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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16315

FusionGeneSummary for HKR1_CEACAM7

check button Fusion gene summary
Fusion gene informationFusion gene name: HKR1_CEACAM7
Fusion gene ID: 16315
HgeneTgene
Gene symbol

HKR1

CEACAM7

Gene ID

284459

1087

Gene nameHKR1, GLI-Kruppel zinc finger family membercarcinoembryonic antigen related cell adhesion molecule 7
SynonymsZNF875CGM2
Cytomap

19q13.12

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-related zinc finger protein 1oncogene HKR1zinc finger protein 875carcinoembryonic antigen-related cell adhesion molecule 7carcinoembryonic antigen CGM2carcinoembryonic antigen gene family member 2
Modification date2018052320180522
UniProtAcc

P10072

Q14002

Ensembl transtripts involved in fusion geneENST00000591471, ENST00000589218, 
ENST00000544914, ENST00000591417, 
ENST00000592168, ENST00000392153, 
ENST00000589392, ENST00000324411, 
ENST00000591259, ENST00000541583, 
ENST00000591134, ENST00000586897, 
ENST00000599715, ENST00000006724, 
ENST00000338196, ENST00000401731, 
ENST00000602225, 
Fusion gene scores* DoF score7 X 4 X 6=1684 X 3 X 4=48
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HKR1 [Title/Abstract] AND CEACAM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A891-01AHKR1chr19

37838774

+CEACAM7chr19

42191152

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000591471ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000591471ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000591471ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000591471ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000591471ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
intron-5UTRENST00000589218ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
intron-5UTRENST00000589218ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
intron-5UTRENST00000589218ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
intron-5UTRENST00000589218ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
intron-5UTRENST00000589218ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000544914ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000544914ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000544914ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000544914ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5UTR-5UTRENST00000544914ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591417ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591417ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591417ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591417ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591417ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000592168ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000592168ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000592168ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000592168ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000592168ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000392153ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000392153ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000392153ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000392153ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000392153ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000589392ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000589392ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000589392ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000589392ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000589392ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000324411ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000324411ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000324411ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000324411ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000324411ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591259ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591259ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591259ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591259ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591259ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000541583ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000541583ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000541583ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000541583ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000541583ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591134ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591134ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591134ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591134ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000591134ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000586897ENST00000599715HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000586897ENST00000006724HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000586897ENST00000338196HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000586897ENST00000401731HKR1chr19

37838774

+CEACAM7chr19

42191152

-
5CDS-5UTRENST00000586897ENST00000602225HKR1chr19

37838774

+CEACAM7chr19

42191152

-

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FusionProtFeatures for HKR1_CEACAM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HKR1

P10072

CEACAM7

Q14002

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HKR1_CEACAM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HKR1_CEACAM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HKR1CDK11ACEACAM7CEACAM1, CEACAM6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HKR1_CEACAM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HKR1_CEACAM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource