	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 16377

FusionGeneSummary for HLA-DRA_SNW1

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-DRA_SNW1
	Fusion gene ID: 16377
		Hgene	Tgene
	Gene symbol	HLA-DRA	SNW1
	Gene ID	3122	22938
	Gene name	major histocompatibility complex, class II, DR alpha	SNW domain containing 1
	Synonyms	HLA-DRA1	Bx42\|FUN20\|NCOA-62\|PRPF45\|Prp45\|SKIIP\|SKIP\|SKIP1
	Cytomap	6p21.32	14q24.3
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen, DR alpha chainMHC class II antigen DRAhistocompatibility antigen HLA-DR alpha	SNW domain-containing protein 1SKI interacting proteinhomolog of Drosophila BX42nuclear protein SkiPnuclear receptor coactivator NCoA-62nuclear receptor coactivator, 62-kDski-interacting protein
	Modification date	20180522	20180519
	UniProtAcc	P01903	Q13573
	Ensembl transtripts involved in fusion gene	ENST00000395388, ENST00000374982, ENST00000383127, ENST00000459705, ENST00000434866, ENST00000416883, ENST00000481943, ENST00000411505, ENST00000414698, ENST00000546379, ENST00000493431, ENST00000418111, ENST00000383259, ENST00000551750, ENST00000461633, ENST00000383258, ENST00000442960, ENST00000549531, ENST00000482781, ENST00000415767, ENST00000411524, ENST00000553193, ENST00000498597, ENST00000427753,	ENST00000261531, ENST00000554775, ENST00000555761,
Fusion gene scores	* DoF score	6 X 6 X 2=72	15 X 4 X 12=720
	# samples	7	16
	** MAII score	log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/720*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HLA-DRA [Title/Abstract] AND SNW1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HLA-DRA	GO:0002503	peptide antigen assembly with MHC class II protein complex	1448172\|7606781\|22733780
Hgene	HLA-DRA	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	21502329
Hgene	HLA-DRA	GO:0002506	polysaccharide assembly with MHC class II protein complex	21502329
Tgene	SNW1	GO:0000122	negative regulation of transcription by RNA polymerase II	14985122
Tgene	SNW1	GO:0000398	mRNA splicing, via spliceosome	15194481\|28076346
Tgene	SNW1	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	11278756
Tgene	SNW1	GO:0043923	positive regulation by host of viral transcription	15905409
Tgene	SNW1	GO:0045892	negative regulation of transcription, DNA-templated	10713164\|15878163
Tgene	SNW1	GO:0045944	positive regulation of transcription by RNA polymerase II	14985122\|19934264
Tgene	SNW1	GO:0048384	retinoic acid receptor signaling pathway	19934264
Tgene	SNW1	GO:0048385	regulation of retinoic acid receptor signaling pathway	14985122
Tgene	SNW1	GO:0070562	regulation of vitamin D receptor signaling pathway	14985122
Tgene	SNW1	GO:0070564	positive regulation of vitamin D receptor signaling pathway	9632709\|11514567
Tgene	SNW1	GO:0071300	cellular response to retinoic acid	19934264

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-EE-A29T-06A	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000395388	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
5CDS-intron	ENST00000395388	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
5CDS-intron	ENST00000395388	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
5CDS-intron	ENST00000374982	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
5CDS-intron	ENST00000374982	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
5CDS-intron	ENST00000374982	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383127	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383127	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383127	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000459705	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000459705	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000459705	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000434866	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000434866	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000434866	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000416883	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000416883	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000416883	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000481943	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000481943	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000481943	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411505	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411505	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411505	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000414698	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000414698	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000414698	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000546379	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000546379	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000546379	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000493431	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000493431	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000493431	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000418111	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000418111	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000418111	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383259	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383259	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383259	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000551750	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000551750	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000551750	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000461633	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000461633	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000461633	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383258	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383258	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000383258	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000442960	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000442960	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000442960	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000549531	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000549531	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000549531	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000482781	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000482781	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000482781	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000415767	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000415767	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000415767	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411524	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411524	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000411524	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000553193	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000553193	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000553193	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000498597	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000498597	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000498597	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000427753	ENST00000261531	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000427753	ENST00000554775	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-
intron-intron	ENST00000427753	ENST00000555761	HLA-DRA	chr6	32412823	+	SNW1	chr14	78189203	-

Top

FusionProtFeatures for HLA-DRA_SNW1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLA-DRA P01903	SNW1 Q13573
Binds peptides derived from antigens that access theendocytic route of antigen presenting cells (APC) and presentsthem on the cell surface for recognition by the CD4 T-cells. Thepeptide binding cleft accommodates peptides of 10-30 residues. Thepeptides presented by MHC class II molecules are generated mostlyby degradation of proteins that access the endocytic route, wherethey are processed by lysosomal proteases and other hydrolases.Exogenous antigens that have been endocytosed by the APC are thusreadily available for presentation via MHC II molecules, and forthis reason this antigen presentation pathway is usually referredto as exogenous. As membrane proteins on their way to degradationin lysosomes as part of their normal turn-over are also containedin the endosomal/lysosomal compartments, exogenous antigens mustcompete with those derived from endogenous components. Autophagyis also a source of endogenous peptides, autophagosomesconstitutively fuse with MHC class II loading compartments. Inaddition to APCs, other cells of the gastrointestinal tract, suchas epithelial cells, express MHC class II molecules and CD74 andact as APCs, which is an unusual trait of the GI tract. To producea MHC class II molecule that presents an antigen, three MHC classII molecules (heterodimers of an alpha and a beta chain) associatewith a CD74 trimer in the ER to form a heterononamer. Soon afterthe entry of this complex into the endosomal/lysosomal systemwhere antigen processing occurs, CD74 undergoes a sequentialdegradation by various proteases, including CTSS and CTSL, leavinga small fragment termed CLIP (class-II-associated invariant chainpeptide). The removal of CLIP is facilitated by HLA-DM via directbinding to the alpha-beta-CLIP complex so that CLIP is released.HLA-DM stabilizes MHC class II molecules until primary highaffinity antigenic peptides are bound. The MHC II molecule boundto a peptide is then transported to the cell membrane surface. InB-cells, the interaction between HLA-DM and MHC class II moleculesis regulated by HLA-DO. Primary dendritic cells (DCs) also toexpress HLA-DO. Lysosomal microenvironment has been implicated inthe regulation of antigen loading into MHC II molecules, increasedacidification produces increased proteolysis and efficient peptideloading.	Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Is required in the specific splicing of CDKN1A pre-mRNA; thefunction probably involves the recruitment of U2AF2 to the mRNA.Is proposed to recruit PPIL1 to the spliceosome. May be involvedin cyclin-D1/CCND1 mRNA stability through the SNARP complex whichassociates with both the 3'end of the CCND1 gene and its mRNA.Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediatedtranscriptional repression, and retinoid-X receptor (RXR)- andvitamin D receptor (VDR)-dependent gene transcription in a cellline-specific manner probably involving coactivators NCOA1 andGRIP1. Is involved in NOTCH1-mediated transcriptional activation.Binds to multimerized forms of Notch intracellular domain (NICD)and is proposed to recruit transcriptional coactivators such asMAML1 to form an intermediate preactivation complex whichassociates with DNA-bound CBF-1/RBPJ to form a transcriptionalactivation complex by releasing SNW1 and redundant NOTCH1 NICD.{ECO:0000269\|PubMed:10644367, ECO:0000269\|PubMed:11278756,ECO:0000269\|PubMed:11371506, ECO:0000269\|PubMed:11514567,ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12840015,ECO:0000269\|PubMed:14985122, ECO:0000269\|PubMed:15194481,ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:18794151,ECO:0000269\|PubMed:19818711, ECO:0000269\|PubMed:21245387,ECO:0000269\|PubMed:21460037, ECO:0000269\|PubMed:28076346,ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:9632709}. (Microbial infection) Is recruited by HIV-1 Tat toTat:P-TEFb:TAR RNA complexes and is involved in Tat transcriptionby recruitment of MYC, MEN1 and TRRAP to the HIV promoter.{ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:19818711}. (Microbial infection) Proposed to be involved intranscriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressedpromoters. {ECO:0000269\|PubMed:10644367}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for HLA-DRA_SNW1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HLA-DRA_SNW1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
HLA-DRA	HLA-DMB, MBP, CD82, CD63, PKM, HSP90AA1, HSPA8, ANXA11, HSP90AB1, ATP1B1, YWHAE, MS4A1, MARCH1, KIAA0922, ATP2B2, CELSR1, DCBLD2, NETO2, STIM1, EIF2AK3, PLXNA1, HLA-DRB1, HLA-DRB5, SCARB1, TMEM97, POMT2, SLC25A16, LNPEP, CHST12, TCTN2, KLK4, CNTNAP3, LRIG1, IMPAD1, TMEM206, EPHB4, EPHA3, MAN2A2, LRFN3, DDX19B, TLR3, TOLLIP, KCNIP4	SNW1	SKI, RBPJ, CIR1, HDAC2, SIN3A, NCOR2, SND1, NOTCH1, NOTCH3, ASCC2, RB1, RBL1, RBL2, SMAD2, SMAD3, SMAD4, SKIL, VDR, PABPN1, MYOD1, RXRA, NCOA2, NCOA1, TCEA2, CCNT1, MYC, CDK9, KMT2A, MEN1, IKBKG, PCBD2, TRIM15, ZSCAN1, SRRM1, NCOR1, EP300, TADA2A, PRPF8, UBR5, ZMAT3, EFTUD2, HNRNPU, DDB1, SFPQ, DDX23, CDC5L, HSPA5, PFKL, ABCF2, TUBB4A, EEF1G, EEF1A1, TUBB1, MSH2, NR0B1, NR0B2, ACTN2, CKAP5, MAPK6, TNNT1, VAV2, SIRT7, PRKAA2, CUL3, CUL2, DAXX, LNX1, MAGEA1, TOP1, PABPC1, CWC27, DHX38, SKIV2L2, DHX15, SNRPD2, DDX5, RAD21, EIF4A3, MAGOH, NHP2L1, SART1, CTNNBL1, XAB2, SNIP1, MFAP1, ZNF830, CXorf56, TTC14, HDAC11, HECW2, AURKB, TP53, TUBGCP3, GOLGA2, TRAF1, IKZF1, MTUS2, TFIP11, PPIL1, CEP55, TEX11, RINT1, LZTS2, KRT40, NXF1, MSL1, ZDHHC17, CUL7, OBSL1, SIRT1, RARA, SUZ12, RNF2, BMI1, OCLN, SNRPA1, DHX8, TSSC4, USB1, FHL3, PPIE, WDR83, CCDC94, LUC7L2, HSPB1, NTRK1, GCN1L1, HARS, HNRNPR, PFKM, PRPF4, SEPT2, SEPT7, SNRNP200, BUD31, CDC40, CRNKL1, PFKP, PLRG1, PRPF19, SARS, TRMT6, SYF2, TTC37, VARS, MUS81, KRAS, SF3B4, SYNCRIP, CPSF4, HNRNPA0, EBNA1BP2, CLP1, CPSF6, SRSF3, HNRNPA3, RBMX, CPSF1, HNRNPA1, HNRNPAB, HNRNPD, NCBP1, PCF11, LUC7L3, PPP2R1B, PRPF40A, METTL3, SRSF2, SRSF5, SRSF6, SNRPB2, RBM10, SRSF11, DDX46, PPP1CA, LOC102724594, BCAS2, SF3A1, CHERP, SF3A3, SF3B2, DDX42, U2AF2, HNRNPK, TRUB1, CSTF3, ELAVL1, XRN2, SNW1, U2SURP, TARDBP, SF3B3, SF3B1, PRPF6, FUS, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HSPA8, HNRNPM, NONO, GEMIN4, PCBP1, SF3B6, CPSF3, EXOSC10, CPSF2, LUC7L, RBM4, SRSF1, SMN1, SMN2, SNRNP70, SNRPD3, U2AF1, CPSF7, RBM17, HNRNPLL, SNRNP40, RBM39, BZW1, PDCD6IP, SNUPN, ACTR1A, CDK3, STAG1, TUBB3, SEC23B, ARFGEF2, MAGED2, COPS6, CHD3, CHD4, WDR5, PKP3, KTI12, ARAP1, CSK, DCTN1, DDX1, DHX9, DOCK1, DOCK2, MLKL, CTTN, PUF60, ACIN1, WAPAL, XPO6, DNAJC13, SRRM2, GTPBP4, XRCC6, NIPBL, SEC31B, LDLRAP1, KIAA1279, ZNF326, BABAM1, GSPT1, OLA1, PIK3R4, IK, ILK, KPNA1, MLH1, ATM, PAK1, METTL13, CDK12, POLE, ATR, APBB1IP, ATRX, PPP2R1A, KIF27, UBE2Q1, CHD7, PRKAG1, ASUN, EXOC1, CAND1, MAP2K2, MAP2K3, LRRC47, TAOK1, PURA, WIZ, BLM, NCAPG, RBM15, YTHDC2, SRP19, AURKA, TTK, VASP, VRK1, NUP37, SPATA5L1, SHOC2, FIP1L1, DIAPH3, RIOK1, USP48, FYTTD1, RAE1, COPS3, API5, AP3B1, FUBP1, CPNE3, OTULIN, BCL7C, TRIP12, GNA14, AQR, CDK1, TOX4, G3BP2, NUP153, PSMC3, ACTB, SMC4, DNM1L, TUBB, ACTR2, RAD50, TRAP1, TUBA4A, PSMC6, DDX39A, PAK4, TUBB4B, NDC80, DCTN2, CCT7, CCT4, CCT2, EXOC5, KHDRBS1, CCT8, NUDC, SEPT9, TUBGCP2, RUVBL2, SUGT1, EHD1, KIF2C, CHEK1, DDX19B, PSMC1, RBM45, COPA, COPB1, CSE1L, AP1B1, SPATA5, DFNA5, DIAPH1, DYNC1LI2, DNM2, DSP, FASN, LRWD1, FEN1, COPG1, RALY, CCT5, CNOT1, MDN1, EXOC7, SMCHD1, NCAPH, ORC6, ORC3, KIF4A, HSPA12A, INTS1, PHGDH, VPS33B, COPG2, ZNF638, FHOD1, RACGAP1, MSH6, PARVB, HDLBP, HELLS, EHD4, DNAJA1, HSP90AA1, HSP90AB1, HSPD1, ARCN1, KIF11, KPNB1, KPNA2, LIMS1, LMNA, MRE11A, MYH9, NBN, DRG1, NSF, ORC2, ORC4, ORC5, UCHL5, DDX41, GULP1, RTCB, PLEC, PLK1, PNN, POLD1, ANLN, RIF1, FANCI, DDX19A, ABCF3, WDR33, CDKN2AIP, KIF21A, FERMT1, LRRC40, SCYL2, NSUN5, IPO9, ENAH, PARVA, EXOC2, PKN2, UNC45A, PRKDC, MAP2K7, RAD18, SMARCAD1, PSMC2, PSMC4, PSMC5, PSMD1, PSMD2, PSMD3, PSMD11, PSMD12, PSMD13, WDR18, TWF1, SHROOM3, CHD8, RANBP2, RANGAP1, RBBP5, RBBP7, UPF1, RFC2, RFC3, RFC4, RFC5, EXOC4, RPA1, SRSF7, ANAPC1, EPS8L2, FAM129B, INTS3, HLTF, SPTAN1, SPTBN1, SRP54, SRP68, SRP72, TCP1, BUB1, BUB1B, TLN1, TMPO, HSP90B1, CCT3, TUBG1, UBE2N, VIM, AHNAK, DDX39B, CDC73, UBA5, MYO15B, SYMPK, SEH1L, CAPG, SMC1A, UBL4A, ARID1A, CAPZA1, PICALM, EPPK1, NUF2, MAD1L1, CUL1, SMARCA5, RUVBL1, CDC23, IQGAP1, CCNB1, HIP1R, UBE2M, BTAF1, CCT6A, SMC3, ARHGEF1, DEPDC7, ARHGEF2, BUB3, PDLIM7, TRIP13, ROCK2, CHD1L, NUP155, NCAPD2, OXSR1, CDC27, MVP, TUBA1B, EXOC3, SNRPE, DVL3, ELAVL2, C11orf57, SNRPG, KIAA1143, SNRPF, ZC3H18, CD2BP2, EAPP

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for HLA-DRA_SNW1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for HLA-DRA_SNW1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-DRA	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	HLA-DRA	C0026769	Multiple Sclerosis	1	CTD_human
Hgene	HLA-DRA	C0030567	Parkinson Disease	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 16377

FusionGeneSummary for HLA-DRA_SNW1

FusionProtFeatures for HLA-DRA_SNW1

FusionGeneSequence for HLA-DRA_SNW1

FusionGenePPI for HLA-DRA_SNW1

RelatedDrugs for HLA-DRA_SNW1

RelatedDiseases for HLA-DRA_SNW1