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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16411

FusionGeneSummary for HMBOX1_FSTL5

check button Fusion gene summary
Fusion gene informationFusion gene name: HMBOX1_FSTL5
Fusion gene ID: 16411
HgeneTgene
Gene symbol

HMBOX1

FSTL5

Gene ID

79618

56884

Gene namehomeobox containing 1follistatin like 5
SynonymsHNF1LA|HOT1|PBHNF-
Cytomap

8p21.1-p12

4q32.2

Type of geneprotein-codingprotein-coding
Descriptionhomeobox-containing protein 1homeobox telomere-binding protein 1homeobox-containing protein PBHNFfollistatin-related protein 5follistatin-like protein 5
Modification date2018052020180519
UniProtAcc

Q6NT76

Q8N475

Ensembl transtripts involved in fusion geneENST00000403668, ENST00000444075, 
ENST00000287701, ENST00000558662, 
ENST00000523613, ENST00000397358, 
ENST00000519047, ENST00000355231, 
ENST00000524238, ENST00000517386, 
ENST00000306100, ENST00000379164, 
ENST00000536695, ENST00000427802, 
ENST00000511170, 
Fusion gene scores* DoF score8 X 6 X 6=2882 X 1 X 1=2
# samples 81
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: HMBOX1 [Title/Abstract] AND FSTL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHMBOX1

GO:0000122

negative regulation of transcription by RNA polymerase II

21839858

HgeneHMBOX1

GO:0032212

positive regulation of telomere maintenance via telomerase

23685356

HgeneHMBOX1

GO:0045892

negative regulation of transcription, DNA-templated

19757162

HgeneHMBOX1

GO:0051973

positive regulation of telomerase activity

23685356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2O-01AHMBOX1chr8

28837673

+FSTL5chr4

162508727

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000403668ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000403668ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000403668ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000403668ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000403668ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000444075ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000444075ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000444075ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000444075ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000444075ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000287701ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000287701ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000287701ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000287701ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000287701ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000558662ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000558662ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000558662ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000558662ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000558662ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000523613ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000523613ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000523613ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000523613ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000523613ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000397358ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000397358ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000397358ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000397358ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000397358ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000519047ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000519047ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000519047ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000519047ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000519047ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000355231ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000355231ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000355231ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000355231ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000355231ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000524238ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000524238ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000524238ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
Frame-shiftENST00000524238ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000524238ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
intron-3CDSENST00000517386ENST00000306100HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
intron-3CDSENST00000517386ENST00000379164HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
intron-3CDSENST00000517386ENST00000536695HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
intron-3CDSENST00000517386ENST00000427802HMBOX1chr8

28837673

+FSTL5chr4

162508727

-
intron-5UTRENST00000517386ENST00000511170HMBOX1chr8

28837673

+FSTL5chr4

162508727

-

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FusionProtFeatures for HMBOX1_FSTL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HMBOX1

Q6NT76

FSTL5

Q8N475

Transcription factor. Isoform 1 acts as atranscriptional repressor. Isoform 4 has very low activity as atranscriptional repressor. {ECO:0000269|PubMed:16825764,ECO:0000269|PubMed:19757162}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HMBOX1_FSTL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HMBOX1_FSTL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HMBOX1APP, MDC1, ENTPD2, ATP5O, BYSL, CCNG1, DAB1, MFAP1, PRKAA1, PRKAA2, RPL9, SNRPB2, VPS72, PIP4K2B, FXR2, ZBTB24, KAT5, MRPL28, FARS2, MORF4L1, ZNF337, MAGEH1, ZNF581, FAM206A, UBA6, CBX8, SH2D4A, CARD9, MRPL11, UBE2Z, C8orf33, C20orf195, HMBOX1, SAP30L, FAM161A, LNX1, ZNF587, REEP6, SFR1, AEBP2, FRMD6, ASB7, DYNLL2, ZNF417, ZMAT2, RBMY2FP, TCEANC, FAM13C, PKD1P1, FAM74A4, MEMO1, MED23, DPF2, DSCC1, COBLL1, AMOTL1, IFFO1, FAM117A, CDADC1, WT1FSTL5PYCARD, WBP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HMBOX1_FSTL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HMBOX1_FSTL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource