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Fusion gene ID: 1646 |
FusionGeneSummary for ANAPC1_LIMS1 |
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Fusion gene information | Fusion gene name: ANAPC1_LIMS1 | Fusion gene ID: 1646 | Hgene | Tgene | Gene symbol | ANAPC1 | LIMS1 | Gene ID | 64682 | 3987 |
Gene name | anaphase promoting complex subunit 1 | LIM zinc finger domain containing 1 | |
Synonyms | APC1|MCPR|TSG24 | PINCH|PINCH-1|PINCH1 | |
Cytomap | 2q13 | 2q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | anaphase-promoting complex subunit 1anaphase-promoting complex 1 (meiotic checkpoint regulator)cyclosome subunit 1mitotic checkpoint regulatortestis-specific gene 24 protein | LIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9H1A4 | P48059 | |
Ensembl transtripts involved in fusion gene | ENST00000341068, ENST00000489177, | ENST00000544547, ENST00000332345, ENST00000393310, ENST00000410093, ENST00000409441, ENST00000338045, ENST00000462817, ENST00000542845, ENST00000393314, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ANAPC1 [Title/Abstract] AND LIMS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANAPC1 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
Tgene | LIMS1 | GO:0045892 | negative regulation of transcription, DNA-templated | 21390327 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-C5-A7X5-01A | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000341068 | ENST00000544547 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
Frame-shift | ENST00000341068 | ENST00000332345 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
Frame-shift | ENST00000341068 | ENST00000393310 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
Frame-shift | ENST00000341068 | ENST00000410093 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
Frame-shift | ENST00000341068 | ENST00000409441 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
Frame-shift | ENST00000341068 | ENST00000338045 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
5CDS-intron | ENST00000341068 | ENST00000462817 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
5CDS-intron | ENST00000341068 | ENST00000542845 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
5CDS-intron | ENST00000341068 | ENST00000393314 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000544547 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000332345 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000393310 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000410093 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000409441 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-3CDS | ENST00000489177 | ENST00000338045 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-intron | ENST00000489177 | ENST00000462817 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-intron | ENST00000489177 | ENST00000542845 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
intron-intron | ENST00000489177 | ENST00000393314 | ANAPC1 | chr2 | 112596015 | - | LIMS1 | chr2 | 109292334 | + |
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FusionProtFeatures for ANAPC1_LIMS1 |
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Hgene | Tgene |
ANAPC1 | LIMS1 |
Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. | Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cellsurface receptor tyrosine kinases and growth factor receptors.Involved in the regulation of cell survival, cell proliferationand cell differentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANAPC1_LIMS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANAPC1_LIMS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANAPC1 | CDC27, ANAPC4, ANAPC5, CDC16, CDC23, ANAPC2, ANAPC7, CDC20, RPAP3, RPAP1, MDC1, SMARCAD1, SIRT7, COPS2, FBXO5, ANAPC10, CDC26, PAXIP1, TP53BP1, NOTCH1, ANAPC15, UBC, TRIM33, SOX2, PHF8, LATS2, HECW2, UBE2S, MOV10, NXF1, USP1, FZR1, SIRT6, BUB1B, PENK, GRAP2, MAGIX, KNG1, TTLL1, LIPH, PIFO, NCL, TAF4, ANAPC16, NAP1L4, NTRK1, KRAS, CEP120, CEP19, MAD2L1, CFAP97, TCF4, FOXQ1, USP37, SNW1, CDC5L, USP15, ANAPC13, C16orf87, KIAA1683, L3MBTL1, GPR156, ANO6, SKP2, CRYL1, WBP2, TRIM25 | LIMS1 | ILK, RBBP8, LPXN, EHMT2, ACP6, NCK2, STK11, HNRNPU, MBIP, MAPT, STUB1, RSU1, TYMS, MYO18A, PARVA, PARVB, CMAS, SRRT, RABGAP1, REPS1, MYH7, PXN, TRIP6, BMP2K, PARVG, KIF22, XRCC5, TMEM132A, SGOL1, ASPM, SNW1, CDC5L, MYH4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANAPC1_LIMS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANAPC1_LIMS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANAPC1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |