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Fusion gene ID: 1645 |
FusionGeneSummary for ANAPC1_CLK1 |
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Fusion gene information | Fusion gene name: ANAPC1_CLK1 | Fusion gene ID: 1645 | Hgene | Tgene | Gene symbol | ANAPC1 | CLK1 | Gene ID | 64682 | 78989 |
Gene name | anaphase promoting complex subunit 1 | collectin subfamily member 11 | |
Synonyms | APC1|MCPR|TSG24 | 3MC2|CL-K1-I|CL-K1-II|CL-K1-IIa|CL-K1-IIb|CLK1 | |
Cytomap | 2q13 | 2p25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | anaphase-promoting complex subunit 1anaphase-promoting complex 1 (meiotic checkpoint regulator)cyclosome subunit 1mitotic checkpoint regulatortestis-specific gene 24 protein | collectin-11Collectin K1collectin kidney protein 1collectin sub-family member 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H1A4 | P49759 | |
Ensembl transtripts involved in fusion gene | ENST00000341068, ENST00000489177, | ENST00000321356, ENST00000409769, ENST00000434813, ENST00000492793, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ANAPC1 [Title/Abstract] AND CLK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANAPC1 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF212224 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000341068 | ENST00000321356 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-intron | ENST00000341068 | ENST00000409769 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-intron | ENST00000341068 | ENST00000434813 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-5UTR | ENST00000341068 | ENST00000492793 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-5UTR | ENST00000489177 | ENST00000321356 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-intron | ENST00000489177 | ENST00000409769 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-intron | ENST00000489177 | ENST00000434813 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
intron-5UTR | ENST00000489177 | ENST00000492793 | ANAPC1 | chr2 | 112595897 | + | CLK1 | chr2 | 201729362 | - |
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FusionProtFeatures for ANAPC1_CLK1 |
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Hgene | Tgene |
ANAPC1 | CLK1 |
Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. | Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex and may bea constituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 andPTPN1. Regulates the alternative splicing of tissue factor (F3)pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANAPC1_CLK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANAPC1_CLK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANAPC1_CLK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANAPC1_CLK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANAPC1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |