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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1646

FusionGeneSummary for ANAPC1_LIMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC1_LIMS1
Fusion gene ID: 1646
HgeneTgene
Gene symbol

ANAPC1

LIMS1

Gene ID

64682

3987

Gene nameanaphase promoting complex subunit 1LIM zinc finger domain containing 1
SynonymsAPC1|MCPR|TSG24PINCH|PINCH-1|PINCH1
Cytomap

2q13

2q12.3

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 1anaphase-promoting complex 1 (meiotic checkpoint regulator)cyclosome subunit 1mitotic checkpoint regulatortestis-specific gene 24 proteinLIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen
Modification date2018052320180522
UniProtAcc

Q9H1A4

P48059

Ensembl transtripts involved in fusion geneENST00000341068, ENST00000489177, 
ENST00000544547, ENST00000332345, 
ENST00000393310, ENST00000410093, 
ENST00000409441, ENST00000338045, 
ENST00000462817, ENST00000542845, 
ENST00000393314, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ANAPC1 [Title/Abstract] AND LIMS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC1

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneLIMS1

GO:0045892

negative regulation of transcription, DNA-templated

21390327


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-C5-A7X5-01AANAPC1chr2

112596015

-LIMS1chr2

109292334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341068ENST00000544547ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
Frame-shiftENST00000341068ENST00000332345ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
Frame-shiftENST00000341068ENST00000393310ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
Frame-shiftENST00000341068ENST00000410093ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
Frame-shiftENST00000341068ENST00000409441ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
Frame-shiftENST00000341068ENST00000338045ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
5CDS-intronENST00000341068ENST00000462817ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
5CDS-intronENST00000341068ENST00000542845ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
5CDS-intronENST00000341068ENST00000393314ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000544547ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000332345ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000393310ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000410093ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000409441ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-3CDSENST00000489177ENST00000338045ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-intronENST00000489177ENST00000462817ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-intronENST00000489177ENST00000542845ANAPC1chr2

112596015

-LIMS1chr2

109292334

+
intron-intronENST00000489177ENST00000393314ANAPC1chr2

112596015

-LIMS1chr2

109292334

+

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FusionProtFeatures for ANAPC1_LIMS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC1

Q9H1A4

LIMS1

P48059

Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANAPC1_LIMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANAPC1_LIMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANAPC1CDC27, ANAPC4, ANAPC5, CDC16, CDC23, ANAPC2, ANAPC7, CDC20, RPAP3, RPAP1, MDC1, SMARCAD1, SIRT7, COPS2, FBXO5, ANAPC10, CDC26, PAXIP1, TP53BP1, NOTCH1, ANAPC15, UBC, TRIM33, SOX2, PHF8, LATS2, HECW2, UBE2S, MOV10, NXF1, USP1, FZR1, SIRT6, BUB1B, PENK, GRAP2, MAGIX, KNG1, TTLL1, LIPH, PIFO, NCL, TAF4, ANAPC16, NAP1L4, NTRK1, KRAS, CEP120, CEP19, MAD2L1, CFAP97, TCF4, FOXQ1, USP37, SNW1, CDC5L, USP15, ANAPC13, C16orf87, KIAA1683, L3MBTL1, GPR156, ANO6, SKP2, CRYL1, WBP2, TRIM25LIMS1ILK, RBBP8, LPXN, EHMT2, ACP6, NCK2, STK11, HNRNPU, MBIP, MAPT, STUB1, RSU1, TYMS, MYO18A, PARVA, PARVB, CMAS, SRRT, RABGAP1, REPS1, MYH7, PXN, TRIP6, BMP2K, PARVG, KIF22, XRCC5, TMEM132A, SGOL1, ASPM, SNW1, CDC5L, MYH4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANAPC1_LIMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANAPC1_LIMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANAPC1C0001973Alcoholic Intoxication, Chronic1PSYGENET