGTTGTGTGGTGGAACCTAATGACTGTTGAAA |
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FusionGenePPI for HMGN1_UBE2G2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HMGN1 | YWHAZ, HMGN1, NFE2, ERCC6, EP300, HDGF, SPP1, TERF2, POLR2A, ERCC8, PPIP5K1, LIG4, PPP1CC, PRKCA, PRKACG, RPS6KA3, SLC38A3, TRPV5, CHEK2, CEP290, SPICE1, MYH6, PDK1, MDM2, PARP1, C4orf27, G3BP1 | UBE2G2 | AMFR, USP15, AUP1, MALT1, CORO1A, BIRC8, MDM2, MGRN1, RFFL, RNF111, RNF146, RNF157, RNF168, RNF26, TRIM3, TRIM43, ZNRF4, TRIM9, UBC, KIAA0368, PARK2, RNF5, RNF139, RBX1, UBL4A, BAG3, HBS1L, CPOX, MLLT6, NDUFS4, VAMP8, FARP2, POLR3F, KDM2A, CNNM3, ARL14, TMEM45B, UBE2G2, SHFM1, EGFR, UBA1, UBA6, MUL1, ERLEC1, FBXW11, HNRNPAB, HNRNPD, HNRNPDL, TMEM216, RC3H2, RC3H1, OTUB1, DUSP6, PTPRO, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HMGN1_UBE2G2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HMGN1_UBE2G2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HMGN1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
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