![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 16311 |
FusionGeneSummary for HK2_ZNF121 |
![]() |
Fusion gene information | Fusion gene name: HK2_ZNF121 | Fusion gene ID: 16311 | Hgene | Tgene | Gene symbol | HK2 | ZNF121 | Gene ID | 29911 | 7675 |
Gene name | hook microtubule tethering protein 2 | zinc finger protein 121 | |
Synonyms | HK2 | D19S204|ZHC32|ZNF20 | |
Cytomap | 19p13.13 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Hook homolog 2h-hook2hHK2hook homolog 2 | zinc finger protein 121zinc finger protein 121 (clone ZHC32)zinc finger protein 20 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P52789 | P58317 | |
Ensembl transtripts involved in fusion gene | ENST00000290573, ENST00000409174, | ENST00000590933, ENST00000586602, ENST00000320451, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: HK2 [Title/Abstract] AND ZNF121 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A891-01A | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000290573 | ENST00000590933 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
5CDS-5UTR | ENST00000290573 | ENST00000586602 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
5CDS-5UTR | ENST00000290573 | ENST00000320451 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
5CDS-intron | ENST00000409174 | ENST00000590933 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
5CDS-5UTR | ENST00000409174 | ENST00000586602 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
5CDS-5UTR | ENST00000409174 | ENST00000320451 | HK2 | chr2 | 75101576 | + | ZNF121 | chr19 | 9679758 | - |
Top |
FusionProtFeatures for HK2_ZNF121 |
![]() |
Hgene | Tgene |
HK2 | ZNF121 |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HK2_ZNF121 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HK2_ZNF121 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
HK2 | UBQLN1, PRKCE, ELAVL1, SLC2A4, UBQLN4, NUDCD3, ITGA4, PARK2, FBXO6, ARIH2, FNTA, H2AFV, HEXB, IPO5, NUBP1, PDLIM1, WDR61, PYGL, EGFR, MAGEA12, CNBP, BUB3, HYOU1, PPME1, SRM, TBCB, TPP2, MARS, SEPT10, SEPT6, NTRK1, HSP90AA1, RAD18, IRF3, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, COQ9, NDUFA4, C15orf48, HK1, HK3, TES | ZNF121 | MYC, BARD1, RPSA, MPHOSPH8, ZBTB48, ZNF324B, CDX1, ZNF169, ZNF286A, RPS14, ZNF2, RBM4, ZNF512, GLTSCR2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HK2_ZNF121 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HK2_ZNF121 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HK2 | C0028754 | Obesity | 1 | CTD_human |
Hgene | HK2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |